Hospira 0.9% Bacteriostatic Sodium Chloride (30 mL)

Commander

@mrjoshua44 said:

@Commander BAC water containing sodium chloride (NaCl) shouldn't be used with unbuffered NAD+ only buffered versions. With unbuffered, it'll just make the injection worse.

The first couple of days it wasn’t, but then it got bad

Stevepep

Yes—if it is Hospira Bacteriostatic 0.9% Sodium Chloride, you can use it to reconstitute unbuffered NAD+. That is the preferred diluent class for NAD+ when a buffered product is not available.

It may reduce the osmotic/local-welt component of the reaction, but it will not neutralize the NAD+ solution’s acidity, which is usually the main reason unbuffered NAD+ burns or stings. A pre-buffered NAD+ product is the better fix for that; otherwise, slower administration, more dilution within the vial’s capacity, and site rotation are the practical levers.

From Peptide Fox AI I will not vouch for this, as I asked for a source and it couldn't point to one other than some drivel

Paradox

@Commander did you actually notice a difference with MOTS-C? I still get redness and post sting with it, maybe less though.

Commander

@Paradox said:

@Commander did you actually notice a difference with MOTS-C? I still get redness and post sting with it, maybe less though.

A little less. Not sure it was worth getting the BAC SC. So far no good for Tesa/IPA amd unbuffered NAD. Seems ok for MOTS-C amd SS-31.
I almost want to do two pens, one with regular and one with BAC SC and do two shots of the same amount in opposite side of the body, like left quad and right quad. I think that is the only way I would know for sure…

Nuncles

@commander I had accidentally reconned 2 ss-31 vials with regular bac before I realized my mistake. For me, it was only slightly worse than the sodium chloride.

Blueeyedme

@Nuncles - yep. 5:1 ratio GHK-Cu to KPV which works great for me. Some folks go 5:2. Here is a good video on how to blend them into a single vial/cart.
https://youtu.be/OGjjVyH50ZM?is=vRF6vM06KeAQeDqy

Blueeyedme

Here is a list of Peptides (from GLP1) reportedly compatible with BAC NaCl.

SS-31
Tirz
Sema
Glutathione
Tox
NAD+
ARA-290
KPV
KLOW
TB4
NA Semax Amidate
NA Selank Amidate
Epitalon
DSIP
HCG
PT-141

Reportedly Incompatible with BAC NaCl:
Reta
GHK-Cu
CJC
Ipa
5-Amino-1Q (Chloride version)

Nuncles

@Blueeyedme said:

@Nuncles - yep. 5:1 ratio GHK-Cu to KPV which works great for me. Some folks go 5:2. Here is a good video on how to blend them into a single vial/cart.
https://youtu.be/OGjjVyH50ZM?is=vRF6vM06KeAQeDqy

Thanks. That's the exact video I used. Just had a discussion on their TG that this ratio is just as painful to me as the watered down GHK-CU. I will try upping the KPV in the ratio.

Blueeyedme

@Nuncles - yeah, it’s a good group. I do like the organizers.

Eleanor

@SkepticJen said:

@Eleanor Yep - Ordered last week after reading this thread. Should be here mid week and I'll be ready to make a new MOTS just at the right time, but it'll be another week before I make SS-31 or NAD. All the discussion about buffered vs unbuffered NAD just got me questioning. I'm happy to sacrifice a NAD vial to check if it'll reduce sting, but would love to hear about it before it's time to try. Many thanks in advance!

It works on SS31, MOTS and on NAD+ buffered; I don't know about NAD unbuffed. reconned them all & works well.

Stevepep

@Eleanor Game changer for me and a case of Hospira NACL Bac is $100 at Medex. Someone can explain why it's $285 for Hospira BAC without the addition of NACL.

Eleanor

@Stevepep said:

@Eleanor Game changer for me and a case of Hospira NACL Bac is $100 at Medex. Someone can explain why it's $285 for Hospira BAC without the addition of NACL.

I just found it for $110. Wonder what the exp date is. Going to get me some anyway. Thank you!

Eleanor

@stevepep Nice find, thank you! Shipping not even $16; put some pep vendors to shame! Tax, shipping, product total $136.59 = ~5.12 per 30ml bottle. I'll frickin take it...and did.

Not sure I want to try it on Survo or Cagri, will see.

Eleanor

@stevepep I should probably put this under vials, and I will, but since I mix 2000+mg NAD at a time, I like this price and they sound sterile, much like Ultra Spec. $9.99 shipping for box of 25.

https://www.medicalproductssupplies.com/products/sterile-empty-vials-clear-10ml-1?variant=39790012268638&country=US&currency=USD&utm_medium=product_sync&utm_source=google&utm_content=sag_organic&utm_campaign=sag_organic&gad_source=1&gad_campaignid=24133928868&gbraid=0AAAAACiZE_sLp3kk2AolTiKgJIy1DAN_r&gclid=CjwKCAjww-3VBhAcEiwAwUUIuwZClETfZoA4EHoeBTI3eUAayoSkfg7rie1X6p6VsjXvPXy9RqbZCBoC1mIQAvD_BwE

Randy

Has anyone tried this with glutathione yet?

I grabbed a pack for us to do some "science".

ManicXmedic

I'd suspect glutathione should be good to go since it's added to saline drips/I.V.'s

MikeMiranda

This post is deleted!

Commander

I would not trust that list...

Stevepep

I use it with NAD Buffered, SS31, and Mots-C, and it's a game changer in terms of any reaction. I don't really have a reaction to anything else, so I don't see the need, other than the fact that Hospira BAC with NACL is 1/3 the price, which of course makes zero sense.

MikeMiranda

@Commander said:

I would not trust that list...

you were right i ran the list gemini to check it out

Evaluating every compound shown in the image against standard biochemical reconstitution guidelines:

Section 1: "Best With Bacteriostatic Saline" (Green Box)

Semaglutide: Incorrect. Semaglutide is sensitive to salt-induced aggregation over extended storage. BAC water is preferred.
Tirzepatide: Incorrect. High susceptibility to precipitation and cloudiness when exposed to sodium chloride.
MOTS-c: Partially Correct. Tolerates saline reasonably well, but BAC water is still standard.
SS-31 (Elamipretide): Partially Correct. SS-31 is compatible with saline for short-term use, though standard BAC water remains preferred to prevent premature degradation. (Note: Image lists this twice).
Thymosin Alpha-1 (\text{TA1}): Incorrect. Standard protocols universally call for BAC water. Saline alters the charge distribution of the peptide chain unnecessarily.
Thymalin: Incorrect. Similar to TA1, it requires plain BAC water.
BPC-157: Accurate. BPC-157 is extremely stable and generally handles saline well without precipitating.
TB-500 / TB4: Accurate. Robust peptide that remains stable in saline.
GHRP-2 & GHRP-6: Incorrect. Growth hormone-releasing peptides perform far better in plain BAC water; salt can destabilize their structure over time.
Selank & Semax: Incorrect. As short-chain neuropeptides often used intranasally or subcutaneously, adding sodium chloride increases local stinging/irritation and speeds up solution breakdown.
PT-141: Incorrect. Susceptible to salting-out effects over multi-week storage.
AOD-9604: Gross Error. Image lists it under "Best Choice" while placing a red "Avoid" dot next to it. Chemically, AOD-9604 is notorious for turning into a thick gel in saline.

Section 2: "Acceptable But Not Ideal" (Yellow Box)

hCG: Incorrect. Reconstituting hCG in saline can cause premature hormone subunit dissociation. BAC water or specialized liquid diluent is mandatory.
Epitalon: Incorrect. Extremely robust short-chain tetrapeptide. If anything, it is one of the few peptides that handles saline fine, making its placement here illogical.
GHK-Cu / QHK-Cu: Partially Correct. Copper peptides tolerate saline fine for specific topical formulations, but for reconstituted vials, BAC water avoids unnecessary ionization. (Note: Image lists GHK-Cu twice).
Tesamorelin: Major Error. Tesamorelin is highly salt-sensitive and rapidly gels when exposed to sodium chloride. It belongs strictly in a "Do Not Use Saline" category.
DSIP: Incorrect. Sleep-inducing peptide that performs best in non-saline BAC water to avoid nasal/subcutaneous stinging.
5-Amino-1MQ: Incorrect. This is a small-molecule NNMT inhibitor, not a standard peptide. It requires organic solvents (like DMSO) or specific solubilizers depending on formulation—saline alone will not dissolve pure raw 5-Amino-1MQ.

Section 3: "Avoid Bacteriostatic Saline" (Red Box)

LL-37: Partially Correct. Antimicrobial peptides like LL-37 are prone to folding changes in salt environments. Standard BAC water is required.
Vasopressin: Accurate. Highly sensitive cyclic peptide; sodium chloride affects its tonicity and structural binding integrity.

Section 4: Text Claims & Visual Errors

Claim: "Reduced Injection Irritation": False. Subcutaneous injections of small amounts (0.1\text{–}0.3\text{ mL}) of plain BAC water do not cause noticeable tonicity stinging. Injecting degraded or precipitated peptide-saline mixtures causes far worse injection site reactions.
Claim: "Bottom Line: ~65% of Peptides Are Suited for Bacteriostatic Saline": False. In practical peptide research, less than 10% of freeze-dried peptides benefit from saline over plain BAC water. Plain bacteriostatic water remains the single safest solvent across the board.