Hi All,
I’m new to peptides and glad to be here. I started tirzepatide in July 2026 for diabetes, and I was really impressed with my lab results. That got me curious about peptides more broadly.

I’ve been reading online and watching YouTube, and I started an Excel cheat sheet to keep my own notes organized. When I went looking for reliable sources, I found that most places had too many filters and a lot of conflicting information. I came across this community through a search on Claude AI, and it feels like a real find. The depth of knowledge and the sources people share here are exactly what I was looking for.

Thank you for building such a helpful space. I’m looking forward to learning from you all and contributing where I can.
Regards,
Zack

@Randy said:

If noise is the issue tirz is king. Titrate to max would be my vote. Ive run both. Glucagon increased my rats hunger

Yes, I'll probably stick to tirzepatide long-term. Food noise is still an issue, and I've plateaued on my current dose, so it's time to up it anyway. Thanks for reply.

Welcome from Fellow Newbie!

I’m researching a possible switch and wanted to hear from anyone who has actually done this sequence: starting on tirzepatide, moving to retatrutide, then returning to tirzepatide. I haven’t tried it myself, so I’m hoping to learn from people who have. How did your A1C and weight change after each move, and did tirzepatide work as well the second time around? I’m also curious about side effects, bloodwork like lipids and liver enzymes, energy and sleep, and whether you had to restart at a lower dose when you went back. If you can share your doses, how long you stayed on each, and whether you had labs before and after, that would help a lot. Thanks for any experiences you can share!

@seadracos said:

Hi here, I've been using Tirz for about 3 months now and was thinking of switching from a weekly dose to a 5 day dose since the half life is 5 days.

My hope is that this week curb some of the food noise I've started to have at the end of the week while remaining on my low dose. I'm aware that this will up the amount I take per month.

I think I'll give it a try and if it doesn't work I'll just titrate up a bit like normal. I'm at the baby dosages still so I have room to do that.

Had anybody else tried this or something similar?

Hi,
I have also been on tirzepatide since July and am currently taking a 5 mg dose (Mon–Sun). I start to get hungry on Fri–Sun as well, though I try to eat healthy.

There are more knowledgeable people here who will share more and better opinions, and I am not too sure about the 5-day dose protocol. However, since I am in a somewhat similar situation as you, here are the options I am considering (you could try the first two and see what works best):

Option #1: Simple and straightforward—just increase to the next dose of tirzepatide.
Option #2: Split the dose. For example, at 5 mg, take 2.5 mg on Monday and the remaining 2.5 mg on Thursday (or 3 mg on Monday and 2 mg on Thursday).
Option #3: I am personally debating starting 4 mg of tirzepatide and 1 mg of retatrutide starting this monday to kill the trying reta itch.
Let us know whatever works for you. Thanks