The "ghetto" Reta Stack. Tirz + Survo/Maz
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@Randy Are you taking them all on same day or dosing each separately throughout the week? I just hit my three month mark today with compounded Tirzepatide and thinking about adding in some Survodutide to the mix. I’ve been extremely responsive to the Tirz and have gone from 332 lbs to 291 lbs. Also just recently increased my dose to 4.25mg of Tirz.
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@mrjoshua44 Im on week 10 of Tirzepatide at 5mg and week 3 of Servo .7mg after 3 days. I was stalled a bit and added 5 amino 1mq for about 2 weeks. I finished that vial and kind of miss that bump of energy in the am.
@beachfun How much of the 5-amino were you doing?
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@beachfun How much of the 5-amino were you doing?
@mrjoshua44 Im on my 2nd vial of doing 5mg everyday. I am conservative in this research but feel good after the sub q usually in my glutes while waiting for my coffee. It is not an all day boost but my weight is going down while muscle mass is going up according to my In body scan.
I recently just added the cjc/ipa at night for more muscle and sleep is very deep, just doing it 3 hours after eating. -
Any good reports for Tirz/Maz results? I don't see a lot out there as far as research results for Maz, unless I haven't looked in the right places which is a good possibility
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P PeptideCritic moved this topic from Weight Management Peptides on
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I'm on 4mg tirz and started 600mcg survo 6 days ago. I'm having a hard time eating. I eat a couple spoons of Greek yogurt and I feel like I'm getting my money's worth at a buffet. I was hoping to speed up my losing, but I'm not eating enough calories to get out of starvation mode. You aren't kidding "survo hits hard".
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i was on the 7.5 mounjaro and did an experiment with the Reta , it was a learning experience and prolly will do it again but now insted of adding the Reta i am experimenting with the Cagri , I (oops i mean Clouse the Lab Mouse) likes it as well
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Thats a massive drop on the tirz. Reta is either tolerated or you feel like you were sunburned in every spot on your body and itch like a maniac. People opt for survo or maz for the ghetto stack because it has no GIP and lower GLP.
@Randy funny with the sunburn or itch. heard magnesium fixes itches. were at 4mg with zero negatives except a little gi. but weights not dropping as fast as id like. so little bad little good?
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Happy Friday. Randy research rat, your content is always appreciated so thank you!
My research specimen is currently on 7mg Tirz, and still seeing progressive results- 235lbs to 198lbs in 3 months. Also taking tesamorelin and glow stack.Few questions: 1. Of these two, which one might be better considering the other peptides, (leaning towards survo) 2. Any RUO companies here that you may recommend 3. What might be good testing for survo maz to ensure healthy baseline monitoring? Assuming same as other GLP GIP Glucagon agonists?
Thanks!
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Happy Friday. Randy research rat, your content is always appreciated so thank you!
My research specimen is currently on 7mg Tirz, and still seeing progressive results- 235lbs to 198lbs in 3 months. Also taking tesamorelin and glow stack.Few questions: 1. Of these two, which one might be better considering the other peptides, (leaning towards survo) 2. Any RUO companies here that you may recommend 3. What might be good testing for survo maz to ensure healthy baseline monitoring? Assuming same as other GLP GIP Glucagon agonists?
Thanks!@jborja I got my Survo from EZ peptides and like they have the QR code of the COA right on the label. My 1 10 mg vial has lasted over 2 months. I really noticed the effects when I reached the 1mg. I stayed at 5mg of Tirz and see no reason to tirade up. I will probably stop both after this week as Ive met my weight loss goals. I just want to cut that visceral fat to tone up my abs.
My plan now is to try some Reta maybe 5mg weekly with my cjc/ipa .3mg nightly 5 times a week and some MotsC 5mg 3x a week. Not sure about stacking some Tesamoreline with the nightly shot. Anybody want to share thoughts? -
@jborja I got my Survo from EZ peptides and like they have the QR code of the COA right on the label. My 1 10 mg vial has lasted over 2 months. I really noticed the effects when I reached the 1mg. I stayed at 5mg of Tirz and see no reason to tirade up. I will probably stop both after this week as Ive met my weight loss goals. I just want to cut that visceral fat to tone up my abs.
My plan now is to try some Reta maybe 5mg weekly with my cjc/ipa .3mg nightly 5 times a week and some MotsC 5mg 3x a week. Not sure about stacking some Tesamoreline with the nightly shot. Anybody want to share thoughts? -
@Randy Well I lost 22lbs and gained 7lbs muscle mass. Im now at 192lbs. It gets windy here in Nevada so I don’t want to lose too much weight. I just reconstituted some tesamoreline to try a stack with my cjc/ipa to hit that little chunk of love handles.
I want to try some reta too that Ive heard so much about. -
For research use only. Not medical advice.
The goal:
Tirzepatide = GLP-1 + GIP
Survodutide or Mazdutide = GLP-1 + Glucagon
→ Combined effect = GLP-1 + GIP + Glucagon, i.e., a retatrutide-like profile.Because both second agents have a glucagon hit, titration must be slower than usual to avoid nausea, low appetite floor, or excessive gastric slowing.
Why do this?
- You stockpiled too much tirz.
- Break a stall.
- Reta itch/allodynia or other intolerable side effects when researching reta.
1. Tirzepatide + Survodutide
Survodutide has a stronger glucagon hit than mazdutide. This is the more potent combination.
Weekly Titration Schedule
Weeks 1–4
Tirzepatide: 2.5 mg weekly
Survodutide: 0.3 mg weekly
Purpose: Establish baseline tolerability. Survo kicks hard early.Weeks 5–8
Tirzepatide: 5 mg weekly
Survodutide: 0.6 mg weekly
Notes: Appetite suppression becomes extremely strong for many subjects here.Weeks 9–12
Tirzepatide: 7.5 mg weekly
Survodutide: 1.0 mg weekly
This is the sweet spot for most research models. Strong “reta-like” effect emerges.
Week 13+ Maintenance
Two viable approaches:
Standard Maintenance
Tirzepatide: 7.5–10 mg
Survodutide: 1.0–1.5 mg
High-End (Aggressive) Maintenance
Tirzepatide: 10–12.5 mg
Survodutide: 1.5–2.0 mg
Only for researchers replicating the high-end metabolic punch of retatrutide.
Notes
Survodutide plus tirz amplifies appetite suppression so hard that most people do not need high tirz dosing.
Escalate slowly — both compounds slow gastric emptying.
This combo is more GC-heavy than mazdutide, so itch issues are less common compared to retatrutide, but GI load is higher.
- Tirzepatide + Mazdutide (Ghetto Reta v2 — Milder, Cleaner)
Mazdutide has a slightly softer glucagon hit and a less aggressive appetite cliff.
This stack is smoother and usually more tolerable.Tirzepatide + Mazdutide
Weeks 1–4
Tirzepatide: 2.5 mg weekly
Mazdutide: 2 mg weekly
Weeks 5–8
Tirzepatide: 5 mg weekly
Mazdutide: 4 mg weekly
Weeks 9–12
Tirzepatide: 7.5 mg weekly
Mazdutide: 6 mg weekly
This combo mimics a “mid-dose retatrutide” effect without the itch or violent GI spike.
Week 13+ Maintenance
Tirzepatide: 7.5–10 mg
Mazdutide: 6–8 mg
High-End (Not common)
Tirzepatide: 10–12.5 mg
Mazdutide: 8–10 mg
Notes
Mazdutide is smoother but still synergistic with tirz.
Appetite suppression is strong but less harsh than survo stacks.
GI load increases if escalated too fast — keep 4-week steps.
-
For research use only. Not medical advice.
The goal:
Tirzepatide = GLP-1 + GIP
Survodutide or Mazdutide = GLP-1 + Glucagon
→ Combined effect = GLP-1 + GIP + Glucagon, i.e., a retatrutide-like profile.Because both second agents have a glucagon hit, titration must be slower than usual to avoid nausea, low appetite floor, or excessive gastric slowing.
Why do this?
- You stockpiled too much tirz.
- Break a stall.
- Reta itch/allodynia or other intolerable side effects when researching reta.
1. Tirzepatide + Survodutide
Survodutide has a stronger glucagon hit than mazdutide. This is the more potent combination.
Weekly Titration Schedule
Weeks 1–4
Tirzepatide: 2.5 mg weekly
Survodutide: 0.3 mg weekly
Purpose: Establish baseline tolerability. Survo kicks hard early.Weeks 5–8
Tirzepatide: 5 mg weekly
Survodutide: 0.6 mg weekly
Notes: Appetite suppression becomes extremely strong for many subjects here.Weeks 9–12
Tirzepatide: 7.5 mg weekly
Survodutide: 1.0 mg weekly
This is the sweet spot for most research models. Strong “reta-like” effect emerges.
Week 13+ Maintenance
Two viable approaches:
Standard Maintenance
Tirzepatide: 7.5–10 mg
Survodutide: 1.0–1.5 mg
High-End (Aggressive) Maintenance
Tirzepatide: 10–12.5 mg
Survodutide: 1.5–2.0 mg
Only for researchers replicating the high-end metabolic punch of retatrutide.
Notes
Survodutide plus tirz amplifies appetite suppression so hard that most people do not need high tirz dosing.
Escalate slowly — both compounds slow gastric emptying.
This combo is more GC-heavy than mazdutide, so itch issues are less common compared to retatrutide, but GI load is higher.
- Tirzepatide + Mazdutide (Ghetto Reta v2 — Milder, Cleaner)
Mazdutide has a slightly softer glucagon hit and a less aggressive appetite cliff.
This stack is smoother and usually more tolerable.Tirzepatide + Mazdutide
Weeks 1–4
Tirzepatide: 2.5 mg weekly
Mazdutide: 2 mg weekly
Weeks 5–8
Tirzepatide: 5 mg weekly
Mazdutide: 4 mg weekly
Weeks 9–12
Tirzepatide: 7.5 mg weekly
Mazdutide: 6 mg weekly
This combo mimics a “mid-dose retatrutide” effect without the itch or violent GI spike.
Week 13+ Maintenance
Tirzepatide: 7.5–10 mg
Mazdutide: 6–8 mg
High-End (Not common)
Tirzepatide: 10–12.5 mg
Mazdutide: 8–10 mg
Notes
Mazdutide is smoother but still synergistic with tirz.
Appetite suppression is strong but less harsh than survo stacks.
GI load increases if escalated too fast — keep 4-week steps.
@Randy Is Reta itch issue due to GIP or combination or all three RAs?
I'm stocked up like crazy on Reta and now wondering if that was the right decision. I came across Survo later when I fell in the peptide rabbit hole deep.
Dropped Tirz from 10mg to 5mg due to horrible fatigue and inability to lift prior weights on 10mg.
Added Survo 3 weeks ago.
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@tony49_49 nooooo
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@Randy Is Reta itch issue due to GIP or combination or all three RAs?
I'm stocked up like crazy on Reta and now wondering if that was the right decision. I came across Survo later when I fell in the peptide rabbit hole deep.
Dropped Tirz from 10mg to 5mg due to horrible fatigue and inability to lift prior weights on 10mg.
Added Survo 3 weeks ago.
@pep_researcher We dont know what it is but i havent had it with maz or survo
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@Randy Well I lost 22lbs and gained 7lbs muscle mass. Im now at 192lbs. It gets windy here in Nevada so I don’t want to lose too much weight. I just reconstituted some tesamoreline to try a stack with my cjc/ipa to hit that little chunk of love handles.
I want to try some reta too that Ive heard so much about. -
@tony49_49 nooooo
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@beachfun Yeah I do Tirz on Saturday, and Survo on Tue or Wed.
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@jborja I got my Survo from EZ peptides and like they have the QR code of the COA right on the label. My 1 10 mg vial has lasted over 2 months. I really noticed the effects when I reached the 1mg. I stayed at 5mg of Tirz and see no reason to tirade up. I will probably stop both after this week as Ive met my weight loss goals. I just want to cut that visceral fat to tone up my abs.
My plan now is to try some Reta maybe 5mg weekly with my cjc/ipa .3mg nightly 5 times a week and some MotsC 5mg 3x a week. Not sure about stacking some Tesamoreline with the nightly shot. Anybody want to share thoughts?@beachfun Excellent to know these numbers. Those are my exact same target numbers and I'm adding Survo very very slowly keeping Tirz at 4-5mg.
It will take me 3 months to finish my first 10mg Survo vial as I'm titrating up very slowly.
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