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Super beginner question (Reta and Klow)

Scheduled Pinned Locked Moved Peptide Discussion
stackbeginner-questionglp3-rklow
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  • P Offline
    P Offline
    PeptideEd
    wrote last edited by
    #4

    @curiousseeker One other thing I'd mention from my own experience starting Reta: remain calm. I also started at 0.25mg and worked up slowly. My first dose though was... weird. Not at all bad. Just weird. I had been warned possible side effects included nausea. I didn't get nauseous. I did get a slightly odd feeling that might have been nausea adjacent, but wasn't unpleasant. Didn't get that feeling after the first couple of doses, even though I've gone up in dose since then.

    I mention all this so in the event you feel something weird you find it easier to remain calm: at that low a dose you are going to be fine 🙂

    1 Reply Last reply
    2
    • ResearchCatR Offline
      ResearchCatR Offline
      ResearchCat
      wrote last edited by
      #5

      Good points. The two main side effects I got when I was on tirz for a while were constipation and just not eating. You don’t notice them at first. I had to force myself to eat for a while. That is why I am now on the lowest dose.

      The nausea and diarrhea get all the attention. They are the GLP-1 side effects rock stars. 🤣

      Yeah, well, I’m just here for the research, man. - The Dude

      If I haven’t liked your post, no offense. I have exceeded my daily allowance.

      quicksilver80Q 1 Reply Last reply
      1
      • ResearchCatR ResearchCat

        Good points. The two main side effects I got when I was on tirz for a while were constipation and just not eating. You don’t notice them at first. I had to force myself to eat for a while. That is why I am now on the lowest dose.

        The nausea and diarrhea get all the attention. They are the GLP-1 side effects rock stars. 🤣

        quicksilver80Q Online
        quicksilver80Q Online
        quicksilver80
        wrote last edited by quicksilver80
        #6

        @ResearchCat if you are having constipation. i cant promote the no/low carb mission tortillas any more than i have. they also have keto bread thats insanely high in fiber. if they dont work. prune juice warmed up with a knob of butter will move a mountain through the eye of a needle. lord haha

        Stan DouglasS 1 Reply Last reply
        4
        • quicksilver80Q quicksilver80

          @ResearchCat if you are having constipation. i cant promote the no/low carb mission tortillas any more than i have. they also have keto bread thats insanely high in fiber. if they dont work. prune juice warmed up with a knob of butter will move a mountain through the eye of a needle. lord haha

          Stan DouglasS Offline
          Stan DouglasS Offline
          Stan Douglas
          wrote last edited by
          #7

          @quicksilver80
          I find 1000mg of Vit C in the morning and another 1000 with dinner keep me constant in this area.

          1 Reply Last reply
          2
          • P Offline
            P Offline
            PeptideEd
            wrote last edited by PeptideEd
            #8

            @stan-douglas I find taking high dose magnesium (particularly Magnesium Breakthrough ) fixes any drift towards constipation (and is less acidic 😉 )

            Stan DouglasS 1 Reply Last reply
            2
            • B Offline
              B Offline
              brandenscheidecker
              wrote last edited by
              #9

              I started at 2mg had zero side effects, I don't see how microdose does anything. unless your 100lbs then what are you doing taking it? lol

              quicksilver80Q 1 Reply Last reply
              0
              • B brandenscheidecker

                I started at 2mg had zero side effects, I don't see how microdose does anything. unless your 100lbs then what are you doing taking it? lol

                quicksilver80Q Online
                quicksilver80Q Online
                quicksilver80
                wrote last edited by
                #10

                @brandenscheidecker weirdly enough i had more side effects than a friend that is allergic to the air basicly.which is great for them. but im like. now how the heck does that work? haha

                1 Reply Last reply
                1
                • ResearchCatR Offline
                  ResearchCatR Offline
                  ResearchCat
                  wrote last edited by
                  #11

                  Side effects vary a lot from person to person. My bride is on a much higher dose of Tirz than me. She doesn’t get the side effects I get, and she doesn’t get the suppression of desire for booze or other stuff(games, etc).

                  Thanks for the suggestions all. Will try them.

                  Yeah, well, I’m just here for the research, man. - The Dude

                  If I haven’t liked your post, no offense. I have exceeded my daily allowance.

                  1 Reply Last reply
                  0
                  • P Offline
                    P Offline
                    PeptideEd
                    wrote last edited by
                    #12

                    @researchcat Do remember to check pancreatic enzymes when on high doses... many Doctors miss it. I have a personal friend who was hospitalized with pancreatitis from his physician prescribing basically the max dose out the gate. Not a common side effect, but a serious one, and one you can monitor for very cheaply.

                    1 Reply Last reply
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                    • ResearchCatR Offline
                      ResearchCatR Offline
                      ResearchCat
                      wrote last edited by
                      #13

                      Yeah, my pancreatic numbers were high a few months ago and I lowered my dose. Currently focused on the cardiac signs, but will get tested again in June and hopefully the numbers will be normal. My bride’s labs were a lot better than mine.

                      My inflammation numbers were all very high, but everything is being addressed. Sadly, I had to go back on a statin as all that bullshit everyone on Youtube says did not, in fact, improve any of my numbers the way statins do. I will just snort more creatine and dihexa to fight off dementia later.

                      Yeah, well, I’m just here for the research, man. - The Dude

                      If I haven’t liked your post, no offense. I have exceeded my daily allowance.

                      1 Reply Last reply
                      0
                      • P PeptideEd

                        @stan-douglas I find taking high dose magnesium (particularly Magnesium Breakthrough ) fixes any drift towards constipation (and is less acidic 😉 )

                        Stan DouglasS Offline
                        Stan DouglasS Offline
                        Stan Douglas
                        wrote last edited by
                        #14

                        @PeptideEd
                        I take my Magnesium in the evening... I don't think I'd want it to do that 😲

                        The VitC acts as a co-factor to activate the collagen in the bone broth I drink post workout. Stacks with the Creatine and healing peps for tissue repair and joint resilience... IN MY RAT!

                        1 Reply Last reply
                        0
                        • B Offline
                          B Offline
                          brandenscheidecker
                          wrote last edited by
                          #15

                          @gym.rat no I have only had reta from one vendor it has been consistent

                          1 Reply Last reply
                          0
                          • ResearchCatR Offline
                            ResearchCatR Offline
                            ResearchCat
                            wrote last edited by
                            #16

                            Graphic content! ;0 Hoping this helps people.

                            I thought I would follow up on this. I have continued working through and dealing with constipation and (fun!) hemorrhoids. They pre-date me using GLP-1’s, but have gotten worse. I finally talked to my colorectal specialist again. What they told me might be useful.

                            First, they recommended hydrocortisone suppositories which may be prescription, but otherwise you can use lidocaine or benzocaine, sitz baths, and all the usual stuff.

                            What was really interesting to me was with respect to laxatives. She recommended taking Miralax twice a day rather than once, and taking it on an ongoing basis as needed. This was really interesting to me because both the bottle and the assholes (sorry) on the internet say you shouldn’t use more than recommended or for long periods of time. The nurse confirmed it is completely safe to use as needed to keep your stool soft and moving.

                            She also suggested not using Dulcolax, not because it doesn’t work, but because if you have compacted stool, Dulcolax helps move it, which isn’t the problem you are trying to solve. The problem you (well, I) are trying to solve is that your system is moving so slow that your stool gets hard and dry and doesn’t move at all.

                            Anyway, good talk. 😉 I hope this is helpful to someone out there.

                            Yeah, well, I’m just here for the research, man. - The Dude

                            If I haven’t liked your post, no offense. I have exceeded my daily allowance.

                            quicksilver80Q 1 Reply Last reply
                            0
                            • ResearchCatR Offline
                              ResearchCatR Offline
                              ResearchCat
                              wrote last edited by
                              #17

                              WRT my comment about assholes on the internet, I mean Reddit, not anyone here. I hate reddit, and 95% of the garbage AI is telling you is from Reddit, which is why so much of what AI tells you is garbage. /rant

                              Yeah, well, I’m just here for the research, man. - The Dude

                              If I haven’t liked your post, no offense. I have exceeded my daily allowance.

                              1 Reply Last reply
                              0
                              • ResearchCatR ResearchCat

                                Graphic content! ;0 Hoping this helps people.

                                I thought I would follow up on this. I have continued working through and dealing with constipation and (fun!) hemorrhoids. They pre-date me using GLP-1’s, but have gotten worse. I finally talked to my colorectal specialist again. What they told me might be useful.

                                First, they recommended hydrocortisone suppositories which may be prescription, but otherwise you can use lidocaine or benzocaine, sitz baths, and all the usual stuff.

                                What was really interesting to me was with respect to laxatives. She recommended taking Miralax twice a day rather than once, and taking it on an ongoing basis as needed. This was really interesting to me because both the bottle and the assholes (sorry) on the internet say you shouldn’t use more than recommended or for long periods of time. The nurse confirmed it is completely safe to use as needed to keep your stool soft and moving.

                                She also suggested not using Dulcolax, not because it doesn’t work, but because if you have compacted stool, Dulcolax helps move it, which isn’t the problem you are trying to solve. The problem you (well, I) are trying to solve is that your system is moving so slow that your stool gets hard and dry and doesn’t move at all.

                                Anyway, good talk. 😉 I hope this is helpful to someone out there.

                                quicksilver80Q Online
                                quicksilver80Q Online
                                quicksilver80
                                wrote last edited by
                                #18

                                @ResearchCat +1 on miralax. If i made a gift basket of glp1 support. A multipack of costco miralax would be center stage hahaha.

                                E 1 Reply Last reply
                                2
                                • quicksilver80Q quicksilver80

                                  @ResearchCat +1 on miralax. If i made a gift basket of glp1 support. A multipack of costco miralax would be center stage hahaha.

                                  E Offline
                                  E Offline
                                  Eleanor
                                  wrote last edited by
                                  #19

                                  @quicksilver80 said:

                                  @ResearchCat +1 on miralax. If i made a gift basket of glp1 support. A multipack of costco miralax would be center stage hahaha.

                                  No laughing matter (even if it is). Oh, the pain! - Dr. Smith

                                  Proud to be on a gubmint watch list

                                  1 Reply Last reply
                                  1
                                  • B Offline
                                    B Offline
                                    brandenscheidecker
                                    wrote last edited by
                                    #20

                                    https://speciesnutrition.com/products/fiberlyze?variant=5350996099

                                    this stuff tastes horrible, both flavors but it works!

                                    1 Reply Last reply
                                    1
                                    • MacLeeezyM Offline
                                      MacLeeezyM Offline
                                      MacLeeezy
                                      wrote last edited by
                                      #21

                                      I started at 2mg with no side effects and titrated up as needed every 4 weeks. Down 51lbs since February. I also run tesamorelin for visceral fat and Ipamoralin. For me too not get constipated in the beginning, I Stayed super hydrated. I also take 2 scoops of psyllium husk in a morning protein shake every morning and constipation isn’t an issue.

                                      1 Reply Last reply
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