Tirzepatide — Weekly Research Dosing Protocol
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For research use only. Not medical advice.
Overview
Tirzepatide is typically explored in ranges from 2.5–15 mg once weekly, with 4-week titration steps to manage GI load. Its ~5-day half-life supports stable once-weekly administration. Dose increases are slow and structured to minimize nausea, reflux, and gastric-emptying issues.
Weekly Titration Schedule
Weeks 1–4: Intro Phase
Dose: 2.5 mg once weekly
Purpose: Establish tolerability before entering the active range.
Notes: Most subjects experience mild effects at this level, which helps avoid early GI complaints.
Weeks 5–8: Low Phase
Dose: 5 mg once weekly
This is where meaningful appetite suppression begins for most subjects.
If subjects show nausea or slowed digestion, researchers may extend the 2.5 mg phase another 2–4 weeks.
Weeks 9–12: Moderate Phase
Dose: 7.5 mg once weekly
Represents a strong working dose in many research settings.
If this phase causes issues, holding at 5 mg longer is common before retrying escalation.
Weeks 13–16: High Phase
Dose: 10 mg once weekly
This is the upper tier for many subjects and provides robust metabolic effects.
Only escalate if 7.5 mg is well tolerated for at least 4 weeks.
Advanced Escalation (Only if Well Tolerated)
After the 10 mg phase, experienced researchers may continue upward:
Weeks 17–20 (optional)
12.5 mg once weekly
Weeks 21–24 (optional)
15 mg once weekly
This represents the maximum common research dose and was the top dose studied in clinical trials.
Escalation to 12.5–15 mg should be done only when subjects tolerate 10 mg with minimal GI events.
Frequency & Timing
Once weekly, same day each week.
Consistency smooths out side-effect profiles due to the peptide’s long half-life.
Delayed nausea is common on Days 2–3 post-dose; escalation should not be rushed.
Cycle Length
Standard titration: 16 weeks to reach 10 mg.
Full research cycles often run 24+ weeks, especially when exploring 12.5–15 mg maintenance.
Common Research Notes
GI side effects correlate strongly with dose; slower titration dramatically improves tolerability.
If symptoms appear during escalation, researchers normally hold or step back the dose rather than pushing forward.
Tirzepatide is significantly more potent than pure GLP-1 agonists; many subjects respond strongly even at 5–7.5 mg.
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I just hit 3 months on Tirz, and did my blood work the day before I started and today, I already got my results back and 3 months ago, everything was near or in the danger zone..... Today, all, and I mean EVERY marker, has me in the "healthy" zone now. What a turn around. 3 mos ago I was 40 pounds heavier and prediabetes with fatty liver and kidney markers indicating future disease. Not anymore...Soon I'll be on maintenance.
I'm so glad I finally got a PA that knew about GLP1's and suggested i try rather than dissuade me like the prior 2 snobby losers who had a problem with them did...
A special thanks Randy and this page for the continuing education, vendor reviews and helpful videos.
Cheers all!! -
My research rat Eddy has been on Tirz since late July of last year. He is on 15 mg and hit a wall and is stalled out on weight loss. HAs zero side effects. no Nausea or eating issues. Feels like he needs to lose another 20 lbs of fat. Any Advice for Eddy? I was wondering about the Surotutide and glucagon. Also, was wondering about How Sermorelin Complements Tirzepatide?
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My research rat Eddy has been on Tirz since late July of last year. He is on 15 mg and hit a wall and is stalled out on weight loss. HAs zero side effects. no Nausea or eating issues. Feels like he needs to lose another 20 lbs of fat. Any Advice for Eddy? I was wondering about the Surotutide and glucagon. Also, was wondering about How Sermorelin Complements Tirzepatide?
@VelocityT
I'm using Cagrilintide and it works well for me, makes me fuller quicker, I've heard Survodutide is also a good add to Tirz. If Cagri wasn't working for me I'd try the Survo stack. -
I just added 250mcg uncle wangs cagri to my tirz/survo stack. To try to offset some of the hunger from ipamorelin. It works...but Im dropping the ipa for the time being because that Ghrelin really makes me want to eat the cheese...ill keep the cagri in the mix but at a really low dose. Closer to 100mcg for the love of the game.
Sermorelin did increase my appetite a smidge but nothing like the Ipamorelin. My experience was less weight loss but better recovery and better workouts. Its a great compound and I feel like its underrated.
As for the "Ghetto Reta" stack. I love it. I'm up to 3mg of survo with 15 of tirz. Monday Tirz and Thursday Survo. Someone much smarter told me to research them like they are separate compounds and that's how I am approaching them. Another option is maz. The consensus in my circle of friends is Mazdutide is the go to if GI upset is a problem.
I titrated upping my dose every two weeks starting around 300mcg. Outlined here
The trials started higher but im stacking glps so better to go on the lighter end.
If hunger is a big issue cagri is the one. if you want a taste of the glucagon with some increase in the satiety of more GLP go survo or mazdutide. Either way theyre great options.
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Eddy, Does anyone have any ideas on split dosing? I find that after my fifth day, I get really hungry for two days. I was thinking before stacking, I might try doing half of the amount, and then in three and a half days doing half the other amount. Has anyone tried this, and does that work for them? What have you guys found?
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Eddy, Does anyone have any ideas on split dosing? I find that after my fifth day, I get really hungry for two days. I was thinking before stacking, I might try doing half of the amount, and then in three and a half days doing half the other amount. Has anyone tried this, and does that work for them? What have you guys found?
@VelocityT yeah some people split dose and love it. You might run into similar satiety issues with your rat. Cagri has murdered my hunger for cheese.
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I just added 250mcg uncle wangs cagri to my tirz/survo stack. To try to offset some of the hunger from ipamorelin. It works...but Im dropping the ipa for the time being because that Ghrelin really makes me want to eat the cheese...ill keep the cagri in the mix but at a really low dose. Closer to 100mcg for the love of the game.
Sermorelin did increase my appetite a smidge but nothing like the Ipamorelin. My experience was less weight loss but better recovery and better workouts. Its a great compound and I feel like its underrated.
As for the "Ghetto Reta" stack. I love it. I'm up to 3mg of survo with 15 of tirz. Monday Tirz and Thursday Survo. Someone much smarter told me to research them like they are separate compounds and that's how I am approaching them. Another option is maz. The consensus in my circle of friends is Mazdutide is the go to if GI upset is a problem.
I titrated upping my dose every two weeks starting around 300mcg. Outlined here
The trials started higher but im stacking glps so better to go on the lighter end.
If hunger is a big issue cagri is the one. if you want a taste of the glucagon with some increase in the satiety of more GLP go survo or mazdutide. Either way theyre great options.
@Randy said in Tirzepatide — Weekly Research Dosing Protocol:
The trials started higher but im stacking glps so better to go on the lighter end.
If hunger is a big issue cagri is the one. if you want a taste of the glucagon with some increase in the satiety of more GLP go survo or mazdutide. Either way theyre great options.
Maz is really expensive!.... and kinda hard to find. I have a 10mg vial that someone gifted me, will give it a go one of these days. Until then the Cagri is currently doing the job and i found a kit of Survo if cagri starts to wear down. I'm close to goal weight so I don't see myself doing all 3
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For a while I was injecting every 5th day since that is the 50% half life of Tirz. Or you can split doses. I know that is common for Reta. I am currently using 5mg Tirz/week and find my appetite does increase a lot Fridays and Saturdays(Saturday night is dose night) but overall my weight is stable to slightly down, my overall calories are in line, and I get to enjoy larger meals once or twice a week.
A friend’s rat does split dosing for Reta and is happy with the results so far.
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For a while I was injecting every 5th day since that is the 50% half life of Tirz. Or you can split doses. I know that is common for Reta. I am currently using 5mg Tirz/week and find my appetite does increase a lot Fridays and Saturdays(Saturday night is dose night) but overall my weight is stable to slightly down, my overall calories are in line, and I get to enjoy larger meals once or twice a week.
A friend’s rat does split dosing for Reta and is happy with the results so far.
@ResearchCat said in Tirzepatide — Weekly Research Dosing Protocol:
For a while I was injecting every 5th day since that is the 50% half life of Tirz. Or you can split doses. I know that is common for Reta. I am currently using 5mg Tirz/week and find my appetite does increase a lot Fridays and Saturdays(Saturday night is dose night) but overall my weight is stable to slightly down, my overall calories are in line, and I get to enjoy larger meals once or twice a week.
A friend’s rat does split dosing for Reta and is happy with the results so far.
I couldn't do the split dosing, just didn't work for me, there has been times when I decide to take my weekly a day, or even a couple days before my pinning day. but i don't do that continually, just as needed. I chalk it up to perhaps I dosed a little less on the last shot, hard for me to be perfectly exact with dosing, even after buying .5cc syringes. I have ordered a couple different pens that I hope will make that easier.
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I definitely suggest going slow and listening to your body. My wife was on Sema and then i started using Tirz. She then went to Tirz. My response has been much greater than hers, and I have no desire for alcohol anymore where she still has some. And I am on a much lower dose. Point being, do what works for you and not what everyone else is telling you. (It probably also helps that I work out a lot, load protein, bleed creatine, and am not menopausal.)
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I definitely suggest going slow and listening to your body. My wife was on Sema and then i started using Tirz. She then went to Tirz. My response has been much greater than hers, and I have no desire for alcohol anymore where she still has some. And I am on a much lower dose. Point being, do what works for you and not what everyone else is telling you. (It probably also helps that I work out a lot, load protein, bleed creatine, and am not menopausal.)
@ResearchCat hahaha, I like your humor!
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@VelocityT yeah some people split dose and love it. You might run into similar satiety issues with your rat. Cagri has murdered my hunger for cheese.
@Randy I ordered my Cagri. It arrives today! I am excited. Split dosing on just Triz was a disaster for me. I am trying the Cagri....I will check back with results either way. Does this schedule seem correct? what do other researchers recommend?The 16-Week Clinical Titration Schedule:
Phase Weekly Dose Duration Total Phase Dose Purpose
Month 1 0.3 mg Weeks 1–4 1.2 mg Initial receptor sensitization
Month 2 0.6 mg Weeks 5–8 2.4 mg Escalation 1
Month 3 1.2 mg Weeks 9–12 4.8 mg Escalation 2 (The "Wall" for many)
Month 4 1.8 mg Weeks 13–16 7.2 mg Escalation 3
Maintenance 2.4 mg Week 17+ 2.4 mg/week Full therapeutic dose -
@Randy I ordered my Cagri. It arrives today! I am excited. Split dosing on just Triz was a disaster for me. I am trying the Cagri....I will check back with results either way. Does this schedule seem correct? what do other researchers recommend?The 16-Week Clinical Titration Schedule:
Phase Weekly Dose Duration Total Phase Dose Purpose
Month 1 0.3 mg Weeks 1–4 1.2 mg Initial receptor sensitization
Month 2 0.6 mg Weeks 5–8 2.4 mg Escalation 1
Month 3 1.2 mg Weeks 9–12 4.8 mg Escalation 2 (The "Wall" for many)
Month 4 1.8 mg Weeks 13–16 7.2 mg Escalation 3
Maintenance 2.4 mg Week 17+ 2.4 mg/week Full therapeutic dose@VelocityT be ready to stop escalation when it works.
Protocol looks very familiar
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@VelocityT be ready to stop escalation when it works.
Protocol looks very familiar
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@Randy I am very surprised how well it works. I have struggled with the desire to eat my whole life. This is incredibly empowering being able to have control over my own body. TY.
@VelocityT Im with you. The pizza thoughts at 1am are gone. My drug was always food.
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8 months in, I am dropping my Tirz to 2.5mg from 5mg. I only got up to 10mg in October and by then had no appetite. I got to my original target weight in December and have been flat to slightly down since then. My goal at this point is to continue building muscles, and I just can’t eat enough over 5mg. Plus (TMI) the only bad side effect I’ve had is constipation. So i hope this helps.
I have noticed a bit more food noise and booze noise, though that is up from nothing. I gotta say that I really enjoy having no desire for booze, mobile games, and a lot of other stuff. Makes me wonder what other things it suppresses.
Note: I also cycle CJC/Ipa, which some people say increases appetite. And improves sleep. I haven’t noticed either, but who can say.
I encourage you to play with lower doses of your GLP-1’s, especially if you are working out, watching your macros, and researching other peptides. Big Pharma wants you on the maximum dose, but you don’t necessarily need to be on it for it to be effective.
Stay healthy, happy researching, and take more creatine.
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Have you tried other GLP's from vendors like Nextchems Retatrutide?
