GLP-1 Research on behavior

[pep_researcher]

@Snake-Pepskin said:

which agonist has this particular effect. The GLP1, GIP.

It's GLP-1. There's enough research on this aspect and trials underway already. You can search on the Internet and YouTube has some videos about this too.

[Snake Pepskin]

I did some digging in the past few days and created this graph to design more suited protocols. I didn’t consider amylin agonists yet, but I will incorporate in the future.

My rat had a bit of an overactive libido, so this actually worked in his favor, but it’s a fascinating journey.

[MyB]

@Snake-Pepskin said:

What I’m wondering, is which agonist has this particular effect.

It’s the GLP-1

https://pmc.ncbi.nlm.nih.gov/articles/PMC7848227/

[EXTROPIAN]

@CapmanCrunch maybe we are sooo overly stimulated and we made it a norm. Our food/'slop is unusually addictive, they are hitting us psychologically via human engineering, entertainment, social media apps, porn.... Maybe anhedonia is a blessing. It does dial down impulsivity to allow to do what's needs to done. the level of anhedonianis not that bad, I am still interested in peptides.

[boogiescoffer]

THIS is 1000% real. Didn’t notice it with Liraglutide, Dulaglutide, or Semaglutide, but Tirzepatide… I’m not going to list the things I stopped doing, thinking about (and being addicted to). Legitimately. Overwhelmingly positive overall in every way. I think Tirzepatide may actually have saved my life.

[ResearchCat]

It’s a bit disingenuous to generalize in saying it’s the GLP-1. Not trying to start a fight, but there is a lot of research and anecdotal evidence that Tirzepatide, for whatever reason, does a better job with food, booze, and other noise than Sema or Reta. And different people have different results. I have a very strong response to Tirz and lose most desire to drink or other vices. My bride gets better weight loss results with Tirz than she did with Sema, but much less booze noise suppression than I do.

So yes, it is the GLP-1, but the three compounds are not the same with respect to how users respond, the synergy of the components, and how you individually might respond. It probably doesn’t help that doctors want to get you blasting a maximum dose ASAP, which, imo interferes with your ability to maximize the effectiveness of the drug and go right into overload/stall zones.

(And, you know, lose your mind when, after 6 months of starving yourself, your hair starts falling out, your skin looks like shit, and you have Ozempic face bc your collagen has vaporized.)

Oops, I ranted again.

[boogiescoffer]

In my own case.. all positive. I easily got 50% more attractive overall, with a corresponding decline in any desire to abuse that privilege.

[Eleanor]

I personally don't know any women on Reta. The ladies I work with are all on either Semi or Tirz. The ones on Semi have no libido problems. Those on Tirz have next to no libido, no taste for alcohol and low energy; making exercise very difficult.

[Rev]

I spent a year on semaglutide and did not notice this effect. I've been on Reta since March and it's very apparent. I bumped into some info yesterday about it being related to dopamine. I couldn't put together the words to explain it so here is what AI has to say. "GLP-1 receptor agonists such as semaglutide and tirzepatide modulate dopamine signaling primarily by dampening or blunting the release of dopamine in the brain's mesolimbic reward pathway. Rather than increasing overall dopamine levels, these medications reduce the reward value and salience of highly palatable foods and addictive substances, effectively lowering the intense "wanting" or craving signals driven by dopamine spikes.

This mechanism involves GLP-1 receptors located in key reward centers like the ventral tegmental area (VTA), nucleus accumbens, and lateral septum. Activation of these receptors decreases phasic dopamine release in response to rewarding stimuli, which helps stabilize blood sugar, reduce "food noise," and interrupt compulsive reward-seeking behaviors associated with obesity and addiction. "

Basically the meds (can) decrease your desire not only for food, but for everything. I'm trying out some supplements to increase production of dopamine and will see if that helps. Being single, getting skinny and attractive, summer time and now having no desire to leave the house and interact with anyone feels real lame!

[beachfun]

@atlas01 I started TRT when I started Tirz so that mostly may have had an effect on my strong libido and wood.