New tesamorelin user
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@EXTROPIAN great thread - thanks all. I have some tesa coming to start tomorrow night, and I was thinking 500 mcg before bed, 5/2. I only bought enough for one month because I figure that'll give me time to decide if this is for me. And it gave me a reason to try the new pen
@EXTROPIAN great thread - thanks all. I have some tesa coming to start tomorrow night, and I was thinking 500 mcg before bed, 5/2. I only bought enough for one month because I figure that'll give me time to decide if this is for me. And it gave me a reason to try the new pen
Good luck. Definitely lower dose to start is a great idea. I and many others have seen results at 1mg, so I think 500mcg especially combined with Ipamorelin you will likely have positive results.
Remember those Tesa study participants on 2mg not only were HIV+, they didn't use Ipamorelin, and I'm almost positive they were not even bothering to pin around fasted times which we know drastically increases the effectiveness.
To top all that off, I believe they were specifically chosen as having excessive visceral fat (lipodystrophy) which blunts GHRH response, so it's likely the 2mg standard dose you see many start with/what the study used is actually a very high end dosage that was needed specifically for them given their preexisting health conditions.
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@EXTROPIAN great thread - thanks all. I have some tesa coming to start tomorrow night, and I was thinking 500 mcg before bed, 5/2. I only bought enough for one month because I figure that'll give me time to decide if this is for me. And it gave me a reason to try the new pen
@SkepticJen While I don’t have a problem with you running a one month test to see how you tolerate Tesa, be aware that like sermorelin, you likely won’t see tangible results in only one month. Tesa really needs 3-4 months. Sermorelin even longer. One of the reasons people rave about CJC/Ipa is that you often see results starting in 4-6 weeks and two month cycles show meaningful improvements.
My last run of tesa was two months - i stopped because 2mg was too much, and the biometrics and mirror didn’t show much difference. I immediately ran two months of CJC/Ipa and saw definitely improvement in definition and marginal reduction in visceral fat.
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Go big or go home! 2mg tesa/.300 ipa 7 days a week! 6 months! melt that fat away!
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Or be patient if you want to improve your health and good body composition. If you want to get shredded or close to it. Just listen to some of these boys. But common guys, what would happen if you boost your testosterone? lt can be micro dosed as well for its metabolic benefits and you will look good.
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During testing Egrifta/Tesa was tested at 26weeks
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During testing Egrifta/Tesa was tested at 26weeks
During testing Egrifta/Tesa was tested at 26weeks
What is kinda crazy is that the study participants didn't even pin fasted. Who knows how much bettter the results would have been had they made that change in the protocol. Also makes you wonder if that was even a known thing among the researchers who developed the study. You'd think they would have known that?
Hopefully Big Pharma is paying attention to the discoveries going on in the RUO communities.
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During testing Egrifta/Tesa was tested at 26weeks
What is kinda crazy is that the study participants didn't even pin fasted. Who knows how much bettter the results would have been had they made that change in the protocol. Also makes you wonder if that was even a known thing among the researchers who developed the study. You'd think they would have known that?
Hopefully Big Pharma is paying attention to the discoveries going on in the RUO communities.
During testing Egrifta/Tesa was tested at 26weeks
What is kinda crazy is that the study participants didn't even pin fasted. Who knows how much bettter the results would have been had they made that change in the protocol. Also makes you wonder if that was even a known thing among the researchers who developed the study. You'd think they would have known that?
Hopefully Big Pharma is paying attention to the discoveries going on in the RUO communities.
Makes me wonder if pinning fasted isn't as big as big of a deal as we make it or the patients were so bad off on health pinning fasted or not had little impact on their response.
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During testing Egrifta/Tesa was tested at 26weeks
What is kinda crazy is that the study participants didn't even pin fasted. Who knows how much bettter the results would have been had they made that change in the protocol. Also makes you wonder if that was even a known thing among the researchers who developed the study. You'd think they would have known that?
Hopefully Big Pharma is paying attention to the discoveries going on in the RUO communities.
Makes me wonder if pinning fasted isn't as big as big of a deal as we make it or the patients were so bad off on health pinning fasted or not had little impact on their response.
During testing Egrifta/Tesa was tested at 26weeks
What is kinda crazy is that the study participants didn't even pin fasted. Who knows how much bettter the results would have been had they made that change in the protocol. Also makes you wonder if that was even a known thing among the researchers who developed the study. You'd think they would have known that?
Hopefully Big Pharma is paying attention to the discoveries going on in the RUO communities.
Makes me wonder if pinning fasted isn't as big as big of a deal as we make it or the patients were so bad off on health pinning fasted or not had little impact on their response.
I think its all of the above. Pinning fasted helps, but perhaps its only say 25% more effective (total guess there, have no idea) and the patients had such little igf-1 signaling going on for years that even something as mild as a single peptide secretagogue, taken without being fasted so perhaps with blunted effectiveness, still moved the needle quite a bit in a positive direction.
It does also lean into my hypothesis that 2mg is actually a very high dosage, and that was needed for all the reasons mentioned above in order to get the most favorable outcomes from the participants.
It really all points in a positive direction for Tesamorelin and its effectiveness. The study certainly wasn't designed for optimal outcomes (reasons I noted above) and was actually quite handicapped, the participants were far from healthy subjects to begin with (quite the opposite actually) and despite all that the outcomes were pretty favorable.
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In this document the recommended dosage ws 1.28-1.4 in different variations of egrifta
https://www.accessdata.fda.gov/drugsatfda_docs/label/2025/022505s020lbl.pdf
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In this document the recommended dosage ws 1.28-1.4 in different variations of egrifta
https://www.accessdata.fda.gov/drugsatfda_docs/label/2025/022505s020lbl.pdf
In this document the recommended dosage ws 1.28-1.4 in different variations of egrifta
https://www.accessdata.fda.gov/drugsatfda_docs/label/2025/022505s020lbl.pdf
Mean age was 48 as well, even older than I would have assumed.
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