SS-31 Dosage for Researching
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P PeptideCritic moved this topic from Healing & Recovery on
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I've now switched over to adding 0.6 ml to a 30 mg vial of SS-31 for a 50mg/ml concentration. At that concentration:
20 units = 10 mg
I injected 20 units last night and did not experience any ISR at all. For those (like me) who get nervous about high concentrations... thought you'd like to know.
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Any thoughts on the recent study: Gudiksen et al., Free Radical Biology and Medicine (2026) that talks about potentially running SS31 and Mots-c together instead of Ss31 first and then Motsc? Josh Holyfield posted a video about it that was interesting on YouTube. https://m.youtube.com/watch?v=Arx8CD6TA0Y&pp=ygU5R3VkaWtzZW4gZXQgYWwuLCBGcmVlIFJhZGljYWwgQmlvbG9neSBhbmQgTWVkaWNpbmUgKDIwMjYp
Just curious how your mice prefer to run both? Together or staggered?
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Any thoughts on the recent study: Gudiksen et al., Free Radical Biology and Medicine (2026) that talks about potentially running SS31 and Mots-c together instead of Ss31 first and then Motsc? Josh Holyfield posted a video about it that was interesting on YouTube. https://m.youtube.com/watch?v=Arx8CD6TA0Y&pp=ygU5R3VkaWtzZW4gZXQgYWwuLCBGcmVlIFJhZGljYWwgQmlvbG9neSBhbmQgTWVkaWNpbmUgKDIwMjYp
Just curious how your mice prefer to run both? Together or staggered?
@MacLeeezy said in SS-31 Dosage for Researching:
Any thoughts on the recent study: Gudiksen et al., Free Radical Biology and Medicine (2026) that talks about potentially running SS31 and Mots-c together instead of Ss31 first and then Motsc?
Just curious how your mice prefer to run both? Together or staggered?
I have only ever considered running both at the same time. Complimentary in every way. No such thing as "repair" then "grow" in my point of view, silly concept.
My stack: SS-31/NAD+/MOTS/5-AMINO to start, titrated up in frequency/dose, then when I completed and discontinued the SS-31 50mg per day for 60 days, added O-304/SLU/BAM-15 to the others. LOVE IT. Keep in mind, I am very well optimized in general, so working on the top of the pyramid. Not the stack for everybody depending upon individual sensitivities.
Freebie- if you are serious about optimizing mitochondria, you darn well better be incorporating the very best EPA/DHA/DPA sources, specifically fish eggs, preferably sturgeon (suggest the reader research it as I did). The fatty acids are taken up into the all your cell membranes over time. It's freaking crazy stuff, search it and learn it. No one ever talks about this...except me. A "superpower" addition to a serious and effective mitochondrial stack. You're welcome
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@peptideed do you have a preferred source of sturgeon eggs?
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@peptideed do you have a preferred source of sturgeon eggs?
@PeptideEd said in SS-31 Dosage for Researching:
@peptideed do you have a preferred source of sturgeon eggs?
Yeah...you have to let your wallet be your guide on this one
In nutritional ranked order (seriously, big differences):Sturgeon- I look for 1kg tins which is where best value per gm/oz is found and last me 1.5-2 weeks per tin in spite of the suggestion they be used in days. I keep the tin(s) in a vacuum bag except when serving. Look for discounts which is what I do. I personally like Bester, but others are good and can be found on Amazon.
Paddlefish is an alternative but releases oil in the tin and flavor/texture not as nice, price is approx -50% vs sturgeon.
Salmon roe is even lower cost per gm/oz but definitely an acquired taste, buy the wild ones shipped frozen!
Trout/flying fish roe is wholly inferior nutritional quality, I would not use.
Repair...Optimize (roe)...Uncouple. My big picture protocol.
This approach I'm sure sounds batshit crazy to some, but serious researchers will understand.
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@MacLeeezy said in SS-31 Dosage for Researching:
Any thoughts on the recent study: Gudiksen et al., Free Radical Biology and Medicine (2026) that talks about potentially running SS31 and Mots-c together instead of Ss31 first and then Motsc?
Just curious how your mice prefer to run both? Together or staggered?
I have only ever considered running both at the same time. Complimentary in every way. No such thing as "repair" then "grow" in my point of view, silly concept.
My stack: SS-31/NAD+/MOTS/5-AMINO to start, titrated up in frequency/dose, then when I completed and discontinued the SS-31 50mg per day for 60 days, added O-304/SLU/BAM-15 to the others. LOVE IT. Keep in mind, I am very well optimized in general, so working on the top of the pyramid. Not the stack for everybody depending upon individual sensitivities.
Freebie- if you are serious about optimizing mitochondria, you darn well better be incorporating the very best EPA/DHA/DPA sources, specifically fish eggs, preferably sturgeon (suggest the reader research it as I did). The fatty acids are taken up into the all your cell membranes over time. It's freaking crazy stuff, search it and learn it. No one ever talks about this...except me. A "superpower" addition to a serious and effective mitochondrial stack. You're welcome
@PeptidePete right on. I appreciate the feedback. Time to do my sturgeon homework!
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@peptidepete Shopping at Bester... is there any particular variety they sell you'd recommend?
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@peptidepete Shopping at Bester... is there any particular variety they sell you'd recommend?
@PeptideEd said in SS-31 Dosage for Researching:
@peptidepete Shopping at Bester... is there any particular variety they sell you'd recommend?
A couple steps up from "the bottom", as finances allow. Better flavor, texture, coloration, roe size, and not as much oil comes out and collects in the bottom of the tin (some may enjoy this or not care in exchange for better "value").
All the same nutrient benefits accrue regardless of species as long as it is sturgeon, just becomes a matter of sensory appreciation.
Mitochondrial optimization is so multi-faceted, it is a lot of fun to explore and research. A shit-load more to it than just "running 2mg SS-31 every few days"...haha
I am going in for labs (again) this Friday AM, and two weeks ago submitted my second quarterly TruDiagnostic blood sample for methylation and telomere testing and all the other stuff they do. BTW I have been very hard-core carnivore for 2 3/4 years now. -
@PeptideEd said in SS-31 Dosage for Researching:
@peptidepete Shopping at Bester... is there any particular variety they sell you'd recommend?
A couple steps up from "the bottom", as finances allow. Better flavor, texture, coloration, roe size, and not as much oil comes out and collects in the bottom of the tin (some may enjoy this or not care in exchange for better "value").
All the same nutrient benefits accrue regardless of species as long as it is sturgeon, just becomes a matter of sensory appreciation.
Mitochondrial optimization is so multi-faceted, it is a lot of fun to explore and research. A shit-load more to it than just "running 2mg SS-31 every few days"...haha
I am going in for labs (again) this Friday AM, and two weeks ago submitted my second quarterly TruDiagnostic blood sample for methylation and telomere testing and all the other stuff they do. BTW I have been very hard-core carnivore for 2 3/4 years now.@PeptidePete Did your results come in on that testing? I'd love to hear the news.
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@peptidepete I love everything about you recommending caviar to supplement my peptide research. I think this year’s barbeque is going to feature a ‘metabolic enhancement’ table along with 8 different kinds of smoked meat.
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@PeptidePete Did your results come in on that testing? I'd love to hear the news.
@gym.rat said in SS-31 Dosage for Researching:
@PeptidePete Did your results come in on that testing? I'd love to hear the news.
All was as expected, essentially same/same with exception of telomere biological age where I went from 50.6->48.7 in the elapsed period of 3 months...lol (I am 65 years old). Was that attributable to my 10mg/20night course of Epithalon? Maybe. I take other stuff too...so...
Oh yeah- that is the TruDiagnostic stuff. My regular and customary labs which I do every 4-6 weeks are pristine.
Also as noted either here or somewhere, I live right, eat right (carnivore for nearly 3 years), resistance exercise (never cardio) and pin peps using aggressive protocols.
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@peptidepete I love everything about you recommending caviar to supplement my peptide research. I think this year’s barbeque is going to feature a ‘metabolic enhancement’ table along with 8 different kinds of smoked meat.
@ResearchCat said in SS-31 Dosage for Researching:
@peptidepete I love everything about you recommending caviar to supplement my peptide research. I think this year’s barbeque is going to feature a ‘metabolic enhancement’ table along with 8 different kinds of smoked meat.
There you go! PeptidePete approved!
I always shop the buy 2 get one free sturgeon egg sales. 1kg lasts me and the wife nearly 2 weeks. If finances allow it is a KEY piece of puzzle along with meats from multigastric animals and correct seafoods. It's all science and evolution backed. Just don't ever eat Monkfish liver (or ANY fish liver), FULL of PFAS, I found out the hard way...
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Update related to SS-31. Because sometimes my decisions are wrong I deployed an aggressive SS-31 course to fix a mistake. I started to research a course of Ostarine (SARM). Big fucking mistake, all sorts of bad reactions- cardiac, cognitive, energy, that shit is pure poison. I stopped it within 7 days and immediately began 40mg daily SS-31 to good end. I will continue the repair protocol for a total of 4 weeks.
SS-31 for the win. The stuff is pure gold. Find the high-mg per vial and low-cost per/mg to help with affordability. I shopped several sales to STOCK UP big time.
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I am going to start the SS-31 protocol from above phase 1 and 2 but probably skip 3 once my order arrives and testing clears. There is no mention in this thread about MOTS. I have done several cycles in the past of MOTS at 5mg every other day for 6-8 weeks. Can I incorporate that same cycle of MOTS along with the SS-31 phase 1 and 2 protocol from above simultaneously?
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I am going to start the SS-31 protocol from above phase 1 and 2 but probably skip 3 once my order arrives and testing clears. There is no mention in this thread about MOTS. I have done several cycles in the past of MOTS at 5mg every other day for 6-8 weeks. Can I incorporate that same cycle of MOTS along with the SS-31 phase 1 and 2 protocol from above simultaneously?
@Shaqdiesel said:
I am going to start the SS-31 protocol from above phase 1 and 2 but probably skip 3 once my order arrives and testing clears. There is no mention in this thread about MOTS. I have done several cycles in the past of MOTS at 5mg every other day for 6-8 weeks. Can I incorporate that same cycle of MOTS along with the SS-31 phase 1 and 2 protocol from above simultaneously?
MOTS is part of my "forever" pins, I personally would never cycle it. Totally different mechanisms of action and benefits from SS-31, so it stands separately and on its own. As a user of GH, I want the added insulin sensitivity and glucose metabolism boost, which has nothing to do with SS-31
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@PeptidePete
I wouldn't disagree with that at all. I do the Tes/Ipa, not straight gh. I also like thew MOTS during that cycle for the added insulin sensitivity. However, the cost factor plays into things so I don't do it as a forever. So running the MOTS alongside the SS-31 isn't prohibitive and potentially even synergistic? I should be starting a Epitalon/Pinealon cycle even sooner. I am excited about the Pinealon potential. I have done Epitalon solo in the past and can't say much for what it did for me. -
@peptidepete I second that. I am not researching currently, but MOTS-C has earned its spot on the short list of things on the permanent roster.
I got an injury recently and have been doubling up on KLOW. I am starting to think ‘maintenance’ dose might be way below where it should be.
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@PeptidePete
I wouldn't disagree with that at all. I do the Tes/Ipa, not straight gh. I also like thew MOTS during that cycle for the added insulin sensitivity. However, the cost factor plays into things so I don't do it as a forever. So running the MOTS alongside the SS-31 isn't prohibitive and potentially even synergistic? I should be starting a Epitalon/Pinealon cycle even sooner. I am excited about the Pinealon potential. I have done Epitalon solo in the past and can't say much for what it did for me.@Shaqdiesel All the new research coming out is exactly that, take SS-31 and Mots-C together.
The previous thought was SS-31 first, but that is wrong.
My question since I seem to be sensitive to certain peptides....does SS-31 sting or leave a welt? I have some, just haven't started yet. The stories about Mots-C scare me. Not sure I want to go there b/c I'm likely the one who will get all the side effects.
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