SS-31 Dosage for Researching
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About 6 weeks ago I restarted my SS-31 research at 60mg per day, every day. Following up on my previously posted multi-month course of 40mg per day. I feel great, no negatives. Some subjective improvements. Will conclude research at 8 weeks daily use (two weeks from now). I am very well optimized and use this to ameliorate any possible negs from compounds such as O-304 and/or occasional AAS oral/oil.
Mitochondrial related bloodwork is pristine, as 65 years old, so N=1 is thrilled.
There is zero evidence that microdosing gives any results. The one human trial at 4mg showed zero efficacy. Zero. Only 40mg daily showed results.
Go big or don't bother is my opinion of this material.
Know what you are doing and why you are doing it.
There is very thought-provoking discussion "out there" in regards to the damage leaky membranes (cardiolipin) cause. ROS, free-radicals, etc. Very nasty. What are the downstream affects of that, not fcking good that's what.
SS-31 will be something I run multiple times per year. The benefits are NOT one-and-done. Pull on that string. Gotta keep working on that particular pathway.
Research is your friend.
@PeptidePete I will be watching this. I do feel like the 4mg a day that I have been doing for this past month has been good and noticeable. However, the high dosing intrigues me. I am only scared away by the cost. I think I will start stockpiling SS-31 for a future high dosing protocol. You don't think 25mgs a day would be enough? I could do a 50mg vial a day instead of 1 vials worth over 2 days. I will just need a bunch of it. Do you think 4 weeks would be good enough to get that repair and base down or are you sold on at least 8 weeks? If I am going to do it, I hate to go half ass.
On a side note I do get a little itch for a short period of time at the injection site. Do you get anything similar? I only use normal BAC for recon. Do I need to go NaCl BAC or is my standard Hospira BAC okay as long as I don't see anything worse than a slight itch? Would you think this slight itch would blow up into something much more serious if I took doses 10x+ greater? -
@shaqdiesel What changes/differences have you noticed on a 4mg/day dosing schedule?
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@shaqdiesel What changes/differences have you noticed on a 4mg/day dosing schedule?
@ResearchCat It is subtle but there. A much better overall endurance(exercise as well as just day to day activities), background energy(not like a stimulant), my eyes don't burn throughout the day like they use to. But what will 40-60mgs do for me? I am curious and will now start hoarding kits to try it.
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@shaqdiesel What changes/differences have you noticed on a 4mg/day dosing schedule?
@peptidepete 5 - 50mg kits on the way. I am really looking forward to your thoughts on the high dose protocol you're doing. I was thinking a vial a day for 4 to 8 weeks. I still have some 40mg vials at home to take me to a full 8 weeks if I decide to do that.
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It’s worth looking at the PC posted protocol. It is pretty standard, and starts you out at lower doses before moving up to 10mg daily and eventually 50mg+ 3x/week. I doubt it would hurt you to start blasting it if you have tolerance, but you might save some money. Also, depending on your age and health, saturation dosing - which is what Pete’s doing - might not be necessary.
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It’s worth looking at the PC posted protocol. It is pretty standard, and starts you out at lower doses before moving up to 10mg daily and eventually 50mg+ 3x/week. I doubt it would hurt you to start blasting it if you have tolerance, but you might save some money. Also, depending on your age and health, saturation dosing - which is what Pete’s doing - might not be necessary.
@ResearchCat I agree. The 1gram protocol here is pretty solid, I THINK @peptidepete did it, and upped it on the 2nd protocol.
I did the 1gram which titrates up and ends with a high dose of ss-31.
If you already did it then i think for a 2nd round makes sense.
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I am only at the 4 mg a day dose right now after ~6 weeks. I am 53 and will start low and work up to 50mg a day for 4-8 weeks somewhere I think. I am waiting for the peps which will take some time to get and I want to hear how @peptidepete does on his current 60mg run. I really would love to see some eyesight improvements from it. My eyesight is bad and getting worse.
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About 6 weeks ago I restarted my SS-31 research at 60mg per day, every day. Following up on my previously posted multi-month course of 40mg per day. I feel great, no negatives. Some subjective improvements. Will conclude research at 8 weeks daily use (two weeks from now). I am very well optimized and use this to ameliorate any possible negs from compounds such as O-304 and/or occasional AAS oral/oil.
Mitochondrial related bloodwork is pristine, as 65 years old, so N=1 is thrilled.
There is zero evidence that microdosing gives any results. The one human trial at 4mg showed zero efficacy. Zero. Only 40mg daily showed results.
Go big or don't bother is my opinion of this material.
Know what you are doing and why you are doing it.
There is very thought-provoking discussion "out there" in regards to the damage leaky membranes (cardiolipin) cause. ROS, free-radicals, etc. Very nasty. What are the downstream affects of that, not fcking good that's what.
SS-31 will be something I run multiple times per year. The benefits are NOT one-and-done. Pull on that string. Gotta keep working on that particular pathway.
Research is your friend.
@PeptidePete - ...or anyone else who has done the 1 gram protocol at listed. When you are doing your high doses of 50mg, what concentration are you reconstituting to? Thanks!
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@PeptidePete - ...or anyone else who has done the 1 gram protocol at listed. When you are doing your high doses of 50mg, what concentration are you reconstituting to? Thanks!
@Blueeyedme i think that all depends on your supply. If you get a ss-31 vial of 50mg you add 1 ml and pin the hole bottle
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Agree with diegoc. I don’t have issues pinning SS-31, so it’s a matter of how much you can or are willing to stuff into a cart, and how much you want to inject. I think my last run of 10mg/day x 30 days was 40-ish units per day but that was mainly because i only had 10mg vials. Speaking of, I need to order more from Nexaph. along with some other stuff.
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Agree with diegoc. I don’t have issues pinning SS-31, so it’s a matter of how much you can or are willing to stuff into a cart, and how much you want to inject. I think my last run of 10mg/day x 30 days was 40-ish units per day but that was mainly because i only had 10mg vials. Speaking of, I need to order more from Nexaph. along with some other stuff.
@ResearchCat i agree. If your doing a high dose ss-31 protocol buy a kit or kits and calculate the entire protocol.
Your pocket book will tell you how much you can dose and for how long
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@Blueeyedme i think that all depends on your supply. If you get a ss-31 vial of 50mg you add 1 ml and pin the hole bottle
@diegoc - Cute...I've got plenty on hand in 100 & 150mg vials. What I am asking is if anyone knows the solubility limit for SS-31? If not, I'll figure it out. Thanks!
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Anyone doing Urolithin A along with any mito stack? There’s a ton of human data on Urolithin A for mito health and even muscle and cognitive health. I’m doing it along with ss-31 10mg daily before I start Mots. Human data with Urolithin A says to run it at least 4 months for muscle benefit.
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@diegoc - Cute...I've got plenty on hand in 100 & 150mg vials. What I am asking is if anyone knows the solubility limit for SS-31? If not, I'll figure it out. Thanks!
@Blueeyedme on a high dose vial like that i would mix 1ml bac and do 2 shots of 50mg, the 150mg vial you can do 1.5ml bac
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@Blueeyedme on a high dose vial like that i would mix 1ml bac and do 2 shots of 50mg, the 150mg vial you can do 1.5ml bac
@diegoc - that makes sense. Keeps the volume at a comfortable 50 units with a 100mg/mL concentration. Hopefully at that concentration it remains stable and fully dissolved.
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About 6 weeks ago I restarted my SS-31 research at 60mg per day, every day. Following up on my previously posted multi-month course of 40mg per day. I feel great, no negatives. Some subjective improvements. Will conclude research at 8 weeks daily use (two weeks from now). I am very well optimized and use this to ameliorate any possible negs from compounds such as O-304 and/or occasional AAS oral/oil.
Mitochondrial related bloodwork is pristine, as 65 years old, so N=1 is thrilled.
There is zero evidence that microdosing gives any results. The one human trial at 4mg showed zero efficacy. Zero. Only 40mg daily showed results.
Go big or don't bother is my opinion of this material.
Know what you are doing and why you are doing it.
There is very thought-provoking discussion "out there" in regards to the damage leaky membranes (cardiolipin) cause. ROS, free-radicals, etc. Very nasty. What are the downstream affects of that, not fcking good that's what.
SS-31 will be something I run multiple times per year. The benefits are NOT one-and-done. Pull on that string. Gotta keep working on that particular pathway.
Research is your friend.
@PeptidePete```
Thanks Pete, much appreciated on the update. Definitely multiple courses here per year. I turn mine up each time as well. It’s been a game changer. -
Update- just finished the course last week, crazy strong urine stream (I'm 65 yr old), unexpected effect but awesome...lol
May be a synergistic combination with Klotho, so I'd be super curious to hear other data points here.This material gives most people a bump and itch and redness for a few hours or less. I suggest doing oral antihistamine until you acclimate.
QSC/Tracy (love them) has it for .70/mg
In regards to reconstitution I worked up to tolerating 1ml BAC to 50-60mg vial, but I also tried 2ml split between two pins. Do what works for you.
In regards to doses under 40mg/day, there is no evidence for efficacy that I have seen, if someone has it, please post.
I am a bit surprised, but heartened, to read the enthusiasm and success reports! Do you own deep research and do what is best for you, for sure.
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Update- just finished the course last week, crazy strong urine stream (I'm 65 yr old), unexpected effect but awesome...lol
May be a synergistic combination with Klotho, so I'd be super curious to hear other data points here.This material gives most people a bump and itch and redness for a few hours or less. I suggest doing oral antihistamine until you acclimate.
QSC/Tracy (love them) has it for .70/mg
In regards to reconstitution I worked up to tolerating 1ml BAC to 50-60mg vial, but I also tried 2ml split between two pins. Do what works for you.
In regards to doses under 40mg/day, there is no evidence for efficacy that I have seen, if someone has it, please post.
I am a bit surprised, but heartened, to read the enthusiasm and success reports! Do you own deep research and do what is best for you, for sure.
@PeptidePete does Tracy have any recent COA’s for SS31 - 50? The last one I saw was 2025.
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