CJC-1295 NO DAC (Mod GRF 1–29) Research Dosing Protocol
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For research use only. Not medical advice.
Overview
CJC-1295 NO DAC (Modified GRF 1–29) is a short-acting GHRH analog with a ~30-minute half-life that produces physiologic GH pulses rather than sustained elevation.
Because of its short duration, it is typically administered once daily to support natural GH rhythm, or stacked with GH secretagogues like ipamorelin for synergistic pulses.Daily Dosing Protocol (Subcutaneous)
Standard Daily Range
100–300 mcg once daily
Researchers generally start low and increase gradually to minimize flushing and injection-site irritation.
Titration Schedule
Weeks 1–2
100 mcg daily
Establishes baseline tolerability.
Weeks 3–4
150 mcg daily
Weeks 5–6
200 mcg daily
Weeks 7–8
250 mcg daily
Weeks 9–10
300 mcg daily
Common upper end of daily dosing for standalone CJC-1295 NO DAC protocols.
Timing
Typically administered before bedtime to align with nocturnal GH release.
Can also be paired with ipamorelin or other GHRPs taken at the same time for a stronger GH pulse.
Alternative timing strategies used in some research settings:
Morning fasted
Post-workout
2–3× per day micro-pulsing (advanced protocols; not necessary for standard use)
Cycle Length
Typical Mod GRF 1–29 research cycles:
8–12 weeks on, followed by
2–4 weeks off to reduce receptor fatigue
Longer cycles are common when stacked with GHRPs.
Common Research Notes
Produces clean GH pulses without the water retention sometimes seen with long-acting GH analogs.
Stacks exceptionally well with ipamorelin, GHRP-2, or GHRP-6 for dual-pathway GH stimulation.
Side effects are usually mild: warmth, flushing, or transient lightheadedness shortly after administration.
Should be taken away from food, as nutrients—especially carbs/fats—may blunt GH output.
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i stated taking this 4 nights ago. My vial is mixed 5mg CJC, 5mg Ipamorelin. My sleeps have been nice and deep. I usually wake up for a bit pee around 4am but i have found that common since starting all of my other peptides Jan 20th.
I look forward to seeing how I progress with this.
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Dr Ashley Froese dropped a video yesterday about CJC-1295 and how ipamorelin work well together
https://youtu.be/kdQ83_Je_qs?si=oen7AtRAJamxzZgF -
She’s blowing up. Her videos are great. I wonder when/if she is going to get into telehealth. (Though, she is not a chiropractor so she may not be qualified to prescribe peptide therapies.)
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P PeptideCritic moved this topic from Growth & Performance on
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For research use only. Not medical advice.
Overview
CJC-1295 NO DAC (Modified GRF 1–29) is a short-acting GHRH analog with a ~30-minute half-life that produces physiologic GH pulses rather than sustained elevation.
Because of its short duration, it is typically administered once daily to support natural GH rhythm, or stacked with GH secretagogues like ipamorelin for synergistic pulses.Daily Dosing Protocol (Subcutaneous)
Standard Daily Range
100–300 mcg once daily
Researchers generally start low and increase gradually to minimize flushing and injection-site irritation.
Titration Schedule
Weeks 1–2
100 mcg daily
Establishes baseline tolerability.
Weeks 3–4
150 mcg daily
Weeks 5–6
200 mcg daily
Weeks 7–8
250 mcg daily
Weeks 9–10
300 mcg daily
Common upper end of daily dosing for standalone CJC-1295 NO DAC protocols.
Timing
Typically administered before bedtime to align with nocturnal GH release.
Can also be paired with ipamorelin or other GHRPs taken at the same time for a stronger GH pulse.
Alternative timing strategies used in some research settings:
Morning fasted
Post-workout
2–3× per day micro-pulsing (advanced protocols; not necessary for standard use)
Cycle Length
Typical Mod GRF 1–29 research cycles:
8–12 weeks on, followed by
2–4 weeks off to reduce receptor fatigue
Longer cycles are common when stacked with GHRPs.
Common Research Notes
Produces clean GH pulses without the water retention sometimes seen with long-acting GH analogs.
Stacks exceptionally well with ipamorelin, GHRP-2, or GHRP-6 for dual-pathway GH stimulation.
Side effects are usually mild: warmth, flushing, or transient lightheadedness shortly after administration.
Should be taken away from food, as nutrients—especially carbs/fats—may blunt GH output.
@Randy
I'm about 2 months into my cycle CJC [no dac] +P.
The dosage I picked up goes .3MG x3 per day on workout days, once on non-workout days.Seeing good results out of it.
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I am back on my CJC-1295/IPA cycle after a full 30 days off, longest time off I have taken from GH related peptides in....years. Flush was strong these first couple days, I don't mind it. Based on some new research I have been reading I am experimenting with longer stretches off (30 full days this time) to really freshen up the receptors. Prior my time off was always 1 week/10 days/2 weeks or something similar.
I also tried going nighttime inject to mix things up. Bad idea, wide awake 4 hours after falling asleep. Double on top of that is having this fresh receptors really amplified that. Back to a.m. dosing as usual!
Running this about 100 days, then taking another 30 day break. I am going to investigate some ways to enhance GH outside of GH secretagogues for my next 30 day break. One option is L Dopa + Citrillune (essentially a very mild GHRH + GHRP). L Dopa is your GHRH, Citrillune is your GHRP. First thing a.m. fasted, what I am doing already. Also looking at a 30-40 day cycle of HGH as my go between. Perhaps both.
I've got labs coming up in September. I'll keep ya'll updated on where this moves my igf-1.
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You may know this already but its well documented in studies that BPC-157 increases the expression of growth hormone receptors, its a nice addition. I'm about to take a 30 day break, I'm going to miss those deep sleeps but look forward to the fresh receptors.
I first had issues sleeping with night time dosing until I built a nightime regime that included sleep hygene and focus on lowering cortisol. Now its no problem and helps with my sleep. Takes me forever to actually get into to bed though, like an hour+ wind down routine, no screens or junk light, the room is red light only, warm shower, cold water on the face for 45 seconds, stretch 15 minutes then legs on the wall yoga pose with 4-7-8 breathwork for 20 sets followed up with my dose of GH peptides hitting the bed with a 24 minute pulsetto vegal nerve stimulator sleep session while I listen to a tibetan singing bowl recordings, ear plugs in and eye covers on, lights out. Becasue the GH peptides will temporarily increase cortisol if your levels are already high from something like a rigurous exercise routine, artificial light, screens, stressfull work day etc. the GH peptides can be the cherry on top or straw that breaks the camels back when it comes to sleep disturbances.
-
You may know this already but its well documented in studies that BPC-157 increases the expression of growth hormone receptors, its a nice addition. I'm about to take a 30 day break, I'm going to miss those deep sleeps but look forward to the fresh receptors.
I first had issues sleeping with night time dosing until I built a nightime regime that included sleep hygene and focus on lowering cortisol. Now its no problem and helps with my sleep. Takes me forever to actually get into to bed though, like an hour+ wind down routine, no screens or junk light, the room is red light only, warm shower, cold water on the face for 45 seconds, stretch 15 minutes then legs on the wall yoga pose with 4-7-8 breathwork for 20 sets followed up with my dose of GH peptides hitting the bed with a 24 minute pulsetto vegal nerve stimulator sleep session while I listen to a tibetan singing bowl recordings, ear plugs in and eye covers on, lights out. Becasue the GH peptides will temporarily increase cortisol if your levels are already high from something like a rigurous exercise routine, artificial light, screens, stressfull work day etc. the GH peptides can be the cherry on top or straw that breaks the camels back when it comes to sleep disturbances.
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