@HockeyRat said: @ResearchCat I never had any acid reflux issues while one Reta until recently I started 5mg daily tadalifil and its absolutely horrible. I started taking 10mg of pepcid along with the tadalifil. Does the water have an effect also? Ive been drinking at least a gallon a day to help with high hematocrit. Yeah, the tadalafil will make reflux worse because it relaxes the lower esophageal sphincter. I started taking it in the morning and it got a lot better. I still get a bit of reflux but not as bad as it was. I think the water may also make it worse just because i drink lots of it and think maybe it makes things back up a bit.