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  3. Freezing compounded liquid tirzepatide?
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Freezing compounded liquid tirzepatide?

Scheduled Pinned Locked Moved Peptide Discussion
reconstitutionglp2-tstoragelab-test
22 Posts 10 Posters 1.7k Views 1 Watching
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  • NewenoughN Offline
    NewenoughN Offline
    Newenough
    wrote last edited by Newenough
    #2

    Where did you find that story @pep_researcher?

    Standard warnings are to discard if frozen. I'd of course recommend not to do it. Either give away or toss it when the time comes. Just take the win if it was me, as tirz is cheap, not worth the risk.

    pep_researcherP 1 Reply Last reply
    3
    • NewenoughN Newenough

      Where did you find that story @pep_researcher?

      Standard warnings are to discard if frozen. I'd of course recommend not to do it. Either give away or toss it when the time comes. Just take the win if it was me, as tirz is cheap, not worth the risk.

      pep_researcherP Offline
      pep_researcherP Offline
      pep_researcher
      wrote last edited by pep_researcher
      #3

      @Newenough said:

      Where did you find that story

      Know it from someone I know 😜

      They tried asking close friends who are more adventurous, but they too now do RUO research and don't want T.

      The other friends are skeptical newbs who won't touch such molecules due to misconceptions like it will alter their brains, even if for the better. They don't want to lose their lovely food noise and binge eating. For the love of God! 😂

      NewenoughN 1 Reply Last reply
      2
      • pep_researcherP pep_researcher

        @Newenough said:

        Where did you find that story

        Know it from someone I know 😜

        They tried asking close friends who are more adventurous, but they too now do RUO research and don't want T.

        The other friends are skeptical newbs who won't touch such molecules due to misconceptions like it will alter their brains, even if for the better. They don't want to lose their lovely food noise and binge eating. For the love of God! 😂

        NewenoughN Offline
        NewenoughN Offline
        Newenough
        wrote last edited by
        #4

        It will alter their brains, even if for the better 😄 😄 😄

        Love it.

        1 Reply Last reply
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        • N Offline
          N Offline
          Nuncles
          wrote last edited by
          #5

          I've read instances on Reddit that people have frozen and used their compounded tirzepatide with no ill effects. Personally that's not my comfort level. But its people on Reddit. Take it for what it's worth.

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          • ResearchCatR Offline
            ResearchCatR Offline
            ResearchCat
            wrote last edited by
            #6

            I wouldn’t freeze it, assuming you mean indefinitely until you find some use for it or someone to buy it. Just use it or unload it before it expires. Not sure what the market for that looks like but it sounds sketchy.

            Yeah, well, I’m just here for the research, man. - The Dude

            If I haven’t liked your post, no offense. I have exceeded my daily allowance.

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            • pep_researcherP Offline
              pep_researcherP Offline
              pep_researcher
              wrote last edited by
              #7

              @newenough @nuncles @researchcat Thanks. Yeah had huge doubts. But Redditters seemed super confident with their frozen compounded tirz, so a thought crept in... MAYBE!

              Reg giving it away, yeah the person can't put it up on FB marketplace or eBay definitely. And within the closest trusted friends there are only two kinds — those fully submerged in RUO and new research, and others sticking to their food noise, binging, and conventional stuff... So no takers unfortunately.

              Stan DouglasS 1 Reply Last reply
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              • pep_researcherP pep_researcher

                @newenough @nuncles @researchcat Thanks. Yeah had huge doubts. But Redditters seemed super confident with their frozen compounded tirz, so a thought crept in... MAYBE!

                Reg giving it away, yeah the person can't put it up on FB marketplace or eBay definitely. And within the closest trusted friends there are only two kinds — those fully submerged in RUO and new research, and others sticking to their food noise, binging, and conventional stuff... So no takers unfortunately.

                Stan DouglasS Offline
                Stan DouglasS Offline
                Stan Douglas
                wrote last edited by
                #8

                @pep_researcher said:

                But Redditters seemed super confide...

                You can't sell it to these true-believers?

                pep_researcherP 1 Reply Last reply
                0
                • Stan DouglasS Stan Douglas

                  @pep_researcher said:

                  But Redditters seemed super confide...

                  You can't sell it to these true-believers?

                  pep_researcherP Offline
                  pep_researcherP Offline
                  pep_researcher
                  wrote last edited by pep_researcher
                  #9

                  @Stan-Douglas Nahh the person's not going to deal with random folks for this.

                  Also they are not sure if they want to get rid of the stock as yet. They started new research only recently, so undecided yet and so exploring ways to extend the molecule validity.

                  1 Reply Last reply
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                  • ResearchCatR Offline
                    ResearchCatR Offline
                    ResearchCat
                    wrote last edited by
                    #10

                    Honestly, I expect that it would be fine to use well past the expiration date. When I was buying compounded Tirzepatide, it regularly came with ‘extended BUD’ indicating it was good for 6 months or longer past its original best used by date. It won’t be good indefinitely, but it will be fine for a while. Unfortunately, it’s just a difficult item to offload.

                    My bride is finishing the last compounded vial I bought, which was bottled over a year ago and is past its extended BUD. It still works, though it may be less potent.

                    I love my tirz.

                    Yeah, well, I’m just here for the research, man. - The Dude

                    If I haven’t liked your post, no offense. I have exceeded my daily allowance.

                    pep_researcherP 1 Reply Last reply
                    2
                    • ResearchCatR ResearchCat

                      Honestly, I expect that it would be fine to use well past the expiration date. When I was buying compounded Tirzepatide, it regularly came with ‘extended BUD’ indicating it was good for 6 months or longer past its original best used by date. It won’t be good indefinitely, but it will be fine for a while. Unfortunately, it’s just a difficult item to offload.

                      My bride is finishing the last compounded vial I bought, which was bottled over a year ago and is past its extended BUD. It still works, though it may be less potent.

                      I love my tirz.

                      pep_researcherP Offline
                      pep_researcherP Offline
                      pep_researcher
                      wrote last edited by
                      #11

                      @ResearchCat Right. The expiration dates are usually very conservatively placed to avoid any liability issues.

                      The question was more about whether deep freezing the liquid form would extend expiration by several months/years, but doesn't seem to be the case.

                      Apparently there was some fringe study that found that doing freeze-thaw on GLP-3 made it lose much of the Glucagon component efficacy. GLP-1 seemed okay, but T also has GIP and there's no lab data on free-thaw on it.

                      1 Reply Last reply
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                      • NewenoughN Offline
                        NewenoughN Offline
                        Newenough
                        wrote last edited by
                        #12

                        Yeah, I would think 6 months after would be good still. Do these pens allow you to observe the med? Look for any cloudiness or changes? Never used one...

                        pep_researcherP 1 Reply Last reply
                        0
                        • NewenoughN Newenough

                          Yeah, I would think 6 months after would be good still. Do these pens allow you to observe the med? Look for any cloudiness or changes? Never used one...

                          pep_researcherP Offline
                          pep_researcherP Offline
                          pep_researcher
                          wrote last edited by
                          #13

                          @Newenough No the auto injectors have less visibility. Unsure of the new KwikPens.

                          But no there's not so much worry about cloudiness and all if they are in sealed original containers.

                          1 Reply Last reply
                          1
                          • K Offline
                            K Offline
                            kevin26
                            wrote last edited by
                            #14

                            I used to pick up my tirzepatide from the compounding pharmacy and it was always frozen. I asked why and was only told that they had to. It never felt any different from the name brand, though it was mixed with L-caritine

                            1 Reply Last reply
                            0
                            • M Offline
                              M Offline
                              mindyswartz1
                              wrote last edited by
                              #15

                              I'd be worried about water expansion in the pen probably more than the tirzepatide honestly.

                              pep_researcherP 1 Reply Last reply
                              0
                              • M mindyswartz1

                                I'd be worried about water expansion in the pen probably more than the tirzepatide honestly.

                                pep_researcherP Offline
                                pep_researcherP Offline
                                pep_researcher
                                wrote last edited by
                                #16

                                @emkay Did you read the whole message especially the last line?

                                1 Reply Last reply
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                                • atlas01A Online
                                  atlas01A Online
                                  atlas01
                                  wrote last edited by
                                  #17

                                  Idk man I’d probably toss it. Is it still good? Maybe. I’d rather use a fresh vial.

                                  1 Reply Last reply
                                  0
                                  • Snake PepskinS Online
                                    Snake PepskinS Online
                                    Snake Pepskin
                                    wrote last edited by
                                    #18

                                    I would love to see Randy or Peptide Crafters do a study on this. It would make sense for the peptide not to be affected, since lyophilization involves freezing, but freezing, as opposed to freeze drying, the crystallization could theoretically affect the peptide bonds.

                                    It would be interesting to find out.

                                    “Knowledge is the ultimate power.
                                    It’s not what you know that defines you, it’s that which you share, that defines you.”

                                    1 Reply Last reply
                                    1
                                    • ResearchCatR Offline
                                      ResearchCatR Offline
                                      ResearchCat
                                      wrote last edited by
                                      #19

                                      @kevinfay I have also received compounded tirz that was reconstituted with both saline and with bac water, which might make a difference. Both pharmacies said not to freeze and not to use if it did freeze. Might be nonsense. 🤷‍♂️

                                      Yeah, well, I’m just here for the research, man. - The Dude

                                      If I haven’t liked your post, no offense. I have exceeded my daily allowance.

                                      pep_researcherP 2 Replies Last reply
                                      0
                                      • E Offline
                                        E Offline
                                        Eleanor
                                        wrote last edited by
                                        #20

                                        I have never frozen a 0.9% saline solution in lab but it could be that once the peptide is reconned, it would be subject to crenation once frozen and thawed due to osmotic pressure. Guessing...

                                        Proud to be on a gubmint watch list

                                        1 Reply Last reply
                                        1
                                        • ResearchCatR ResearchCat

                                          @kevinfay I have also received compounded tirz that was reconstituted with both saline and with bac water, which might make a difference. Both pharmacies said not to freeze and not to use if it did freeze. Might be nonsense. 🤷‍♂️

                                          pep_researcherP Offline
                                          pep_researcherP Offline
                                          pep_researcher
                                          wrote last edited by
                                          #21
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