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  • P

    DIY Topical Peptide Serum with GHK-Cu + Snap-8 | Base, Mixing & Clean Handling (Video Tutorial)

    🎬 Watch on RandyTube: DIY Topical Peptide Serum with GHK-Cu + Snap-8 | Base, Mixing & Clean Handling (Video Tutorial)

    In this video we make a simple topical serum with GHK-Cu and Snap-8 for a fraction of what pre-made serums cost. It covers choosing a base, getting the peptides into it without wrecking them, keeping everything clean, and an optional roller for application. Patch test first.


    Comments posted here show up under the video on PeptideCritic.com, and vice versa. Questions about the technique, gear or the math are all welcome.


    You don't state how much Snap-8 you added in the video? 10mg? I have purchased Snap-8 bulk in a Lyophilized powder so not sure if I can add directly to the HA serum?
  • J

    New to peps, has anyone used Glaciers Mito Blend and if so what is proper dosing for beginning and maintenance - thx.


  • RandyR

    In this video, Jeff and Randy demonstrate the V4 Plastique, the next step in reusable peptide pen design. It delivers up to 60 units, leaves substantially less solution behind than the V1 and many other pen models, and will not dial past the amount remaining in the cartridge. If only 12 units are left, the pen stops at 12, so you know what can actually be delivered.

    That low-residual design comes with a tradeoff: the V4 Plastique requires a firmer push than the standard V4. I compare the two designs, explain why the mechanism feels different, and cover who may prefer reduced waste over the lightest possible injection stroke.

    https://x.com/PeptideCritic/status/2102125721909108854?s=20

    https://rumble.com/v7fsrxc-v4-plastique-pen-explained-60-unit-delivery-less-waste-and-smarter-dosing.html


    @mrjoshua44 now you can sell
  • N

    Apologies if this is the incorrect place for this post. I figure it has to do with pens, so this may work?

    I've recently made the switch to peptide pens and have become a huge fan of the convenience and consistency (thanks Randy!). Since I'm also on TRT, I started wondering whether testosterone could be used with pens as well.

    After finding a forum thread where several people were doing exactly that, I decided to run some tests of my own.

    Goal: Determine whether Testosterone Cypionate can be delivered accurately and consistently through a peptide pen.

    Setup:
    Pen: ConviPen (auto-injector)
    Testosterone: Testosterone Cypionate 200 mg/mL in cottonseed oil
    Needles: EasyTouch 29g 1/2" pen needles

    I chose the ConviPen because it uses a metal drive rod and I suspected an auto-injector would have an easier time pushing a more viscous oil. I am still considering testing a manual pen (V4) for comparison.

    Testing Performed:
    Test #1: I loaded a cart into the pen and measured output directly into an insulin syringe. To do this, I inserted the syringe into the cart and dispensed a dose from the pen, allowing me to measure the volume.

    Approximately 10 repetitions were performed.

    Result:
    Output was extremely consistent.
    15 units delivered essentially what was expected each time.

    Test #2: I then attached a 29g pen needle and repeated the testing by dispensing through the needle into the open end of a syringe. This method was less precise than Test #1, as some of the oil adhered to the sides of the syringe and could not be measured perfectly.

    Approximately 30+ repetitions were performed.

    Result:

    Output remained consistent.
    Measured delivery was roughly 1 unit lower than expected.
    Because of this, I began testing a setting of 16 units to achieve an effective 15-unit delivery.

    Test #3: I then did an actual subcu injection for my regular dose. When I pressed the trigger at 16 units, the dose indicator rapidly dropped to approximately 5 units remaining, then continued clicking all the way down to 0. I left the needle in place for approximately 10 seconds after the indicator reached 0.

    This behavior was very different from my syringe testing and raises the question of whether tissue resistance affects delivery compared to bench testing.

    Preliminary Conclusions:
    • Testosterone Cypionate in cottonseed oil can be delivered through a peptide pen.
    • A 29g pen needle appears to work (shout out to the forum users who stated this in another post!!)
    • Pens are mechanically capable of pushing oil-based testosterone.
    • I still need long-term validation through TRT labs to confirm that Total Testosterone and Free Testosterone remain consistent with pre-pen values.
    • I am unsure whether an auto-injector or manual pen is ultimately the better platform for oil-based compounds.

    Questions: For those who have experimented with TRT in peptide pens:
    • Have you found auto-injectors or manual pens to be more reliable?
    • Has anyone validated dose accuracy through bloodwork or measured output testing?
    • What are some other factors I should be considering?

    I'm still early in this experiment, but so far, things are looking promising!

    P.S. For those wondering, I wasn't burning through my actual TRT supply for science. A friend had an old blended testosterone vial that was never going to be used, so it became the sacrificial test subject for this project.


    I like it simple. Enethate of Cyp in MCT
  • mrjoshua44M

    This was me at my heaviest at 332 lbs. And today coming in at 243 lbs. thanks to compounded Tirzepatide and hitting the gym. And yes, that is a fitting room selfie from Cabela's.
    White and Green Simple Wedding Photo Collage.jpeg


    It can be done. Well done brother!
  • P

    This is the official discussion thread for a vendor on PeptideCritic.com.

    📖 View the vendor profile: Apex Peptides


    Share your experiences with this vendor, ask questions, or add information that might help other community members.

    Please keep discussions respectful and factual.


    @stevepep performance enhancers [image: 1790464274241-img_7273.jpeg]
  • P

    Disposable Peptide Pens | Types & How to Load Them (Step-by-Step Tutorial)

    🎬 Watch on RandyTube: Disposable Peptide Pens | Types & How to Load Them (Step-by-Step Tutorial)

    This comprehensive tutorial provides an overview of disposable peptide pens, covering the different types available and their specific features. Learn step-by-step instructions for properly loading these pens, including essential tips for maintaining sterility, handling cartri…


    Comments posted here show up under the video on PeptideCritic.com, and vice versa. Questions about the technique, gear or the math are all welcome.


    @Showme24 bigger hole on the needle less resistance.
  • EXTROPIANE

    Is Anhedonia really a side effect? Anhedonia by its literal Greek definition means "without pleasure". The exact opposite of anhedonia is hedonia, which is the normal human capacity to experience pleasure, comfort, and satisfaction. Thats is where Hedonism comes from. Hedonism is the philosophical and lifestyle belief that pleasure and happiness are the highest goods and the ultimate aims of human life.

    So what gives? Glp-1 bunts the hedo' in you. We can titrate up and we can titrate down. Were we given a control dial? Do we really have it this good?


    Sorry to hear you and others have this side effect. Feeling lucky I've never had to experience this.
  • R

    Got a chance to get in on a GB for this but can't find any protocol on it. Reta 10mg / Elora 2.5 mg


    @Mydogdaryl423 said: @mmp that's a 15% off code. These were specific codes being given out at the even thst got you an additional 30%.
  • D

    On Southern Aminos website, I viewed Adamax (that's what I was looking for).
    When I clicked on the selection, I had two options Adamax Prime ($42) and Adamax Apex ($70.40). When I looked at the COAs, they both showed only Adamax and at a 99.3-99.5% purity (roughly). My point is that both vials, per the MOA, have 10mgs of high purity Adamax. Why is one significantly more expensive. Like I said, the COAs only show Adamax; neither are blends and Both Show 10mgs.
    I asked via email,

    "Please explain the difference between Adamax Prime and Adamax Apex? They appear to both be the same amount in mgs, and both high grade Adamax, so why is Apex much more expensive? I thought perhaps Apex was a blend, but no other peptides are shown on the COAs.
    I want to buy Adamax but need to know the answer to my question before making a purchase."

    I have not received a response to my email, which was sent three days ago. If someone knows, please let me know. I purchased Adamax from another vendor this time, but with 60% off, I wanted to take advantage and get a lot.
    Thank you!
    Joel


    @SouthernAminos - I understand the COAs show which one is which, but my question in this thread and the one I asked in my email to your company was "What is the difference between the Adamax 984 and Adamax 1032? other than the numbers after Adamax?" They repeat the same naming convention on the COAs as the listing. I didn't know what 1032 and 984 represented. That is something that could have been answered. I looked at the COAs before I sent the email and posted here. I know now what they mean, thanks to @CDaze812 and the forum here on PeptideCritic.com
  • E

    My hunch and semesters of Organic Chemistry paid off. I took the GIP out of the equation and the constipation is gone! No powdered muck, softeners, etc. (I figured most of you knew about this GIP problem already.) If you had normal movement before, you'll have it again. It takes about 2 weeks or so for the GIP to leave your system and the gut to relax into normal peristalsis and it's so worth it!

    I've lost the vast majority of weight I needed to lose; the rest will be slower anyway and it's more than a fair trade-off for 30 minutes on the porcelain and an asshole that's sore, cracked and bleeding at times. The constipation caused more fatigue than I thought, therefore, more natural energy is returning. Anxiety also accompanied all this, whether conscious of it or not. Just a general feeling of relief followed this battle.

    I realize there are many of you who don't mind taking the usual meds for this issue but please consider that there's a high likelihood you will be harmed by continued constipation; whether with polyps or worse. I'm speaking from experience.

    For those of you who've reached a point where you don't want to fight it anymore, a combo of Cagri (on Fri night) & Survo (on Tues night) might help you and I take near starter doses of each. I can't swear for every individual on this forum, butt, it might be worth a try.

    For the record, I do use other peps: NAD+buf & MOTS-C both in AM and KPV before bed.

    Wishing Y'all great Holiday sales!


    @pep_researcher said: @Eleanor Yeah I read a slightly different version of this recipe on Reddit too. IIRC, a nurse had posted that they use prune juice + butter + salt for colon screening patients to clean out their gut before colonoscopy. So it's medical grade solution. Hehe It is not a medical grade solution! I've had numerous colonoscopies and used something like it once and was still dirty when they scoped me. I don't care one iota what someone on Reddit said. You do what you want. I'm just expressing what I know worked for someone (me) who has history of colon cancer in family, has had polyps removed, has had gut literally split in half and had to wear a poop bag for 6 months, then, resected. When you put lots of pressure on the bowel to move on a consistent basis, if you have an unknown weakness, it could cause you to go through much the same as I did. This isn't accounting for the runny mess after taking stool softeners, etc. that moves through those perforations. Grain allergies, lactose intolerance; there's a whole host of food/drink and drugs that can cause perforations in the bowel that you don't know you have. You are literally taking your life in your hands and alleged Reddit nurse does NOT have the answer.
  • D

    For those of you who do a lot of testing, I know the fees get very expensive. In the current inflationary market, most people have far less disposable income than before. This is also expensive, but if you plan to buy peptides for the coming years and continue sending batches out for testing, this may be way to mitigate the costs. Like I said, it's expensive. If you have a business, you can always deduct a significant portion from tax returns. Someone could also charge lesser prices than the big labs and start a testing business.
    So, if any of these things apply to you, here is a link to buy a machine to do peptide testing:

    https://amc-essentials.com/shop/uv-visible-spectrophotometer-for-dna-rna-protein-analysis-1-8-nm-bandwidth/

    Probably not for many, but it could be for some of you.


    People mix up three different questions: Purity - what fraction of the UV-absorbing stuff is the main peak Identity - is that peak the peptide on the label Amount - how many mg of actual peptide are in the vial A used Agilent 1100/1200 + C18 column + 0.1 mg balance will do #1 and a version of #3. It will not do #2. FOr #2 you need a Mass Spec machine. HPLC separates by hydrophobicity and measures peak area at 214/220 nm. Purity is just: main peak area / all peak areas Practical cheap setup for HPLC: complete used 1100/1200 gradient HPLC with UV/DAD, one new C18, HPLC ACN/water/TFA, 0.1 mg balance. Ballpark $8–15k could be less on used lab equipment sites but need to make sure it has all the modules. Not easy to keep these machines working well without knowhow. For identity of what is in the vial you need Mass Spec Best cheap option: ESI single-quad LC-MS Agilent 6120/6130/6140, Shimadzu LCMS-2020, Waters QDa/SQD. Used working ones usually ask $35k–$55k. “Powers on” eBay units at $8k–$20k are often dead. Also really tough to run and maintain - need nitrogen tank at home etc.
  • J

    This is a vendor review submitted by Jaypeg on PeptideCritic.com.

    Rating: ⭐⭐⭐⭐⭐ (5/5)


    Review

    Placed my second order from flawless this week first order was for some Tesa and Reta. Delivered in two days after hitting buy. So far no issues Coas were readily available online. But will update if any of the multiple vials I have give me issues but so far they seem pretty reasonably priced.


    🛒 Shop Flawless Compounds

    📖 Read the full review on Flawless Compounds' page

    Discuss this review, share your own experiences, or ask questions about the vendor.

    Please keep discussions respectful and factual.


    @MJ227 haven’t bad to contact them. Hope never have to
  • G

    Dear Peptide Critic Community,

    The GenPeptide Team wishes to thank you for all the support you have given us over the past several months. We are excited to announce that we will be transitioning to 7x testing for all new peptide batches, and we anticipate having 90% of our products with 7x testing by the end of 2026. We have also added endotoxin and heavy metal testing (5x testing) to 10 current batches.

    Batches currently with 7x testing (identity, purity, mass amount, endotoxins, sterility, heavy metals, conformity):

    • Tirz-GP (GLP-2TZ) 60 mg - GPTIR60090526
    • KLOW - GPKLO80090526
    • Reta-GP (GLP-3RT) 10 mg - GP-3P1008192026-04
    • SS-31 30 mg - GP-ATP3008152026-02

    Batches with 5x testing (identity, purity, mass amount, endotoxins, heavy metals):

    • BPC-157 10 mg - GPBPC10051626
    • Cagrilintide 5 mg - GPCAG05061726
    • GHK-Cu 50 mg - GPGHK50061726
    • GHK-Cu 100 mg - GPGHK100053126
    • KPV 10 mg - GPKPV10071226
    • MOTS-C 10 mg - GPMOT10080426
    • NAD+ (buffered) 500 mg - GPNAD500071326
    • Tesamorelin/ipamorelin blend 10/3 mg - GPTEI103071326
    • Tirz-GP (GLP-2TZ) 20 mg - GPTIR20061726
    • Tirz-GP (GLP-2TZ) 30 mg - GPTIR30071326

    We also wish to announce expanded build-a-kit functionality. We now include the option of a 10-vial kit (30% off), in addition to the 5-vial kit (20% off). These kits are mix-and-match and can include any product on our website in any combination you choose.

    Thank you for your continued support.

    GenPeptide Team


    @Genpeptide I’m actually really happy to hear this. As we see more and more blind test of not only the peptide distributors but now on the labs themselves there are fewer vendors I will buy from based on which lab they use. 7x testing is less important to me than a quality labs and endotoxin screening.
  • mmpM

    Below is supposedly UBT251 molecular structure from patent https://patents.google.com/patent/CN117062618B/en noted in today's k-hole article https://krysia0430.substack.com/p/has-the-grey-market-worked-out-what

    I expected much more differences
    UBT251: Y-Aib-Q-G-T-αMeF-T-S-D-Y-S-I-αMeL-L-D-K-K(AEEAc-AEEAc-γGlu-CO(CH₂)₁₈COOH)-A-Q-Aib-A-F-I-E-Y-L-L-E-S-H-P-S-S-G-A-P-P-Ac3c-S-NH₂

    Reta: Y-Aib-Q-G-T-F-T-S-D-Y-S-I-αMeL-L-D-K-K(AEEA-γGlu-C20)-A-Q-Aib-A-F-I-E-Y-L-L-E-G-G-P-S-S-G-A-P-P-P-S-NH₂

    It works better than reta. Here is some comparison found on internet

    ad73b5f0-81e0-478e-8eb4-5e9687823324-image.jpeg


    @mmp Aren’t we talking UBT? But I see your point. In the Phase Ia single-dose trial in healthy subjects, across the 1.0–4.5 mg dose range the mean half-life for each dose arm was 137–170 hours, which supported once-weekly dosing. That's roughly 5.7–7 days, consistent with once-weekly subcutaneous injection. Hard to beat the Elora-Tirz stack.
  • P

    This is the official discussion thread for a vendor on PeptideCritic.com.

    📖 View the vendor profile: Apex Amino


    Share your experiences with this vendor, ask questions, or add information that might help other community members.

    Please keep discussions respectful and factual.


    I posted under the wrong company.
  • EXTROPIANE

    "PNC-27 and PNC-28 are experimental p53-derived chimeric peptides studied for their potential anti-cancer properties by selectively inducing tumor cell necrosis"

    Anyone researched these?


  • J

    Hello,

    Has anyone tried Value Research Labs or Northline Peptides? Value Research Labs has some good deals but not sure if its legit. I’m new to the peptide game so any help would be appreciated. Thank you.


    read more →
    I’ve ordered from Northline labs. Definitely legit. Prices similar to most. For orders of more than one or two, Nexaph is hard to beat unless you’re going Grey.
  • SpaceGhostS

    I pure Nimbot M2 because of you guys. Initially, it worked as expected, but recently it has developed a really annoying habit. This is the iOS version on my iPad.

    If I want to edit an existing label,I select the text block I want to alter, and click the “content” tab. Usually, this pops up an editable instance of that text and I can add, delete, or alter as needed.

    Recently, when I click on the content tab, the keyboard pops up, blocking the editable text block. Flipping between landscape/portrait does nothing.

    The only way to edit that text block is to retype the entire thing, blind.

    Has anyone else encountered this? Am I just missing some super obvious step?
    It’s the weekend so support is unavailable. Hence annoying you bunch of enablers!


    Amazon prime days are coming, and if that doesn’t work, Christmas is on the way!
  • EXTROPIANE

    PNC-141 peptide against cancer? Anyone heard of this?


    @Randy Thank you sir. Will do my homework. I heard it on the fly and couldn't find any info.