Tesamorelin Research Dosing Protocol
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Im really struggling with Tesa over CJC. It requires much higher dosing (like 8x more expensive just based on 250mcg vs 2mg dosing), is less stable in the vial from what I gather, and essentially does the same thing.
Is it the FDA approval? I know it is hailed as the 'visceral fat' pick for these GHRH analogs but the reason for that is because it was tested for it...the others are going to do the same thing, which is getting the downstream IGF-1 boost.
What am I missing?
Im really struggling with Tesa over CJC. It requires much higher dosing (like 8x more expensive just based on 250mcg vs 2mg dosing), is less stable in the vial from what I gather, and essentially does the same thing.
Is it the FDA approval? I know it is hailed as the 'visceral fat' pick for these GHRH analogs but the reason for that is because it was tested for it...the others are going to do the same thing, which is getting the downstream IGF-1 boost.
What am I missing?
You're not missing anything. The same reason why Tesa burns visceral fat is the same reason why CJC does - GHRH --> GH --> IGF-1
The reason why Tesa is a thing is entirely because it was modified slightly so they could patent and sell it for profit, as they couldn't do that with CJC-1295
The main difference is that CJC-1295 is much stronger and has a slightly longer half life, which means it must be dosed at a much careful/supervised amount, and there is less wiggle room for side effects. Meaning, theoretically, with Tesa you're likely to have more wiggle room for dosing experimentation across a wide range of people and less likely to run into issues given.
You can have a blanket recommendation of say 1mg per day of Tesa as a starting dose and 150mcg of CJC-1295. Because Tesa has a shorter half life and doesn't illicit as strong of a GHRH response, it's likely going to be safer across a population of thousands of people using the drug.
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Im really struggling with Tesa over CJC. It requires much higher dosing (like 8x more expensive just based on 250mcg vs 2mg dosing), is less stable in the vial from what I gather, and essentially does the same thing.
Is it the FDA approval? I know it is hailed as the 'visceral fat' pick for these GHRH analogs but the reason for that is because it was tested for it...the others are going to do the same thing, which is getting the downstream IGF-1 boost.
What am I missing?
@hunt_ak
Dr Ashley Froese did a YouTube video about tesamorelin a few weeks back that I thought contained some decent information. Its called: Dr Amazed - Tesamorelin DECIMATES Visceral Fat and MORE
There does appear to be some science behind why tesa targets visceral fat better vs CJC or sermorelin beyond the IGF-1 increase, if that is your primary goal.
Is it worth the extra $$ and potential side effects - that really varies. Everyone reacts differently to peps. I personally did not like tesa at all, but others love it. -
@hunt_ak
Dr Ashley Froese did a YouTube video about tesamorelin a few weeks back that I thought contained some decent information. Its called: Dr Amazed - Tesamorelin DECIMATES Visceral Fat and MORE
There does appear to be some science behind why tesa targets visceral fat better vs CJC or sermorelin beyond the IGF-1 increase, if that is your primary goal.
Is it worth the extra $$ and potential side effects - that really varies. Everyone reacts differently to peps. I personally did not like tesa at all, but others love it.@christexer said:
@hunt_ak
Dr Ashley Froese did a YouTube video about tesamorelin a few weeks back that I thought contained some decent information. Its called: Dr Amazed - Tesamorelin DECIMATES Visceral Fat and MORE
There does appear to be some science behind why tesa targets visceral fat better vs CJC or sermorelin beyond the IGF-1 increase, if that is your primary goal.
Is it worth the extra $$ and potential side effects - that really varies. Everyone reacts differently to peps. I personally did not like tesa at all, but others love it.Another caveat I forgot to mention above, in that I do like Tesa for the simple fact that I always like to cycle my GHRH analogs to prevent potential antibody response. I do like to have complete down time with no exogenous GHRH usage, but I also like to cycle various GHRH peptides in and out. So it's nice to have another option in Tesa alongside CJC-1295 and Sermorelin.
As far as Tesa vs. CJC-1295 and the purported science behind why Tesa burns visceral fat better, I don't believe that it does at all and I haven't seen any science or evidence that proves that. I'll check out Dr. Ashley's video out and see what she has to say.
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12 weeks did me very well. I am currently just finishing week 6 of a planned 16 week cycle. You do have to be patient but you will see results if you have all the other things dialed in.(diet, exercise, sleep)
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@Stevepep
The Hume is the scale I was talking about. I bought it. Went for a dexa scan, came home from the scan and got on the Hume, more than 50% off..@Commander Wow totally different experience it was the same with my wife within 1pct of Dexa maybe it's a body type thing.
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The HR increase/pounding for the first bit after dosing CJC is definitely something that tells me 'hello, I'm working in here!' haha
I do have a vial of Tesa that I'm going to do when I cycle off the CJC/Ipa blend for 4 weeks. We shall see how it goes!
The HR increase/pounding for the first bit after dosing CJC is definitely something that tells me 'hello, I'm working in here!' haha
I do have a vial of Tesa that I'm going to do when I cycle off the CJC/Ipa blend for 4 weeks. We shall see how it goes!
I don't get the increased HR, but I do get the warm fuzzy flushy feeling in my face. I actually like it, especially on a chilly morning inside a cold laboratory in a northern climate. Good way to start the day.
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I have 20mg vials coming in a couple of days, so I guess I will find out
I have seen those around, and was previously thinking that 20 days is way too long to have Tesa recon in use (I go 1mg per day).
Your experiences have me thinking otherwise. I try not to get dogmatic about things and I will experiment and tinker if it makes sense, within reason.
I have previously ran them for 10 days (not fridged) with no issues at all.
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I’d love to see @randy run his next batch of testing on research grade Tesa, so we can finally see if it stays potent for a few weeks after reconstitution and if being in the fridge or room temp really matters (pretty please)?
I’d love to see @randy run his next batch of testing on research grade Tesa, so we can finally see if it stays potent for a few weeks after reconstitution and if being in the fridge or room temp really matters (pretty please)?
I have 2 vials of 10mg Tesa powder in the fridge from Penguin I will donate to Randy if he will test. Might as well donate it bc I can't take it with the side effects.
@randy What says you, rat?
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I’d love to see @randy run his next batch of testing on research grade Tesa, so we can finally see if it stays potent for a few weeks after reconstitution and if being in the fridge or room temp really matters (pretty please)?
I have 2 vials of 10mg Tesa powder in the fridge from Penguin I will donate to Randy if he will test. Might as well donate it bc I can't take it with the side effects.
@randy What says you, rat?
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@jborja said in Tesamorelin Research Dosing Protocol:
Hey friends, @randy might have opined on this also, but curious to hear what others think. I saw another video that nightly tesamorelin might be impacted for those taking Tirz or Reta due to slowed gastric emptying, meaning that folks are not as truly fasted and still carrying heavier insulin when they poke before bed.
I like Tesamorelin/ipa at nights due to restful and deeper sleep (even with toddlers), but I am on tirz and try to have my last bite 3 hours before bed. Not sure if eating dinner 4 hrs before is doable..
Curious to hear your thoughts about a morning routine instead? For you morning folks, do you just wait at least 30 mins before a pre workout? I was gonna try Tesa at night and Cjc in the morning but might be reconsidering this to not have duplicative secretagogues at the same time. Ty!I only research my GHRH/GHRP peptides in the a.m., first thing fasted now, for a whole bunch of reasons. It's just easier and more convenient for me, I know I'm totally fasted with insulin at its lowest point (and therefore getting the strongest amount of receptor saturation as possible).
Plus I'm just more awake/alert in the a.m., easier to pin and reconstitute if need be. I spent many late nights in years past pinning/researching before bed after a long day and when tired, it's just difficult.
I wait 2 hours before eating anything. I drink black coffee right away in the morning after pinning and the combo of peptides, coffee and being fasted in the a.m. is a superpower for getting stuff done. Plus I find GH peptides stimulating in a way in the morning.
I like the idea of going natural at night (no GH peps) and really letting my natural production do its thing. I have found that there must be some carry over anyways, because on cycle my rat sleeps better even though he pins in the a.m only.
Rather than trying to find a way to squeeze in Tesa/CJC in the same day, I'd recommend you use one or the other during your cycle. You can flip flop them as well, going back and forth when one vial runs out.
I know I'm totally fasted with insulin at its lowest point
You should really test your daily insulin fluctuation (through correlation with glucose) with 15-days CGM to know levels and timings exactly. I ran CGMs many times, and when I wake up my insulin level is not the lowest of the day. There is so-called "dawn effect" starting at around an hour before you wake up and going for some time, when your insulin goes high because glucose go high because of raising cortisol.
Here is how it looked for me, and I wake up at 6-7. See, there is a raise around the wake time and then it goes down around 7:30a. You can make it personally adjusted, knowing the short half-life of these molecules it may be worth doing.
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I’ve been taking Tesamorelin for 2 weeks—1 mg during the first week and 2 mg at night during the second week. I inject it about 30 minutes before bed, with no food for at least 3 hours beforehand.
Since starting it, my nighttime heart rate has increased. My average resting heart rate used to be around 60, but recently it’s been 86, 70, and 69. My stress levels have been very high, I’m not getting any REM sleep, and I’m having trouble sleeping overall.
I know that this is an evening Peptide, but would AM hour work better maybe? I could pause for a couple of days and see if my heart rate and sleep normalize also.@lancerlot23 Any update on how this went? Researching Reta and Im +10 bpm, with the same negative results you mention. Last thing i need is more BPM's!
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Great summary.
One thing I would add is that monitoring IGF-1 during longer research protocols can be useful since individual responses vary. I also found this Tesamorelin research overview helpful for comparing dosing protocols and cycle lengths: https://peptidescostarica.net/tesamorelin-costa-rica/
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