Luer-Lock Dead Space When Combining Peptides
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I’d like to routinely combine two or three peptides in a 1 cc Luer-lock syringe, using the method shown in Jeff’s excellent video. I tried it today with KPV and GHK-Cu, and it worked perfectly; it also reduced the sting!
My only concern is dead space. I’ve read that the extra volume trapped in a Luer-lock syringe-and-needle setup can range from 0.05 to 0.08 mL. Should I compensate for that loss when calculating the dose, or try to find low deadspace Luer-lock needles? So far, I haven’t found a suitable product or supplier.
Does anyone have a workaround, needle recommendation, or alternative method? -
I had this exact question in my mind when I was using this method. I did some very half-baked testing. I loaded and injected my rat with a few research chemicals all combined into a lure-lock and after the injection I capped and unscrewed the lure-lock needle and took a typical diabetic syringe and stuck the needle into the back end of the used lure-lock needle. Can’t remember exactly but I think I pulled about 5-6 units out. Since then I’ve just been stabbing my poor little rat one injection at a time.
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I’d like to routinely combine two or three peptides in a 1 cc Luer-lock syringe, using the method shown in Jeff’s excellent video. I tried it today with KPV and GHK-Cu, and it worked perfectly; it also reduced the sting!
My only concern is dead space. I’ve read that the extra volume trapped in a Luer-lock syringe-and-needle setup can range from 0.05 to 0.08 mL. Should I compensate for that loss when calculating the dose, or try to find low deadspace Luer-lock needles? So far, I haven’t found a suitable product or supplier.
Does anyone have a workaround, needle recommendation, or alternative method?@Finocchia don’t know how comfortable you are with this but to minimize it you can get draw up a small air bubble and flick the syringe with the needle facing down so the air is at the plunger of the syringe. Many pre drawn up meds in the hospital have air at the back for this exact situation. Just keep it small better to be safe than sorry, but it can minimize loss
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@Finocchia don’t know how comfortable you are with this but to minimize it you can get draw up a small air bubble and flick the syringe with the needle facing down so the air is at the plunger of the syringe. Many pre drawn up meds in the hospital have air at the back for this exact situation. Just keep it small better to be safe than sorry, but it can minimize loss
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I had this exact question in my mind when I was using this method. I did some very half-baked testing. I loaded and injected my rat with a few research chemicals all combined into a lure-lock and after the injection I capped and unscrewed the lure-lock needle and took a typical diabetic syringe and stuck the needle into the back end of the used lure-lock needle. Can’t remember exactly but I think I pulled about 5-6 units out. Since then I’ve just been stabbing my poor little rat one injection at a time.
@WesEqualshXc lol, was thinking of doing this, too! I'm wondering how nasty my ordinary insulin needle would become if I just did a couple of draws directly into the syringe.
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I just draw a little BW first, with draw it, pull in as much air as I'm about to withdraw from the first vial, you know the rest. It's only 3 vials at most, I'm not doing more than 60iU at a time. They're not mixing and reconing with one another in the few seconds it takes to draw and inject them all.
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Just pull a little air in with the pointy end pointing down. Give it a couple gentle flicks. The bubble will rise to the plunger. Keep it pointed while injecting so the bubble stays at the plunger. If you are doing subq you dont have to worry about a air embolism. If you are going into your muscle you still dont have to worry about an air embolism until you get to a couple cc of air.
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