Eloralintide

[Randy]

I guess i start tomorrow

@wisgal64 did you flush out cag first?

[Randy]

Just in case anyone wants a label for their pens

[WisGal64]

@Randy said:

I guess i start tomorrow

@wisgal64 did you flush out cag first?

Ohhh yeah, I didn't last a month on it. It's been 2 months since.
I did start back on Tirz last week, but decided I'll drop it going forward for the time being so I can give the Elo time to do it's thing.

The ENLIGHTEN‑4 clinical trial includes targeting OA so this one is right up my alley Keeping fingers crossed for good results

[Stevepep]

@Randy let us know I am waiting to start

[JtCjEfF]

Ive been looking into this, and it may be the perfect pairing to reta for me to help bring down the RHR issue I have with reta. I am finding claims that the amylin agonists lower heart rate.

Edit: I found some data, if its true.

Heart Rate Reductions by DoseAccording to findings published from its early clinical evaluation, the mean changes in pulse rate from baseline after 12 weeks of treatment are:
3 mg dose: Decreased by 7.1 bpm
6 mg dose: Decreased by 8.3 bpm
12 mg dose: Decreased by 14.4 bpm
Placebo group: Decreased by 3.4 bpm

These reductions are sustained, begin as early as the first week of treatment, and have not been associated with symptomatic bradycardia (abnormally or dangerously slow heart rate) in trials.

[MikeMiranda]

@JtCjEfF said:

Ive been looking into this, and it may be the perfect pairing to reta for me to help bring down the RHR issue I have with reta. I am finding claims that the amylin agonists lower heart rate.

Edit: I found some data, if its true.

Heart Rate Reductions by DoseAccording to findings published from its early clinical evaluation, the mean changes in pulse rate from baseline after 12 weeks of treatment are:
3 mg dose: Decreased by 7.1 bpm
6 mg dose: Decreased by 8.3 bpm
12 mg dose: Decreased by 14.4 bpm
Placebo group: Decreased by 3.4 bpm

These reductions are sustained, begin as early as the first week of treatment, and have not been associated with symptomatic bradycardia (abnormally or dangerously slow heart rate) in trials.

Any links to this data?

[Randy]

@Stevepep im just gonna rip one mg tonight. Its been a week since ive blasted cag so this is very plausible ill regret this.

Someone's got to do the research.

[JtCjEfF]

@MikeMiranda

https://pmc.ncbi.nlm.nih.gov/articles/PMC12992164/#dom70439-sec-0012

3.2.3 Vital Signs

[ResearchCat]

@Randy I am feeling like I am being pulled into an entirely unnecessary research project.

[Randy]

@ResearchCat its very necessary.

[ResearchCat]

@Randy Well then I guess I need to buy some plastiques.

[diegoc]

@JtCjEfF what dose of Reta are you on?

[Randy]

1mg in the rat.

[JtCjEfF]

@diegoc 2mg weekly, split dose. my RHR is up +12bpm and HRV is almost in single digits.

Reta may not be for me... so Ill be watching Randys thread here while I wait for my kit of Elora to show up from Nexaph.

[diegoc]

@JtCjEfF how are you checking your RHR, and what was your baseline RHR.

What time is your last meal

[JtCjEfF]

@diegoc I wear an Apple Watch Ultra 3 AND an Oura 5 24/7. They both get dumped into Bevel Health and tracked. June 6 start on Reta.
Cardio+>12k steps daily+resistance training 3 days a week... cuz I know you.

Ill have similar data obviously after starting Elora.

Sorry for the hi-jack Randy.

IMG_4121.jpg
IMG_4120.jpg

[diegoc]

@JtCjEfF so what time is your last meal before sleep

[JtCjEfF]

@diegoc hard kitchen cuttoff at 6p. bedtime is 9:30.

[diegoc]

Yeah im running some test… I believe RHR moves up on digestion and normally with no GLP a 3hr should be a min.

On a GLP especially Reta it might be like 4-5min.

HOWEVER, your RHR is extremely high which for me im normally in the 66-69 range and on Reta i was 74-75 and i came off it because i felt that the ROI on that was more on the risk side.

I started Tirz around a month ago just to test it because im looking for the plaque reduction benefits and insulin control since im on GH.

Its working good and im contemplating adding Reta at .5mg to see how much the Glucagon will raise my RHR

[diegoc]

@JtCjEfF the HRV can be a mixture of things. How is your carb intake and calories, now on Reta?