The "ghetto" Reta Stack. Tirz + Survo/Maz
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@Randy Well I lost 22lbs and gained 7lbs muscle mass. Im now at 192lbs. It gets windy here in Nevada so I don’t want to lose too much weight. I just reconstituted some tesamoreline to try a stack with my cjc/ipa to hit that little chunk of love handles.
I want to try some reta too that Ive heard so much about. -
For research use only. Not medical advice.
The goal:
Tirzepatide = GLP-1 + GIP
Survodutide or Mazdutide = GLP-1 + Glucagon
→ Combined effect = GLP-1 + GIP + Glucagon, i.e., a retatrutide-like profile.Because both second agents have a glucagon hit, titration must be slower than usual to avoid nausea, low appetite floor, or excessive gastric slowing.
Why do this?
- You stockpiled too much tirz.
- Break a stall.
- Reta itch/allodynia or other intolerable side effects when researching reta.
1. Tirzepatide + Survodutide
Survodutide has a stronger glucagon hit than mazdutide. This is the more potent combination.
Weekly Titration Schedule
Weeks 1–4
Tirzepatide: 2.5 mg weekly
Survodutide: 0.3 mg weekly
Purpose: Establish baseline tolerability. Survo kicks hard early.Weeks 5–8
Tirzepatide: 5 mg weekly
Survodutide: 0.6 mg weekly
Notes: Appetite suppression becomes extremely strong for many subjects here.Weeks 9–12
Tirzepatide: 7.5 mg weekly
Survodutide: 1.0 mg weekly
This is the sweet spot for most research models. Strong “reta-like” effect emerges.
Week 13+ Maintenance
Two viable approaches:
Standard Maintenance
Tirzepatide: 7.5–10 mg
Survodutide: 1.0–1.5 mg
High-End (Aggressive) Maintenance
Tirzepatide: 10–12.5 mg
Survodutide: 1.5–2.0 mg
Only for researchers replicating the high-end metabolic punch of retatrutide.
Notes
Survodutide plus tirz amplifies appetite suppression so hard that most people do not need high tirz dosing.
Escalate slowly — both compounds slow gastric emptying.
This combo is more GC-heavy than mazdutide, so itch issues are less common compared to retatrutide, but GI load is higher.
- Tirzepatide + Mazdutide (Ghetto Reta v2 — Milder, Cleaner)
Mazdutide has a slightly softer glucagon hit and a less aggressive appetite cliff.
This stack is smoother and usually more tolerable.Tirzepatide + Mazdutide
Weeks 1–4
Tirzepatide: 2.5 mg weekly
Mazdutide: 2 mg weekly
Weeks 5–8
Tirzepatide: 5 mg weekly
Mazdutide: 4 mg weekly
Weeks 9–12
Tirzepatide: 7.5 mg weekly
Mazdutide: 6 mg weekly
This combo mimics a “mid-dose retatrutide” effect without the itch or violent GI spike.
Week 13+ Maintenance
Tirzepatide: 7.5–10 mg
Mazdutide: 6–8 mg
High-End (Not common)
Tirzepatide: 10–12.5 mg
Mazdutide: 8–10 mg
Notes
Mazdutide is smoother but still synergistic with tirz.
Appetite suppression is strong but less harsh than survo stacks.
GI load increases if escalated too fast — keep 4-week steps.
-
For research use only. Not medical advice.
The goal:
Tirzepatide = GLP-1 + GIP
Survodutide or Mazdutide = GLP-1 + Glucagon
→ Combined effect = GLP-1 + GIP + Glucagon, i.e., a retatrutide-like profile.Because both second agents have a glucagon hit, titration must be slower than usual to avoid nausea, low appetite floor, or excessive gastric slowing.
Why do this?
- You stockpiled too much tirz.
- Break a stall.
- Reta itch/allodynia or other intolerable side effects when researching reta.
1. Tirzepatide + Survodutide
Survodutide has a stronger glucagon hit than mazdutide. This is the more potent combination.
Weekly Titration Schedule
Weeks 1–4
Tirzepatide: 2.5 mg weekly
Survodutide: 0.3 mg weekly
Purpose: Establish baseline tolerability. Survo kicks hard early.Weeks 5–8
Tirzepatide: 5 mg weekly
Survodutide: 0.6 mg weekly
Notes: Appetite suppression becomes extremely strong for many subjects here.Weeks 9–12
Tirzepatide: 7.5 mg weekly
Survodutide: 1.0 mg weekly
This is the sweet spot for most research models. Strong “reta-like” effect emerges.
Week 13+ Maintenance
Two viable approaches:
Standard Maintenance
Tirzepatide: 7.5–10 mg
Survodutide: 1.0–1.5 mg
High-End (Aggressive) Maintenance
Tirzepatide: 10–12.5 mg
Survodutide: 1.5–2.0 mg
Only for researchers replicating the high-end metabolic punch of retatrutide.
Notes
Survodutide plus tirz amplifies appetite suppression so hard that most people do not need high tirz dosing.
Escalate slowly — both compounds slow gastric emptying.
This combo is more GC-heavy than mazdutide, so itch issues are less common compared to retatrutide, but GI load is higher.
- Tirzepatide + Mazdutide (Ghetto Reta v2 — Milder, Cleaner)
Mazdutide has a slightly softer glucagon hit and a less aggressive appetite cliff.
This stack is smoother and usually more tolerable.Tirzepatide + Mazdutide
Weeks 1–4
Tirzepatide: 2.5 mg weekly
Mazdutide: 2 mg weekly
Weeks 5–8
Tirzepatide: 5 mg weekly
Mazdutide: 4 mg weekly
Weeks 9–12
Tirzepatide: 7.5 mg weekly
Mazdutide: 6 mg weekly
This combo mimics a “mid-dose retatrutide” effect without the itch or violent GI spike.
Week 13+ Maintenance
Tirzepatide: 7.5–10 mg
Mazdutide: 6–8 mg
High-End (Not common)
Tirzepatide: 10–12.5 mg
Mazdutide: 8–10 mg
Notes
Mazdutide is smoother but still synergistic with tirz.
Appetite suppression is strong but less harsh than survo stacks.
GI load increases if escalated too fast — keep 4-week steps.
@Randy Is Reta itch issue due to GIP or combination or all three RAs?
I'm stocked up like crazy on Reta and now wondering if that was the right decision. I came across Survo later when I fell in the peptide rabbit hole deep.
Dropped Tirz from 10mg to 5mg due to horrible fatigue and inability to lift prior weights on 10mg.
Added Survo 3 weeks ago.
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@tony49_49 nooooo
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@Randy Is Reta itch issue due to GIP or combination or all three RAs?
I'm stocked up like crazy on Reta and now wondering if that was the right decision. I came across Survo later when I fell in the peptide rabbit hole deep.
Dropped Tirz from 10mg to 5mg due to horrible fatigue and inability to lift prior weights on 10mg.
Added Survo 3 weeks ago.
@pep_researcher We dont know what it is but i havent had it with maz or survo
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@Randy Well I lost 22lbs and gained 7lbs muscle mass. Im now at 192lbs. It gets windy here in Nevada so I don’t want to lose too much weight. I just reconstituted some tesamoreline to try a stack with my cjc/ipa to hit that little chunk of love handles.
I want to try some reta too that Ive heard so much about. -
@tony49_49 nooooo
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@beachfun Yeah I do Tirz on Saturday, and Survo on Tue or Wed.
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@jborja I got my Survo from EZ peptides and like they have the QR code of the COA right on the label. My 1 10 mg vial has lasted over 2 months. I really noticed the effects when I reached the 1mg. I stayed at 5mg of Tirz and see no reason to tirade up. I will probably stop both after this week as Ive met my weight loss goals. I just want to cut that visceral fat to tone up my abs.
My plan now is to try some Reta maybe 5mg weekly with my cjc/ipa .3mg nightly 5 times a week and some MotsC 5mg 3x a week. Not sure about stacking some Tesamoreline with the nightly shot. Anybody want to share thoughts?@beachfun Excellent to know these numbers. Those are my exact same target numbers and I'm adding Survo very very slowly keeping Tirz at 4-5mg.
It will take me 3 months to finish my first 10mg Survo vial as I'm titrating up very slowly.
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@beachfun Im a big fan of the real thing over the gh releasing peps... Tesa does work though
My back and joints really started aching on Tesamoreline on my first 10mg vial. I had to stop and went back to my cjc/ipa dose before bed. I prefer the more natural pulse of my body producing gh but do love my TRT twice a week. I’ve also tried kisspeptine a few times which was interesting…
