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  3. Freezing compounded liquid tirzepatide?
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Freezing compounded liquid tirzepatide?

Scheduled Pinned Locked Moved Peptide Discussion
reconstitutionglp2-tstoragelab-test
22 Posts 10 Posters 1.7k Views 1 Watching
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  • NewenoughN Offline
    NewenoughN Offline
    Newenough
    wrote last edited by
    #12

    Yeah, I would think 6 months after would be good still. Do these pens allow you to observe the med? Look for any cloudiness or changes? Never used one...

    pep_researcherP 1 Reply Last reply
    0
    • NewenoughN Newenough

      Yeah, I would think 6 months after would be good still. Do these pens allow you to observe the med? Look for any cloudiness or changes? Never used one...

      pep_researcherP Offline
      pep_researcherP Offline
      pep_researcher
      wrote last edited by
      #13

      @Newenough No the auto injectors have less visibility. Unsure of the new KwikPens.

      But no there's not so much worry about cloudiness and all if they are in sealed original containers.

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      • K Offline
        K Offline
        kevin26
        wrote last edited by
        #14

        I used to pick up my tirzepatide from the compounding pharmacy and it was always frozen. I asked why and was only told that they had to. It never felt any different from the name brand, though it was mixed with L-caritine

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        • M Offline
          M Offline
          mindyswartz1
          wrote last edited by
          #15

          I'd be worried about water expansion in the pen probably more than the tirzepatide honestly.

          pep_researcherP 1 Reply Last reply
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          • M mindyswartz1

            I'd be worried about water expansion in the pen probably more than the tirzepatide honestly.

            pep_researcherP Offline
            pep_researcherP Offline
            pep_researcher
            wrote last edited by
            #16

            @emkay Did you read the whole message especially the last line?

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            • atlas01A Offline
              atlas01A Offline
              atlas01
              wrote last edited by
              #17

              Idk man I’d probably toss it. Is it still good? Maybe. I’d rather use a fresh vial.

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              • Snake PepskinS Offline
                Snake PepskinS Offline
                Snake Pepskin
                wrote last edited by
                #18

                I would love to see Randy or Peptide Crafters do a study on this. It would make sense for the peptide not to be affected, since lyophilization involves freezing, but freezing, as opposed to freeze drying, the crystallization could theoretically affect the peptide bonds.

                It would be interesting to find out.

                “Knowledge is the ultimate power.
                It’s not what you know that defines you, it’s that which you share, that defines you.”

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                • ResearchCatR Offline
                  ResearchCatR Offline
                  ResearchCat
                  wrote last edited by
                  #19

                  @kevinfay I have also received compounded tirz that was reconstituted with both saline and with bac water, which might make a difference. Both pharmacies said not to freeze and not to use if it did freeze. Might be nonsense. 🤷‍♂️

                  Yeah, well, I’m just here for the research, man. - The Dude

                  If I haven’t liked your post, no offense. I have exceeded my daily allowance.

                  pep_researcherP 2 Replies Last reply
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                  • E Offline
                    E Offline
                    Eleanor
                    wrote last edited by
                    #20

                    I have never frozen a 0.9% saline solution in lab but it could be that once the peptide is reconned, it would be subject to crenation once frozen and thawed due to osmotic pressure. Guessing...

                    Proud to be on a gubmint watch list

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                    • ResearchCatR ResearchCat

                      @kevinfay I have also received compounded tirz that was reconstituted with both saline and with bac water, which might make a difference. Both pharmacies said not to freeze and not to use if it did freeze. Might be nonsense. 🤷‍♂️

                      pep_researcherP Offline
                      pep_researcherP Offline
                      pep_researcher
                      wrote last edited by
                      #21
                      This post is deleted!
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                      • ResearchCatR ResearchCat

                        @kevinfay I have also received compounded tirz that was reconstituted with both saline and with bac water, which might make a difference. Both pharmacies said not to freeze and not to use if it did freeze. Might be nonsense. 🤷‍♂️

                        pep_researcherP Offline
                        pep_researcherP Offline
                        pep_researcher
                        wrote last edited by
                        #22

                        @ResearchCat LLM tools as well as people on other pep forums (not compounded tirz Subrs) said there's definite molecule fracture that will cause loss of efficacy with freezing and thawing due to the way water behaves.

                        Lyophilization isn't comparable. Worthwhile to run an experiment. Compounded T Redditters claim to do it, but all claims are anecdotal like 'they FELT the same ', no one has a proof with a COA.

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