Klotho / FLGR242 (albumin-bound new tech)
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Josh doesn't know jack about this one. If he tries it for 4 months and then says it doesn't work it will confirm he's a buffoon. If he actually did a trial most likely he'd have to make another video with 'I was wrong' in the title. I sense this might be up your alley though!
Josh doesn't know jack about this one. If he tries it for 4 months and then says it doesn't work it will confirm he's a buffoon. If he actually did a trial most likely he'd have to make another video with 'I was wrong' in the title. I sense this might be up your alley though!
That video tells me everything I need to know...about the person who created the video. Zero credibility. A buffoon.
On a side note, for research purposes, I am shifting to 2.5mg FLGR once per week starting tomorrow (2.5mg every Monday). Just completing a wash-out week to set up for the change. My wife will remain on 2.5mg per week, so we just split a vial per week.
If. IF, FLGR242 response curves parallel the Bimagrumab results, a good possibility but not yet known as fact, then half a year gives me the vast majority of the benefits, and I can taper back until we have a year of more of continued lack of negative signals. In other words, play cautious simply for the sake of doing so until BioLongevityLabs publishes results of currently ongoing human testing.
Last week I did another round of labs and for example my PSA remains unchanged at 0.5, so prostate is happy. Rest of labs look as expected with no surprises, in spite of being on a TRT++ protocol for three months + FLGR, so a worst case, or depending how you look at it, a best case (lol!) scenario.
I remain a researcher of Klotho at one vial per 13 days.
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Just an update. Yes, I realized that Paramount is the out facing vendor for Alpha BioMed, which erroneously publishes that alpha-Klotho LR (MAB) is a monoclonal antibody, which it is not! I just messaged Mike Farber on LinkedIn, and he responded within minutes.
I am now researching both FLGR-242 (5mg) and a-Klotho LR (10 mcg). I purchased from BLL. Both with discounts came to about $174.57/vial.
Chronological age: 66.3-yrs-old. TruAge OMICmAge = 60.8. Symphony Age 62.3. Telomere Biological Age 69.1.
I have since done two rounds of Epithalon + Thymalin. I also take TA65 Rx 500 QD. Pinning Testosterone Cypionate 20U (40 mg) sub-Q every other day--just switched from IM twice a week.
One round of Senolytic FOXO4-DRI.
Cycling Tesa/Ipa - 2mg/200mcg 5d on/2d off.
Started alpha-Klotho 10 mcg Q 2 weeks.
Started FLGR-242 initially at 5mg Q wk, but decided to do 2.5 mg twice a week.
Exercising 5x/week - mostly resistance exercises, but will resume using Peloton.
Regularly checking Biomarkers and DEXA scans. Have done GutID and SelfDecode methylation tests.
I just wanted to share baselines so I can report on changes to biomarkers, body composition, etc.
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Just an update. Yes, I realized that Paramount is the out facing vendor for Alpha BioMed, which erroneously publishes that alpha-Klotho LR (MAB) is a monoclonal antibody, which it is not! I just messaged Mike Farber on LinkedIn, and he responded within minutes.
I am now researching both FLGR-242 (5mg) and a-Klotho LR (10 mcg). I purchased from BLL. Both with discounts came to about $174.57/vial.
Chronological age: 66.3-yrs-old. TruAge OMICmAge = 60.8. Symphony Age 62.3. Telomere Biological Age 69.1.
I have since done two rounds of Epithalon + Thymalin. I also take TA65 Rx 500 QD. Pinning Testosterone Cypionate 20U (40 mg) sub-Q every other day--just switched from IM twice a week.
One round of Senolytic FOXO4-DRI.
Cycling Tesa/Ipa - 2mg/200mcg 5d on/2d off.
Started alpha-Klotho 10 mcg Q 2 weeks.
Started FLGR-242 initially at 5mg Q wk, but decided to do 2.5 mg twice a week.
Exercising 5x/week - mostly resistance exercises, but will resume using Peloton.
Regularly checking Biomarkers and DEXA scans. Have done GutID and SelfDecode methylation tests.
I just wanted to share baselines so I can report on changes to biomarkers, body composition, etc.
@ImaFrogNotaRat hey brother.
Just an opinion.
At your age I would do GH instead of the secretagogues
Maybe 2iu would suffice.
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Also check your Total, and Free test like in 2-3 weeks, dont wait months.
Sometimes Test SQ doesn’t absorb well.
@diegoc Thank you for the advice. My goal with the Tesa/Ipa is to reduce visceral fat (3.5 lbs VAT) and reduce inflammatory causes of atherosclerotic CVD. My reluctance to use the GH is my controlled Type 2 Diabetes. I don't want any acute insulin resistance. Are you implying that the GH would be better from an anabolic perspective?
I'm afraid of messing with the HPA axis.
As for the sub-Q testosterone, that's a good point. Presumably that has to get absorbed somewhere. I could always pin my anterior/lateral thigh. I believe even the 1/2" needle would hit the muscle.
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The GH is more of a longevity protocol, but the secretogoges do work well however mainly for younger age ppl. Just check your IGF levels to not be throwing money away.
I really dont know how it would work with Diabetes, so you might need to check on that.
If your doing a 1/2” in the ventral glute then your doing a shallow IM, thats were i shoot my test and its the best
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Josh doesn't know jack about this one. If he tries it for 4 months and then says it doesn't work it will confirm he's a buffoon. If he actually did a trial most likely he'd have to make another video with 'I was wrong' in the title. I sense this might be up your alley though!
That video tells me everything I need to know...about the person who created the video. Zero credibility. A buffoon.
On a side note, for research purposes, I am shifting to 2.5mg FLGR once per week starting tomorrow (2.5mg every Monday). Just completing a wash-out week to set up for the change. My wife will remain on 2.5mg per week, so we just split a vial per week.
If. IF, FLGR242 response curves parallel the Bimagrumab results, a good possibility but not yet known as fact, then half a year gives me the vast majority of the benefits, and I can taper back until we have a year of more of continued lack of negative signals. In other words, play cautious simply for the sake of doing so until BioLongevityLabs publishes results of currently ongoing human testing.
Last week I did another round of labs and for example my PSA remains unchanged at 0.5, so prostate is happy. Rest of labs look as expected with no surprises, in spite of being on a TRT++ protocol for three months + FLGR, so a worst case, or depending how you look at it, a best case (lol!) scenario.
I remain a researcher of Klotho at one vial per 13 days.
@PeptidePete I agree, Josh doesn't know Jack about a lot of stuff and he recently just self crowned himself as the biggest channel for peptides.
He did a video of 5 amino and he isn't even aware of the difference in bioavailability between oral and subQ. His math said you needed 50 mg of 5 amino based on the rat studies, he then went on to say that the dose required for both Sub Q and oral was the same 50mg and recomended oral becasue the tsablets come in 50 mgs and its cheaper. I actually LOL'd when I watched it.
He also did a GH peptide video where he messed up in a claim about receptor desensitization and I left a comment in his video with a link to the evidence politely but he just deleted my comment within minutes.
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I mean 2 vials is a whole ass cycle if i remember correctly from gc and jays talk.. So if i saw it for like 120 a vial id probably bite. Till then. Ill leave it to you rich old farts lol
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Well fuck -
It's down to 100 a vial with the current discount and JayC coupon buying the 6 pack. Didn't realize 2 vials is a whole cycle. Maybe I will just do that then.
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Weird. Must have misheard
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@quicksilver80 Hi quick! So I would say that it helped weight loss- leaned me out in a way that was different from just losing fat. Before starting FLGR I had lost 20lbs with Reta at a dose of 0.5mg every 6 days. Probably never even benefitted from the glucagon effect with that low dose! But being a hyper-responder has its benefits? When visible changes stalled and the scale wouldn't budge I began to consider Reta might be holding me back from some of the follistatin benefits- you need calories to build muscle. It was time to cycle off reta anyway. The last 5 weeks I've added 4ish lbs which appears to be essentially all muscle. Can't prove it yet as next Dexa isn't until the fall.
You are correct about the supply chain/ gatekeeping. As I can tell you already know, Follistatin has been known and tried for decades. My understanding is that the patent is on the albumin binder, which extends the half-life to something like 2 weeks, not the follistatin itself. Hence unlikely to be found in the wild for a while. Rejoice in economies of scale though- down $300 for a months supply on BioLongevity Labs due to more efficient production! Hope that helps.@quicksilver80 Hi quick! So I would say that it helped weight loss- leaned me out in a way that was different from just losing fat. Before starting FLGR I had lost 20lbs with Reta at a dose of 0.5mg every 6 days. Probably never even benefitted from the glucagon effect with that low dose! But being a hyper-responder has its benefits? When visible changes stalled and the scale wouldn't budge I began to consider Reta might be holding me back from some of the follistatin benefits- you need calories to build muscle. It was time to cycle off reta anyway. The last 5 weeks I've added 4ish lbs which appears to be essentially all muscle. Can't prove it yet as next Dexa isn't until the fall.
You are correct about the supply chain/ gatekeeping. As I can tell you already know, Follistatin has been known and tried for decades. My understanding is that the patent is on the albumin binder, which extends the half-life to something like 2 weeks, not the follistatin itself. Hence unlikely to be found in the wild for a while. Rejoice in economies of scale though- down $300 for a months supply on BioLongevity Labs due to more efficient production! Hope that helps.Stones67 what dosing/timing did you start at and what are you doing now?
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Ordered 12 vials and will do a 6 month period on FLGR242. Will follow the protocol Stones67 posted above. Here are my starting stats. Just had Dexa and labs done again last week. Will get them again after 12 weeks of FLGR242 and resistance training and again at the end of 24 weeks
Male 44
Weight 165.2lbs (Weighed 162 that morning on my own scale without clothing and 159lbs today)
Body Fat: 18.8%
Body Fat: 31 lbs
Lean Mass: 127.1 lbs
Visceral Fat: 0.60 lbsTestosterone: 513
Testosterone Free (Dialysis) 73.6
T4 Free: 1.3
T3 Free: 2.9
IGF 1: 193
Z Score: 0.7
SHBG: 41Currently no resistance training, but a lot of running with a weighted vest. Will cut down on running and focus mainly resistance training on my Tonal as I feel like I look just soft and skinny fat. Would like to do a body recomposition. Will probably get back on a cycle of Tesa/Ipa during the 6 months on FLGR242. In the middle of an 8 week cycle of SS-31/Mots-c/NAD+/5Amino-1mq.
Any advice from PeptidePete, Stones67 or Diegoc on anything you would recommend I do differently I would appreciate it. Will keep you all updated. PeptidePete and Stones67 sold me on trying FLGR242 after reading about their results.
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Ordered 12 vials and will do a 6 month period on FLGR242. Will follow the protocol Stones67 posted above. Here are my starting stats. Just had Dexa and labs done again last week. Will get them again after 12 weeks of FLGR242 and resistance training and again at the end of 24 weeks
Male 44
Weight 165.2lbs (Weighed 162 that morning on my own scale without clothing and 159lbs today)
Body Fat: 18.8%
Body Fat: 31 lbs
Lean Mass: 127.1 lbs
Visceral Fat: 0.60 lbsTestosterone: 513
Testosterone Free (Dialysis) 73.6
T4 Free: 1.3
T3 Free: 2.9
IGF 1: 193
Z Score: 0.7
SHBG: 41Currently no resistance training, but a lot of running with a weighted vest. Will cut down on running and focus mainly resistance training on my Tonal as I feel like I look just soft and skinny fat. Would like to do a body recomposition. Will probably get back on a cycle of Tesa/Ipa during the 6 months on FLGR242. In the middle of an 8 week cycle of SS-31/Mots-c/NAD+/5Amino-1mq.
Any advice from PeptidePete, Stones67 or Diegoc on anything you would recommend I do differently I would appreciate it. Will keep you all updated. PeptidePete and Stones67 sold me on trying FLGR242 after reading about their results.
@denti I know this is off the topic here so maybe a DM but can you tell me the specifics for your 8-week protocol for SS-31/Mots-c/NAD+/5Amino-1mq? How much, when, frequency for each? Results so far?
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Ordered 12 vials and will do a 6 month period on FLGR242. Will follow the protocol Stones67 posted above. Here are my starting stats. Just had Dexa and labs done again last week. Will get them again after 12 weeks of FLGR242 and resistance training and again at the end of 24 weeks
Male 44
Weight 165.2lbs (Weighed 162 that morning on my own scale without clothing and 159lbs today)
Body Fat: 18.8%
Body Fat: 31 lbs
Lean Mass: 127.1 lbs
Visceral Fat: 0.60 lbsTestosterone: 513
Testosterone Free (Dialysis) 73.6
T4 Free: 1.3
T3 Free: 2.9
IGF 1: 193
Z Score: 0.7
SHBG: 41Currently no resistance training, but a lot of running with a weighted vest. Will cut down on running and focus mainly resistance training on my Tonal as I feel like I look just soft and skinny fat. Would like to do a body recomposition. Will probably get back on a cycle of Tesa/Ipa during the 6 months on FLGR242. In the middle of an 8 week cycle of SS-31/Mots-c/NAD+/5Amino-1mq.
Any advice from PeptidePete, Stones67 or Diegoc on anything you would recommend I do differently I would appreciate it. Will keep you all updated. PeptidePete and Stones67 sold me on trying FLGR242 after reading about their results.
@denti
Grade-A. Well thought out analysis and plan. Your labs look good. Ideally a bit more T would be nice but as you trim away some more BF you may. see a bump. Awesome you just had a Dexa. I started FLGR about 2 months after my first Dexa so my second testing results were after 4 months of using. Wish I would have timed this better but such is life. Currently I'm 'blasting' at 5mg weekly (1mg daily Tues-Sat) which BLL considers 'advanced' use. There is no scientific reason for this dosing strategy and I can't dispute those who say weekly or twice a week dosing is the way to go. In roughly 2 months I plan on a break and am currently trying to decide what, if anything, to substitute with (ex. IGF1-LR3 + PEG MGF for 6 weeks- thoughts Pete, Diego, and Co?). Others will chime in I'm sure but I would emphasize Tonal 3-5 times a week (flgr is a muscle building compound after all) and increase protein to 1.5-1.8 gm lean body mass daily. Welcome to the club lab rat! -
I wonder if anybody has formed an opinion on their alphaKlothoLR individually. I learned about Klotho protein and Klotho peptides, that it's considered having a promising rejuvenating effect on many body systems, and might try it. This one is bound to albumin and should stay in the system over 2-week period. Does anybody have an experience using it, especially without FLGR242? I am not sure if I even need Follistatin, but Klotho is interesting.
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@stones67 Yep, the deeper I get into this area, the more it is underscored that you need the foundation to be solid. If you are not exercising, and specifically lifting heavy things, your results will be limited. Same with getting protein, getting your T levels and labs right, etc.
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