The "ghetto" Reta Stack. Tirz + Survo/Maz
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For research use only. Not medical advice.
The goal:
Tirzepatide = GLP-1 + GIP
Survodutide or Mazdutide = GLP-1 + Glucagon
→ Combined effect = GLP-1 + GIP + Glucagon, i.e., a retatrutide-like profile.Because both second agents have a glucagon hit, titration must be slower than usual to avoid nausea, low appetite floor, or excessive gastric slowing.
Why do this?
- You stockpiled too much tirz.
- Break a stall.
- Reta itch/allodynia or other intolerable side effects when researching reta.
1. Tirzepatide + Survodutide
Survodutide has a stronger glucagon hit than mazdutide. This is the more potent combination.
Weekly Titration Schedule
Weeks 1–4
Tirzepatide: 2.5 mg weekly
Survodutide: 0.3 mg weekly
Purpose: Establish baseline tolerability. Survo kicks hard early.Weeks 5–8
Tirzepatide: 5 mg weekly
Survodutide: 0.6 mg weekly
Notes: Appetite suppression becomes extremely strong for many subjects here.Weeks 9–12
Tirzepatide: 7.5 mg weekly
Survodutide: 1.0 mg weekly
This is the sweet spot for most research models. Strong “reta-like” effect emerges.
Week 13+ Maintenance
Two viable approaches:
Standard Maintenance
Tirzepatide: 7.5–10 mg
Survodutide: 1.0–1.5 mg
High-End (Aggressive) Maintenance
Tirzepatide: 10–12.5 mg
Survodutide: 1.5–2.0 mg
Only for researchers replicating the high-end metabolic punch of retatrutide.
Notes
Survodutide plus tirz amplifies appetite suppression so hard that most people do not need high tirz dosing.
Escalate slowly — both compounds slow gastric emptying.
This combo is more GC-heavy than mazdutide, so itch issues are less common compared to retatrutide, but GI load is higher.
- Tirzepatide + Mazdutide (Ghetto Reta v2 — Milder, Cleaner)
Mazdutide has a slightly softer glucagon hit and a less aggressive appetite cliff.
This stack is smoother and usually more tolerable.Tirzepatide + Mazdutide
Weeks 1–4
Tirzepatide: 2.5 mg weekly
Mazdutide: 2 mg weekly
Weeks 5–8
Tirzepatide: 5 mg weekly
Mazdutide: 4 mg weekly
Weeks 9–12
Tirzepatide: 7.5 mg weekly
Mazdutide: 6 mg weekly
This combo mimics a “mid-dose retatrutide” effect without the itch or violent GI spike.
Week 13+ Maintenance
Tirzepatide: 7.5–10 mg
Mazdutide: 6–8 mg
High-End (Not common)
Tirzepatide: 10–12.5 mg
Mazdutide: 8–10 mg
Notes
Mazdutide is smoother but still synergistic with tirz.
Appetite suppression is strong but less harsh than survo stacks.
GI load increases if escalated too fast — keep 4-week steps.
-
For research use only. Not medical advice.
The goal:
Tirzepatide = GLP-1 + GIP
Survodutide or Mazdutide = GLP-1 + Glucagon
→ Combined effect = GLP-1 + GIP + Glucagon, i.e., a retatrutide-like profile.Because both second agents have a glucagon hit, titration must be slower than usual to avoid nausea, low appetite floor, or excessive gastric slowing.
Why do this?
- You stockpiled too much tirz.
- Break a stall.
- Reta itch/allodynia or other intolerable side effects when researching reta.
1. Tirzepatide + Survodutide
Survodutide has a stronger glucagon hit than mazdutide. This is the more potent combination.
Weekly Titration Schedule
Weeks 1–4
Tirzepatide: 2.5 mg weekly
Survodutide: 0.3 mg weekly
Purpose: Establish baseline tolerability. Survo kicks hard early.Weeks 5–8
Tirzepatide: 5 mg weekly
Survodutide: 0.6 mg weekly
Notes: Appetite suppression becomes extremely strong for many subjects here.Weeks 9–12
Tirzepatide: 7.5 mg weekly
Survodutide: 1.0 mg weekly
This is the sweet spot for most research models. Strong “reta-like” effect emerges.
Week 13+ Maintenance
Two viable approaches:
Standard Maintenance
Tirzepatide: 7.5–10 mg
Survodutide: 1.0–1.5 mg
High-End (Aggressive) Maintenance
Tirzepatide: 10–12.5 mg
Survodutide: 1.5–2.0 mg
Only for researchers replicating the high-end metabolic punch of retatrutide.
Notes
Survodutide plus tirz amplifies appetite suppression so hard that most people do not need high tirz dosing.
Escalate slowly — both compounds slow gastric emptying.
This combo is more GC-heavy than mazdutide, so itch issues are less common compared to retatrutide, but GI load is higher.
- Tirzepatide + Mazdutide (Ghetto Reta v2 — Milder, Cleaner)
Mazdutide has a slightly softer glucagon hit and a less aggressive appetite cliff.
This stack is smoother and usually more tolerable.Tirzepatide + Mazdutide
Weeks 1–4
Tirzepatide: 2.5 mg weekly
Mazdutide: 2 mg weekly
Weeks 5–8
Tirzepatide: 5 mg weekly
Mazdutide: 4 mg weekly
Weeks 9–12
Tirzepatide: 7.5 mg weekly
Mazdutide: 6 mg weekly
This combo mimics a “mid-dose retatrutide” effect without the itch or violent GI spike.
Week 13+ Maintenance
Tirzepatide: 7.5–10 mg
Mazdutide: 6–8 mg
High-End (Not common)
Tirzepatide: 10–12.5 mg
Mazdutide: 8–10 mg
Notes
Mazdutide is smoother but still synergistic with tirz.
Appetite suppression is strong but less harsh than survo stacks.
GI load increases if escalated too fast — keep 4-week steps.
@Randy Is Reta itch issue due to GIP or combination or all three RAs?
I'm stocked up like crazy on Reta and now wondering if that was the right decision. I came across Survo later when I fell in the peptide rabbit hole deep.
Dropped Tirz from 10mg to 5mg due to horrible fatigue and inability to lift prior weights on 10mg.
Added Survo 3 weeks ago.
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@tony49_49 nooooo
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@Randy Is Reta itch issue due to GIP or combination or all three RAs?
I'm stocked up like crazy on Reta and now wondering if that was the right decision. I came across Survo later when I fell in the peptide rabbit hole deep.
Dropped Tirz from 10mg to 5mg due to horrible fatigue and inability to lift prior weights on 10mg.
Added Survo 3 weeks ago.
@pep_researcher We dont know what it is but i havent had it with maz or survo
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@Randy Well I lost 22lbs and gained 7lbs muscle mass. Im now at 192lbs. It gets windy here in Nevada so I don’t want to lose too much weight. I just reconstituted some tesamoreline to try a stack with my cjc/ipa to hit that little chunk of love handles.
I want to try some reta too that Ive heard so much about. -
@tony49_49 nooooo
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@beachfun Yeah I do Tirz on Saturday, and Survo on Tue or Wed.
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@jborja I got my Survo from EZ peptides and like they have the QR code of the COA right on the label. My 1 10 mg vial has lasted over 2 months. I really noticed the effects when I reached the 1mg. I stayed at 5mg of Tirz and see no reason to tirade up. I will probably stop both after this week as Ive met my weight loss goals. I just want to cut that visceral fat to tone up my abs.
My plan now is to try some Reta maybe 5mg weekly with my cjc/ipa .3mg nightly 5 times a week and some MotsC 5mg 3x a week. Not sure about stacking some Tesamoreline with the nightly shot. Anybody want to share thoughts?@beachfun Excellent to know these numbers. Those are my exact same target numbers and I'm adding Survo very very slowly keeping Tirz at 4-5mg.
It will take me 3 months to finish my first 10mg Survo vial as I'm titrating up very slowly.
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@beachfun Im a big fan of the real thing over the gh releasing peps... Tesa does work though
My back and joints really started aching on Tesamoreline on my first 10mg vial. I had to stop and went back to my cjc/ipa dose before bed. I prefer the more natural pulse of my body producing gh but do love my TRT twice a week. I’ve also tried kisspeptine a few times which was interesting…
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Survo is a miracle. Just ordered it for my RS and the next day down two pounds after a four month stall and the survo hasn't even arrived yet, just the mere active ordering, it broke the stall.
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Survo is a miracle. Just ordered it for my RS and the next day down two pounds after a four month stall and the survo hasn't even arrived yet, just the mere active ordering, it broke the stall.
@Americanchild What do you mean by "Four times it"? You mean 4 weeks or 4 back to back shots?
Where did you start with Survo dosing?
I dropped Tirz from 10mg to 5mg because of horrible fatigue and inability to eat or workout on 10mg. But now I'm stalled so have added Survo 4 weeks ago.
From week 1 - 0.4, 0.4, 0.6, 0.6....
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@Americanchild What do you mean by "Four times it"? You mean 4 weeks or 4 back to back shots?
Where did you start with Survo dosing?
I dropped Tirz from 10mg to 5mg because of horrible fatigue and inability to eat or workout on 10mg. But now I'm stalled so have added Survo 4 weeks ago.
From week 1 - 0.4, 0.4, 0.6, 0.6....
@pep_researcher should have spell checked. I just ordered and before it came the stall broke. So I guess my RS just needed to know it was coming.
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@pep_researcher should have spell checked. I just ordered and before it came the stall broke. So I guess my RS just needed to know it was coming.
@Americanchild hahahaha. No such luck for my rat.
It was in the freezer for a couple of months and just trying to break the stall with tirz. Tirz and Cagri both made rat horribly fatigued. So dropped Cagri completely, dropped Tirz dose, and added Survo. Let's see.
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Out rats can compair notes.
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Rebekah my fluffy research rat is not impressed with survo 0.300 with 7.5 of tirz. She is fighting me for sweets. She had better sweet control on sema but after 2 years her weight stalled so moved to tirz and weight stalled after an initial small loss of 10 lbs. Rebekah would like me to increase her survo to 0.600 with next dose, despite the fact she only had one dose of survo at 0.300. Is this a bad idea? Any suggestions are welcome.
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Rebekah my fluffy research rat is not impressed with survo 0.300 with 7.5 of tirz. She is fighting me for sweets. She had better sweet control on sema but after 2 years her weight stalled so moved to tirz and weight stalled after an initial small loss of 10 lbs. Rebekah would like me to increase her survo to 0.600 with next dose, despite the fact she only had one dose of survo at 0.300. Is this a bad idea? Any suggestions are welcome.
@Americanchild probably not. Trials started at 0.6mg. So Rebekah is expected to be fine.
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@Americanchild probably not. Trials started at 0.6mg. So Rebekah is expected to be fine.
@pep_researcher thank you
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@Randy Is Reta itch issue due to GIP or combination or all three RAs?
I'm stocked up like crazy on Reta and now wondering if that was the right decision. I came across Survo later when I fell in the peptide rabbit hole deep.
Dropped Tirz from 10mg to 5mg due to horrible fatigue and inability to lift prior weights on 10mg.
Added Survo 3 weeks ago.
@pep_researcher How are you doing on this?
I have MazD and will be starting it Tues. Pinning Tirz on Sat.
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@pep_researcher How are you doing on this?
I have MazD and will be starting it Tues. Pinning Tirz on Sat.
@F8hnGM4Eva I'm stalled for 6 weeks now. I don't have a lot to lose so I'm not pushing it. Right now at 5mg Tirz and 0.8mg Survo 3 days apart. Will keep Tirz same and titrate up Survo to 1mg.
After I finish my T and S vials. I'm going to jump to Reta as I just want to break the stall and move the needle.
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