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MOTS-c reaction….strange

Scheduled Pinned Locked Moved Peptide Discussion
mots-c
48 Posts 21 Posters 5.7k Views 2 Watching
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  • mrjoshua44M mrjoshua44

    @Commander The sodium chloride content makes the solution isotonic to the body, which significantly reduces the injection-site stinging, welting, and localized irritation that many users experience with plain bacteriostatic water.

    Stan DouglasS Offline
    Stan DouglasS Offline
    Stan Douglas
    wrote last edited by
    #32

    @mrjoshua44
    I have a bottle on the way thanks to your post but
    why don't we use this for all our peps then? It's about the same price a regular BW.

    mrjoshua44M 1 Reply Last reply
    1
    • Stan DouglasS Stan Douglas

      @mrjoshua44
      I have a bottle on the way thanks to your post but
      why don't we use this for all our peps then? It's about the same price a regular BW.

      mrjoshua44M Offline
      mrjoshua44M Offline
      mrjoshua44
      wrote last edited by
      #33

      @Stan-Douglas some peptides don't do well the salts so for those use regular BAC water.

      1 Reply Last reply
      1
      • RandyR Randy

        @marcoxd Thats a warning sign. This ones probably not for you.

        M Offline
        M Offline
        marcoxd
        wrote last edited by marcoxd
        #34

        @Randy Interesting, isnt a temp injection site itch a common reaction for mots-c not necessarily an indication of the peptide intolerance? Both ss31 and mots-c give me this reaction. It doesnt get worse with increased injections or higher doses. I've researched ss31 atleast 15 pins at this point and titrated up initially without change to the reaction itself, and mots-c i've done 3 pins. It lasts generally no longer than 30 minutes the redness/itching, its pretty mild itchiness too. Its like once its absorbed the local reaction immediately goes away.

        I've heard of people getting welts and continuous pinning escalated it. But are welts and light injection site reactions the same kind of "warning"? I'd treat welts or reactions that dont clear immediately quite differently.

        1 Reply Last reply
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        • RandyR Online
          RandyR Online
          Randy
          wrote last edited by
          #35

          SS31 we have human data on. MOTS-c we have a bunch of influencers peddling affiliate codes with neck tattoos. One thing I keep seeing over and over again is anaphylaxis with mots. I have yet to see someone on reddit or otherwise blame ss31 for that. My point is be careful. MOTS-c can cause severe allergic reactions (same with cjc1295). This research is not without risk.

          "If it doesnt come in a needle. It doesn't work"

          P 1 Reply Last reply
          7
          • RandyR Randy

            SS31 we have human data on. MOTS-c we have a bunch of influencers peddling affiliate codes with neck tattoos. One thing I keep seeing over and over again is anaphylaxis with mots. I have yet to see someone on reddit or otherwise blame ss31 for that. My point is be careful. MOTS-c can cause severe allergic reactions (same with cjc1295). This research is not without risk.

            P Offline
            P Offline
            PeptidePete
            wrote last edited by
            #36

            @Randy said:

            SS31 we have human data on. MOTS-c we have a bunch of influencers peddling affiliate codes with neck tattoos. One thing I keep seeing over and over again is anaphylaxis with mots. I have yet to see someone on reddit or otherwise blame ss31 for that. My point is be careful. MOTS-c can cause severe allergic reactions (same with cjc1295). This research is not without risk.

            Word to the wise...and WTF with all the GD tattoos? How do folks claim to be all about maximizing a healthy body and then inject toxic inks into it? Makes zero sense.

            Asked my PCP for a EpiPen prescription justttttt to be prepared if ever needed. Peace of mind well worth the price (the co-pay is obscene).

            With that said, man I used to get ISR to the MOTS but I never do any longer.

            M 1 Reply Last reply
            1
            • J Offline
              J Offline
              jackiee
              wrote last edited by jackiee
              #37
              This post is deleted!
              1 Reply Last reply
              0
              • P PeptidePete

                @Randy said:

                SS31 we have human data on. MOTS-c we have a bunch of influencers peddling affiliate codes with neck tattoos. One thing I keep seeing over and over again is anaphylaxis with mots. I have yet to see someone on reddit or otherwise blame ss31 for that. My point is be careful. MOTS-c can cause severe allergic reactions (same with cjc1295). This research is not without risk.

                Word to the wise...and WTF with all the GD tattoos? How do folks claim to be all about maximizing a healthy body and then inject toxic inks into it? Makes zero sense.

                Asked my PCP for a EpiPen prescription justttttt to be prepared if ever needed. Peace of mind well worth the price (the co-pay is obscene).

                With that said, man I used to get ISR to the MOTS but I never do any longer.

                M Offline
                M Offline
                marcoxd
                wrote last edited by
                #38

                @PeptidePete

                I injected a lot slower today, click for click, and got no reaction anymore on neither ss31 nor mots-c. Perhaps i just react differently to cationic peptides.

                P 1 Reply Last reply
                2
                • M marcoxd

                  @PeptidePete

                  I injected a lot slower today, click for click, and got no reaction anymore on neither ss31 nor mots-c. Perhaps i just react differently to cationic peptides.

                  P Offline
                  P Offline
                  PeptidePete
                  wrote last edited by
                  #39

                  @marcoxd said:

                  @PeptidePete

                  I injected a lot slower today, click for click, and got no reaction anymore on neither ss31 nor mots-c. Perhaps i just react differently to cationic peptides.

                  I preloaded with antihistamine for several months as I built up a tolerance to MOTS. Never tried slowing the injection but doesn't hurt to try.

                  1 Reply Last reply
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                  • mrjoshua44M Offline
                    mrjoshua44M Offline
                    mrjoshua44
                    wrote last edited by
                    #40

                    @gym.rat No it is not. Here's what you should use for inhalation and nasal applications.
                    IMG_0931.jpeg

                    vpepsV 1 Reply Last reply
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                    • mrjoshua44M mrjoshua44

                      @gym.rat No it is not. Here's what you should use for inhalation and nasal applications.
                      IMG_0931.jpeg

                      vpepsV Offline
                      vpepsV Offline
                      vpeps
                      wrote last edited by
                      #41

                      @mrjoshua44 I was under impression that adding peptides to saline solutions may be harmful to the molecules, also isn't it irritable for nasal tissue. I am planning to make a nasal solution myself so I bought USP sterile water for that.

                      attentiion is all you need

                      mrjoshua44M 1 Reply Last reply
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                      • M marcoxd

                        Pinned the first dose into my subject today. The reaction is very similar to the SS31 reaction. Turns warm, itchy and red almost immediately. the area spreads out left to right on my stomach perhaps 1 to 1.5 inches. and then up and down half an inch or so. But within 1 hour its gone. AI says its most likely not even a histamine reaction but just a local cell reaction to the peptide itself.

                        But this was just the first pin which was a baby dose (0.5mg) at 10mg/3ml dilution.

                        Robot BabylonR Offline
                        Robot BabylonR Offline
                        Robot Babylon
                        wrote last edited by
                        #42

                        @marcoxd said:

                        Pinned the first dose into my subject today. The reaction is very similar to the SS31 reaction. Turns warm, itchy and red almost immediately. the area spreads out left to right on my stomach perhaps 1 to 1.5 inches. and then up and down half an inch or so. But within 1 hour its gone. AI says its most likely not even a histamine reaction but just a local cell reaction to the peptide itself.

                        But this was just the first pin which was a baby dose (0.5mg) at 10mg/3ml dilution.

                        Try changing to the upper glute or hip area. The stomach can be more of a sensitive spot for some people. Also, let it sit out for about 20-25 minutes before pinning. Both of those things have helped in my household.

                        1 Reply Last reply
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                        • vpepsV vpeps

                          @mrjoshua44 I was under impression that adding peptides to saline solutions may be harmful to the molecules, also isn't it irritable for nasal tissue. I am planning to make a nasal solution myself so I bought USP sterile water for that.

                          mrjoshua44M Offline
                          mrjoshua44M Offline
                          mrjoshua44
                          wrote last edited by
                          #43

                          @vpeptides First, saline is specifically preferred when running nasal spray as it matches the body's natural osmolarity, making it ideal for maintaining physiological balance. Second, most water-soluble peptides work well with BAC 0.9% Sodium Chloride; GLP-1 agonists (semaglutide, tirzepatide, retatrutide), Growth hormone secretagogues (CJC-1295, ipamorelin, sermorelin), Healing peptides (BPC-157, TB-500), Cognitive peptides (Selank, Semax).

                          Critical Exceptions
                          Copper-Containing Peptides GHK-Cu and AHK-Cu, NAD+ and the following require more of an acidic dissolution; IGF-1 LR3, IGF-1 DES, MGF, PEG-MGF, Follistatin, and Melanotan I.

                          For my own research purposes, I've only used it for MOTS-c and SS-31 to reduce injection site reactions.

                          1 Reply Last reply
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                          • D Offline
                            D Offline
                            diegoc
                            wrote last edited by
                            #44

                            My experience with Mots C.

                            I starting in the beginning of the year and maybe 1 month in all good and dandy.

                            This was Subq

                            Then some itching started.

                            Then some welts.

                            Then some allergic reaction with a welt that took 3 weeks to disappear.

                            I took some time off and i came back 1mg IM in the ventral glute. No reaction, then up the dose to 2 then 3mg 3x a week. Ive been like this 2 months and i dont even feel it with 0 reactions.

                            I would test 1mg IM then gradually titrate up to your desired dose. I could do 1mg daily but i use that area for L-cartinine and Test so i do the Motsc 3x a week

                            1 Reply Last reply
                            0
                            • EXTROPIANE Offline
                              EXTROPIANE Offline
                              EXTROPIAN
                              wrote last edited by EXTROPIAN
                              #45

                              I'm back doing MOTS-C. I been doing as follow.

                              1. First day- 1mg MOTS-C, 10mg NAD and 1mg SS-31.
                              2. Second day I Im off and suppliment with CO-Q10 and Methyline Blue.
                                I back and fourth til I finish the peps. Energy is consistent. Push push and coast.

                              2M

                              1 Reply Last reply
                              0
                              • J Offline
                                J Offline
                                jackiee
                                wrote last edited by
                                #46

                                I started back up today, too. I had surgery June 8 and today was my first day back to work. I’m easing my way back. office day today, meetings tomorrow, half day Thursday and holiday on Friday!

                                On Saturday I had my first post surgery outing (other than doctors) and I went to my granddaughter’s dance show case recital. I got fixed up, rode a hour there, watched and cheered for 3 hours and rode an hour home. I was so pooped on Sunday that I stayed home from church and took an 1.5 hour nap in the afternoon (I hardly ever nap, only when sick). I took it today and I felt great all day. No slump at all.

                                1 Reply Last reply
                                0
                                • H Offline
                                  H Offline
                                  hisamjan
                                  wrote last edited by hisamjan
                                  #47

                                  currently been doing motC weekly 10mg split dose 3.33mg before workout in a fasted stated so far no problem got one time took it in the evening resulted me having problem to fall asleep

                                  D 1 Reply Last reply
                                  0
                                  • H hisamjan

                                    currently been doing motC weekly 10mg split dose 3.33mg before workout in a fasted stated so far no problem got one time took it in the evening resulted me having problem to fall asleep

                                    D Offline
                                    D Offline
                                    diegoc
                                    wrote last edited by
                                    #48

                                    @hisamjan

                                    Just an opinion….

                                    Research benefits of working out in a fasted state vs working out with carbs.

                                    Also fasted cardio is good but should be timed separately from gym sessions.

                                    Lastly MotsC works good on fasted cardio, but less on pre gym.

                                    1 Reply Last reply
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