Latest update! Good progress!
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@EXTROPIAN If your pct of body fat is 25pct or more, it's pretty hard to get to a point where lowering calorie intake causes this. This is due to the fact that your body will start breaking down fat and using ketones, which break the blood-brain barrier and require far less energy. If you are in reasonably good shape, say under 20pct body fat, you don't have the fat reserves, and this can be an issue. The metabolic response is to slow down, and you could start losing muscle mass, but this is no overnight deal; it can take weeks or even longer. There are tons of studies on fasting on this subject. I have done 5-day fasts just drinking electrolytes and lost no muscle, continued to work out, and actually felt great. I am at 17pct body fat and was at 19pct at the time. I take 2mg of Reta a week, titrating down from 4. I am trying to say it's not one size fits all; many of these folks are obese and need to titrate up to lose weight, not titrate down. Telling people to eat more and titrate down may be the worst thing they could do, even if it works for you based on your body composition. (Not saying you are doing that, but people may infer that's what they should do)The last thing a person with over 30pct body fat should do is titrate down and increase calorie consumption.
One of the main advantages of Reta is just that fat burning, which creates the energy the body needs to sustain itself; it literally mobilizes fat for fat burning and actually increases energy. Resistance training is the key when taking Retatrutide.
@Stevepep You're correct for sure! Not everyone believes in their efficacy, but I drink Kenetik ketones; one shot per day. Dr Elizabeth Yurth, OG doc for longevity and peptides, likes it. She said if she could only take one supplement it would be the Kenetik shot of Ketones. Here's why these specifically.
Dr. Yurth strongly emphasizes mitochondrial efficiency and reducing systemic inflammation to help joints, muscles, and tissues heal at a cellular level. She publicly argues that most commercial ketone products use "ketone salts" or a mix of chemical isomers that the body cannot easily absorb. She advocates for products like Kenetik because they use pure, bioidentical D-beta-hydroxybutyrate (D-BHB), which she argues is the exact format the brain and muscles use to lower oxidative stress and accelerate physical recovery.
Ketone products (the right ones) can really assist in countering systemic inflammation. It has worked for me. -
@vpeptides All of my lab numbers have gone optimal except Test (low normal) and IGF-1 (low normal). I've lost over 7 inches in waist, so visceral fat is definitely coming off. I've been intentional about NOT titrating up unless progress showed it was needed. The gymbro bull has lots of people doing way too high of a dose for the results they're getting IMO.
@jamiegallien You're on HRT, right? If not, I highly recommend it. It will do nothing but help in EVERY category almost. Not TOO much, just what you are lacking to get to optimal. No need to hang at low normal. I tested 7 years ago at 363. I think at the time the range of normal was 360-1500. They've since lowered the upper range to 750 or close to it. That's because (whatever reason) young men and men in general have lower testosterone levels than my generation. Crazy, it's probably from multiple factors: plastics, food additives, sitting in front of a game console/tv/laptop instead of playing outside, etc. But the main thing is this: There is NO reason to walk around at sub-optimal when you don't have to. I found a doc who told me the same and got me to 1500 where I have been since. I feel much better, have more energy, higher libido, better focus, less brain fog..." So many positives. Good Luck and keep up the good work.
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I am 5'0", 60 y/o female. I started Reta (1.5mg) on 4-21-2026. I was 150 lb. Today, 7-20-2026 I weigh exactly 125 lb. Just 3 lbs left to reach my goal.
I stalled at 129 lb for 4 frustrating weeks. I had stalled before, but not that long. Like Extropian said, dial down the Reta and increase the calories. Also, when I can't stand the sight of food, I find it it easier to choke down the protein if I pair it with a carb. That means hamburgers WITH buns, sandwiches, half of a bagel with cream cheese. Then go low carb again and boom! Listen to your body. If it's craving something, there's a reason. Eat it!
Now I'm trying to figure out the low maintenance dose I will likely stay on forever. Thoughts? 1 unit... which is barely a drop in a 100 unit syringe... lol?!
@investormogulllc If you end up using 1 unit, I highly recommend getting smaller syringes. For small doses, I use a .3 ml syringe with recognizable hash marks for each 1 unit. Don't do a dose that small on a 1 ml syringe; you really can't read that. Especially at 60. I'm 61, I know, Lol.
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@jamiegallien You're on HRT, right? If not, I highly recommend it. It will do nothing but help in EVERY category almost. Not TOO much, just what you are lacking to get to optimal. No need to hang at low normal. I tested 7 years ago at 363. I think at the time the range of normal was 360-1500. They've since lowered the upper range to 750 or close to it. That's because (whatever reason) young men and men in general have lower testosterone levels than my generation. Crazy, it's probably from multiple factors: plastics, food additives, sitting in front of a game console/tv/laptop instead of playing outside, etc. But the main thing is this: There is NO reason to walk around at sub-optimal when you don't have to. I found a doc who told me the same and got me to 1500 where I have been since. I feel much better, have more energy, higher libido, better focus, less brain fog..." So many positives. Good Luck and keep up the good work.
@djoelcassell nope, did my labs and I’m good in that.
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@Stevepep You're correct for sure! Not everyone believes in their efficacy, but I drink Kenetik ketones; one shot per day. Dr Elizabeth Yurth, OG doc for longevity and peptides, likes it. She said if she could only take one supplement it would be the Kenetik shot of Ketones. Here's why these specifically.
Dr. Yurth strongly emphasizes mitochondrial efficiency and reducing systemic inflammation to help joints, muscles, and tissues heal at a cellular level. She publicly argues that most commercial ketone products use "ketone salts" or a mix of chemical isomers that the body cannot easily absorb. She advocates for products like Kenetik because they use pure, bioidentical D-beta-hydroxybutyrate (D-BHB), which she argues is the exact format the brain and muscles use to lower oxidative stress and accelerate physical recovery.
Ketone products (the right ones) can really assist in countering systemic inflammation. It has worked for me.@djoelcassell
I totally agree about mitochondrial efficiency and reducing systemic inflammation. I currently have a cracked spine which has allowed m spinal column to shift forward. I need a 3 segment spinal fusion of L4-S1. Unrelated... I also need a 3 segment spinal fusion in my neck.I was in chronic pain for 30+ years. My neck inflammation kept me from turning my neck making driving difficult. My back pain kept me from playing golf, pickleball and even getting up off the floor after petting my dogs. Nerve pain down my legs kept me from sleeping. As a result, I had brain fog, etc. Life really sucked.
I started on the Reta for weight loss at a mere 1.5 mg and within 2 weeks my pain was ZERO... meaning a big fat donut hole ZERO. I still need surgery but may now be able to delay it as I wait for a better solution than fusion. I am 60 but have always been very athletic even playing on our national soccer team decades ago.
The Reta is also amazing at reducing inflammation. It has been life changing.
I now take KLOW (thinking of switching to Wolverine for bigger doses of the heavy lifters), SS-31 (had BAD, long lasting allergic reaction to MOTS-C), N-acetyl Semax Amidate and now Tesa-Ipa blend for sleep and any remaining visceral fat not lost during my 30 lb drop.
Now I sleep, am pain free and back to living anormal, active life.
And of course then my friends and colleagues started asking me about peptides and it has progressed into more than just me being a lab rat.
So grateful to Randy and this community for keeping me safe while I am learning and for trying to prevent bad actors from ruining the reputation of these amazing substances which can help tens of millions of people. I hope to be an integral part and I hope to help change the lives of others who can truly benefit from peptides.
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@investormogulllc My new thing is SuperKlow. I add a vial of wolverine to my vial of Klow. Basically double dose of BPC157 and TB500, and regular amount of GHK and KPV. Very happy with results.
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@djoelcassell
I totally agree about mitochondrial efficiency and reducing systemic inflammation. I currently have a cracked spine which has allowed m spinal column to shift forward. I need a 3 segment spinal fusion of L4-S1. Unrelated... I also need a 3 segment spinal fusion in my neck.I was in chronic pain for 30+ years. My neck inflammation kept me from turning my neck making driving difficult. My back pain kept me from playing golf, pickleball and even getting up off the floor after petting my dogs. Nerve pain down my legs kept me from sleeping. As a result, I had brain fog, etc. Life really sucked.
I started on the Reta for weight loss at a mere 1.5 mg and within 2 weeks my pain was ZERO... meaning a big fat donut hole ZERO. I still need surgery but may now be able to delay it as I wait for a better solution than fusion. I am 60 but have always been very athletic even playing on our national soccer team decades ago.
The Reta is also amazing at reducing inflammation. It has been life changing.
I now take KLOW (thinking of switching to Wolverine for bigger doses of the heavy lifters), SS-31 (had BAD, long lasting allergic reaction to MOTS-C), N-acetyl Semax Amidate and now Tesa-Ipa blend for sleep and any remaining visceral fat not lost during my 30 lb drop.
Now I sleep, am pain free and back to living anormal, active life.
And of course then my friends and colleagues started asking me about peptides and it has progressed into more than just me being a lab rat.
So grateful to Randy and this community for keeping me safe while I am learning and for trying to prevent bad actors from ruining the reputation of these amazing substances which can help tens of millions of people. I hope to be an integral part and I hope to help change the lives of others who can truly benefit from peptides.
@investormogulllc That's amazing! I am so happy for your relief! It's miserable to go through life in constant pain! I do not need to lose any weight, but I'm going to start taking a microdose of Reta. I wonder if sub 1mg would still lead to pain relief?
And, "playing on our national soccer team decades ago." What an accomplishment! You must have been an amazing player to get to that level!
Good luck on your continued effort to help others heal with Peptides!
Joel
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@djoelcassell nope, did my labs and I’m good in that.
Great! I thought you wrote that was the only thing that wasn't optimal.
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Funny thing, the month of May FELT like a huge stall watching the scale, so I titrated up after cutting calories by 100. Looking back at the trend line, you can't even see the stall. I need to remember that next time I feel a "stall".
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@investormogulllc My new thing is SuperKlow. I add a vial of wolverine to my vial of Klow. Basically double dose of BPC157 and TB500, and regular amount of GHK and KPV. Very happy with results.
@ResearchCat
That's a very creative and GREAT idea! I'm gonna try it! Thanks!
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