Peptides that work with nasal sprays

WisGal64

@diegoc said in Peptides that work with nasal sprays:

Any particular reason as have you tested?

I was just about to whip up VIP and PT141 for shits and giggles

did you figure it out? I'm looking to recon VIP as a spray. There is some info/evidence around it being administered nasally. https://pubmed.ncbi.nlm.nih.gov/23444784/
https://pmc.ncbi.nlm.nih.gov/articles/PMC3738270/

Couldn't find much for subQ

Randy

Intranasal should work for VIP. Two other rats i know have ran it this way and raved.

MyB

Technically anything with a Dalton weight under 500 will work.
Glutathione works because its 307.32 daltons

WisGal64

@MyB said in Peptides that work with nasal sprays:

Technically anything with a Dalton weight under 500 will work.
Glutathione works because its 307.32 daltons

This is what I was looking for! Glad to see it can be nasal, going to give it a try. I wanted to try this route since Liposomal didn't really get anything from it. Don't really want to try the SubQ, GHK sting is bad enough

Do you have a recipe you use?

MyB

@wisgal64 recipe for glutathione intranasal? I use 2ml bac water and 5ml of sterile .9% saline that’s intended for a nebulizer. Adding the bac water helps with absorption because I’ve made it with just saline and it didn’t have the same effect. It will have a sulfur smell. Not overwhelming.
Here’s a research article if you’d like to dive deeper into intranasal administration.
https://wjbphs.com/sites/default/files/fulltext_pdf/WJBPHS-2025-0913.pdf

WisGal64

@MyB said in Peptides that work with nasal sprays:

@wisgal64 recipe for glutathione intranasal? I use 2ml bac water and 5ml of sterile .9% saline that’s intended for a nebulizer. Adding the bac water helps with absorption because I’ve made it with just saline and it didn’t have the same effect. It will have a sulfur smell. Not overwhelming.
Here’s a research article if you’d like to dive deeper into intranasal administration.
https://wjbphs.com/sites/default/files/fulltext_pdf/WJBPHS-2025-0913.pdf

Thank you! I'll check it out

brithus

I have successfully tested the following peptides and efficacy seems as good if not better for most.

VIP
DSIP
Selank
Pinealon
Pe-22-28

pep_researcher

@MyB said in Peptides that work with nasal sprays:

Technically anything with a Dalton weight under 500 will work.

THIS! Yes it has to do with the Dalton molecular weight of the peptide for it to be absorbable via nasal route.

Hammertime65

I've just been told I should make VIP into a nasal spray for my chronic sinus issues (have to use nasal spray at night or my sinuses plug shut, steroids don't help). I don't have a clue how to do that. Didn't even know what VIP was. Are there directions for dummies somewhere?

vpeps

Usually, 2-peptides and 3-peptides work intranasally, with some exceptions like Thymogen dipeptide (Glu-Trp). It's best to check individually. 4+-peptides like epithalon are less absorbable this way due to the larger size.

BPC-157

@MyB said:

Technically anything with a Dalton weight under 500 will work.

The 500 Da limit is about crossing from the bloodstream into the brain (the Blood-Brain Barrier, or BBB).

1,000+ Da is still possible when we are talking about crossing from the nasal cavity into the brain/body (the nasal mucosa and the nose-to-brain pathway).

that's why things like MT2 which is over 1000 Da still work.

when you say "only up to 500 Da," you are thinking of injected peptides trying to cross the BBB.

peptides >1,000 Da still work intranasally, we are talking about sprayed peptides using the nose-to-brain pathway.

MyB

@bpc-157 post your medical/scientific sources.

BPC-157

@MyB be more specific with your question.

you can just look up the Molecular Weight (Da) of any peptide online yourself.

Peptide Approx. Molecular Weight (Da)
examples:

Glutathione ~307
Noopept ~251
KPV ~400
Pinealon ~404
Epithalon ~488
Semax ~751
Selank ~752
TB-500 (fragment) ~889
GHK-CU ~909
AHK-CU ~900-950
PE-22-28 ~900 (estimated)
DSIP ~1,000 (borderline)

Just to be clear: peptides that are >1000 Daltons can still be made to work in spray form like Melanotan II ~1,024 (Da) but they need permeation enhancers to be effective.

you can't just use BAC water on any peptide mix it up and spray expecting results.

the closer you get to 1000 the less effective they will be.
Pinealon, Epithalon, Semax and Selank are widely "researched" intranasally because of their low molecular weight.

MyB

@bpc-157 I use the KISS (keep it simple stupid). When I say 500 daltons it’s because that’s the MW that can pass through skin for absorption. When I say 300 daltons it’s because it can pass to the bloodstream.
You saying 1K dalton works but failing to mention a transporter is required is setting new researchers up for failure.
When I ask for receipts on your citations I was expecting something like this. Which explains absorption pathways, molecular weights, types of transporters, and how lipo, hydro, and charge matter.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6254717/

BeeKind

@BPC-157 oxytocin is over 1000k - that would explain why I have had zero reaction to it in nasal spray form.

stevencarter

I was about to make oxytocin spray because I thought everyone was saying it worked Intranasally. Now @bpc-157 says it dont work. I tried it subq before I knew the difference in systemic effects going subq. 150mcg shot in the belly of my chupacabra gave him a headache like professor x in the one movie where they had the battle of the wheelchair minds with that homeless looking kid. Anyways oxytocin intranasally is a go or no go?

diegoc

Honestly i didnt feel much, not even mixed with PT141

I keep going back to SUBq on everything including semax but i whip up a nasal of semax and when im doing the protocol I inject subq in the morning and nasal in the afternoon.

Im doing Melatonan1 subq and 5m in i start getting nausea, you see i dont see instant gratification with nasal