Mots-c and SS-31
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@vpeptides Regarding NAD+ injections being "useless," any specific research that you can share on this? Anecdotally, the feedback within this community has been overwhelmingly positive (especially between the 50-100mg daily dosage. Could it really be all placebo effect? For context, what dosages were utilized in the studies you're referencing?
@WowwyZowwy See this article, for example.
In a recent pilot study, researchers found that NAD+ IVs did not elevate blood NAD+ until 24 hours after infusion—and then only by about 2% compared to baseline.6 This suggests that much of the infused NAD+ is broken down outside cells into smaller components like nicotinamide (NAM) or ADP-ribose.
In that same pilot study, those receiving NAD+ IV also experienced an elevated white blood cell count, which may indicate an inflammatory immune response. When extracellular NAD+ levels in the bloodstream rise above normal, as can happen with high-dose IV infusions, the body may interpret this as trauma within the body, leading to an immune response, and potentially causing inflammation.
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I came across a great video by Dr Brad Stanfield where he outlines a bunch of the NAD Literature and clinical data. He's not a peptide guy, he's a supplement guy, but the information is still excellent.
The main conclusion of the clinical data as some have already noted, is that high dosing just straight is not only as effective but also significantly cheaper and efficient.
The bigger question that gets covered in the video is 'does raising NAD Levels even make a difference?'. Again, using very recent clinical data as a reference, there isn't much evidence that raising NAD really makes much of a measurable difference.
I don't I'm allowed to post links here, but if you search on YouTube under "New Study Says I Was Wrong About NMN and NR?" , a video from Dr Brad Stanfield should appear and it's worth a listen if you are interested in the literature surrounding NAD.
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@commander running the same thing right now. The most I have stuffed into one cart is 7 vials of epitalon. I can only stuff 2 500mg NAD+ vials into one cart with 2.5ml bac water. A third will not dissolve (or fit.)
@ResearchCat said in Mots-c and SS-31:
@commander running the same thing right now. The most I have stuffed into one cart is 7 vials of epitalon. I can only stuff 2 500mg NAD+ vials into one cart with 2.5ml bac water. A third will not dissolve (or fit.)
I mix it like this...
NAD+ 500mg Bottle:
(25MG = 15iu) Mix 3cc in 500MG Bottle -
I came across a great video by Dr Brad Stanfield where he outlines a bunch of the NAD Literature and clinical data. He's not a peptide guy, he's a supplement guy, but the information is still excellent.
The main conclusion of the clinical data as some have already noted, is that high dosing just straight is not only as effective but also significantly cheaper and efficient.
The bigger question that gets covered in the video is 'does raising NAD Levels even make a difference?'. Again, using very recent clinical data as a reference, there isn't much evidence that raising NAD really makes much of a measurable difference.
I don't I'm allowed to post links here, but if you search on YouTube under "New Study Says I Was Wrong About NMN and NR?" , a video from Dr Brad Stanfield should appear and it's worth a listen if you are interested in the literature surrounding NAD.
@TrueNorth That's what kept me from buying nad+. Doesn't seem to do anything. I do take NH sublingual and that actually jazzed me up a little.
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I saw an ad for clinic and trainers on how to make a ton of money with NAD+ injections and/or IV’s. You basically blast the client with NAD+ for $400-1,000(I have seen $1,800 for IV’s) and the rush and energy they get brings them back every month.
That being said, I am finishing an NAD+ run now (50mg/day) and a MOTS-C cycle next week. I will definitely keep running MOTS-C for the observed increase in work capacity but don’t see the need to run NAD+ again in the short-medium run since I am crushing my current workout load.
(If we are going to talk about useless NAD+, let’s point at all the oral supplement pimps and laugh.
)Please set a funny and sarcastic signature line. It brings me joy. Thank you for your attention in this matter.
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I saw an ad for clinic and trainers on how to make a ton of money with NAD+ injections and/or IV’s. You basically blast the client with NAD+ for $400-1,000(I have seen $1,800 for IV’s) and the rush and energy they get brings them back every month.
That being said, I am finishing an NAD+ run now (50mg/day) and a MOTS-C cycle next week. I will definitely keep running MOTS-C for the observed increase in work capacity but don’t see the need to run NAD+ again in the short-medium run since I am crushing my current workout load.
(If we are going to talk about useless NAD+, let’s point at all the oral supplement pimps and laugh.
)@ResearchCat coming from the bodybuilding bro science i dealt with in highschool to young adulthood. i was always hammered from jump. orals arent safe when it came to anabolics since its more load on the liver and just not worth the efficacy loss. i know the stomach acids make alot of the glps basicly useless in oral form. but are absolutely any of the peptide orals useful? i contemplated looking into slu,atx, and bam. but shy'd away when all i could find is orals currently.
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@gym.rat basicly what i heard from my only pep friend. they vehemently hate slu lol
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@gym.rat i looked at medical journals for aod and adjusted my dose against the normal dosage instructions. and my testing instantly started working again. so. worse case you could double up and see if anything happens. as long as its within normal dosages. think people took as high as 54 mg of aod in testing. so my 1mg should be fine for example. haha
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@iMemphis18 said in Mots-c and SS-31:
@Commander out of curiosity, I don't disagree that its so much faster, but I feel like its a bit of a waste for certain peptides right?
For example, Tesamorelin, 10 MG, with 1ML Bac water, i do 2mg -- which is 20 units. After about 4-5 days, i need to refill again, swap vials etc.
or.... do people combine for example, 3 vials of Tesa, 10mg into the injection pen vial? This will def make each 3ML pen vial last longer. I am just curious on your thoughts. Been debating on $$ vs time saved. Especially since we need to buy the separate needle, then the 3 ML vial to go with the pen.
I put 3 vials of 10mg Tesa in the pen cart. That is how you save time.
@Commander Perfect! That's exactly what I was hoping to hear haha. Thank you so much
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@gym.rat i was giving examples. similar idea different chems. like this is what happens with aod. maybe its similar. if you look into effective dose of slu and adjust your dose with what caps you have left.
https://ujpronline.com/index.php/journal/article/view/1355/1932
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