GLP-1 Research on behavior
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I take my Tirz Saturday night before bed so I can eat on Friday and Saturday. When I started, I was taking it on Thursday night and then I’d have no interest in eating or drinking from Friday through Sunday. Now I can enjoy the weekend some, and get the suppression during the week when I am at work.
The half-life of Tirz is 5 days, so you can definitely optimize your shot around activities that you enjoy, or want to enjoy. I am also on the lowest dose now (2.5mg) because I have been having trouble hitting my macros on higher doses. There is a bit more noise, but it’s manageable. The real challenge is having enough good food around that I don’t go for the garbage.
I am starting to think about when to take various supplements and whether/if there are better times to research different peps.
@ResearchCat I started my Tirz on Monday mornings at a clinic and they recommended Testosterone. For me, the change was huge that I quit looking at food and really started focusing more on my wife. After bloodwork, my trt was around 900 and now continuing with 2 self injections of 35 units each. I have no desire for alcohol, snacking, and just eat healthy dinners. Now that I have lost 20lbs and gained 7 lbs muscle mass, my marriage is amazing, and feel so much better. I did reconstitute a Servo vial that I started on Thursdays .3mg to .5 to now will finish the vial at 1 mg for 3 weeks.
Randy helped me start this as the “Reta getto” as I had such great success with Tirz. After 13 weeks I have 3 weeks left and plan on stopping. I think doing 5 amino 1mq 3 10mg vials helped with muscle and protein powder for lunches and a couple eggs for breakfast.
I am still also on my 1st vial of cjc/ipa before bed which makes deep sleep amazing. Fat seems to be coming off still but staying 2 weeks at 195 lbs.
I have some Reta that I may try but Ill see as I want to do the Ss31 and MotsC protocol to reboot my mitochondria and may add tesamoreline. Doing GLOW and KPV for recovery and my skin and nails seems to be much better.
I do start getting hungry on the weekends but avoided the all you can eat sushi Friday night. Changing habits is what this is about too so bought more protein powder at Costco with some Creatine. I can highly recommend these protocols at 62 working physically hard remodeling houses and still on my honeymoon again. -
I have been using Tirz for two months. The lack of desire for alcohol was immediate and more pronounced for me than it was for food. This has been such a blessing. I actually looked at a bottle of whiskey with disgust. I take it on Saturday mornings and noticed that full effects don’t start until Monday so I still have a single drink on Saturday night and that satisfies me. I have not noticed a change to my libido with Tirz.
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from my experience subject hasnt lost ambition or drive. so much as having more focus. not in the adderal kind of way. but like the decision making? ive had a hard time explaining it to other researchers. subject knows what he has to do and nothing more. as for sex drive and other stuff. i mean its all working not like its broken. but its just not important? you didnt take the dogs bark away but it took away the need to bark at it?
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I have been using Tirz for two months. The lack of desire for alcohol was immediate and more pronounced for me than it was for food. This has been such a blessing. I actually looked at a bottle of whiskey with disgust. I take it on Saturday mornings and noticed that full effects don’t start until Monday so I still have a single drink on Saturday night and that satisfies me. I have not noticed a change to my libido with Tirz.
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My research subject was recently prescribed Addyi and now I’m wondering if it’s even worth taking it. Reta has made their Adderall have ZERO effect even with a double and triple dose.
The way Glp-1 has cut off dopamine, serotonin, and Norepinephrine has been a HUGE negative for my Rat. They are Neurospicy (ASD) so was on the short end of the stick to begin with as far as neurotransmitters go. -
Yep; you have to manage it. I hate using the term ‘journey’, but hopefully most people using GLP-1’s are listening to their bodies as well as their doctors and become aware of these cycles. It only took me a couple of months to realize I got hungry around day 5, and to notice I was also losing interest in other things - which I try to manage for optimal balance. I also read tons about this stuff, so my knowledge is always increasing, even if my wisdom isn’t.
How negative anhedonia is is also a matter of where you are in life. If you are active and dating, a lack of interest in sex is a big problem. If you are older and your partner isn’t interested, it’s less of an issue. If your partner isn’t interested but wants to be, and you also aren’t, well that is a different problem set.
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Yeah this one is real. The desire to date goes out the window anytime I pump myself full of GLP's.
@Randy
It really does!!! If you have an addictive personality, it really evens you out.
Everything is still there, but I have I now have moderation in many ways that I hadn't previously experienced.
The one exception I have noticed is an increased desire and ability to exercise. Anyone else noticed this? -
I agree, there are definitely muted noises, in many aspects. In the intimacy aspect, Oxytocin and PT-141 definitely help, from my research, and my bunny’s as well.
What I’m wondering, is which agonist has this particular effect. The GLP1, GIP. I don’t think it’s the glucagon because I’m researching Tirz currently. I don’t know anyone who is on Selma to ask. Once we figure out which is the culprit, we can adjust. With all the choices available today, it can be tweaked. Once I get closer to my goal, I will research combinations with Survo and/or Cagrilintide, excluding different receptors and see the results. We are researchers after all.
“Knowledge is the ultimate power.
It’s not what you know that defines you, it’s that which you share that defines you.” -
Not gone through each RS experience and comment, but some rat's experience can be complex - they lose the desire to go on random dates, but their libido is still there and sees an uptick as Glucagon works it's way through their system.
It's counterintuitive but potential explanation is - desire date is associated with brain center for reward, and GLP-1 component causes anhedonia, so there's no interest to seek reward through food, date, alcohol etc.
But Glucagon is energy and metabolism uptick, it cleans up blood vessels too, that can cause increased energy and intercourse is the one of the high energy burner exercise.
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I agree, there are definitely muted noises, in many aspects. In the intimacy aspect, Oxytocin and PT-141 definitely help, from my research, and my bunny’s as well.
What I’m wondering, is which agonist has this particular effect. The GLP1, GIP. I don’t think it’s the glucagon because I’m researching Tirz currently. I don’t know anyone who is on Selma to ask. Once we figure out which is the culprit, we can adjust. With all the choices available today, it can be tweaked. Once I get closer to my goal, I will research combinations with Survo and/or Cagrilintide, excluding different receptors and see the results. We are researchers after all.
which agonist has this particular effect. The GLP1, GIP.
It's GLP-1. There's enough research on this aspect and trials underway already. You can search on the Internet and YouTube has some videos about this too.
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I did some digging in the past few days and created this graph to design more suited protocols. I didn’t consider amylin agonists yet, but I will incorporate in the future.
My rat had a bit of an overactive libido, so this actually worked in his favor, but it’s a fascinating journey.
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I agree, there are definitely muted noises, in many aspects. In the intimacy aspect, Oxytocin and PT-141 definitely help, from my research, and my bunny’s as well.
What I’m wondering, is which agonist has this particular effect. The GLP1, GIP. I don’t think it’s the glucagon because I’m researching Tirz currently. I don’t know anyone who is on Selma to ask. Once we figure out which is the culprit, we can adjust. With all the choices available today, it can be tweaked. Once I get closer to my goal, I will research combinations with Survo and/or Cagrilintide, excluding different receptors and see the results. We are researchers after all.
What I’m wondering, is which agonist has this particular effect.
It’s the GLP-1
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@Randy
It really does!!! If you have an addictive personality, it really evens you out.
Everything is still there, but I have I now have moderation in many ways that I hadn't previously experienced.
The one exception I have noticed is an increased desire and ability to exercise. Anyone else noticed this?@CapmanCrunch maybe we are sooo overly stimulated and we made it a norm. Our food/'slop is unusually addictive, they are hitting us psychologically via human engineering, entertainment, social media apps, porn.... Maybe anhedonia is a blessing. It does dial down impulsivity to allow to do what's needs to done. the level of anhedonianis not that bad, I am still interested in peptides.
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THIS is 1000% real. Didn’t notice it with Liraglutide, Dulaglutide, or Semaglutide, but Tirzepatide… I’m not going to list the things I stopped doing, thinking about (and being addicted to). Legitimately. Overwhelmingly positive overall in every way. I think Tirzepatide may actually have saved my life.
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It’s a bit disingenuous to generalize in saying it’s the GLP-1. Not trying to start a fight, but there is a lot of research and anecdotal evidence that Tirzepatide, for whatever reason, does a better job with food, booze, and other noise than Sema or Reta. And different people have different results. I have a very strong response to Tirz and lose most desire to drink or other vices. My bride gets better weight loss results with Tirz than she did with Sema, but much less booze noise suppression than I do.
So yes, it is the GLP-1, but the three compounds are not the same with respect to how users respond, the synergy of the components, and how you individually might respond. It probably doesn’t help that doctors want to get you blasting a maximum dose ASAP, which, imo interferes with your ability to maximize the effectiveness of the drug and go right into overload/stall zones.
(And, you know, lose your mind when, after 6 months of starving yourself, your hair starts falling out, your skin looks like shit, and you have Ozempic face bc your collagen has vaporized.)
Oops, I ranted again.
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In my own case.. all positive. I easily got 50% more attractive overall, with a corresponding decline in any desire to abuse that privilege.
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I spent a year on semaglutide and did not notice this effect. I've been on Reta since March and it's very apparent. I bumped into some info yesterday about it being related to dopamine. I couldn't put together the words to explain it so here is what AI has to say. "GLP-1 receptor agonists such as semaglutide and tirzepatide modulate dopamine signaling primarily by dampening or blunting the release of dopamine in the brain's mesolimbic reward pathway. Rather than increasing overall dopamine levels, these medications reduce the reward value and salience of highly palatable foods and addictive substances, effectively lowering the intense "wanting" or craving signals driven by dopamine spikes.
This mechanism involves GLP-1 receptors located in key reward centers like the ventral tegmental area (VTA), nucleus accumbens, and lateral septum. Activation of these receptors decreases phasic dopamine release in response to rewarding stimuli, which helps stabilize blood sugar, reduce "food noise," and interrupt compulsive reward-seeking behaviors associated with obesity and addiction. "
Basically the meds (can) decrease your desire not only for food, but for everything. I'm trying out some supplements to increase production of dopamine and will see if that helps. Being single, getting skinny and attractive, summer time and now having no desire to leave the house and interact with anyone feels real lame!
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