Eloralintide
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Ive been looking into this, and it may be the perfect pairing to reta for me to help bring down the RHR issue I have with reta. I am finding claims that the amylin agonists lower heart rate.
Edit: I found some data, if its true.
Heart Rate Reductions by DoseAccording to findings published from its early clinical evaluation, the mean changes in pulse rate from baseline after 12 weeks of treatment are:
3 mg dose: Decreased by 7.1 bpm
6 mg dose: Decreased by 8.3 bpm
12 mg dose: Decreased by 14.4 bpm
Placebo group: Decreased by 3.4 bpmThese reductions are sustained, begin as early as the first week of treatment, and have not been associated with symptomatic bradycardia (abnormally or dangerously slow heart rate) in trials.
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Ive been looking into this, and it may be the perfect pairing to reta for me to help bring down the RHR issue I have with reta. I am finding claims that the amylin agonists lower heart rate.
Edit: I found some data, if its true.
Heart Rate Reductions by DoseAccording to findings published from its early clinical evaluation, the mean changes in pulse rate from baseline after 12 weeks of treatment are:
3 mg dose: Decreased by 7.1 bpm
6 mg dose: Decreased by 8.3 bpm
12 mg dose: Decreased by 14.4 bpm
Placebo group: Decreased by 3.4 bpmThese reductions are sustained, begin as early as the first week of treatment, and have not been associated with symptomatic bradycardia (abnormally or dangerously slow heart rate) in trials.
Ive been looking into this, and it may be the perfect pairing to reta for me to help bring down the RHR issue I have with reta. I am finding claims that the amylin agonists lower heart rate.
Edit: I found some data, if its true.
Heart Rate Reductions by DoseAccording to findings published from its early clinical evaluation, the mean changes in pulse rate from baseline after 12 weeks of treatment are:
3 mg dose: Decreased by 7.1 bpm
6 mg dose: Decreased by 8.3 bpm
12 mg dose: Decreased by 14.4 bpm
Placebo group: Decreased by 3.4 bpmThese reductions are sustained, begin as early as the first week of treatment, and have not been associated with symptomatic bradycardia (abnormally or dangerously slow heart rate) in trials.
Any links to this data?
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Ive been looking into this, and it may be the perfect pairing to reta for me to help bring down the RHR issue I have with reta. I am finding claims that the amylin agonists lower heart rate.
Edit: I found some data, if its true.
Heart Rate Reductions by DoseAccording to findings published from its early clinical evaluation, the mean changes in pulse rate from baseline after 12 weeks of treatment are:
3 mg dose: Decreased by 7.1 bpm
6 mg dose: Decreased by 8.3 bpm
12 mg dose: Decreased by 14.4 bpm
Placebo group: Decreased by 3.4 bpmThese reductions are sustained, begin as early as the first week of treatment, and have not been associated with symptomatic bradycardia (abnormally or dangerously slow heart rate) in trials.
Any links to this data?
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@Stevepep im just gonna rip one mg tonight. Its been a week since ive blasted cag so this is very plausible ill regret this.
Someone's got to do the research.
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@Randy I am feeling like I am being pulled into an entirely unnecessary research project.
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@ResearchCat its very necessary.
@Randy Well then I guess I need to buy some plastiques.
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Ive been looking into this, and it may be the perfect pairing to reta for me to help bring down the RHR issue I have with reta. I am finding claims that the amylin agonists lower heart rate.
Edit: I found some data, if its true.
Heart Rate Reductions by DoseAccording to findings published from its early clinical evaluation, the mean changes in pulse rate from baseline after 12 weeks of treatment are:
3 mg dose: Decreased by 7.1 bpm
6 mg dose: Decreased by 8.3 bpm
12 mg dose: Decreased by 14.4 bpm
Placebo group: Decreased by 3.4 bpmThese reductions are sustained, begin as early as the first week of treatment, and have not been associated with symptomatic bradycardia (abnormally or dangerously slow heart rate) in trials.
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@JtCjEfF how are you checking your RHR, and what was your baseline RHR.
What time is your last meal
@diegoc I wear an Apple Watch Ultra 3 AND an Oura 5 24/7. They both get dumped into Bevel Health and tracked. June 6 start on Reta.
Cardio+>12k steps daily+resistance training 3 days a week... cuz I know you.
Ill have similar data obviously after starting Elora.
Sorry for the hi-jack Randy.
IMG_4121.jpg
IMG_4120.jpg -
@diegoc I wear an Apple Watch Ultra 3 AND an Oura 5 24/7. They both get dumped into Bevel Health and tracked. June 6 start on Reta.
Cardio+>12k steps daily+resistance training 3 days a week... cuz I know you.Ill have similar data obviously after starting Elora.
Sorry for the hi-jack Randy.
IMG_4121.jpg
IMG_4120.jpg -
Yeah im running some test… I believe RHR moves up on digestion and normally with no GLP a 3hr should be a min.
On a GLP especially Reta it might be like 4-5min.
HOWEVER, your RHR is extremely high which for me im normally in the 66-69 range and on Reta i was 74-75 and i came off it because i felt that the ROI on that was more on the risk side.
I started Tirz around a month ago just to test it because im looking for the plaque reduction benefits and insulin control since im on GH.
Its working good and im contemplating adding Reta at .5mg to see how much the Glucagon will raise my RHR
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@diegoc I wear an Apple Watch Ultra 3 AND an Oura 5 24/7. They both get dumped into Bevel Health and tracked. June 6 start on Reta.
Cardio+>12k steps daily+resistance training 3 days a week... cuz I know you.Ill have similar data obviously after starting Elora.
Sorry for the hi-jack Randy.
IMG_4121.jpg
IMG_4120.jpg -
Yeah im running some test… I believe RHR moves up on digestion and normally with no GLP a 3hr should be a min.
On a GLP especially Reta it might be like 4-5min.
HOWEVER, your RHR is extremely high which for me im normally in the 66-69 range and on Reta i was 74-75 and i came off it because i felt that the ROI on that was more on the risk side.
I started Tirz around a month ago just to test it because im looking for the plaque reduction benefits and insulin control since im on GH.
Its working good and im contemplating adding Reta at .5mg to see how much the Glucagon will raise my RHR
@diegoc Ouch. Those are some ugly RHR and HRV. I had the same thing happen at 4mg/wk Reta. Not wanting to give up the glucagon benefit, I shifted to 1.5mg/wk Reta and 5mg/wk Tirz. Great appetite control GLP-1, insulin sensitivity GIP, and still a small benefit from Reta hitting the Glucagon receptor. And my RHR and HRV went back to normal, or at least close to normal.
When at my goal (went from 202-178), of 170 pounds, I’ll shift to 1mg Reta and 2.5mg Tirz.
This low-dose baseline is widely noted in transition frameworks as an ideal stack for long-term weight maintenance. It offers continuous, baseline GLP-1/GIP receptor saturation via Tirzepatide while introducing mild glucagon receptor activation via Retatrutide to support metabolic function.
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@diegoc Ouch. Those are some ugly RHR and HRV. I had the same thing happen at 4mg/wk Reta. Not wanting to give up the glucagon benefit, I shifted to 1.5mg/wk Reta and 5mg/wk Tirz. Great appetite control GLP-1, insulin sensitivity GIP, and still a small benefit from Reta hitting the Glucagon receptor. And my RHR and HRV went back to normal, or at least close to normal.
When at my goal (went from 202-178), of 170 pounds, I’ll shift to 1mg Reta and 2.5mg Tirz.
This low-dose baseline is widely noted in transition frameworks as an ideal stack for long-term weight maintenance. It offers continuous, baseline GLP-1/GIP receptor saturation via Tirzepatide while introducing mild glucagon receptor activation via Retatrutide to support metabolic function.
@mikebricker yeah thats probably the test im going to do now. Not so high on Reta because you can get good benefits at even lower dose Reta.
If the heart rate is the issue you can keep the Reta on the really low end and if your looking to drop more weight raise the Tirz.
For me its more of a metabolic test because I dont want tk loose that much weight
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I started a few weeks ago.
Currently 15mg tirz (almost 2 years now titrated from 2.5mg)
5mg survo (4months)
700mcg eloraSw 235. Cw 140. Gw 135
Almost there!I haven't noticed any side effects but I did drop some fat much quicker than I have been.
I tried reta but it had my heart rate up so I couldn't sleep. When I read about Randy's ghetto reta I did that.
I'm also doing tesa/ipa and 5-Amino-1mq m-f.
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