Skip to content
Peptide Critic Community

Peptide Critic Community
  1. Randy the Rats Research Forum
Monthly Contest

No contest currently running. Check back soon!

World

Topics from outside of this forum. Views and opinions represented here may not reflect those of this forum and its members.

A world of content at your fingertips…

Think of this as your global discovery feed. It brings together interesting discussions from across the web and other communities, all in one place.

While you can browse what's trending now, the best way to use this feed is to make it your own. By creating an account, you can follow specific creators and topics to filter out the noise and see only what matters to you.

Ready to dive in? Create an account to start following others, get notified when people reply to you, and save your favorite finds.

Register Login
  • P
    P PeptideCritic
    Peptide Discussion

    Discussion thread for the blog post on PeptideCritic.com.

    📖 Read the article: I Clicked the First Peptide Ad Facebook Showed Me. Every COA Was Stolen.

    Share your thoughts, ask questions, or continue the conversation below!

    6 0 5 Reply
    M mitchelldemeter
    Full disclosure, I work for Peptriva (research-use-only compounds), so read this knowing that. Can't help with anything use-related, but stolen COAs are worth talking about because they're getting more common, not less. The frustrating part is a stolen COA looks exactly like a real one, because it is one. It's just someone else's. A few ways to actually catch it: Check the lot number against what's on the vial you'd receive. Ad-scam sites reuse one document across every product, so the lot either doesn't match anything or shows up on ten different listings. Reverse-image-search the COA or google a distinctive string from it. If the same doc shows up on another vendor's site, there's your answer. Email the lab on the letterhead and ask if they tested that lot for that company. Real labs answer this. Janoshik does, and any ISO 17025 lab will confirm or deny a report they issued. A vendor whose COAs survive that phone call has nothing to hide, and honestly that's the test I'd want buyers applying to us too. And yeah, the fact that these accounts block anyone who asks for documentation tells you everything before the COA does.
  • N
    N NanaNona
    Peptide Discussion

    I’m a beginner. I’m researching Tirzepatide. I look at the COAs and see that the Tirzepatide is eluting at 15 min. I’ve read it should elute at 4-8 minutes. So why can’t I find any? Do you guys know of a lab that sells Tirzepatide that elutes at 4-8 minutes ?

    Thanks in advance.

    10 0 1 Reply
    vpeptidesV vpeptides
    @mitchelldemeter OK, maybe you can answer me this LC-MS question. For example, during synthesis of EDR they messed up and made it in reverse: RDE. Will it be detected or we will think it's EDR because the mass is the same? Or, in a longer peptide chain, if 2 amino acids are swapped because of operator error. Sometimes it is possible, as I understand. The total number of amino acids in the chain will be the same, just the order is different. Can it be detected?
  • J
    J joeyholt
    Vendor Reviews & Orders

    Hello,

    Has anyone tried Value Research Labs or Northline Peptides? Value Research Labs has some good deals but not sure if its legit. I’m new to the peptide game so any help would be appreciated. Thank you.

    3 0 0 Reply
    BeeKindB BeeKind
    @joeyholt as a newbie you're in a really good place if you found this forum. Spend a couple of weeks at least doing research and reading peoples experiences before purchasing or injecting. Just a suggestion. I wish I found this community when I first started, could have saved myself some money and a few weeks of being horribly sick.
  • M
    M mikepinkerton
    Peptide Discussion

    Has anyone made kpv into a oral spray?If so what mix did you use and was it effective?

    0 0 0 Reply
  • M
    M mitchmiller
    Vendor Reviews & Orders

    This is a post is to bring visibility to a vendor practice that I really disagree with. TDLR the issues I had were:
    Vial label didn't match the picture of the label in the COA (this was a minor issue in my mind)
    Vial label purity, mass, did not match the COAs listed purity or mass.
    Vial label QR code for COA went to a completely different COA than the one available on their website for that batch. That "other" COA also didn't match the purity or mass listed on the vial.

    For those still reading I emailed customer support because I wasn't comfortable with those discrepancies and asked for a replacement from a more recent batch. I've had good experiences with SA up until this point and have spent hundreds of dollars with them to date, so I'm not just trying to get a free vial out of it. Their response was dismissive saying that "The batch number and cap color match, that is the only things are need be a concern." They told me to send them back for a refund but they would not send a replacement. Ok I said send me an RMA, return shipping label, and confirmation that I would get a full refund. I also said that I feel like they were being dismissive of my concerns. They're response was the label is for convenience the only thing that matters is the batch number and cap color match the COA (even though the label lists the batch so its obviously more than just convenience), that they weren't dismissive at all, refunded me, and blocked my account.

    I am glad they refunded my order but the manner in which they conducted their business with a customer is really what concerns me about this vendor.

    7 0 1 Reply
    I icynemby
    @mitchmiller , I'm glad you got your money back. I've ordered from them a couple of times. They do post multiple active batches and do have a disclaimer that your order could come from any batch. I am very cautious with them for that reason, notwithstanding the ILS lab drama. If there is a chance that I could get a batch from March, 2026 when they have fresh new batches in inventory, I don't order.
  • BeeKindB
    BeeKindB BeeKind
    Vendor Reviews & Orders

    I know we're not fans of ILS labs right now but wanted to let everyone make their own choices and let them know that Southern Aminos is doing 45% off sitewide + 15% with an affiliate code and they will have flash sales from today through the 30th.

    7 0 1 Reply
    BeeKindB BeeKind
    @Reactive3078 Most of these companies do that, they jack up the price and then discount it to make it seem like a sale or they put an obscure price slashed out next to the "discounted price" - the flash sales however are where the savings are at if you are ever lucky enough to catch one. I don't seem to have that luck .
  • RandyR
    RandyR Randy
    Peptide Discussion

    For research use only. Not medical advice.

    The goal:

    Tirzepatide = GLP-1 + GIP
    Survodutide or Mazdutide = GLP-1 + Glucagon
    → Combined effect = GLP-1 + GIP + Glucagon, i.e., a retatrutide-like profile.

    Because both second agents have a glucagon hit, titration must be slower than usual to avoid nausea, low appetite floor, or excessive gastric slowing.

    Why do this?

    1. You stockpiled too much tirz.
    2. Break a stall.
    3. Reta itch/allodynia or other intolerable side effects when researching reta.

    1. Tirzepatide + Survodutide

    Survodutide has a stronger glucagon hit than mazdutide. This is the more potent combination.

    Weekly Titration Schedule

    Weeks 1–4

    Tirzepatide: 2.5 mg weekly

    Survodutide: 0.3 mg weekly
    Purpose: Establish baseline tolerability. Survo kicks hard early.

    Weeks 5–8

    Tirzepatide: 5 mg weekly

    Survodutide: 0.6 mg weekly
    Notes: Appetite suppression becomes extremely strong for many subjects here.

    Weeks 9–12

    Tirzepatide: 7.5 mg weekly

    Survodutide: 1.0 mg weekly

    This is the sweet spot for most research models. Strong “reta-like” effect emerges.

    Week 13+ Maintenance

    Two viable approaches:

    Standard Maintenance

    Tirzepatide: 7.5–10 mg

    Survodutide: 1.0–1.5 mg

    High-End (Aggressive) Maintenance

    Tirzepatide: 10–12.5 mg

    Survodutide: 1.5–2.0 mg

    Only for researchers replicating the high-end metabolic punch of retatrutide.

    Notes

    Survodutide plus tirz amplifies appetite suppression so hard that most people do not need high tirz dosing.

    Escalate slowly — both compounds slow gastric emptying.

    This combo is more GC-heavy than mazdutide, so itch issues are less common compared to retatrutide, but GI load is higher.

    1. Tirzepatide + Mazdutide (Ghetto Reta v2 — Milder, Cleaner)

    Mazdutide has a slightly softer glucagon hit and a less aggressive appetite cliff.
    This stack is smoother and usually more tolerable.

    Tirzepatide + Mazdutide

    Weeks 1–4

    Tirzepatide: 2.5 mg weekly

    Mazdutide: 2 mg weekly

    Weeks 5–8

    Tirzepatide: 5 mg weekly

    Mazdutide: 4 mg weekly

    Weeks 9–12

    Tirzepatide: 7.5 mg weekly

    Mazdutide: 6 mg weekly

    This combo mimics a “mid-dose retatrutide” effect without the itch or violent GI spike.

    Week 13+ Maintenance

    Tirzepatide: 7.5–10 mg

    Mazdutide: 6–8 mg

    High-End (Not common)

    Tirzepatide: 10–12.5 mg

    Mazdutide: 8–10 mg

    Notes

    Mazdutide is smoother but still synergistic with tirz.

    Appetite suppression is strong but less harsh than survo stacks.

    GI load increases if escalated too fast — keep 4-week steps.

    110 5 8 Reply
    read more →
    RandyR Randy
    @Snake-Pepskin i do all 3. #research
  • S
    S Sunshine_day
    Vendor Reviews & Orders

    I usually use Crush, but I have ordered from Southern Aminos, and Thrive peps. My first ever order was with Compound Sciences before I found other sellers with better stock and prices. I have a couple of work friends that ordered RUO tirzepatide from Peptides 4 Power, and they shared the link with me. It's relatively new I believe. The prices really look pretty darn good, and they have a lot of educational information about the peps and suggested dosing protocols.

    I was almost ready to order from them, but then couldn't find any COA's listed. When I asked the AI chat bot they have, it told me to go to the links on the product page, and I still couldn't find any such links. My friends already took their first injections. Should I encourage my friends to contact the seller and ask that the COA's be emailed to them? When I did some research it seems like the owner and operator is an influencer by the name of David Furka. Does anyone know anything about him? I know new businesses and websites sometimes have to work out kinks, maybe that's all it is. I hope my friends got a good safe product. I left a message on the website too. Who knows, maybe I'm just blind and can't see the COA links, or my phone's browser isn't jiving with the website. I tried it in desktop mode too, and couldn't find anything.

    2 0 0 Reply
    M mitchelldemeter
    Full disclosure, I work for Peptriva (research-use-only compounds), so factor that in. Can't help with anything use-related but COA stuff is basically my whole job, so. Honestly you kind of answered your own question. If you have to go hunting or email a vendor to get a COA, that tells you most of what you need to know. Vendors doing it right just put it on the product page, per batch. If they do send you one, look for the lot number first. No lot number means it's a generic doc they could be reusing across everything. Then check it actually names the methods, LC-MS for identity and HPLC for the purity number. Endotoxin and microbial should show up as their own line items too, the purity % doesn't cover those. One thing people miss: if every product on a site comes back exactly 99.9%, that's worse than seeing a bit of spread. Real results vary. And after the whole Paradigm thing, worth remembering a vendor's own COA can just be made up. The only thing that actually settles it is independent testing, either an ISO 17025 lab or customer-submitted Janoshik results. Same standard applies to us, for what it's worth.
  • senex_musS
    senex_musS senex_mus
    Results & Lifestyle

    Triz 7 weeks. Then transitioned to Reta due to severe stomach problems on triz. 1/4 of a year. Hoping to lose some belly fat soon...

    dexa-scan.jpg

    2 0 6 Reply
    WesEqualshXcW WesEqualshXc
    This is awesome! You’re doing great. I’ll bet your pants fit better and your belt is a notch tighter. The belly fat will come off soon enough. The first person in the elevator is usually the last person to get off.
  • PeppiP
    PeppiP Peppi
    Introductions

    Hey, I love this this platform. Does anybody want to share their rat picture?

    14 0 1 Reply
    senex_musS senex_mus
    my test subject riding the dreaded 5 legged panda! [image: 1786589039976-mouse.jpg]
  • E
    E Eleanor
    Results & Lifestyle

    I'm going to try this because I am as this guy describes, still tired and sleepy after taking it in the AM.

    https://youtu.be/Fj9M2NQs6K0?si=laBzOtoXhOCUD6ZH

    11 0 1 Reply
    E eleiscolton
    Hi im completely new here and have been interested in talking peptides to help my Graves disease. Any information about what I could possibly take would be much appreciated.
  • EXTROPIANE
    EXTROPIANE EXTROPIAN
    Peptide Discussion

    Pets on peptides.
    https://x.com/i/status/2080322162565812621

    19 0 1 Reply
    EXTROPIANE EXTROPIAN
    More pets on PETides https://x.com/i/status/2087299592039932086
  • pep_researcherP
    pep_researcherP pep_researcher
    Peptide Discussion

    The lyophilized peptide vial rubber tops are have become hard to pierce. Hard with all 23G, 25G leur locks, and 30G 31G insulin noodles too.

    Found across vials from multiple vendors and across multiple people I know who do RUO research.

    Anyone else experiencing this? This wasn't happening with RUO vial tops 6 months ago.

    31 0 0 Reply
    EXTROPIANE EXTROPIAN
    [image: 1786580624214-prd2016injectionport401.png] Or you can use an injection-port with a Luer lock needle. You might be able to pull with a insulin needle.
  • P
    P PeptideCritic
    Peptide Discussion

    Discussion thread for the blog post on PeptideCritic.com.

    📖 Read the article: ILS Labs Can’t Fill Out a PDF, but Please "Trust the Science"

    Share your thoughts, ask questions, or continue the conversation below!

    31 0 1 Reply
    K k3p13r
    @pep_researcher Glad to send to Randy but I don't see a way to DM or other contact info. I get a free retest from ILS, going to try that and see if a third time is the charm.
  • P
    P Peptide geek
    Peptide Discussion

    Hey guys , just started researching MT1 been seeing that people take 300 mcgs once a week for 1-2 weeks then go up to about 500 mcgs after that as maintenance, and cycle it about 8 weeks. Just wanted to double check here with what other people have done with solid results.

    Regarding side effects I haven’t really seen anything to concerning , does anybody know any other potential risks with MT1?

    12 0 0 Reply
    vpeptidesV vpeptides
    In the references it's said the lighter is your skin the more of it you need. And you will start noticing the effects in 3-4 weeks.
  • pep_researcherP
    pep_researcherP pep_researcher
    Peptide Discussion

    QQ:

    • If Nexaph and EZ are the same and EZ lyophilize in the US, does that mean Nexaph stuff is US lyophilized too?

    • Is stateside lyophilization better over getting finished vials from China?

    • Reg the recent endotoxin discovery in some batches, was it introduced in lyophilization and finishing process or came from the raw powders?

    • Do stateside lyophilizers conduct any testing on raw powders before lyophilization?

    With the drama around ILS and Kovera, and many original favs moving to them, my vendor choice process needs a revisit.

    31 0 0 Reply
    read more →
    F flyhigh
    @pep_researcher the advantage of stateside freeze/drying (lypho) is it allows for better quality control assuming you start with good raw api, but its an art form as each peptide has its own characteristics of sublimation. 2ndly, endo's can be introduced at any stage of production upto sealing the vial and good practice requires having the raw tested just like a vial before starting the process. So the fill finisher should know what the quality is before production and the API may be used in multiple batches when it is bought in the KG sizes. Also, I believe Nexaph is a stateside fill finisher per K-Hole.
  • C
    C chrisneff
    Vendor Reviews & Orders

    This is a vendor review submitted by chris on PeptideCritic.com.

    Rating: ⭐⭐⭐⭐⭐ (5/5)

    Review

    I can honestly say Studz Peptides has been one of the best vendors I’ve ever dealt with, not just in this space, but in any space period.

    The first thing that stands out is how fast they are. Their processing time is the fastest I’ve ever seen. Orders are handled quickly, shipping is fast, and they even offer shipping insurance, which gives you extra peace of mind. From start to finish, the entire process feels smooth, professional, and reliable.

    Their customer service is also top-tier. They actually care about the people supporting them. They’re easy to talk to, respectful, and willing to work with you through anything. If there’s ever an issue, they make it right instead of brushing people off. That alone says a lot about the type of people running the company.

    The prices are amazing, especially considering the level of service, speed, and care they provide. On top of that, they’re constantly running sales, giveaways, and opportunities for the community. It never feels like they’re only in it for the money. It genuinely feels like they are here to help people, build something real, and take care of the people who support them.

    Another thing I respect is how open they are to feedback. They listen to advice, take suggestions seriously, and are always bringing in new products based on what the community wants. They continue to grow and improve instead of acting like they already have everything figured out.

    They also provide COAs and are constantly having products tested, which shows they care about quality and transparency. That level of accountability is important, and it’s one of the reasons people continue to trust them.

    The community around Studz is another major reason they stand out. It’s not just a vendor; it feels like a real group of people helping each other. The brothers running the company come across as genuine, honest, and passionate about what they’re building. They treat people like family, not just customers.

    Between the fast shipping, insane processing times, great prices, constant sales, giveaways, ambassador opportunities, customer service, testing, transparency, and the community they’ve built, Studz Peptides is easily one of the best companies I’ve ever supported.

    I would recommend them to anyone looking for a vendor that actually cares, listens, and goes above and beyond for their customers.

    🛒 Shop StudzPeptides

    📖 Read the full review: Overall best vendor I’ve ever done buisness with

    Discuss this review, share your own experiences, or ask questions about the vendor.

    Please keep discussions respectful and factual.

    107 0 3 Reply
    S StudzPeptides
    Hey to anyone here that saw our discussions about switching to vanguard, this most recent batch at vanguard came back great! Thank you guys for sticking with us during our transition over to them!
  • B
    B Bronze41
    Vendor Reviews & Orders

    I just want to post this as a compliment to Cain and Nexaph. I had 5 vials from the kit that had no vacuum at all. I was assured by Cain that there were no sterility issues and that 1 out of 3000 vials do not have a vacuum. Needless to say 50% of the kit not having a vacuum is a large statistical anomaly. The caps were not visibly damaged but definitely "askew" on the top of the vial and felt "loose" compared to other pep vials.

    I did not use any of those vials. I have read on telegram that several others have had the same issue with the batch I received as well. After several emails with Cain he graciously gave me a credit and I am very grateful. Just wanted to post this here for information's sake about Nexaph. I will definitely be buying more from them in the future with no hesitancy.

    5 0 7 Reply
    kenhnsyK kenhnsy
    Every time I have found no vacuum in a vial, I also had a split along the top of the crimp due to me removing the cap.
  • E
    E Eric_E_
    Vendor Reviews & Orders

    Company is more than willing to take your money and WILL NOT send the products I ordered. Complete lack of any meaningful communication to resolve the issue even after acknowledging my completed payment. I'm stopping short of calling them thieves at this point but their complete incompetence is criminal in itself. Please, DON'T GET SCAMMED!! ggpeps.net

    16 0 2 Reply
    Stan DouglasS Stan Douglas
    Does the scam site direct you to a look-a-like Discord too?
  • C
    C CapmanCrunch
    Vendor Reviews & Orders

    Received my 5th order from Nexaph today. Fast shipping, good prices and documentation and everything seems to be of good quality. I am relatively new to peptides (been lurking about for a couple of years) but I have tried about 10 different vendors and unless I am looking for a specialty item of some kind, they are the only company that it makes sense for me to buy from at this point.
    I like their kit pricing, but I'm hoping to get better pricing on the wholesale side. The wholesale pricing doesn't seem to be very good from any of the (reputable) venders.
    So overall I am very happy with Nexaph so far.

    85 0 7 Reply
    I icynemby
    No, I defintely was not expecting zero. I guess my initial alarm was twofold: 1) The conflicting answers from AI and 2) I am used to seeing endotoxin test results expressed as EU/ML vs EU/VIAL. In the light of a new day and after doing some more digging, I believe the 6.543 endotoxin level is safe and does NOT reflect poor manufacturing standards. I spent some time arguing with AI last night and it concluded that the output that suggested that the 6.543 level was high was based on a "water measurement" and not dry powder. AI sees anything over a certain number and flags it as high and toxic. I'm good now. Thanks for everyone's help. I'm still learning.