Nexaph 3rd Party Testing
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Newbie question. If this has been asked already, please direct me to the proper posts.
I just purchased the pre-order of NXP-2P 30mg from Nexaph. Only 1 kit if that matters. What is everyone's thoughts on vendor sponsored testing vs the independent third party from places on Telegram like JLC Testing or Montana Peptide Private Testing?
This is my understanding. There are additional costs involved for the independent testing and they may test for more stuff like endotoxins, heavy metals, and such. The vendor sponsored is paid by Nexaph (correct me if I'm wrong) and essentially just validates the Nexaph provided COA. So do you think that the vendor sponsored testing is good enough or is it worth the investment to join in on one of the third party test groups?
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Nexpah for the most part uses Janoshik for batch testing. What's the issue? I may be missing something here as well...just trying to understand it.
@markgroce I assumed that the third party testing is a result some vendors supplying fake COA's and this is just to validate that Nexaph is not.
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Nexaph is highly tested. You can even find 3rd party testing which gets into endos and other more extensive testing on TG.
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That's a valid concern, and why Janoshik keeps all the COA's they've done public so you can personally verify it. Go to https://janoshik.com/verification/. Plug in the Task Number and Unique Key Verification located on the Nexpah COA and confirm it's the same as the one Janoshik has.
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Most vendors I have seen/bought from don’t have endo testing. The COA you get from Nexaph is based on the vials sent to Janoshik by users. One would think that paying customers sending vials they bought in to Janoshik for testing paid for by Nexaph is as reputable if not more so than testing the vendor did on their own without any transparency.
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That's a valid concern, and why Janoshik keeps all the COA's they've done public so you can personally verify it. Go to https://janoshik.com/verification/. Plug in the Task Number and Unique Key Verification located on the Nexpah COA and confirm it's the same as the one Janoshik has.
@markgroce just scan the QR code
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Most vendors I have seen/bought from don’t have endo testing. The COA you get from Nexaph is based on the vials sent to Janoshik by users. One would think that paying customers sending vials they bought in to Janoshik for testing paid for by Nexaph is as reputable if not more so than testing the vendor did on their own without any transparency.
@ResearchCat the endotoxin testing is an interesting topic. According to the Jano guy with purity levels well over 90 pct it’s impossible for the toxins to be high enough not to pass so it’s unnecessary testing.
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@markgroce just scan the QR code
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Most vendors I have seen/bought from don’t have endo testing. The COA you get from Nexaph is based on the vials sent to Janoshik by users. One would think that paying customers sending vials they bought in to Janoshik for testing paid for by Nexaph is as reputable if not more so than testing the vendor did on their own without any transparency.
Most vendors I have seen/bought from don’t have endo testing. The COA you get from Nexaph is based on the vials sent to Janoshik by users. One would think that paying customers sending vials they bought in to Janoshik for testing paid for by Nexaph is as reputable if not more so than testing the vendor did on their own without any transparency.
So you are saying that the COA which Nexaph supplies on their website are not from vials they themselves sent to Jano? He just uses the COA provided by the third party vendor sponsored group?
When I've compared the two COA's they are different. Different dates and task numbers but with the same vial batch number.
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I’m a noob as well but the way I understand it is the Nexaph telegram group is used so that researchers donate a sample from their own kits and Nexaph pays for the test. My understanding is that this gives researchers a reasonable assumption that the company didn’t “hand pick” certain samples they knew would look good on a COA. Thus making it more of a “random” and “fair” test. They only test for mass content and purity. So the benefit of a third party group test in my eyes would be that researchers could do more tests, (sterility, endotoxins, heavy metals) and a plus would be that you could get more samples to average out mass content. Being new to a lot of this. I will do the third party group testing. It just makes me feel more warmer and fuzzier inside.
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If anyone knows it would be interesting to get an answer. If purity is over 99pct most are over 99.5pct is it even statistically possible to have enough endotoxins or heavy metals to fail? The Jano guy straight up said it’s a waste of time. (I am paraphrasing) the Nexaph people apparently feel this way. Same for sterility. Most people believe the difference between 99.5 and 100 or whatever is just moisture from the manufacturing process or degradation. We see this is the random testing on telegram they always pass in the Nexaph threads.
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@nuncles You might be right. I assumed they are the same. The COA’s for batches I have purchased have not been available until the customer testing was done and seemed to match.
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Hopefully this doesn't open a can-o-worms, but are there worse offender(s) than others that are at failing such test at a higher rate? There are only a handful of API producers (5-6?) that I'm aware of and then probably double that or more in finishers/packagers. Are weaker producers making products with lower quality that show in testing results?
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Hopefully this doesn't open a can-o-worms, but are there worse offender(s) than others that are at failing such test at a higher rate? There are only a handful of API producers (5-6?) that I'm aware of and then probably double that or more in finishers/packagers. Are weaker producers making products with lower quality that show in testing results?
@markgroce purepeptides has fake COA’s there are several others. When I was a noob I ordered from there and let’s just say my rat had a bad experience
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@markgroce purepeptides has fake COA’s there are several others. When I was a noob I ordered from there and let’s just say my rat had a bad experience
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@markgroce purepeptides has fake COA’s there are several others. When I was a noob I ordered from there and let’s just say my rat had a bad experience
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If anyone knows it would be interesting to get an answer. If purity is over 99pct most are over 99.5pct is it even statistically possible to have enough endotoxins or heavy metals to fail? The Jano guy straight up said it’s a waste of time. (I am paraphrasing) the Nexaph people apparently feel this way. Same for sterility. Most people believe the difference between 99.5 and 100 or whatever is just moisture from the manufacturing process or degradation. We see this is the random testing on telegram they always pass in the Nexaph threads.
@Stevepep I wonder about the details of this "purity test". What does this 99.5% represent? In the vials we usually see a puck or a tablet-like mass, which has a volume of a something weighting about 1 gram, while the active component may be listed as 10 mg.
Imagine 1 g of salt for instance, a quarter of a teaspoon (1 g), vs. a few grains of salt (10 mg).
The majority of the volume, 99% in this case, is not the active ingredient, it is the "excipients", like glycine or mannitol. I wonder, this 99.5% purity, it is percentage of what? It can't be of the total mass, right? So, it is of the mass of the active ingredient. For that they need to separate it from everything else like those excipients and whatever else is there.
How does this testing perform it? What else is excluded? It is very easy to imagine the dangerous level of heavy metals, bacteria and their derivatives (endotoxins) in 1 gram of a solid matter. -
I’m a noob as well but the way I understand it is the Nexaph telegram group is used so that researchers donate a sample from their own kits and Nexaph pays for the test. My understanding is that this gives researchers a reasonable assumption that the company didn’t “hand pick” certain samples they knew would look good on a COA. Thus making it more of a “random” and “fair” test. They only test for mass content and purity. So the benefit of a third party group test in my eyes would be that researchers could do more tests, (sterility, endotoxins, heavy metals) and a plus would be that you could get more samples to average out mass content. Being new to a lot of this. I will do the third party group testing. It just makes me feel more warmer and fuzzier inside.
@WesEqualshXc You can get links to 3rd party testing groups from the Nexaph TG groups. And that is where all the added testing comes in you'd like to see.
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@Stevepep I wonder about the details of this "purity test". What does this 99.5% represent? In the vials we usually see a puck or a tablet-like mass, which has a volume of a something weighting about 1 gram, while the active component may be listed as 10 mg.
Imagine 1 g of salt for instance, a quarter of a teaspoon (1 g), vs. a few grains of salt (10 mg).
The majority of the volume, 99% in this case, is not the active ingredient, it is the "excipients", like glycine or mannitol. I wonder, this 99.5% purity, it is percentage of what? It can't be of the total mass, right? So, it is of the mass of the active ingredient. For that they need to separate it from everything else like those excipients and whatever else is there.
How does this testing perform it? What else is excluded? It is very easy to imagine the dangerous level of heavy metals, bacteria and their derivatives (endotoxins) in 1 gram of a solid matter.@vpeptides I just read this yesterday and it helped me to understand the purity numbers.
https://peptidecritic.com/blog/why-test-results-vary-between-labs-multi-lab-coa-comparison
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