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Nexaph reliability?

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  • N Nuncles

    @vpeptides So what are the true downsides to 97% instead of 99%? Just a weaker product (less bang for your buck), failure in the lypholization process, or something else?

    vpepsV Offline
    vpepsV Offline
    vpeps
    wrote last edited by
    #52

    @Nuncles That means these 2% of the AUC on HPLC chart belong not to Tesamorelin but to something else, maybe a broken chain or a different peptide. Who knows, they don't show us peasants the charts. But you can't also tell what is it from HPLC chart, you may guess something from LC-MS charts (or whatever they use for identity), but they don't show it either.

    attentiion is all you need

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    • N Nuncles

      @vpeptides So what are the true downsides to 97% instead of 99%? Just a weaker product (less bang for your buck), failure in the lypholization process, or something else?

      S Online
      S Online
      Stevepep
      wrote last edited by Stevepep
      #53

      @Nuncles anaphylactic response risk increases with less purity. It’s probably fine in most people but those who are sensitive can have a response to the impurities. Also less actual peptide.

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      • N Offline
        N Offline
        Nuncles
        wrote last edited by
        #54

        @steve @vpeptides Thanks for the education. Where, or which process, does this "other 2%" most likely come from? Any educated guesses of the most likely place/cause? I don't have a complete understanding of how peptides are created and the process it takes to get to us, but I'm trying to somewhat fill in the blanks.

        S 1 Reply Last reply
        0
        • N Nuncles

          @steve @vpeptides Thanks for the education. Where, or which process, does this "other 2%" most likely come from? Any educated guesses of the most likely place/cause? I don't have a complete understanding of how peptides are created and the process it takes to get to us, but I'm trying to somewhat fill in the blanks.

          S Online
          S Online
          Stevepep
          wrote last edited by Stevepep
          #55

          @Nuncles if it’s Nexaph it’s likely degradation. Could be moisture or salt. That’s a guess because it could be anything like a breakdown in the chain, another peptide etc. I am familiar with the nutraceutical space so I know the process. We don’t get enough info on the COA to really make that determination because they don’t show the compounds individually

          vpepsV 1 Reply Last reply
          3
          • S Stevepep

            @Nuncles if it’s Nexaph it’s likely degradation. Could be moisture or salt. That’s a guess because it could be anything like a breakdown in the chain, another peptide etc. I am familiar with the nutraceutical space so I know the process. We don’t get enough info on the COA to really make that determination because they don’t show the compounds individually

            vpepsV Offline
            vpepsV Offline
            vpeps
            wrote last edited by vpeps
            #56

            @Stevepep actually Freedom COA shows MS chart, here what it is, and it is not a full intact Tesa molecule, it's a contaminant. Freedom also identifies Histidine spike but it is ignored, and its m/z doesn't match these levels.

            0ffa5b79-9310-44eb-844a-e9aeadf4d13b-image.jpeg

            AI guesses it can be Phenylalanine or another source-induced breakdown product of Tesamorelin. It could even be created by the measurement operation itself.

            attentiion is all you need

            S 1 Reply Last reply
            1
            • vpepsV vpeps

              @Stevepep actually Freedom COA shows MS chart, here what it is, and it is not a full intact Tesa molecule, it's a contaminant. Freedom also identifies Histidine spike but it is ignored, and its m/z doesn't match these levels.

              0ffa5b79-9310-44eb-844a-e9aeadf4d13b-image.jpeg

              AI guesses it can be Phenylalanine or another source-induced breakdown product of Tesamorelin. It could even be created by the measurement operation itself.

              S Online
              S Online
              Stevepep
              wrote last edited by Stevepep
              #57

              @vpeptides to be honest I have zero faith in the ms chart from freedom they identified the purity over 99pct but it is a side chain so who knows

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              • C Commander

                I wish Nexaph had lower prices… They were not too bad before that price jump, still not as cheap as the other grey market suppliers but reasonable enough where it was a good place for people to go buy 1 or 2 kits at a time from. But $468 for a kit of KLOW, who could really afford that, not me I don’t have that kind of cash...

                M Offline
                M Offline
                michellefouch
                wrote last edited by
                #58

                @Commander said:

                I wish Nexaph had lower prices… They were not too bad before that price jump, still not as cheap as the other grey market suppliers but reasonable enough where it was a good place for people to go buy 1 or 2 kits at a time from. But $468 for a kit of KLOW, who could really afford that, not me I don’t have that kind of cash...

                We gave in and ordered the KLOW from them but disappointed when we checked the COA that the gku-cu is lower than it should be and the copper was well below most. Hopefully it still has enough in it to help. Thankfully we got it when they did the extra 15% off....still pricey though.

                C ResearchCatR 2 Replies Last reply
                0
                • M michellefouch

                  @Commander said:

                  I wish Nexaph had lower prices… They were not too bad before that price jump, still not as cheap as the other grey market suppliers but reasonable enough where it was a good place for people to go buy 1 or 2 kits at a time from. But $468 for a kit of KLOW, who could really afford that, not me I don’t have that kind of cash...

                  We gave in and ordered the KLOW from them but disappointed when we checked the COA that the gku-cu is lower than it should be and the copper was well below most. Hopefully it still has enough in it to help. Thankfully we got it when they did the extra 15% off....still pricey though.

                  C Offline
                  C Offline
                  Commander
                  wrote last edited by
                  #59

                  @michellefouch said:

                  @Commander said:

                  I wish Nexaph had lower prices… They were not too bad before that price jump, still not as cheap as the other grey market suppliers but reasonable enough where it was a good place for people to go buy 1 or 2 kits at a time from. But $468 for a kit of KLOW, who could really afford that, not me I don’t have that kind of cash...

                  We gave in and ordered the KLOW from them but disappointed when we checked the COA that the gku-cu is lower than it should be and the copper was well below most. Hopefully it still has enough in it to help. Thankfully we got it when they did the extra 15% off....still pricey though.

                  That sucks. And Nexaph’s KLOW is expensive. But remember , anyone selling peptides is Grey. You just have domestic grey and Chinese Grey. The difference is how fast you get it and if you can pay with credit car or just crypto.

                  My guess (and in this space everything is just a guess) is that we will start to see domestic vendors start to only take crypto soon. Elli is coming down hard on people selling peptides and one of the ways they do it, is going after the merchant service providers. So eventually they will not be able to take credit cards…

                  Please excuse my typos. Small Phone & Bad Eyes

                  S ResearchCatR 2 Replies Last reply
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                  • C Commander

                    @michellefouch said:

                    @Commander said:

                    I wish Nexaph had lower prices… They were not too bad before that price jump, still not as cheap as the other grey market suppliers but reasonable enough where it was a good place for people to go buy 1 or 2 kits at a time from. But $468 for a kit of KLOW, who could really afford that, not me I don’t have that kind of cash...

                    We gave in and ordered the KLOW from them but disappointed when we checked the COA that the gku-cu is lower than it should be and the copper was well below most. Hopefully it still has enough in it to help. Thankfully we got it when they did the extra 15% off....still pricey though.

                    That sucks. And Nexaph’s KLOW is expensive. But remember , anyone selling peptides is Grey. You just have domestic grey and Chinese Grey. The difference is how fast you get it and if you can pay with credit car or just crypto.

                    My guess (and in this space everything is just a guess) is that we will start to see domestic vendors start to only take crypto soon. Elli is coming down hard on people selling peptides and one of the ways they do it, is going after the merchant service providers. So eventually they will not be able to take credit cards…

                    S Online
                    S Online
                    Stevepep
                    wrote last edited by Stevepep
                    #60

                    @Commander nexaph does manufacture in the US so there is that distinction. I see this as important as they can control batches accurately with caps and crimps and batch numbers. To me it’s the biggest selling point because you have the best chance of getting what you ordered. Like @randy says it’s the easy button no worries. The downside is the cost, it’s more than true grey.

                    I think Nexaph starts going to 15pct off for crypto and 5 for bank payments. The processing fees have apparently gone up to 9pct with a large hold back.

                    S 1 Reply Last reply
                    0
                    • C Commander

                      @michellefouch said:

                      @Commander said:

                      I wish Nexaph had lower prices… They were not too bad before that price jump, still not as cheap as the other grey market suppliers but reasonable enough where it was a good place for people to go buy 1 or 2 kits at a time from. But $468 for a kit of KLOW, who could really afford that, not me I don’t have that kind of cash...

                      We gave in and ordered the KLOW from them but disappointed when we checked the COA that the gku-cu is lower than it should be and the copper was well below most. Hopefully it still has enough in it to help. Thankfully we got it when they did the extra 15% off....still pricey though.

                      That sucks. And Nexaph’s KLOW is expensive. But remember , anyone selling peptides is Grey. You just have domestic grey and Chinese Grey. The difference is how fast you get it and if you can pay with credit car or just crypto.

                      My guess (and in this space everything is just a guess) is that we will start to see domestic vendors start to only take crypto soon. Elli is coming down hard on people selling peptides and one of the ways they do it, is going after the merchant service providers. So eventually they will not be able to take credit cards…

                      ResearchCatR Offline
                      ResearchCatR Offline
                      ResearchCat
                      wrote last edited by
                      #61

                      @Commander TBH, given what I have seen in the 2A space, I am surprised that the government stooges paid for by big pharma(i.e. the Senate) haven’t tried to debank peptide sellers sooner. I assume it’s because it isn’t as easy to identify a peptide vendor as it is a firearms and related items vendor.

                      My state has convinced most sellers in the 2A space to refuse to ship here even when it is perfectly legal to do so simply because the threat of a lawsuit would bankrupt most small companies. Similarly, most vendors won’t ship ‘diabetes supplies’ here either, which is why there are a bunch of threads about finding syringes and needles.

                      Yeah, well, I’m just here for the research, man. - The Dude

                      If I haven’t liked your post, no offense. I have exceeded my daily allowance.

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                      • M michellefouch

                        @Commander said:

                        I wish Nexaph had lower prices… They were not too bad before that price jump, still not as cheap as the other grey market suppliers but reasonable enough where it was a good place for people to go buy 1 or 2 kits at a time from. But $468 for a kit of KLOW, who could really afford that, not me I don’t have that kind of cash...

                        We gave in and ordered the KLOW from them but disappointed when we checked the COA that the gku-cu is lower than it should be and the copper was well below most. Hopefully it still has enough in it to help. Thankfully we got it when they did the extra 15% off....still pricey though.

                        ResearchCatR Offline
                        ResearchCatR Offline
                        ResearchCat
                        wrote last edited by
                        #62

                        @michellefouch I know it isn’t always ideal, but you can try to wait until the COA is out before buying to make sure the mix works for you. I know this sometimes means the batch will sell out prior to that. I am a bit more flexible on blends like KLOW, but I also haven’t gotten a batch that hasn’t been at least 10-15% overfilled yet. The ‘worst’ I’ve gotten was right at label strength.

                        Yeah, well, I’m just here for the research, man. - The Dude

                        If I haven’t liked your post, no offense. I have exceeded my daily allowance.

                        M 1 Reply Last reply
                        1
                        • ResearchCatR ResearchCat

                          @michellefouch I know it isn’t always ideal, but you can try to wait until the COA is out before buying to make sure the mix works for you. I know this sometimes means the batch will sell out prior to that. I am a bit more flexible on blends like KLOW, but I also haven’t gotten a batch that hasn’t been at least 10-15% overfilled yet. The ‘worst’ I’ve gotten was right at label strength.

                          M Offline
                          M Offline
                          michellefouch
                          wrote last edited by
                          #63

                          @ResearchCat sigh I should have waited but everything else we've purchased from them was overfilled so just went for it. Thankfully it isn't way off..... GHK-Cu tested at GHK 43.32 Cu 6.02 & GHK 42.98 CU 5.79 & GHK 42.29 Cu 5.85. All the other tested between 11.3 and 11.94. Live a learn. On a positive note it won't sting as much.

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                          0
                          • ResearchCatR Offline
                            ResearchCatR Offline
                            ResearchCat
                            wrote last edited by
                            #64

                            That might be the batch I just got. I haven’t opened it yet to check the COA. This is the first time I have ever seen or noticed the GHK and Cu broken into two separate amounts.

                            Yeah, well, I’m just here for the research, man. - The Dude

                            If I haven’t liked your post, no offense. I have exceeded my daily allowance.

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                            • S Stevepep

                              @Commander nexaph does manufacture in the US so there is that distinction. I see this as important as they can control batches accurately with caps and crimps and batch numbers. To me it’s the biggest selling point because you have the best chance of getting what you ordered. Like @randy says it’s the easy button no worries. The downside is the cost, it’s more than true grey.

                              I think Nexaph starts going to 15pct off for crypto and 5 for bank payments. The processing fees have apparently gone up to 9pct with a large hold back.

                              S Offline
                              S Offline
                              Superpep
                              wrote last edited by
                              #65

                              @Stevepep wrong. They do not manufacture in the U.S. They lyopholize. They source all the raw powder from China and then lyopholize it here in the U.S

                              S 1 Reply Last reply
                              1
                              • S Superpep

                                @Stevepep wrong. They do not manufacture in the U.S. They lyopholize. They source all the raw powder from China and then lyopholize it here in the U.S

                                S Online
                                S Online
                                Stevepep
                                wrote last edited by
                                #66

                                @Superpep Not sure whats wrong. They actually are owned by the company supplying the raws so they source from themselves and then they complete the manufacturing process by freeze drying and batch control, which occurs here on US soil. So once again, not sure what was wrong. The actual point was they have control over batches, so the COA's are meaningful as they relate to an actual batch with cap colors and crimps which THEY CONTROL without relying on a factory in China. Hope that cleared that up for ya

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