GLP-1 Research on behavior
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My research subject was recently prescribed Addyi and now I’m wondering if it’s even worth taking it. Reta has made their Adderall have ZERO effect even with a double and triple dose.
The way Glp-1 has cut off dopamine, serotonin, and Norepinephrine has been a HUGE negative for my Rat. They are Neurospicy (ASD) so was on the short end of the stick to begin with as far as neurotransmitters go. -
Yep; you have to manage it. I hate using the term ‘journey’, but hopefully most people using GLP-1’s are listening to their bodies as well as their doctors and become aware of these cycles. It only took me a couple of months to realize I got hungry around day 5, and to notice I was also losing interest in other things - which I try to manage for optimal balance. I also read tons about this stuff, so my knowledge is always increasing, even if my wisdom isn’t.
How negative anhedonia is is also a matter of where you are in life. If you are active and dating, a lack of interest in sex is a big problem. If you are older and your partner isn’t interested, it’s less of an issue. If your partner isn’t interested but wants to be, and you also aren’t, well that is a different problem set.
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Yeah this one is real. The desire to date goes out the window anytime I pump myself full of GLP's.
@Randy
It really does!!! If you have an addictive personality, it really evens you out.
Everything is still there, but I have I now have moderation in many ways that I hadn't previously experienced.
The one exception I have noticed is an increased desire and ability to exercise. Anyone else noticed this? -
I agree, there are definitely muted noises, in many aspects. In the intimacy aspect, Oxytocin and PT-141 definitely help, from my research, and my bunny’s as well.
What I’m wondering, is which agonist has this particular effect. The GLP1, GIP. I don’t think it’s the glucagon because I’m researching Tirz currently. I don’t know anyone who is on Selma to ask. Once we figure out which is the culprit, we can adjust. With all the choices available today, it can be tweaked. Once I get closer to my goal, I will research combinations with Survo and/or Cagrilintide, excluding different receptors and see the results. We are researchers after all.
“Knowledge is the ultimate power.
It’s not what you know that defines you, it’s that which you share that defines you.” -
Not gone through each RS experience and comment, but some rat's experience can be complex - they lose the desire to go on random dates, but their libido is still there and sees an uptick as Glucagon works it's way through their system.
It's counterintuitive but potential explanation is - desire date is associated with brain center for reward, and GLP-1 component causes anhedonia, so there's no interest to seek reward through food, date, alcohol etc.
But Glucagon is energy and metabolism uptick, it cleans up blood vessels too, that can cause increased energy and intercourse is the one of the high energy burner exercise.
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I agree, there are definitely muted noises, in many aspects. In the intimacy aspect, Oxytocin and PT-141 definitely help, from my research, and my bunny’s as well.
What I’m wondering, is which agonist has this particular effect. The GLP1, GIP. I don’t think it’s the glucagon because I’m researching Tirz currently. I don’t know anyone who is on Selma to ask. Once we figure out which is the culprit, we can adjust. With all the choices available today, it can be tweaked. Once I get closer to my goal, I will research combinations with Survo and/or Cagrilintide, excluding different receptors and see the results. We are researchers after all.
which agonist has this particular effect. The GLP1, GIP.
It's GLP-1. There's enough research on this aspect and trials underway already. You can search on the Internet and YouTube has some videos about this too.
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I did some digging in the past few days and created this graph to design more suited protocols. I didn’t consider amylin agonists yet, but I will incorporate in the future.
My rat had a bit of an overactive libido, so this actually worked in his favor, but it’s a fascinating journey.
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I agree, there are definitely muted noises, in many aspects. In the intimacy aspect, Oxytocin and PT-141 definitely help, from my research, and my bunny’s as well.
What I’m wondering, is which agonist has this particular effect. The GLP1, GIP. I don’t think it’s the glucagon because I’m researching Tirz currently. I don’t know anyone who is on Selma to ask. Once we figure out which is the culprit, we can adjust. With all the choices available today, it can be tweaked. Once I get closer to my goal, I will research combinations with Survo and/or Cagrilintide, excluding different receptors and see the results. We are researchers after all.
What I’m wondering, is which agonist has this particular effect.
It’s the GLP-1
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@Randy
It really does!!! If you have an addictive personality, it really evens you out.
Everything is still there, but I have I now have moderation in many ways that I hadn't previously experienced.
The one exception I have noticed is an increased desire and ability to exercise. Anyone else noticed this?@CapmanCrunch maybe we are sooo overly stimulated and we made it a norm. Our food/'slop is unusually addictive, they are hitting us psychologically via human engineering, entertainment, social media apps, porn.... Maybe anhedonia is a blessing. It does dial down impulsivity to allow to do what's needs to done. the level of anhedonianis not that bad, I am still interested in peptides.
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THIS is 1000% real. Didn’t notice it with Liraglutide, Dulaglutide, or Semaglutide, but Tirzepatide… I’m not going to list the things I stopped doing, thinking about (and being addicted to). Legitimately. Overwhelmingly positive overall in every way. I think Tirzepatide may actually have saved my life.
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It’s a bit disingenuous to generalize in saying it’s the GLP-1. Not trying to start a fight, but there is a lot of research and anecdotal evidence that Tirzepatide, for whatever reason, does a better job with food, booze, and other noise than Sema or Reta. And different people have different results. I have a very strong response to Tirz and lose most desire to drink or other vices. My bride gets better weight loss results with Tirz than she did with Sema, but much less booze noise suppression than I do.
So yes, it is the GLP-1, but the three compounds are not the same with respect to how users respond, the synergy of the components, and how you individually might respond. It probably doesn’t help that doctors want to get you blasting a maximum dose ASAP, which, imo interferes with your ability to maximize the effectiveness of the drug and go right into overload/stall zones.
(And, you know, lose your mind when, after 6 months of starving yourself, your hair starts falling out, your skin looks like shit, and you have Ozempic face bc your collagen has vaporized.)
Oops, I ranted again.
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In my own case.. all positive. I easily got 50% more attractive overall, with a corresponding decline in any desire to abuse that privilege.
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I spent a year on semaglutide and did not notice this effect. I've been on Reta since March and it's very apparent. I bumped into some info yesterday about it being related to dopamine. I couldn't put together the words to explain it so here is what AI has to say. "GLP-1 receptor agonists such as semaglutide and tirzepatide modulate dopamine signaling primarily by dampening or blunting the release of dopamine in the brain's mesolimbic reward pathway. Rather than increasing overall dopamine levels, these medications reduce the reward value and salience of highly palatable foods and addictive substances, effectively lowering the intense "wanting" or craving signals driven by dopamine spikes.
This mechanism involves GLP-1 receptors located in key reward centers like the ventral tegmental area (VTA), nucleus accumbens, and lateral septum. Activation of these receptors decreases phasic dopamine release in response to rewarding stimuli, which helps stabilize blood sugar, reduce "food noise," and interrupt compulsive reward-seeking behaviors associated with obesity and addiction. "
Basically the meds (can) decrease your desire not only for food, but for everything. I'm trying out some supplements to increase production of dopamine and will see if that helps. Being single, getting skinny and attractive, summer time and now having no desire to leave the house and interact with anyone feels real lame!
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I've been on Tirz for a month and this totally tracks. No desire for alcohol, dating, gaming, or any other vices. I can focus my attention on work, family, gym, and hobbies for the first time in a while.
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