Agree, patients and baby steps. On my first Reta vial I started w .5mg on my first week. I felt it right away within my first the week. Second and third week I titrated to 1mg. Fourth I titrated to 2mg. My goal was to eventually max 4mg. I had to dialed it down because I started to feel allodynia. Lesson here is find your sweet spot. With enough hunger to supplement a heathy diet of protein at the center of your meal to prevent muscle loss. Find your sweet spot, mine still is 1mg of Reta and 1mg of MOTs-C and NAD+ daily or every other day.