Study: RUO Reta Underperformed Lilly's Trials
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Came across this study on RUO reta that was conducted by a Massachusetts based data analytics company nference and published as a preprint (not peer reviewed). I just wanted to share because I found it interesting. I am taking RUO reta so don't flame me! Lol
People who obtained RUO retatrutide outside of trial participation lost an average of 4.7%, 5.3% and 7.2% of their weight after taking it for three months, six months and between six and 12 months, respectively.
By contrast, records on patients who enrolled in Lilly’s trials showed that they lost more than twice as much weight — averages of 5.7%, 11.9% and 15.5%, respectively, at the same time points.
As seen above, the weight lost on RUO reta was more than that shown with semaglutide, about the same as tirzepatide studies, but less that Lilly's reta trials.
Full study here: https://www.preprints.org/frontend/manuscript/4a50510817135f57f7eb38ebedeb03f8/download_pub
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Its possible, but I suspect Lilly picked the perfect candidates, as the candidates they select are not just rando. On the other hand, I suspect many RUO peptides do lack potency, because of sequencing, folding, hidden tfa and residual salts, water. I have had mixed responses on this when asking the labs on K-Hole. Some say net peptide content (NPC) is the actual potency while others say make sure the NPC number you get back from a lab account for residual tfa, residual solvents, free tfa, salts and water content.
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Most of the people posting online are taking way less than the doses Lilly is giving participants in the trials. It is very common to see people posting that they are taking 0.5mg-6mg. In the trials they start at 2mg and titrate up to 12mg by the 17th week. A lot of users online seem to be people who aren't even obese as well so they have much less to lose.
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Yeah, I just hit six months and have lost 20.5% on RUO and have not gone above 4.5mg.
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They are desperate and frustrated that their cat got out of the bag and FDA isn't bending easily to their biologic demands. Crony capitalism peaked here.
I also suspect now that they are delaying Reta submission for approval to wait out this administration and get the new pharma friendly one.
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@Newenough ROTFL yeah ask them to send vials to Jano!
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I decided to look at my trajectory vs the phase 3 trials recently because there are two of us doing this together and she is only using 2mg/ week and I'm using 8 - both with the concept of least effective dose. I'm amazed how different we are with the exact same peps, batch, reconstitution (I make the cartridges at the same time). Fascinating science fair project. We've both lost the same amount (different percentages). I'm at 16% at 13 weeks. Shows the need for personalized dosing!
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Honestly Lilly. I don’t care about percentages over time period. I want to go slow and cautiously because my $12 per month COAed glp3r is working just fine at 0.5mg every 4 days. Further, I know it can bring the heat if I need it. If it doesn’t do the trick I can throw Cagrilintide and Tesemorelin or hgh at it for another $24 a month.
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8 months. Husbands rat 3mg and 12% loss. My rat 4mg and 11%. Our goal is not to lose as much as possible as fast as possible. It’s to lose as slow as possible to sustain loss long term.
My friends rat did a fast and high titration like the trials and lost 25% in 6 months. She now does 4mg for maintenance. Anything lower and she starts to gain weight.
My theory, RUO of low and slow will be better for longer term sustained results. -
I’m down 26% since Feb…. Tesa, gym and other steps were involved but this stuff works crazy good. Almost ready to back way off to maintanence
@MacLeeezy When and how did you add in Tesa? Trying to learn about that - seeing wildly different protocols
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I mean, practically speaking if the takeaway is that RUO Reta is 82.3854% as effective as Lilly reta for 10% of the cost, most researchers would be happy taking 1.22x RUO Reta and have money to buy a car rather than spend full boat just for Reta.
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Don't forget the trials likely offer nutrition advice, accountability etc. Those alone can go along way to losing weight. I'm actually impressed RUO/stand alone efforts work 82% as well as a clinically controlled setting.
They could have picked much better examples of RUO reta "not working". Like a friend's rat. He was complaining that reta didn't work at all, blamed the drug then the vendor. Curious, I asked what dose used and how it impacted his diet/alcohol. I had to walk away when he said he hadn't taken reta in 3 weeks and only intermittently before then. Said he treated it like blood pressure meds. When he was thinking he'd be hungry he'd do a shot.
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@Newenough ROTFL yeah ask them to send vials to Jano!
@Newenough ROTFL yeah ask them to send vials to Jano!
Im actually curious if they did. A study needs to know what they are working with....
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Most of the people posting online are taking way less than the doses Lilly is giving participants in the trials. It is very common to see people posting that they are taking 0.5mg-6mg. In the trials they start at 2mg and titrate up to 12mg by the 17th week. A lot of users online seem to be people who aren't even obese as well so they have much less to lose.
@Shifted I think this is the biggest difference in such a study that doesn't compare dosing regimen of RUO vs Lilly reta.
RUO dosing isn't as "standardized" and has people starting lower (as low as 0.5mg) and not titrating as fast as Lilly. Many people don't cross 4mg.
Lilly protocol, on the other hand, starts at 2mg and essentially doubles dose every month for the next 4 months - till it hits 12mg/week. This aggressive titration leads to higher weight loss.
Interestingly, the heart rate increase was see in both RUO reta and Lilly's reta. So, that side effect is compound specific. Sema/tirz did not see any change in heart rates.
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Most of the people posting online are taking way less than the doses Lilly is giving participants in the trials. It is very common to see people posting that they are taking 0.5mg-6mg. In the trials they start at 2mg and titrate up to 12mg by the 17th week. A lot of users online seem to be people who aren't even obese as well so they have much less to lose.
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