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  1. Randy the Rats Research Forum
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  3. Nexaph reliability?
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Nexaph reliability?

Scheduled Pinned Locked Moved Peptide Discussion
57 Posts 23 Posters 2.2k Views 2 Watching
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  • RandyR Randy

    @Commander said:

    s the other grey market suppliers but reasonable enough where it was a good place for people to go buy 1 or 2 kits at a time from. But $468 for a kit of KLOW, who could really afford that, not me I don’t have that kind of cash...

    yeah the klow price hike is insane. Used to be 178

    J Offline
    J Offline
    JtCjEfF
    wrote last edited by
    #48

    @Randy Is this due to the recent "China is banning KPV production" scare, or something else?

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    • S Stevepep

      @PeptideEd I just clicked on the box with the arrow, and it takes you directly to the COA on Janoshiks website

      vpeptidesV Offline
      vpeptidesV Offline
      vpeptides
      wrote last edited by vpeptides
      #49

      @Stevepep This new 97% tested batch of Tesa is now on EZ and AMP too. I appreciate the honesty too, but the previous batches were tested over 99% at Janoshik. I kind of get used already to see 99+% for the products I buy. There is 99.9% COA from Freedom for the same batch though, but we know there are issues with them. In Nexaph TG group they stated that they looked for "97% purity or more" from the test, so they got what they expected, but there are other products at higher level, and their own previous batches were at 99.7% levels.

      attentiion is all you need

      N 1 Reply Last reply
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      • vpeptidesV vpeptides

        @Stevepep This new 97% tested batch of Tesa is now on EZ and AMP too. I appreciate the honesty too, but the previous batches were tested over 99% at Janoshik. I kind of get used already to see 99+% for the products I buy. There is 99.9% COA from Freedom for the same batch though, but we know there are issues with them. In Nexaph TG group they stated that they looked for "97% purity or more" from the test, so they got what they expected, but there are other products at higher level, and their own previous batches were at 99.7% levels.

        N Offline
        N Offline
        Nuncles
        wrote last edited by Nuncles
        #50

        @vpeptides So what are the true downsides to 97% instead of 99%? Just a weaker product (less bang for your buck), failure in the lypholization process, or something else?

        vpeptidesV S 2 Replies Last reply
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        • RandyR Randy

          @Commander said:

          s the other grey market suppliers but reasonable enough where it was a good place for people to go buy 1 or 2 kits at a time from. But $468 for a kit of KLOW, who could really afford that, not me I don’t have that kind of cash...

          yeah the klow price hike is insane. Used to be 178

          N Offline
          N Offline
          Nuncles
          wrote last edited by
          #51

          @Randy $178 sounds more reasonable. At 400 plus dollars, those kits just push me towards the more grey vendors and group buys. The greater cost only pushes people to greater risks in my opinion. At least it does for me.

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          • N Nuncles

            @vpeptides So what are the true downsides to 97% instead of 99%? Just a weaker product (less bang for your buck), failure in the lypholization process, or something else?

            vpeptidesV Offline
            vpeptidesV Offline
            vpeptides
            wrote last edited by
            #52

            @Nuncles That means these 2% of the AUC on HPLC chart belong not to Tesamorelin but to something else, maybe a broken chain or a different peptide. Who knows, they don't show us peasants the charts. But you can't also tell what is it from HPLC chart, you may guess something from LC-MS charts (or whatever they use for identity), but they don't show it either.

            attentiion is all you need

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            • N Nuncles

              @vpeptides So what are the true downsides to 97% instead of 99%? Just a weaker product (less bang for your buck), failure in the lypholization process, or something else?

              S Online
              S Online
              Stevepep
              wrote last edited by Stevepep
              #53

              @Nuncles anaphylactic response risk increases with less purity. It’s probably fine in most people but those who are sensitive can have a response to the impurities. Also less actual peptide.

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              • N Offline
                N Offline
                Nuncles
                wrote last edited by
                #54

                @steve @vpeptides Thanks for the education. Where, or which process, does this "other 2%" most likely come from? Any educated guesses of the most likely place/cause? I don't have a complete understanding of how peptides are created and the process it takes to get to us, but I'm trying to somewhat fill in the blanks.

                S 1 Reply Last reply
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                • N Nuncles

                  @steve @vpeptides Thanks for the education. Where, or which process, does this "other 2%" most likely come from? Any educated guesses of the most likely place/cause? I don't have a complete understanding of how peptides are created and the process it takes to get to us, but I'm trying to somewhat fill in the blanks.

                  S Online
                  S Online
                  Stevepep
                  wrote last edited by Stevepep
                  #55

                  @Nuncles if it’s Nexaph it’s likely degradation. Could be moisture or salt. That’s a guess because it could be anything like a breakdown in the chain, another peptide etc. I am familiar with the nutraceutical space so I know the process. We don’t get enough info on the COA to really make that determination because they don’t show the compounds individually

                  vpeptidesV 1 Reply Last reply
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                  • S Stevepep

                    @Nuncles if it’s Nexaph it’s likely degradation. Could be moisture or salt. That’s a guess because it could be anything like a breakdown in the chain, another peptide etc. I am familiar with the nutraceutical space so I know the process. We don’t get enough info on the COA to really make that determination because they don’t show the compounds individually

                    vpeptidesV Offline
                    vpeptidesV Offline
                    vpeptides
                    wrote last edited by vpeptides
                    #56

                    @Stevepep actually Freedom COA shows MS chart, here what it is, and it is not a full intact Tesa molecule, it's a contaminant. Freedom also identifies Histidine spike but it is ignored, and its m/z doesn't match these levels.

                    0ffa5b79-9310-44eb-844a-e9aeadf4d13b-image.jpeg

                    AI guesses it can be Phenylalanine or another source-induced breakdown product of Tesamorelin. It could even be created by the measurement operation itself.

                    attentiion is all you need

                    S 1 Reply Last reply
                    1
                    • vpeptidesV vpeptides

                      @Stevepep actually Freedom COA shows MS chart, here what it is, and it is not a full intact Tesa molecule, it's a contaminant. Freedom also identifies Histidine spike but it is ignored, and its m/z doesn't match these levels.

                      0ffa5b79-9310-44eb-844a-e9aeadf4d13b-image.jpeg

                      AI guesses it can be Phenylalanine or another source-induced breakdown product of Tesamorelin. It could even be created by the measurement operation itself.

                      S Online
                      S Online
                      Stevepep
                      wrote last edited by Stevepep
                      #57

                      @vpeptides to be honest I have zero faith in the ms chart from freedom they identified the purity over 99pct but it is a side chain so who knows

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