Opinion/experience on MOTS-C cycle/protocol
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I read Jeff’s protocol (thanks Jeff), where Randy was testing a daily dose, titrating up to 1mg over a few weeks.
I’ve also seen protocols to inject a higher dose, 5mg every couple of days.
Which is best, small doses daily or large doses 2/3 times a week?
What are people’s opinions/experiences?
Thanks
@Lady-Hamilton
I personally 'researched' MOTS-C from a couple of different vendors and tried low doses, various injection sites, etc - and every time I ended up with a super unpleasant histamine reaction (beyond a local injection site response) that seemed to get worse with progressive use. MOTS-C is just not for me I guess
From what I've read, this isn't necessarily unique to me, so my advice would be to start low to gauge your tolerance first. -
I am currently doing 1 mg/day. It definitely improves cardio and I have more energy, but I feel pretty good anyway and haven’t been pushing lately.
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Found a video by vigorous steve suggesting 1-5mg motsc 3x week, 5mg methylen blue daily and 200-300mcg slu pp 32 1-3x per day. Its cheap to run and the rat using has been very happy with 1.5mg motsc 3x day, 5mg methylene blue daily and 200mcg slu 2x day the energy levels during a mild cut (-500 cal/day). It feels like not even being calorie deficient.
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@derekg1 I love methylene blue, but for folks less familiar with it, do be aware that it can raise blood pressure, and is an MAO inhibitor (so if you are taking anything that messes with your serotonin, like an SSRI, beware). The blood pressure raise isn't terrible, but if you are already hypertensive, you may need to sit this one out
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My fox has been researching with MOTS-c for about 5 weeks now. The little guy started at 200mcg and had no negative side effects for the first 2 weeks. But on the last dose of the second week started getting ISR that were pretty bad. I kept him at 200mcg past 2 weeks because of this and even reconstituted another vile (with Hospira both times) and the ISRs continued. We moved from a daily dose to a 3x per week dose, started taking Zyertec daily, and moved the injection site to the upper glute with no change. I’m considering ending my research with this pep. The benefits just aren’t out weighing the drawbacks for this particular fox.
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I do the 1.5 daily, I love it. I want to switch to a higher dose 3 times a week, but are worried that it won’t be as effective for me.
It has been such a game changer for me I don’t think I will ever stop taking it. I know I have to take a break from it here and there and I am dreading that. One thing, I have to take these now everyday.
https://www.amazon.com/dp/B0DLWYK1GY?ref=ppx_pop_mob_ap_share BioActive Vitamin B Complex -... https://www.amazon.com/dp/B0DLWYK1GY?ref=ppx_pop_mob_ap_share
I didn’t have to take them for the first couple of months taking MOTSC, but then I started feeling like I was running out of fuel. I started taking these with it and now I am good. I read some article on it. -
B Complex and TMG along with MOTS is a must for me! Otherwise I run into the same problem as @commander.
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@derekg1 I love methylene blue, but for folks less familiar with it, do be aware that it can raise blood pressure, and is an MAO inhibitor (so if you are taking anything that messes with your serotonin, like an SSRI, beware). The blood pressure raise isn't terrible, but if you are already hypertensive, you may need to sit this one out
@derekg1 I love methylene blue, but for folks less familiar with it, do be aware that it can raise blood pressure, and is an MAO inhibitor (so if you are taking anything that messes with your serotonin, like an SSRI, beware). The blood pressure raise isn't terrible, but if you are already hypertensive, you may need to sit this one out
High doses for sure. I monitor my rat's bp daily and so far this lower dose combo has had zero impact on his bp numbers. They actually gone down some thanks to the weight loss. But def a good call out. I figure all the mitochondrial up regulators have an outside chance of impacting bp just by "reving the engine" a bit.
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B Complex and TMG along with MOTS is a must for me! Otherwise I run into the same problem as @commander.
@Shaqdiesel What is TMG? I've been running Mots for a month and a half 3.3 MWF. I used to do daily. But my afternoons drag on the day I dose Mots. I do take a methylated B vitamin. Have been researching Ss31 for over a month also.
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@Shaqdiesel What is TMG? I've been running Mots for a month and a half 3.3 MWF. I used to do daily. But my afternoons drag on the day I dose Mots. I do take a methylated B vitamin. Have been researching Ss31 for over a month also.
@Hammertime65 trimethyl glycine? Ive been taking it for a month or two along with epicatechin and hmb and i feel as a stack they help in the gym.
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B Complex and TMG along with MOTS is a must for me! Otherwise I run into the same problem as @commander.
@Shaqdiesel
It is that special L-METHYLFOLATE (5-MTHF) FOLATE that seems to make the difference -
This post is deleted!
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@Shaqdiesel What is TMG? I've been running Mots for a month and a half 3.3 MWF. I used to do daily. But my afternoons drag on the day I dose Mots. I do take a methylated B vitamin. Have been researching Ss31 for over a month also.
@Hammertime65 TMG is recommended to anyone using NAD+ to replenish methyl groups. Methylated versions of vitamin B12 and B9 are also used for that.
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@Shaqdiesel What is TMG? I've been running Mots for a month and a half 3.3 MWF. I used to do daily. But my afternoons drag on the day I dose Mots. I do take a methylated B vitamin. Have been researching Ss31 for over a month also.
@Hammertime65 @commander (Trimethylglycine)
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So if I'm taking a methyl B complex, I should be covered once I start nad?
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So if I'm taking a methyl B complex, I should be covered once I start nad?
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@Hammertime65 check yourself by testing for homocysteine levels. I brought mine down from 11-12 to 7 by using tmg etc.
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@vpeptides Blood test?
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@Lady-Hamilton
I personally 'researched' MOTS-C from a couple of different vendors and tried low doses, various injection sites, etc - and every time I ended up with a super unpleasant histamine reaction (beyond a local injection site response) that seemed to get worse with progressive use. MOTS-C is just not for me I guess
From what I've read, this isn't necessarily unique to me, so my advice would be to start low to gauge your tolerance first.
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