Klotho / FLGR242 (albumin-bound new tech)
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@stevencarter
Josh Holyfield's take...
https://youtube.com/shorts/W7_ajSR8-S8?si=b4nv03GgjMgZTEW1@stevencarter
Josh Holyfield's take...
https://youtube.com/shorts/W7_ajSR8-S8?si=b4nv03GgjMgZTEW1Dude...
This clown (Holyfield) has no clue what he is talking about, as already noted multiple times downthread.
If you don't understand my comment, then you are not understanding Follistatin (details downthread). AI generated slop does not equal wisdom.
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@PeptidePete I did watch the video, thank you, I really liked it. That's why I asked. She didn't directly reference FOXO4-DRI, only said it is only her hypothesis, not a theory, no proof, that it's not a great idea to use senolytics because in the bone marrow you are going to wash out the senescent precursor cells to the stem cells, and it is better to have at least senescent cells there than just empty holes.
I don't see why necessarily a senescent precursor cell is better than no cell, it's not dividing anyway. I may guess those holes might be filled with new younger cells because there will be space there now. Maybe she is right, maybe not.
I bought FOXO4-DRI for research at some point. I was planning to use it in a very short course, maybe 2-3 injections over a week, follow it with plasmapheresis to wash out the dead cell material from the blood, and also (important) precede FOXO with a course of Humanin to try bringing as many as possible cells out of senescence first. Then FOXO4-DRI would only affect the cells that can't be rejuvenated.
But I may reconsider using FOXO4-DRI with this information in mind.
There is also a bone marrow peptide extract Bonomarlot (Bonocore) that is claimed to restore red bone marrow to supply stem cells, I am planning to research it too.@vpeptides said:
@PeptidePete I did watch the video, thank you, I really liked it. That's why I asked. She didn't directly reference FOXO4-DRI, only said it is only her hypothesis, not a theory, no proof, that it's not a great idea to use senolytics because in the bone marrow you are going to wash out the senescent precursor cells to the stem cells, and it is better to have at least senescent cells there than just empty holes.
There is also a bone marrow peptide extract Bonomarlot (Bonocore) that is claimed to restore red bone marrow to supply stem cells, I am planning to research it too.The point is that once you lose/kill/remove the few stem cells you have remaining, THAT'S IT. They NEVER grow back or can be replaced. That is the current understanding. I'm 65, I only have a few left unless I already burned them with my FOX04 course.
Humanin...I researched this heavily before dosing, I was very interested, and chose NOT to use it even once. I'd urge you to look very carefully before using it.
Spoiler- research the different versions of humanin, I would not touch it.
No humanin, sure as hell no FOX04. Far too many unknowns, said as a peptide fan who ran GHK-Cu at 15-20mg per day for months.
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@vpeptides I would recommend more research before researching FOX-04. I was very enthusiastic about it until I dug a bit deeper and got into how they don’t entirely know if senescent cells are all bad, whether cleared stem cells would be replaced, etc. There are a few other unknowns as well. It looks promising, but there are too many unknowns even for this risk taker.
I gotta do more research on Cell Factors and build a Follistatin/FLGR242 protocol for the winter.
Yeah, well, I’m just here for the research, man. - The Dude
If I haven’t liked your post, no offense. I have exceeded my daily allowance.
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@vpeptides I would recommend more research before researching FOX-04. I was very enthusiastic about it until I dug a bit deeper and got into how they don’t entirely know if senescent cells are all bad, whether cleared stem cells would be replaced, etc. There are a few other unknowns as well. It looks promising, but there are too many unknowns even for this risk taker.
I gotta do more research on Cell Factors and build a Follistatin/FLGR242 protocol for the winter.
@ResearchCat Cell Factors look very very interesting. I am planning to research α-Klotho, and a low dose of
R242 to see the effect on fat%, in the tests and overall. FOXO4-DRI can wait 20 years or so in my case.
But I am surprised you all are skeptical on Humanin. I do need to research more. -
For anybody interested in FLGR242, currently SlimAssist (FLGR242 2MG / 500mcg B Complex) vial is on sale for $62.50 AND Buy 3 Get 2 FREE deal. So, if you get 3 vials and get 2 free ones, you get 10MG of FLGR242 for $187.50 minus 15% JayC discount. It is even cheaper than $249.50 for 10mg sale.
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Hey, sorry if this has already been covered, but with regard FLGR-242: How has the fatigue experience been?
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Hey, sorry if this has already been covered, but with regard FLGR-242: How has the fatigue experience been?
@jamesboyles
Fatigue isn't much of a problem as long as you EAT. Like, a lot. Your body is building muscle. Give it the building blocks! -
Hey Klotho contingent. So picked up a stash for me and the missus to run 6 months each. Thoughts on using standard dosing every 2 weeks vs half dose weekly. Chime in dudes!
@Stones67 As I understand, with αKlothoLR (if you are talking about that one) you don't have much choice, the dosage is fixed, definitely not more:
Induction: 10mcg Every 2-4 Weeks (Months 0-6).
Maintenance: 10mcg Every 4 Weeks. No cycling required
biological half-life of albumin it attaches to is 18-21 days, you need to avoid overdosing that 10mcg.
I guess if you dose 5 mcg every week it may cause a higher concentration, which is dangerous. -
Hey Klotho contingent. So picked up a stash for me and the missus to run 6 months each. Thoughts on using standard dosing every 2 weeks vs half dose weekly. Chime in dudes!
@Stones67 i dont think @vpeptides is correct in his reply to you. Hes not on Klotho @peptidepete is and so im I.
The bottle of Klotho is 10mg and the dose was intended to take 1 bottle 10mg Every 2 weeks.
Some ppl actually take it every 13 days.
If you get the same 10mg dose and split it m, your taking 5mg weekly, its not a higher dose.
I actually take it weekly splitting the dose.
Maybe Pete can chime in to see if he dose 5mg weekly or 10mg every 13 days or 14days
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@Stones67 i dont think @vpeptides is correct in his reply to you. Hes not on Klotho @peptidepete is and so im I.
The bottle of Klotho is 10mg and the dose was intended to take 1 bottle 10mg Every 2 weeks.
Some ppl actually take it every 13 days.
If you get the same 10mg dose and split it m, your taking 5mg weekly, its not a higher dose.
I actually take it weekly splitting the dose.
Maybe Pete can chime in to see if he dose 5mg weekly or 10mg every 13 days or 14days
@diegoc I don't see that your reply is much different than mine, other than you confused micrograms with milligrams. Klotho from Biolongevity Labs is dosed in 10 mcg vials.
But the point of splitting the dose is usually to smooth-out the concentration, but in this case the biggest danger comes from overdosing it. I read it directly from BLL flyer on Klotho.! CRITICAL SAFETY WARNING - DO NOT
EXCEED DOSE
Supraphysiological Klotho causes the OPPOSITE of its
benefits: vascular calcification, hypophosphatemia,
hypokalemia, kidney damage, cardiac arrhythmia, and
endothelial malfunction. The body naturally produces
only -4 mcg/day. NEVER exceed 10 mcg every 2 weeks.It's up to you how you dose it. I wouldn't suggest it to tweak the schedule though. What are you trying to achieve with it?
With albumin half-life of 20 days, if you use 5mcg, then, in 7 days, another 5mcg, and another 5mcg in another 7 days, you may end up with potentially albumin from all 3 injections in the body, with higher concentration from last 2 injections. If you do as suggested, the maximum concentration will not be as high.
You may play with https://peptidesplotter.com/ to evaluate what protocol is safer. Again, it's your body, but I would play safe in this case.
Yes, I'm not using it yet, but it's in my fridge, waiting for its time
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Thanks guys. For clarification I'm asking about split dosing. 5mcg weekly vs 10mcg every 2 weeks. I've heard ya clearly not to exceed the 10mcg/2weeks. Unlike FLGR I'm not trying to be fancy and constantly tweak the dosing and schedule. The question stems from some of the discussion up-thread about dosing and stability after reconstitution. The wifely likes the idea of taking a smaller, weekiy dose. And since we'd split it there's little concern about degradation. I'll let you guys know how this sorts out!
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This is a great thread and I appreciate everyone’s thoughts, experiences, and recommendations. FWIW, I am lurking hard.
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@diegoc I don't see that your reply is much different than mine, other than you confused micrograms with milligrams. Klotho from Biolongevity Labs is dosed in 10 mcg vials.
But the point of splitting the dose is usually to smooth-out the concentration, but in this case the biggest danger comes from overdosing it. I read it directly from BLL flyer on Klotho.! CRITICAL SAFETY WARNING - DO NOT
EXCEED DOSE
Supraphysiological Klotho causes the OPPOSITE of its
benefits: vascular calcification, hypophosphatemia,
hypokalemia, kidney damage, cardiac arrhythmia, and
endothelial malfunction. The body naturally produces
only -4 mcg/day. NEVER exceed 10 mcg every 2 weeks.It's up to you how you dose it. I wouldn't suggest it to tweak the schedule though. What are you trying to achieve with it?
With albumin half-life of 20 days, if you use 5mcg, then, in 7 days, another 5mcg, and another 5mcg in another 7 days, you may end up with potentially albumin from all 3 injections in the body, with higher concentration from last 2 injections. If you do as suggested, the maximum concentration will not be as high.
You may play with https://peptidesplotter.com/ to evaluate what protocol is safer. Again, it's your body, but I would play safe in this case.
Yes, I'm not using it yet, but it's in my fridge, waiting for its time
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@vpeptides Nd whats the time your waiting for, more research on timing and dosing?
Or do you buy first research later?
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Thanks guys. For clarification I'm asking about split dosing. 5mcg weekly vs 10mcg every 2 weeks. I've heard ya clearly not to exceed the 10mcg/2weeks. Unlike FLGR I'm not trying to be fancy and constantly tweak the dosing and schedule. The question stems from some of the discussion up-thread about dosing and stability after reconstitution. The wifely likes the idea of taking a smaller, weekiy dose. And since we'd split it there's little concern about degradation. I'll let you guys know how this sorts out!
-
Thanks guys. For clarification I'm asking about split dosing. 5mcg weekly vs 10mcg every 2 weeks. I've heard ya clearly not to exceed the 10mcg/2weeks. Unlike FLGR I'm not trying to be fancy and constantly tweak the dosing and schedule. The question stems from some of the discussion up-thread about dosing and stability after reconstitution. The wifely likes the idea of taking a smaller, weekiy dose. And since we'd split it there's little concern about degradation. I'll let you guys know how this sorts out!
@Stones67 Albumin breakdown in the body follows a first-order exponential decay, which can be described with formula {initial amount} * (0.5)^({day} / 20)
Assuming all klotho binds to albumin, it will degrade as fast as albumin does. We can easily create a table for both schedules.
It looks like you'll be fine either way, weekly is smoother.
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