Tesamorelin Research Dosing Protocol
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I have 20mg vials coming in a couple of days, so I guess I will find out
I have seen those around, and was previously thinking that 20 days is way too long to have Tesa recon in use (I go 1mg per day).
Your experiences have me thinking otherwise. I try not to get dogmatic about things and I will experiment and tinker if it makes sense, within reason.
I have previously ran them for 10 days (not fridged) with no issues at all.
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I’d love to see @randy run his next batch of testing on research grade Tesa, so we can finally see if it stays potent for a few weeks after reconstitution and if being in the fridge or room temp really matters (pretty please)?
I’d love to see @randy run his next batch of testing on research grade Tesa, so we can finally see if it stays potent for a few weeks after reconstitution and if being in the fridge or room temp really matters (pretty please)?
I have 2 vials of 10mg Tesa powder in the fridge from Penguin I will donate to Randy if he will test. Might as well donate it bc I can't take it with the side effects.
@randy What says you, rat?
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I’d love to see @randy run his next batch of testing on research grade Tesa, so we can finally see if it stays potent for a few weeks after reconstitution and if being in the fridge or room temp really matters (pretty please)?
I have 2 vials of 10mg Tesa powder in the fridge from Penguin I will donate to Randy if he will test. Might as well donate it bc I can't take it with the side effects.
@randy What says you, rat?
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@jborja said in Tesamorelin Research Dosing Protocol:
Hey friends, @randy might have opined on this also, but curious to hear what others think. I saw another video that nightly tesamorelin might be impacted for those taking Tirz or Reta due to slowed gastric emptying, meaning that folks are not as truly fasted and still carrying heavier insulin when they poke before bed.
I like Tesamorelin/ipa at nights due to restful and deeper sleep (even with toddlers), but I am on tirz and try to have my last bite 3 hours before bed. Not sure if eating dinner 4 hrs before is doable..
Curious to hear your thoughts about a morning routine instead? For you morning folks, do you just wait at least 30 mins before a pre workout? I was gonna try Tesa at night and Cjc in the morning but might be reconsidering this to not have duplicative secretagogues at the same time. Ty!I only research my GHRH/GHRP peptides in the a.m., first thing fasted now, for a whole bunch of reasons. It's just easier and more convenient for me, I know I'm totally fasted with insulin at its lowest point (and therefore getting the strongest amount of receptor saturation as possible).
Plus I'm just more awake/alert in the a.m., easier to pin and reconstitute if need be. I spent many late nights in years past pinning/researching before bed after a long day and when tired, it's just difficult.
I wait 2 hours before eating anything. I drink black coffee right away in the morning after pinning and the combo of peptides, coffee and being fasted in the a.m. is a superpower for getting stuff done. Plus I find GH peptides stimulating in a way in the morning.
I like the idea of going natural at night (no GH peps) and really letting my natural production do its thing. I have found that there must be some carry over anyways, because on cycle my rat sleeps better even though he pins in the a.m only.
Rather than trying to find a way to squeeze in Tesa/CJC in the same day, I'd recommend you use one or the other during your cycle. You can flip flop them as well, going back and forth when one vial runs out.
I know I'm totally fasted with insulin at its lowest point
You should really test your daily insulin fluctuation (through correlation with glucose) with 15-days CGM to know levels and timings exactly. I ran CGMs many times, and when I wake up my insulin level is not the lowest of the day. There is so-called "dawn effect" starting at around an hour before you wake up and going for some time, when your insulin goes high because glucose go high because of raising cortisol.
Here is how it looked for me, and I wake up at 6-7. See, there is a raise around the wake time and then it goes down around 7:30a. You can make it personally adjusted, knowing the short half-life of these molecules it may be worth doing.
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I’ve been taking Tesamorelin for 2 weeks—1 mg during the first week and 2 mg at night during the second week. I inject it about 30 minutes before bed, with no food for at least 3 hours beforehand.
Since starting it, my nighttime heart rate has increased. My average resting heart rate used to be around 60, but recently it’s been 86, 70, and 69. My stress levels have been very high, I’m not getting any REM sleep, and I’m having trouble sleeping overall.
I know that this is an evening Peptide, but would AM hour work better maybe? I could pause for a couple of days and see if my heart rate and sleep normalize also.@lancerlot23 Any update on how this went? Researching Reta and Im +10 bpm, with the same negative results you mention. Last thing i need is more BPM's!
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Great summary.
One thing I would add is that monitoring IGF-1 during longer research protocols can be useful since individual responses vary. I also found this Tesamorelin research overview helpful for comparing dosing protocols and cycle lengths: https://peptidescostarica.net/tesamorelin-costa-rica/ -
I’ve been taking Tesamorelin for 2 weeks—1 mg during the first week and 2 mg at night during the second week. I inject it about 30 minutes before bed, with no food for at least 3 hours beforehand.
Since starting it, my nighttime heart rate has increased. My average resting heart rate used to be around 60, but recently it’s been 86, 70, and 69. My stress levels have been very high, I’m not getting any REM sleep, and I’m having trouble sleeping overall.
I know that this is an evening Peptide, but would AM hour work better maybe? I could pause for a couple of days and see if my heart rate and sleep normalize also.@lancerlot23 probably should listen to your rat's body and lower the dose. that's a huge jump in heart rate.
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So my metabolic stacks up like this now.
Tesa 500mcgs-1mg daily
Reta 2mg wkly
5-amino 1mg, Slu-pp .500mcgs every other day
Utilizing MOTSC 1-2mg NAD 10-20mg every other day from my mitochondrial stack.
Wolverine, , epitholine, ss-31 and LL-37 1mg each every other day on the background for support, repair and immunity.
All these stacks can be stacked different. They all support each the one way or another. -
So my metabolic stacks up like this now.
Tesa 500mcgs-1mg daily
Reta 2mg wkly
5-amino 1mg, Slu-pp .500mcgs every other day
Utilizing MOTSC 1-2mg NAD 10-20mg every other day from my mitochondrial stack.
Wolverine, , epitholine, ss-31 and LL-37 1mg each every other day on the background for support, repair and immunity.
All these stacks can be stacked different. They all support each the one way or another. -
@EXTROPIAN If you haven't tried Pinealon its worth trying for great sleep. I am just cycling off and going to try DSIP. My sleep scores are through the roof and they were horrible before I started
@Stevepep Oh I'm sure it's good but I never had any trouble getting some good rest. I REM even in my naps. You set your phone alarm and just take notes. I wake up on time and all my agendas are notes. Just let go and sleep. Pineolon is in my Neuro future stack. Semax and Selank are doing me wonders right now.
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I’ve run Tesa for 16 weeks while I was waiting for my HGH test results. It did start to make my hands numb after week 10. I was running 4mgs every morning at 5am the last 6 weeks. Definitely less water retention than 3mg of GH daily.
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I’ve run Tesa for 16 weeks while I was waiting for my HGH test results. It did start to make my hands numb after week 10. I was running 4mgs every morning at 5am the last 6 weeks. Definitely less water retention than 3mg of GH daily.
@jimmy4407th Dial tesa down and be patient. The stuff is is strong even at 1mg. Well for me it is. Water retention, inflammation, tingling... That's you body telling you to chill.
Your body has your best interest. It is constantly keeping you alive regardless what you do to it. Be patient and listen to it. -
@jimmy4407th Dial tesa down and be patient. The stuff is is strong even at 1mg. Well for me it is. Water retention, inflammation, tingling... That's you body telling you to chill.
Your body has your best interest. It is constantly keeping you alive regardless what you do to it. Be patient and listen to it.@jimmy4407th Dial tesa down and be patient. The stuff is is strong even at 1mg. Well for me it is. Water retention, inflammation, tingling... That's you body telling you to chill.
Your body has your best interest. It is constantly keeping you alive regardless what you do to it. Be patient and listen to it.Similar experiences. 1mg is plenty if your pituitary is functional. Especially if you're running Ipamorelin (which you should be) alongside it.
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@jimmy4407th Dial tesa down and be patient. The stuff is is strong even at 1mg. Well for me it is. Water retention, inflammation, tingling... That's you body telling you to chill.
Your body has your best interest. It is constantly keeping you alive regardless what you do to it. Be patient and listen to it.Similar experiences. 1mg is plenty if your pituitary is functional. Especially if you're running Ipamorelin (which you should be) alongside it.
@Neil-McCauley The reason I am even doing Tesa is because I have a kit with one vial reconstituted. It was from a CJC+Ipa no dac and tesa stack I was going to run. I had the local histamine reaction from CJC+Ipa that I couldn't tolerate for a daily dose. I kept my tesa and here I am. There has been good results from a Reta/tesa stack. I'm been running Reta for a while and now running Tesa.
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