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  3. Lyophilized Peps + Heat in Shipping Truck
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Lyophilized Peps + Heat in Shipping Truck

Scheduled Pinned Locked Moved Peptide Discussion
researchingbeginner-questionstorage
28 Posts 10 Posters 3.1k Views 1 Watching
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  • D djoelcassell

    @Jake_PepTron Great question! I don't know 100% at what temperature peptides start to quickly degrade, but I do know this 100% - Lyophilized peptides are WAY more hardy than you think...and what you are led to believe. BUT, and it's a BIG but, like I said, I do not have the data on super high temps and peptide degradation. But Lyophilized peptides are hardy.

    D Offline
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    djoelcassell
    wrote on last edited by djoelcassell
    #21

    Direct sunlight is MUCH more damaging to peptides than heat! Photons degrade peptides and break the covalent bonds rendering the peptides useless after just days of direct exposure. According to a study in the Journal of Peptide Science, UV light exposure for just 48 hours can reduce the potency of certain lyophilized peptides by 15% to 20%. Heat takes weeks or months to cause that level of damage to freeze dried lyophilized peptides. I think it would do damage, but not much, if the peptides were in a shipping container in 110 degree Fahrenheit heat for a week or more. I get that after reading that journal of peptide science article reporting. https://adonyxbio.com/the-art-and-science-of-storing-lyophilized-peptides-a-deep-dive-into-stability-and-longevity/ and the reports below.

    https://www.perfectb.com/how-to-store-peptides/

    https://www.sciencedirect.com/science/article/pii/S1010603023000928

    AND THIS ONE HITS THE HEAT THRESHOLD almost perfectly.

    https://onyxbiolabs.com/2026/01/25/peptide-stability-guide-freezer-vs-refrigerator-storage-protocols/?srsltid=AfmBOoo-_9H4UylTlqB93pD8mQ6noOc-d8BoCXwyWs722sOc6RjwbNlL

    "lyophilized peptides easily tolerate brief, transient heat exposures up to 40°C–45°C (104°F–113°F) during transit with no measurable loss in purity. Thermal energy alone simply lacks the power to easily break covalent bonds in a completely dry, glassy matrix."

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      Eleanor
      wrote on last edited by
      #22

      The old saying again: "It's not the heat, it's the humidity (where I live).

      Proud to be on a gubmint watch list

      D 1 Reply Last reply
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      • E Eleanor

        The old saying again: "It's not the heat, it's the humidity (where I live).

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        djoelcassell
        wrote on last edited by
        #23

        @Eleanor HAHA! That's pretty funny.
        And totally true! Example: Iraq in July 138 F, Ft Benning GA in July 98 w/90% humidity. MUCH hotter at Benning!! Much more miserable! Not even close! Lol

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        • D djoelcassell

          @Eleanor HAHA! That's pretty funny.
          And totally true! Example: Iraq in July 138 F, Ft Benning GA in July 98 w/90% humidity. MUCH hotter at Benning!! Much more miserable! Not even close! Lol

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          Eleanor
          wrote on last edited by
          #24

          @djoelcassell said:

          @Eleanor HAHA! That's pretty funny.
          And totally true! Example: Iraq in July 138 F, Ft Benning GA in July 98 w/90% humidity. MUCH hotter at Benning!! Much more miserable! Not even close! Lol

          It's one of those things, "You have to be there" to understand.

          Proud to be on a gubmint watch list

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          • E Eleanor

            @BeeKind If you ever remember who they are, please let me know. I will say that Nexaph ships a slender boxed set inside of a bigger box which creates an airspace that tends to be protective, temperature wise.

            (OMG, I was talking aloud while typing this and my friend watching news started singing song from old SNL skit "Dick In A Box". Can't breathe, laughing too hard...)

            BeeKindB Offline
            BeeKindB Offline
            BeeKind
            wrote on last edited by
            #25

            @Eleanor I found it! It was renova peptides they offer:
            "Thermal Protection Packaging
            Your order ships with ice packs in an insulated thermal bag to reduce temperature exposure during transit."
            for $12.99!
            renovapeptides.net

            Just someone with a fridge full of research and a browser history that would concern my doctor.

            E 1 Reply Last reply
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            • BeeKindB Offline
              BeeKindB Offline
              BeeKind
              wrote on last edited by
              #26

              @eleanor also their counterpart retaonelabs.com - they offer cold shipping too. They have some things on one site and not the other.

              Just someone with a fridge full of research and a browser history that would concern my doctor.

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              • BeeKindB BeeKind

                @Eleanor I found it! It was renova peptides they offer:
                "Thermal Protection Packaging
                Your order ships with ice packs in an insulated thermal bag to reduce temperature exposure during transit."
                for $12.99!
                renovapeptides.net

                E Online
                E Online
                Eleanor
                wrote on last edited by
                #27

                @BeeKind Nice find! Thank you Bee!

                Proud to be on a gubmint watch list

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                • WisGal64W WisGal64 referenced this topic on
                • E Eleanor

                  @djoelcassell said:

                  @Eleanor HAHA! That's pretty funny.
                  And totally true! Example: Iraq in July 138 F, Ft Benning GA in July 98 w/90% humidity. MUCH hotter at Benning!! Much more miserable! Not even close! Lol

                  It's one of those things, "You have to be there" to understand.

                  D Offline
                  D Offline
                  djoelcassell
                  wrote on last edited by
                  #28

                  @Eleanor Not really, you get it. You don't have to be there to understand. You just need to be sweating bullets in a humid region one time and anyone will get it.

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