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MOTS-c reaction….strange

Scheduled Pinned Locked Moved Peptide Discussion
mots-c
48 Posts 21 Posters 5.7k Views 2 Watching
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  • J Offline
    J Offline
    jackiee
    wrote last edited by
    #24

    The weird thing about mine is, I am fine taking 3.33mg three times per week. But taking 1.5mg every day caused a reaction, starting on the 5th day.

    1 Reply Last reply
    -1
    • Stan DouglasS Offline
      Stan DouglasS Offline
      Stan Douglas
      wrote last edited by
      #25

      Instead of dropping dosage in my uniratosaur I doubled the bac water.
      Instead of 25us it was still 5mg but at 50u this morning and I have no itching, swelling, space maggots spewing out, or any involuntary traversment of time to report at this hour.

      L 1 Reply Last reply
      3
      • Stan DouglasS Stan Douglas

        Instead of dropping dosage in my uniratosaur I doubled the bac water.
        Instead of 25us it was still 5mg but at 50u this morning and I have no itching, swelling, space maggots spewing out, or any involuntary traversment of time to report at this hour.

        L Offline
        L Offline
        Lady Hamilton
        wrote last edited by
        #26

        @Stan-Douglas Space maggots! 😂
        I’ve just heavily diluted mine too, fingers crossed 🤞🏻

        1 Reply Last reply
        1
        • mrjoshua44M Online
          mrjoshua44M Online
          mrjoshua44
          wrote last edited by
          #27

          One thing you could try, and this goes for SS-31 as well. Try using Bacteriostatic 0.9% Sodium Chloride to reconstitute your MOTS-c. It just might help get rid of the reaction you're having.

          IMG_0711.jpeg

          C 1 Reply Last reply
          1
          • Stan DouglasS Offline
            Stan DouglasS Offline
            Stan Douglas
            wrote last edited by
            #28

            @mrjoshua44
            You're reconstituting with that or diluting it?

            mrjoshua44M 1 Reply Last reply
            1
            • Stan DouglasS Stan Douglas

              @mrjoshua44
              You're reconstituting with that or diluting it?

              mrjoshua44M Online
              mrjoshua44M Online
              mrjoshua44
              wrote last edited by
              #29

              @Stan-Douglas Reconstituting just like you would with regular BAC water.

              1 Reply Last reply
              1
              • mrjoshua44M mrjoshua44

                One thing you could try, and this goes for SS-31 as well. Try using Bacteriostatic 0.9% Sodium Chloride to reconstitute your MOTS-c. It just might help get rid of the reaction you're having.

                IMG_0711.jpeg

                C Offline
                C Offline
                Commander
                wrote last edited by
                #30

                @mrjoshua44 said in MOTS-c reaction….strange:

                One thing you could try, and this goes for SS-31 as well. Try using Bacteriostatic 0.9% Sodium Chloride to reconstitute your MOTS-c. It just might help get rid of the reaction you're having.

                IMG_0711.jpeg

                Why does using this help?

                Please excuse my typos. Small Phone & Bad Eyes

                mrjoshua44M 1 Reply Last reply
                0
                • C Commander

                  @mrjoshua44 said in MOTS-c reaction….strange:

                  One thing you could try, and this goes for SS-31 as well. Try using Bacteriostatic 0.9% Sodium Chloride to reconstitute your MOTS-c. It just might help get rid of the reaction you're having.

                  IMG_0711.jpeg

                  Why does using this help?

                  mrjoshua44M Online
                  mrjoshua44M Online
                  mrjoshua44
                  wrote last edited by
                  #31

                  @Commander The sodium chloride content makes the solution isotonic to the body, which significantly reduces the injection-site stinging, welting, and localized irritation that many users experience with plain bacteriostatic water.

                  Stan DouglasS 1 Reply Last reply
                  2
                  • mrjoshua44M mrjoshua44

                    @Commander The sodium chloride content makes the solution isotonic to the body, which significantly reduces the injection-site stinging, welting, and localized irritation that many users experience with plain bacteriostatic water.

                    Stan DouglasS Offline
                    Stan DouglasS Offline
                    Stan Douglas
                    wrote last edited by
                    #32

                    @mrjoshua44
                    I have a bottle on the way thanks to your post but
                    why don't we use this for all our peps then? It's about the same price a regular BW.

                    mrjoshua44M 1 Reply Last reply
                    1
                    • Stan DouglasS Stan Douglas

                      @mrjoshua44
                      I have a bottle on the way thanks to your post but
                      why don't we use this for all our peps then? It's about the same price a regular BW.

                      mrjoshua44M Online
                      mrjoshua44M Online
                      mrjoshua44
                      wrote last edited by
                      #33

                      @Stan-Douglas some peptides don't do well the salts so for those use regular BAC water.

                      1 Reply Last reply
                      1
                      • RandyR Randy

                        @marcoxd Thats a warning sign. This ones probably not for you.

                        M Offline
                        M Offline
                        marcoxd
                        wrote last edited by marcoxd
                        #34

                        @Randy Interesting, isnt a temp injection site itch a common reaction for mots-c not necessarily an indication of the peptide intolerance? Both ss31 and mots-c give me this reaction. It doesnt get worse with increased injections or higher doses. I've researched ss31 atleast 15 pins at this point and titrated up initially without change to the reaction itself, and mots-c i've done 3 pins. It lasts generally no longer than 30 minutes the redness/itching, its pretty mild itchiness too. Its like once its absorbed the local reaction immediately goes away.

                        I've heard of people getting welts and continuous pinning escalated it. But are welts and light injection site reactions the same kind of "warning"? I'd treat welts or reactions that dont clear immediately quite differently.

                        1 Reply Last reply
                        0
                        • RandyR Offline
                          RandyR Offline
                          Randy
                          wrote last edited by
                          #35

                          SS31 we have human data on. MOTS-c we have a bunch of influencers peddling affiliate codes with neck tattoos. One thing I keep seeing over and over again is anaphylaxis with mots. I have yet to see someone on reddit or otherwise blame ss31 for that. My point is be careful. MOTS-c can cause severe allergic reactions (same with cjc1295). This research is not without risk.

                          "If it doesnt come in a needle. It doesn't work"

                          P 1 Reply Last reply
                          7
                          • RandyR Randy

                            SS31 we have human data on. MOTS-c we have a bunch of influencers peddling affiliate codes with neck tattoos. One thing I keep seeing over and over again is anaphylaxis with mots. I have yet to see someone on reddit or otherwise blame ss31 for that. My point is be careful. MOTS-c can cause severe allergic reactions (same with cjc1295). This research is not without risk.

                            P Offline
                            P Offline
                            PeptidePete
                            wrote last edited by
                            #36

                            @Randy said:

                            SS31 we have human data on. MOTS-c we have a bunch of influencers peddling affiliate codes with neck tattoos. One thing I keep seeing over and over again is anaphylaxis with mots. I have yet to see someone on reddit or otherwise blame ss31 for that. My point is be careful. MOTS-c can cause severe allergic reactions (same with cjc1295). This research is not without risk.

                            Word to the wise...and WTF with all the GD tattoos? How do folks claim to be all about maximizing a healthy body and then inject toxic inks into it? Makes zero sense.

                            Asked my PCP for a EpiPen prescription justttttt to be prepared if ever needed. Peace of mind well worth the price (the co-pay is obscene).

                            With that said, man I used to get ISR to the MOTS but I never do any longer.

                            M 1 Reply Last reply
                            1
                            • J Offline
                              J Offline
                              jackiee
                              wrote last edited by jackiee
                              #37
                              This post is deleted!
                              1 Reply Last reply
                              0
                              • P PeptidePete

                                @Randy said:

                                SS31 we have human data on. MOTS-c we have a bunch of influencers peddling affiliate codes with neck tattoos. One thing I keep seeing over and over again is anaphylaxis with mots. I have yet to see someone on reddit or otherwise blame ss31 for that. My point is be careful. MOTS-c can cause severe allergic reactions (same with cjc1295). This research is not without risk.

                                Word to the wise...and WTF with all the GD tattoos? How do folks claim to be all about maximizing a healthy body and then inject toxic inks into it? Makes zero sense.

                                Asked my PCP for a EpiPen prescription justttttt to be prepared if ever needed. Peace of mind well worth the price (the co-pay is obscene).

                                With that said, man I used to get ISR to the MOTS but I never do any longer.

                                M Offline
                                M Offline
                                marcoxd
                                wrote last edited by
                                #38

                                @PeptidePete

                                I injected a lot slower today, click for click, and got no reaction anymore on neither ss31 nor mots-c. Perhaps i just react differently to cationic peptides.

                                P 1 Reply Last reply
                                2
                                • M marcoxd

                                  @PeptidePete

                                  I injected a lot slower today, click for click, and got no reaction anymore on neither ss31 nor mots-c. Perhaps i just react differently to cationic peptides.

                                  P Offline
                                  P Offline
                                  PeptidePete
                                  wrote last edited by
                                  #39

                                  @marcoxd said:

                                  @PeptidePete

                                  I injected a lot slower today, click for click, and got no reaction anymore on neither ss31 nor mots-c. Perhaps i just react differently to cationic peptides.

                                  I preloaded with antihistamine for several months as I built up a tolerance to MOTS. Never tried slowing the injection but doesn't hurt to try.

                                  1 Reply Last reply
                                  0
                                  • mrjoshua44M Online
                                    mrjoshua44M Online
                                    mrjoshua44
                                    wrote last edited by
                                    #40

                                    @gym.rat No it is not. Here's what you should use for inhalation and nasal applications.
                                    IMG_0931.jpeg

                                    vpepsV 1 Reply Last reply
                                    0
                                    • mrjoshua44M mrjoshua44

                                      @gym.rat No it is not. Here's what you should use for inhalation and nasal applications.
                                      IMG_0931.jpeg

                                      vpepsV Online
                                      vpepsV Online
                                      vpeps
                                      wrote last edited by
                                      #41

                                      @mrjoshua44 I was under impression that adding peptides to saline solutions may be harmful to the molecules, also isn't it irritable for nasal tissue. I am planning to make a nasal solution myself so I bought USP sterile water for that.

                                      attentiion is all you need

                                      mrjoshua44M 1 Reply Last reply
                                      0
                                      • M marcoxd

                                        Pinned the first dose into my subject today. The reaction is very similar to the SS31 reaction. Turns warm, itchy and red almost immediately. the area spreads out left to right on my stomach perhaps 1 to 1.5 inches. and then up and down half an inch or so. But within 1 hour its gone. AI says its most likely not even a histamine reaction but just a local cell reaction to the peptide itself.

                                        But this was just the first pin which was a baby dose (0.5mg) at 10mg/3ml dilution.

                                        Robot BabylonR Offline
                                        Robot BabylonR Offline
                                        Robot Babylon
                                        wrote last edited by
                                        #42

                                        @marcoxd said:

                                        Pinned the first dose into my subject today. The reaction is very similar to the SS31 reaction. Turns warm, itchy and red almost immediately. the area spreads out left to right on my stomach perhaps 1 to 1.5 inches. and then up and down half an inch or so. But within 1 hour its gone. AI says its most likely not even a histamine reaction but just a local cell reaction to the peptide itself.

                                        But this was just the first pin which was a baby dose (0.5mg) at 10mg/3ml dilution.

                                        Try changing to the upper glute or hip area. The stomach can be more of a sensitive spot for some people. Also, let it sit out for about 20-25 minutes before pinning. Both of those things have helped in my household.

                                        1 Reply Last reply
                                        0
                                        • vpepsV vpeps

                                          @mrjoshua44 I was under impression that adding peptides to saline solutions may be harmful to the molecules, also isn't it irritable for nasal tissue. I am planning to make a nasal solution myself so I bought USP sterile water for that.

                                          mrjoshua44M Online
                                          mrjoshua44M Online
                                          mrjoshua44
                                          wrote last edited by
                                          #43

                                          @vpeptides First, saline is specifically preferred when running nasal spray as it matches the body's natural osmolarity, making it ideal for maintaining physiological balance. Second, most water-soluble peptides work well with BAC 0.9% Sodium Chloride; GLP-1 agonists (semaglutide, tirzepatide, retatrutide), Growth hormone secretagogues (CJC-1295, ipamorelin, sermorelin), Healing peptides (BPC-157, TB-500), Cognitive peptides (Selank, Semax).

                                          Critical Exceptions
                                          Copper-Containing Peptides GHK-Cu and AHK-Cu, NAD+ and the following require more of an acidic dissolution; IGF-1 LR3, IGF-1 DES, MGF, PEG-MGF, Follistatin, and Melanotan I.

                                          For my own research purposes, I've only used it for MOTS-c and SS-31 to reduce injection site reactions.

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