GLP-1 effects on dopamine
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@kerryh I believe if you use it long enough you'll rewire new habits to maintain your new body and mind composition (epigenetics). If you pay attention you will learn your biology, diet, physic, learning what it takes to be in a healthy state. Mind, body and soul. If you have to microdose .5mg of reta for the rest of my life now in then I will, considering the consequences in the state of health most are in. I am out of this system of manage decline slowly killing you and bleeding your wealth.
@EXTROPIAN Discussion and semi-debate:
How long is long enough to rewire a person? All supposition and no solid human trials, except for GLP's & very few others; the rest is guesswork. Consider if a person starts at a young enough age (birth thru 20's, perhaps), without extreme injuries and continues at length; yeah, maybe. If any later in life, probably not. My conjecture is just as valid as yours on this subject and I'm sick of the influencers pushing this for their own benefit ($$$$$).Want the obvious answer to pass the century mark? You'll probably have to live as they did in the early 20th century thru about the 1940's, with little chemical (or govt) interference in water and food; the air is questionable, depending upon where you live. To make it work today, you'd more or less end up living as The Amish do. Once the 'clean cycle' is broken and the family unit splits, it's downhill from there.
I can say these things with a type of experience that counts; 40+ hours per week, aged and injured people, some genetics involved, others not. Also, mental and emotional stressors have a major influence on a person's longevity; oftentimes breaking their desire to continue to live. Keep in mind, everyone you once knew and loved are likely gone and the landscape around you has become unrecognizable. I'm sure most here have seen something like this process and I see it every day.
If you still want to live to 100+, stem cells are the way to go, but you really need to save up those nickels and dimes to afford it.
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@EXTROPIAN Discussion and semi-debate:
How long is long enough to rewire a person? All supposition and no solid human trials, except for GLP's & very few others; the rest is guesswork. Consider if a person starts at a young enough age (birth thru 20's, perhaps), without extreme injuries and continues at length; yeah, maybe. If any later in life, probably not. My conjecture is just as valid as yours on this subject and I'm sick of the influencers pushing this for their own benefit ($$$$$).Want the obvious answer to pass the century mark? You'll probably have to live as they did in the early 20th century thru about the 1940's, with little chemical (or govt) interference in water and food; the air is questionable, depending upon where you live. To make it work today, you'd more or less end up living as The Amish do. Once the 'clean cycle' is broken and the family unit splits, it's downhill from there.
I can say these things with a type of experience that counts; 40+ hours per week, aged and injured people, some genetics involved, others not. Also, mental and emotional stressors have a major influence on a person's longevity; oftentimes breaking their desire to continue to live. Keep in mind, everyone you once knew and loved are likely gone and the landscape around you has become unrecognizable. I'm sure most here have seen something like this process and I see it every day.
If you still want to live to 100+, stem cells are the way to go, but you really need to save up those nickels and dimes to afford it.
@Eleanor Don't forget, we are the rats. The trial is live. Dial down the chatter, more presence, more experience and enjoy the ride.
The greatest story ever told is yours. So live it the best you can. These peptides are a blessing. I now in then still question. Why are these peptides all the sudden out at a time when most are metabolically unhealthy? -
@EXTROPIAN I’m listening to a longevity researcher who is talking about GLP-1’s as a lifelong thing along with metformin and rapamycin. I am not a big fan of taking meds, or taking anything for life, but if we are talking about living past 100 (150 is what he is talking about) and being mentally and physically capable, I am willing to negotiate.
I am playing the longest game.
@ResearchCat in this state of the world I'm not hopeful for the future so I'm good with not extending my lifespan too long. But while I'm here Id like to be as healthy as possible to have a better quality of life.
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@ResearchCat in this state of the world I'm not hopeful for the future so I'm good with not extending my lifespan too long. But while I'm here Id like to be as healthy as possible to have a better quality of life.
@ResearchCat in this state of the world I'm not hopeful for the future so I'm good with not extending my lifespan too long. But while I'm here Id like to be as healthy as possible to have a better quality of life.
@beekind That's the idea! Thank you!
@extropian I can't help but be amused when someone tells a 70+ year old to "enjoy the ride", as if I haven't lived to the fullest already. And "live it the best you can". What the heck fire do you think I'm doing?! NO offense meant; I just can't help but chuckle, so thanks for that.
These peptides are a blessing. I now in then still question. Why are these peptides all the sudden out at a time when most are metabolically unhealthy?
Agree with that completely.
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@ResearchCat in this state of the world I'm not hopeful for the future so I'm good with not extending my lifespan too long. But while I'm here Id like to be as healthy as possible to have a better quality of life.
@beekind That's the idea! Thank you!
@extropian I can't help but be amused when someone tells a 70+ year old to "enjoy the ride", as if I haven't lived to the fullest already. And "live it the best you can". What the heck fire do you think I'm doing?! NO offense meant; I just can't help but chuckle, so thanks for that.
These peptides are a blessing. I now in then still question. Why are these peptides all the sudden out at a time when most are metabolically unhealthy?
Agree with that completely.
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@Eleanor I am 55 and still on the roller coaster ride anticipating the next turn. Is wonder completely gone after 70? Ah man, I want off this ride! lol And a red head. Irish?
@EXTROPIAN Slainte Bro!
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@ResearchCat in this state of the world I'm not hopeful for the future so I'm good with not extending my lifespan too long. But while I'm here Id like to be as healthy as possible to have a better quality of life.
@ResearchCat in this state of the world I'm not hopeful for the future so I'm good with not extending my lifespan too long. But while I'm here Id like to be as healthy as possible to have a better quality of life.
The future is going to be great. There will be some bumps and bruises, but if you rip the overlays of politics off, this is a great time to be alive - and the only one you get.
There is a very common human frailty that we indulge that the time we live in is both worse than every other time, and more consequential than every other time. Right now, everyone thinks the 80’s and 90’s were the best. But it’s kind of like everyone who is done with boot camp tells you stories about how great it was.

From a secular perspective, we are in what is called a fourth turning, which is going to be rough no matter what the current batch of idiots is doing. But most of us will be alive for the upswing. (Basically, we are at the ‘weak men make hard times’ period of the cycle. It is an actual thing, as it turns out.)
I was listening to David Sinclair this week and he was talking about how the first person who will live to be 150 is alive today. That’s amazing. Probably won’t be me.
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Tl;DR version of the above.
We can’t choose the times we live in; we can only choose what to do with the time we are given. - Gandalf
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Tl;DR version of the above.
We can’t choose the times we live in; we can only choose what to do with the time we are given. - Gandalf
@ResearchCat I'm still ok with not living to 150. Its not promised that it will get better and with technology, AI, data centers, politics, the economy, war, hatred and the lack of humanity in humans, I don't see how any of those things improve without a major catastrophic event. So 75-85 years is ok by me. Life is getting far too expensive. I'm one of those who will probably work until I die because I wasn't given the tools I needed to make good financial decisions early in life so working until 150 sounds AWFUL.
Im still going to enjoy the life I have and do the best to make a better future for my child but I'm not chasing immortality.
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Before Reta, the Beaver enthusiastically did 3 set lifting workouts, swam sets until time to go to work (which is swimming for a beaver).
Reta, slowly decayed to 2 sets, minimal swim sets.
After doing the high dose SS-31 protocol, down to one lifting set per workout and I am in no hurry to get the beaver to the gym on time.
But the beaver feels great. Resting energy is like in its 20s. No more of that viscous friction in the legs when climbing stairs. Dopamine patches help a little. But at what point does one cycle off of Reta to readjust the brain chemistry? Too tell the truth, the beaver is kind of Jonesing for another SS-31 cycle.
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