Efficacy of nasal vs. subQ for neuro peptides
-
I recently did a trial of subQ PE-22-28 to evaluate mood enhancement and increased memory and learning with my post-stroke research guinea pig.
While there was some improvement it was slight so I decided to run a trial with nasal administration. The difference is very noticeable! Onset is much quicker and benefits are much more obvious.
I'm looking into possibly trialing DSIP & pinealon. Curious if anyone has researched others on subQ vs nasal that were revealed to have better efficacy with nasal route?
-
I do glutathione as a nasal spray because it crosses the blood brain barrier easier. It also increases glutathione in the brain significantly over subq or iv. As long as your peptide has a molecule weight under 500 daltons it is a candidate for nasal administration. If it is a peptide that crosses the BBB you will get better concentrations in the brain and nervous system via nasal administration.
You can test using a nasal dart. It is an atomizer with luer lock end. It can be reused as long as it is only reused on the same research subject. You will also want to dilute with saline because bac water alone stings something terrible.Follows research backed science, not the gym bro’s.
-
P PeptideCritic moved this topic from Cognition & Neuro on
-
I do glutathione as a nasal spray because it crosses the blood brain barrier easier. It also increases glutathione in the brain significantly over subq or iv. As long as your peptide has a molecule weight under 500 daltons it is a candidate for nasal administration. If it is a peptide that crosses the BBB you will get better concentrations in the brain and nervous system via nasal administration.
You can test using a nasal dart. It is an atomizer with luer lock end. It can be reused as long as it is only reused on the same research subject. You will also want to dilute with saline because bac water alone stings something terrible. -
@MyB oooh where do i get this nasal dart. the sites ive seen require licensed auth.
@yvonnehien-moore Amazon is where I got mine. They cost about $10 each.
Curaplex Dart Nasal Atomization...
amazon.com/dp/B08JY5NX53 -
@gym.rat In my experience, the GH stuff targets your deep sleep while the pinealon/epitalon target the REM sleep. That has been my experience during my research. I do use a ring to track my overall sleep, deep and REM. Cool stuff.
-
@gym.rat Dang that sucks. I guess that is why we all must do our own research. Everyone gets a different outcome and degrees of outcome.
Hello! It looks like you're interested in this conversation, but you don't have an account yet.
Getting fed up of having to scroll through the same posts each visit? When you register for an account, you'll always come back to exactly where you were before, and choose to be notified of new replies (either via email, or push notification). You'll also be able to save bookmarks and upvote posts to show your appreciation to other community members.
With your input, this post could be even better 💗
Register Login