Peptides that work with nasal sprays

[pep_researcher]

@MyB said in Peptides that work with nasal sprays:

Technically anything with a Dalton weight under 500 will work.

THIS! Yes it has to do with the Dalton molecular weight of the peptide for it to be absorbable via nasal route.

[Hammertime65]

I've just been told I should make VIP into a nasal spray for my chronic sinus issues (have to use nasal spray at night or my sinuses plug shut, steroids don't help). I don't have a clue how to do that. Didn't even know what VIP was. Are there directions for dummies somewhere?

[vpeptides]

Usually, 2-peptides and 3-peptides work intranasally, with some exceptions like Thymogen dipeptide (Glu-Trp). It's best to check individually. 4+-peptides like epithalon are less absorbable this way due to the larger size.

[BPC-157]

@MyB said:

Technically anything with a Dalton weight under 500 will work.

The 500 Da limit is about crossing from the bloodstream into the brain (the Blood-Brain Barrier, or BBB).

1,000+ Da is still possible when we are talking about crossing from the nasal cavity into the brain/body (the nasal mucosa and the nose-to-brain pathway).

that's why things like MT2 which is over 1000 Da still work.

when you say "only up to 500 Da," you are thinking of injected peptides trying to cross the BBB.

peptides >1,000 Da still work intranasally, we are talking about sprayed peptides using the nose-to-brain pathway.

[MyB]

@bpc-157 post your medical/scientific sources.

[BPC-157]

@MyB be more specific with your question.

you can just look up the Molecular Weight (Da) of any peptide online yourself.

Peptide Approx. Molecular Weight (Da)
examples:

Glutathione ~307
Noopept ~251
KPV ~400
Pinealon ~404
Epithalon ~488
Semax ~751
Selank ~752
TB-500 (fragment) ~889
GHK-CU ~909
AHK-CU ~900-950
PE-22-28 ~900 (estimated)
DSIP ~1,000 (borderline)

Just to be clear: peptides that are >1000 Daltons can still be made to work in spray form like Melanotan II ~1,024 (Da) but they need permeation enhancers to be effective.

you can't just use BAC water on any peptide mix it up and spray expecting results.

the closer you get to 1000 the less effective they will be.
Pinealon, Epithalon, Semax and Selank are widely "researched" intranasally because of their low molecular weight.

[MyB]

@bpc-157 I use the KISS (keep it simple stupid). When I say 500 daltons it’s because that’s the MW that can pass through skin for absorption. When I say 300 daltons it’s because it can pass to the bloodstream.
You saying 1K dalton works but failing to mention a transporter is required is setting new researchers up for failure.
When I ask for receipts on your citations I was expecting something like this. Which explains absorption pathways, molecular weights, types of transporters, and how lipo, hydro, and charge matter.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6254717/

[BeeKind]

@BPC-157 oxytocin is over 1000k - that would explain why I have had zero reaction to it in nasal spray form.

[stevencarter]

I was about to make oxytocin spray because I thought everyone was saying it worked Intranasally. Now @bpc-157 says it dont work. I tried it subq before I knew the difference in systemic effects going subq. 150mcg shot in the belly of my chupacabra gave him a headache like professor x in the one movie where they had the battle of the wheelchair minds with that homeless looking kid. Anyways oxytocin intranasally is a go or no go?

[diegoc]

Honestly i didnt feel much, not even mixed with PT141

I keep going back to SUBq on everything including semax but i whip up a nasal of semax and when im doing the protocol I inject subq in the morning and nasal in the afternoon.

Im doing Melatonan1 subq and 5m in i start getting nausea, you see i dont see instant gratification with nasal