Mots-c dosing
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@Cancun_coach Hola Cancun, I am one who researched MOTSc 1mg, NAD+ 10-20mg and SS31 1mg synergistically. At first it was daily and now every other day. In between I suppliment COQ10, methylene blue, aminos such as L-carnitene, Arginine, Aspartate... I am back on board another cycle of the same and it does not kick in like before. I see that as a sign I do t really need it because my mitochondria is on point, well point enough. We can't be throddling the mitochondria without a good foundation. My only challenge is finding the right diet to keep supporting it. Some foods do tax you.
I would use the 5:2 as a base line and research if titrating the dose will make any different. If 1mg is working for you stick to it
If you want to explore other protocols and it is within you budget go for it. Do what works for you. Its your research and share it. If you hit a platue and want to push energy further there are options. Dont forget to share your finds. Be patient, titrate up until you find your sweet spot. Listen to your body. If it is right for you it will feel right. You don't have to tolerate anything.@EXTROPIAN Two things: First, CoQ10 is critical, especially if you are on statins or Lp(a)/ApoB meds.
Second, I’d agree with your assessment wrt your metabolism. My friend just restarted the MOTS-C/SS-31/NAD+ protocol and said he feels much more energized than the first time he ran it. Though, he is researching a higher dosing protocol than what you listed.
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I want to add MOTSc to what I'm already doing which is 1.5mg SS-31 daily and Reta. I am concerned about any side effects associated with MOTSc. To the boards knowledge are there any side effects that should be of concern? And I'm also considering adding Tesa into mix as well as AOD-9604. So far, I've lost 11 pounds in my first month. Any advice or suggestions would be greatly appreciated.
@charlescoyle I don’t mean to quibble, but side effects and adverse reactions aren’t quite the same thing. Some, maybe a lot of people, have ISR’s and histamine reactions to MOTS-C, which is why it’s recommended to titrate up slowly from 200mcg to see if it bothers you. I have not had a reaction to it at all so far.
SS-31 and MOTS-C work synergistically, so if you have been researching SS-31, the MOTS-C should be more effective (which doesn’t have anything to do with whether you have a reaction to it.)
Happy researching!
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@EXTROPIAN Two things: First, CoQ10 is critical, especially if you are on statins or Lp(a)/ApoB meds.
Second, I’d agree with your assessment wrt your metabolism. My friend just restarted the MOTS-C/SS-31/NAD+ protocol and said he feels much more energized than the first time he ran it. Though, he is researching a higher dosing protocol than what you listed.
@ResearchCat my energy has been stable since my first cycle. I ran another one just to see if it levels up. You know, I am also doing intranasal adamax, selank and celebrolysin. A few minutes after dosing motsc, nad and ss31. I feel it in my head with a light face flush that never happened before. Maybe it is going straight to my head. lol
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@charlescoyle I don’t mean to quibble, but side effects and adverse reactions aren’t quite the same thing. Some, maybe a lot of people, have ISR’s and histamine reactions to MOTS-C, which is why it’s recommended to titrate up slowly from 200mcg to see if it bothers you. I have not had a reaction to it at all so far.
SS-31 and MOTS-C work synergistically, so if you have been researching SS-31, the MOTS-C should be more effective (which doesn’t have anything to do with whether you have a reaction to it.)
Happy researching!
@ResearchCat Thank you for your reply, yes, I should have been clearer. For instance, one side effect of my research with Reta is with my sleep. I'm hoping that along with the many other benefits of researching Tesa will be better sleep. I have not had any adverse reactions from any compound, Reta Tirz, or SS-31. I'm about to add AOD-9604 to my list as well. I plan to research SS-31 for a month and then add the MOTSc. I really like this forum as it is so informative and educational and always in a respectful manner. Thanks again
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I have been using for 3 weeks. The recommendation i got was 5 days on 2 days off 1mg dosing prior to AM workout. Then I am reading some do 3mg 3 days a week. What has worked best for you? Thanks in advance.
@Cancun_coach This is in from Dr.William Seeds Peptide Protocol Volume 1. (see below)
I had consultations with a doctor from Yale Medicine with a PHD in peptides and he recomends the conceptual protocol as listed here by Dr. Seeds. But you can start lower than 5 mg to test your tolerance and work up to 5mg or beyone depending on your age and if it is necessary, the older you are the more effecatious this peptide seems to be, is the observations by these doctors. The higher doses provide increased signalling as there has been greater depletion of MOTS-C with age is the thought process. The recomendation against daiy is due to the 48 hour downstream kaskade of effects from the peptide and also allows clearance and calming of the mast cells and histamine response deminishing the chances of an over active immune reaction to the peptide. I even find a two day gap between doses at a little higher bolus to be really effective for my Reaserch. ie) 6-7.5 twice a week vs 5 mg 3x per week. for Context I'm 51 year old male healthy. But i worked up to those numbers of course over the years to find my sweet spot and dosing protocols.
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my rat is ding 1mg per dose, 3xweek. Effect on endurance is very noticable, as in, being able to run longer and easier at higher heart rate zones (4 and 5). So i see no need yet to increase to 2mg per injection, mots-c is not that cheap after all (relatively speaking).
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my rat is ding 1mg per dose, 3xweek. Effect on endurance is very noticable, as in, being able to run longer and easier at higher heart rate zones (4 and 5). So i see no need yet to increase to 2mg per injection, mots-c is not that cheap after all (relatively speaking).
@eurouser Interesting I was doing 2mg a day and getting a nice ISR but dealt with it. I have had noticeable physical fitness results running. My sprint times have gotten noticeably better. I just switched yesterday to saline BAC, and it made a massive difference in my last two shots no ISR at all. A little itchy feeling for a couple of minutes but thats it. I am thinking about reducing it to 1mg a day. I can't see taking 4-5mg at one time
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@eurouser Interesting I was doing 2mg a day and getting a nice ISR but dealt with it. I have had noticeable physical fitness results running. My sprint times have gotten noticeably better. I just switched yesterday to saline BAC, and it made a massive difference in my last two shots no ISR at all. A little itchy feeling for a couple of minutes but thats it. I am thinking about reducing it to 1mg a day. I can't see taking 4-5mg at one time
@Stevepep what exact differences did you notice with sprinting? i'm really interested in that as i am planning on getting back to sprinting once i lose the remaining 20lbs.
One thing that helped my rat with ISR btw was to wait a second after every 2 clicks. Say total pin dosage is 10 units, he would pause 5 times. It made ISR almost completely gone (only using normal BAC water)
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@Stevepep what exact differences did you notice with sprinting? i'm really interested in that as i am planning on getting back to sprinting once i lose the remaining 20lbs.
One thing that helped my rat with ISR btw was to wait a second after every 2 clicks. Say total pin dosage is 10 units, he would pause 5 times. It made ISR almost completely gone (only using normal BAC water)
@eurouser Its an interesting thing I am associating with the Stack of SS31, NAD and Mots. I was running 4 miles at about 7:30 per mile without a sprint at the end. I do this 4x per week and lift heavy the other 3 days. I am now running 7:12 minute miles for 3 miles and sprint the last mile and I am getting just over a 6 minute mile on that last mile. When I do this on the treadm1ll I am running 3 miles at 8.5 to 9 and then last at 12. Its pretty crazy. I am in my mid 50's. I literally never had the energy to even think about sprinting at the end. One other thing I added was branched cyclic dextrin. @bfuller turned me on to it for high stress workouts. I think it has helped a lot as well. I feel fully recovered after I workout and I had high Estrogen in my monthly bloodwork, which is an indicator of lack of recovery. My estrogen levels are now Optimum.
In terms of sprinting I run 1/4miles on the treadmill at 15 which takes a minute and then walk for one minutes and do it again. 4x. I typically do this once a week after lifting. This is excellent heart exercise, with peaks and valleys.
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@jackiee I'd never heard of it before but found some here...
https://www.mountainside-medical.com/products/bacteriostatic-sodium-chloride-0-9-vial-10-ml -
@eurouser Its an interesting thing I am associating with the Stack of SS31, NAD and Mots. I was running 4 miles at about 7:30 per mile without a sprint at the end. I do this 4x per week and lift heavy the other 3 days. I am now running 7:12 minute miles for 3 miles and sprint the last mile and I am getting just over a 6 minute mile on that last mile. When I do this on the treadm1ll I am running 3 miles at 8.5 to 9 and then last at 12. Its pretty crazy. I am in my mid 50's. I literally never had the energy to even think about sprinting at the end. One other thing I added was branched cyclic dextrin. @bfuller turned me on to it for high stress workouts. I think it has helped a lot as well. I feel fully recovered after I workout and I had high Estrogen in my monthly bloodwork, which is an indicator of lack of recovery. My estrogen levels are now Optimum.
In terms of sprinting I run 1/4miles on the treadmill at 15 which takes a minute and then walk for one minutes and do it again. 4x. I typically do this once a week after lifting. This is excellent heart exercise, with peaks and valleys.
@Stevepep oh i see, you mean the "final sprint" at the end of the run not sprinting as a sport. In any case, i had the same results in that regard, as in, huge benefit in the higher heart rate zones. At your age, if you are running 7:12 for 3 miles, that means your heart rate is already around 170 minimum at the end of those three miles, so the fact that you can get to a 6 minute pace on the last mile is exactly zone 5 training which you are holding for much longer than "considered normal".
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3-5mg subcutaneous, 1–3× per week. 4–6 weeks on, 2–4 weeks off. Morning dosing, typically 60–90 min before exercise.
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What are your thoughts on MOTS-C now? Is it worth the money and the risk?
If yes, are you using it regularly or cycling?@mmp Not sure if your question was for me, but for me personally it helped me a lot. Using it in conjunction with a GLP-1, L-Carnitine, NAD+ and SS-31, gave me the necessary energy for my workouts. Over the last 30+ years, I didn't lead that healthy of a lifestyle, so when I started to learn about the possible metabolic improvement benefits of MOTS-c and had to give it a try. Now for someone that is younger and lives a pretty healthy lifestyle, you probably won't see much benefit from MOTS-c. But my last cycle for this stack I ran for 12 weeks.
SS-31 runs daily through week 8; after that, continue daily while the response is still building or move to 2–3× weekly once stable. Maintenance protocols pulse MOTS-c alongside NAD+ at 100–250 mg total weekly. MOTS-c enters in week 2 once the opening SS-31 response is stable.
If you do decide to try MOTS-c, begin with a low dose to see how well you tolerate it, and titrate slowly as well. And I have seen examples of folks when they go to start a 2nd cycle they have a very serious allergic reaction to the MOTS-c. So just use caution.
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