Freezing compounded liquid tirzepatide?
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@newenough @nuncles @researchcat Thanks. Yeah had huge doubts. But Redditters seemed super confident with their frozen compounded tirz, so a thought crept in... MAYBE!
Reg giving it away, yeah the person can't put it up on FB marketplace or eBay definitely. And within the closest trusted friends there are only two kinds — those fully submerged in RUO and new research, and others sticking to their food noise, binging, and conventional stuff... So no takers unfortunately.
But Redditters seemed super confide...
You can't sell it to these true-believers?
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But Redditters seemed super confide...
You can't sell it to these true-believers?
@Stan-Douglas Nahh the person's not going to deal with random folks for this.
Also they are not sure if they want to get rid of the stock as yet. They started new research only recently, so undecided yet and so exploring ways to extend the molecule validity.
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Honestly, I expect that it would be fine to use well past the expiration date. When I was buying compounded Tirzepatide, it regularly came with ‘extended BUD’ indicating it was good for 6 months or longer past its original best used by date. It won’t be good indefinitely, but it will be fine for a while. Unfortunately, it’s just a difficult item to offload.
My bride is finishing the last compounded vial I bought, which was bottled over a year ago and is past its extended BUD. It still works, though it may be less potent.
I love my tirz.
Yeah, well, I’m just here for the research, man. - The Dude
If I haven’t liked your post, no offense. I have exceeded my daily allowance.
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Honestly, I expect that it would be fine to use well past the expiration date. When I was buying compounded Tirzepatide, it regularly came with ‘extended BUD’ indicating it was good for 6 months or longer past its original best used by date. It won’t be good indefinitely, but it will be fine for a while. Unfortunately, it’s just a difficult item to offload.
My bride is finishing the last compounded vial I bought, which was bottled over a year ago and is past its extended BUD. It still works, though it may be less potent.
I love my tirz.
@ResearchCat Right. The expiration dates are usually very conservatively placed to avoid any liability issues.
The question was more about whether deep freezing the liquid form would extend expiration by several months/years, but doesn't seem to be the case.
Apparently there was some fringe study that found that doing freeze-thaw on GLP-3 made it lose much of the Glucagon component efficacy. GLP-1 seemed okay, but T also has GIP and there's no lab data on free-thaw on it.
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Yeah, I would think 6 months after would be good still. Do these pens allow you to observe the med? Look for any cloudiness or changes? Never used one...
@Newenough No the auto injectors have less visibility. Unsure of the new KwikPens.
But no there's not so much worry about cloudiness and all if they are in sealed original containers.
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I'd be worried about water expansion in the pen probably more than the tirzepatide honestly.
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I'd be worried about water expansion in the pen probably more than the tirzepatide honestly.
@emkay Did you read the whole message especially the last line?
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I would love to see Randy or Peptide Crafters do a study on this. It would make sense for the peptide not to be affected, since lyophilization involves freezing, but freezing, as opposed to freeze drying, the crystallization could theoretically affect the peptide bonds.
It would be interesting to find out.
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@kevinfay I have also received compounded tirz that was reconstituted with both saline and with bac water, which might make a difference. Both pharmacies said not to freeze and not to use if it did freeze. Might be nonsense.
️Yeah, well, I’m just here for the research, man. - The Dude
If I haven’t liked your post, no offense. I have exceeded my daily allowance.
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@kevinfay I have also received compounded tirz that was reconstituted with both saline and with bac water, which might make a difference. Both pharmacies said not to freeze and not to use if it did freeze. Might be nonsense.
️This post is deleted! -
@kevinfay I have also received compounded tirz that was reconstituted with both saline and with bac water, which might make a difference. Both pharmacies said not to freeze and not to use if it did freeze. Might be nonsense.
️@ResearchCat LLM tools as well as people on other pep forums (not compounded tirz Subrs) said there's definite molecule fracture that will cause loss of efficacy with freezing and thawing due to the way water behaves.
Lyophilization isn't comparable. Worthwhile to run an experiment. Compounded T Redditters claim to do it, but all claims are anecdotal like 'they FELT the same ', no one has a proof with a COA.
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