NAD+ Buffered vs non-Buffered

[WowwyZowwy]

Currently on a 5-on/2-off protocol of SS-31 4mg/day + MOTS-C 2mg/day. Honestly, I may have a marginal energy boost from this although it's a little tough to tell at the moment as I am also in my 7th week of a Reta cycle and the calorie deficit has my ass dragging. Introduced the SS-31 and MOTS-C around week 4 and the lethargy is about 70% gone so maybe this is an indicaiton that the MOTS-C/SS-31 are doing something.

From many of these threads, I see that when people add NAD+ (in sufficient amounts) to a protocol like this, typically, a clean energy surge kicks into gear. So I'm going ot give it a try. I could use a surge!!!

My question is around the NAD+ buffered vs non-buffered. My understanding is NAD+ is inherently acidic. Buffer can bring the ph up to a ~6 which makes these 100mg injections a bit more tollerable.

Some sites sell only buffered, some sell only non-buffered. Does anybody have any experience using both and do you see any significant differences in effecacy or administration?

Context:
50 yo
Male
Current Pins: Reta (wk 7), GHK-cu (just started), BP157, MOTS-C, SS-31
5'11"
155 lbs
Dexa = 9.5% body fat

[PeptidePete]

My buffered NAD already stings like hell for 5-10 seconds upon pinning, would not want even more of that

[WowwyZowwy]

@PeptidePete
Hmmmm…. Good to know, Thx! Happy with your results of your buffered?

[PeptidePete]

@WowwyZowwy said in NAD+ Buffered vs non-Buffered:

y

I love NAD+ and pin 100mg daily after waking.

It can be an intense sensation in the first 5-10 minutes (I enjoy it now), I would suggest research be conducted at infrequent low dosing until response is individually characterized (as with any new material)

[ResearchCat]

Yeah, my first couple days at 50mg was something. Puts the CJC flush to shame.

[Randy]

Buffering is a must for this rat.

[justalittleprick]

Have you thought about eating more calories and then fasting 1 day/week or 1-2 times a moonth.

I'm on reta, KLOW, SLU-PP-332, and Tesa/Ipa blend and have considerably more weight to lose than you, but I've been keeping my daily calories about 400 under my TDEE and then doing a 24-36 hour fast once a week and I'm dropping weight and still have energy for the 5 days a week in the gym.

The fast creates the calorie deficit and otherwise maintaining a higher calorie count is keeping my metabolism and energy up. The day after I break the fast my energy lags, but by the 2nd day I'm back to normal.

[ResearchCat]

I am finding my problem is that I need to eat more, not less. My results have been good, but recently I have hit a bit of a wall and need to transition to something approaching maintenance/build. It’s hard building muscle when your muscles don’t have fuel, even with the creatine, peptides, etc.

[WowwyZowwy]

@justalittleprick

I hadn’t thought of that, but I think it’s a great alternative strategy. I should have done something like this from the get-go.

I originally posted because I’m considering adding NAD+ to boost my energy. I’m about to pull the trigger on an Ipamorelin, CJC-1295, and Tesamorelin stack and hit the gym hard, so I’ll definitely need the extra fuel. I’m also planning to start tapering off Retatrutide; while my sub-Q fat has diminished significantly, I still have some visceral fat I’d like to target.

I’m approaching the fine-tuning phase now, so I need to put away the bazooka and pull out the sniper rifle. My goal isn’t to hit 6–8% body fat, as I believe maintaining that level of leanness comes with a whole host of other issues (IMHO).

Thanks for the insight!

[WowwyZowwy]

@ResearchCat This is exactly where I'm at...

[WowwyZowwy]

Well, just ordered from the new batch that came in at Nexaph. Theirs is buffered. Should be here today…. Hopefully I’m immune to the sting (but based on my reaction to MOTS-c, GHK-cu, and even SS-31, I’m doubtful).