SS-31 (Elamipretide) — Research Dosing Protocol
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Food for thought: Liz Parrish, CEO of BioViva Science has said the senescent cells act as placeholders, AND, some are stem cells, and if you are already old and have few, may wipe out the reservoir to draw from using a regeneration process. Do your own due diligence. I did a round of FOX04-DRI and now regret it, aside from the fact it gave me an ISR I will never forget.
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That is really timely. I was just starting to look at FOX-04 DRI, and just saw a new video on it. It seems like with all the attention SS-31/MOTS-C/NAD+ are getting that FOX is as well. Clearing out senescent cells sounds like a great idea, but I’d be a bit concerned with killing off 10%(one number I saw) of my cells without better understanding of what they get replaced with.
Definitely requires a bit more research on my part. Thank goodness it’s expensive.
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You arent wrong. I just checked that on ez/nexaph/paramount and the item not longer has a hyperlink in my order history.
@Randy when you buy from Nexaph, is it normal to be required to register with a separate company as a researcher?
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Yeah that's a new thing so they don't lose their payment processor. That research group you have to join is a third party that a bunch of research vendors are signing up with. But it's okay because you are a researcher
.If you will want to avoid that and save 5% just pay with crypto.
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Food for thought: Liz Parrish, CEO of BioViva Science has said the senescent cells act as placeholders, AND, some are stem cells, and if you are already old and have few, may wipe out the reservoir to draw from using a regeneration process. Do your own due diligence. I did a round of FOX04-DRI and now regret it, aside from the fact it gave me an ISR I will never forget.
@PeptidePete Im not 100% sure its bad to do fox04 thats to be seen however the ISR is pretty radical.
I still have a welt on my ass over 1 month ago and doesn’t go away, pretty weird what it did in that spot of my butt
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I am not at all an expert, but the gist of it (concern about researching FOX-04) is that some senescent cells may still be performing useful functions, some may be stem cells, and others are okay to clear. It isn’t clear at this point whether FOX-04 only targets senescent cells that are okay to clear out, or if it will target all of them, and whether there are deleterious affects associated with that.
The research I have seen targets the cells in particular parts of the body and does show beneficial effects. I haven’t found anything on system/organism-wide research so far.
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Yeah that's a new thing so they don't lose their payment processor. That research group you have to join is a third party that a bunch of research vendors are signing up with. But it's okay because you are a researcher
.If you will want to avoid that and save 5% just pay with crypto.
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@Randy awww, thank you so much! I might just save up a few things i need to buy and get a few 10 vial orders in.
Im designing the my next year's protocols and it would be nice to have it ready.
@theckman80 its a slippery slope. I've bought the owner a small car in the last few years
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@theckman80 its a slippery slope. I've bought the owner a small car in the last few years
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A friend sent me an invite to an FB group; If I followed their suggestions I would be researching all the peptides all the time and constantly increase quantities. Planning a rational schedule makes a lot of sense. And as stated elsewhere, at some point, more isn’t going to help you any more.
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A friend sent me an invite to an FB group; If I followed their suggestions I would be researching all the peptides all the time and constantly increase quantities. Planning a rational schedule makes a lot of sense. And as stated elsewhere, at some point, more isn’t going to help you any more.
@ResearchCat I couldn't agree more. Im doing my best to understand what I'm doing and make a conscious effort to solve specific problems. The more I start to understand (on whatever level it is), the more i wish I knew more before I started. Like, on, started on Reta, probably should have run a protocol of SS-31 and MOTS-C before doing that. Now, I've done that and im getting more out of the reta, weight loss wise. My doc wanted to know what I've been doing after seeing my labs. Said I get the prize for best a1c change. He is also a type 2 diabetic.
Now that ss-31 passed fda approval (not that it means much), I might actually talk to him about this stuff.
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PGC-1α gene therapy is one of the current "Holy Trinity" of Klotho, Follistatin and PCG-1α gene therapies. My research focused on Elamipretide (SS-31), MOTS-C and NAD+ as an effective substitute for the PGC-1α gene therapy. It's a big deal if you understand the research implications. Food for thought:
"Overall Assessment: Adding sub-q NAD+ would complement (and potentially amplify) the PGC-1α-normalizing benefits of elamipretide + MOTS-c by providing the necessary cofactor for SIRT1-mediated PGC-1α activation and downstream mitochondrial improvements. This non-genetic triad could more robustly mimic PGC-1α gene therapy effects in mitochondrial dysfunction contexts, with greater safety and titratability. While preclinical and emerging clinical data support synergy, large-scale human trials on this exact combination remain limited—consult a specialist for personalized application."
The "specialist" is n=1...me (and you). Finding the water in the desert is a personal endeavor.
I'm starting the SS-31 High Dose Pulse phase described above today. LFG!
Follow-up edit: "Adding sub-q Glutathione would likely amplify (rather than merely normalize) PGC-1α benefits by bolstering antioxidant capacity at the mitochondrial level, creating a more robust, multi-layered defense against dysfunction. This non-genetic approach could further mimic PGC-1α gene therapy effects safely."
SS-31 thread that becomes a stacking thread...sorry about that...
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This is great info, thanks! I have seen the SS/MOTS/NAD cycle going around but not that familiar with it and it is pretty aggressive as far as the amounts go. Currently researching Epitalon, and planning SS-31 /MOTS-C cycle after that. Not sure if i will do them sequentially or together. Still researching the protocol I want to follow.
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PGC-1α gene therapy is one of the current "Holy Trinity" of Klotho, Follistatin and PCG-1α gene therapies. My research focused on Elamipretide (SS-31), MOTS-C and NAD+ as an effective substitute for the PGC-1α gene therapy. It's a big deal if you understand the research implications. Food for thought:
"Overall Assessment: Adding sub-q NAD+ would complement (and potentially amplify) the PGC-1α-normalizing benefits of elamipretide + MOTS-c by providing the necessary cofactor for SIRT1-mediated PGC-1α activation and downstream mitochondrial improvements. This non-genetic triad could more robustly mimic PGC-1α gene therapy effects in mitochondrial dysfunction contexts, with greater safety and titratability. While preclinical and emerging clinical data support synergy, large-scale human trials on this exact combination remain limited—consult a specialist for personalized application."
The "specialist" is n=1...me (and you). Finding the water in the desert is a personal endeavor.
I'm starting the SS-31 High Dose Pulse phase described above today. LFG!
Follow-up edit: "Adding sub-q Glutathione would likely amplify (rather than merely normalize) PGC-1α benefits by bolstering antioxidant capacity at the mitochondrial level, creating a more robust, multi-layered defense against dysfunction. This non-genetic approach could further mimic PGC-1α gene therapy effects safely."
SS-31 thread that becomes a stacking thread...sorry about that...
@PeptidePete let us know how it goes. I just finished it a few days ago. My only real complaint is the itchy ISR i got as the dose went up.
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@PeptidePete let us know how it goes. I just finished it a few days ago. My only real complaint is the itchy ISR i got as the dose went up.
@Randy said in SS-31 (Elamipretide) — Research Dosing Protocol:
@PeptidePete let us know how it goes. I just finished it a few days ago. My only real complaint is the itchy ISR i got as the dose went up.
Will do
Yes, it is a bit itchy for me as well, but no big deal.
I thank you again for sharing this protocol! Not for the faint of heart or wallet but what's the value of having rejuvenated and repaired mitochondria? Priceless in my world.
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It’s funny, this research world. I was talking to a friend about my upcoming SS-31 research protocol and he thought I was loopy telling him about the one above that I am planning to replicate as best I can up to the pulse phase and see from there.
I guess he is currently running the popular SS-31/MOTS-C one which has you running it if not forever, then quite frequently.
But he is telling me that after 2 weeks at 2mg/day, he is seething with energy. I am mostly looking for the metabolic repair and reset so will run this course after finishing epitalon, then do a MOTS-C cycle, and look into NAD+ down the road.
Funny story; my whole journey into this stuff started last year when I was researching longevity and started taking NAD, NMN, and a few other supplements that turn out to have terrible oral availability. And down the rabbit hole I went. I still take pterostilbene because in theory anyway, this comes from blueberries and has decent bioavailability when taken orally.
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@PeptidePete let us know how it goes. I just finished it a few days ago. My only real complaint is the itchy ISR i got as the dose went up.
@Randy said in SS-31 (Elamipretide) — Research Dosing Protocol:
@PeptidePete let us know how it goes. I just finished it a few days ago. My only real complaint is the itchy ISR i got as the dose went up.
Currently finishing up some 40mg vials which I was reconstituting with <1ml and it was too uncomfortable at that concentration in one pin in one spot. Switched to doubling the dilution, two 1ml pins in adjacent sites. Everything hunky-dory now.
Also was pinning in the AM, now switched to PM as my pin load is less at night. Less chance of cross-talk issues, and perhaps its magic works better while the body is doing other clean up. Who knows.
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That is really timely. I was just starting to look at FOX-04 DRI, and just saw a new video on it. It seems like with all the attention SS-31/MOTS-C/NAD+ are getting that FOX is as well. Clearing out senescent cells sounds like a great idea, but I’d be a bit concerned with killing off 10%(one number I saw) of my cells without better understanding of what they get replaced with.
Definitely requires a bit more research on my part. Thank goodness it’s expensive.
@ResearchCat Im a bit conservative about jumping in to that Fox clean out…Doing a 7 day fast should do the clearing out of damaged cells naturally. I started with MotsC now going to run Just SS 31 with 5 amino 1Q for a month. I had been exposed to mold at times and leaning more on healing and recovery before anything too aggressive. Diego has some knowledge but is aggressive. Im 62 and still working hard so I will try this for restoration. I did love the MotC for the week but felt it was needing more each day so fixing the leaking mitochondria seems to be my plan.
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I just started the SS-31 protocol Randy shared above. Question for the community....what is a good follow up protocol moving onto MOT-C when I finish the SS-31 protocol? When I repair the good remaining cells, what's a good cycle for fueling them? Thank you for your input!
