Peptides that work with nasal sprays
-
Following up on today’s excellent video, I was wondering if you can provide a list of peptides that are compatible and effective with nasal sprays. Obviously Semax. I have heard oxytocin. What else works as a spray?
-
Any particular reason as have you tested?
I was just about to whip up VIP and PT141 for shits and giggles
@diegoc said in Peptides that work with nasal sprays:
Any particular reason as have you tested?
I was just about to whip up VIP and PT141 for shits and giggles
did you figure it out? I'm looking to recon VIP as a spray. There is some info/evidence around it being administered nasally. https://pubmed.ncbi.nlm.nih.gov/23444784/
https://pmc.ncbi.nlm.nih.gov/articles/PMC3738270/Couldn't find much for subQ
-
P PeptideCritic moved this topic from Injection Pens & Devices on
-
Technically anything with a Dalton weight under 500 will work.
Glutathione works because its 307.32 daltons@MyB said in Peptides that work with nasal sprays:
Technically anything with a Dalton weight under 500 will work.
Glutathione works because its 307.32 daltonsThis is what I was looking for! Glad to see it can be nasal, going to give it a try. I wanted to try this route since Liposomal didn't really get anything from it. Don't really want to try the SubQ, GHK sting is bad enough
Do you have a recipe you use?
-
@wisgal64 recipe for glutathione intranasal? I use 2ml bac water and 5ml of sterile .9% saline that’s intended for a nebulizer. Adding the bac water helps with absorption because I’ve made it with just saline and it didn’t have the same effect. It will have a sulfur smell. Not overwhelming.
Here’s a research article if you’d like to dive deeper into intranasal administration.
https://wjbphs.com/sites/default/files/fulltext_pdf/WJBPHS-2025-0913.pdfFollows research backed science, not the gym bro’s.
-
@wisgal64 recipe for glutathione intranasal? I use 2ml bac water and 5ml of sterile .9% saline that’s intended for a nebulizer. Adding the bac water helps with absorption because I’ve made it with just saline and it didn’t have the same effect. It will have a sulfur smell. Not overwhelming.
Here’s a research article if you’d like to dive deeper into intranasal administration.
https://wjbphs.com/sites/default/files/fulltext_pdf/WJBPHS-2025-0913.pdf@MyB said in Peptides that work with nasal sprays:
@wisgal64 recipe for glutathione intranasal? I use 2ml bac water and 5ml of sterile .9% saline that’s intended for a nebulizer. Adding the bac water helps with absorption because I’ve made it with just saline and it didn’t have the same effect. It will have a sulfur smell. Not overwhelming.
Here’s a research article if you’d like to dive deeper into intranasal administration.
https://wjbphs.com/sites/default/files/fulltext_pdf/WJBPHS-2025-0913.pdfThank you! I'll check it out
-
Technically anything with a Dalton weight under 500 will work.
Glutathione works because its 307.32 daltons@MyB said in Peptides that work with nasal sprays:
Technically anything with a Dalton weight under 500 will work.
THIS! Yes it has to do with the Dalton molecular weight of the peptide for it to be absorbable via nasal route.
-
I've just been told I should make VIP into a nasal spray for my chronic sinus issues (have to use nasal spray at night or my sinuses plug shut, steroids don't help). I don't have a clue how to do that. Didn't even know what VIP was. Are there directions for dummies somewhere?
-
Technically anything with a Dalton weight under 500 will work.
Glutathione works because its 307.32 daltonsTechnically anything with a Dalton weight under 500 will work.
The 500 Da limit is about crossing from the bloodstream into the brain (the Blood-Brain Barrier, or BBB).
1,000+ Da is still possible when we are talking about crossing from the nasal cavity into the brain/body (the nasal mucosa and the nose-to-brain pathway).
that's why things like MT2 which is over 1000 Da still work.
when you say "only up to 500 Da," you are thinking of injected peptides trying to cross the BBB.
peptides >1,000 Da still work intranasally, we are talking about sprayed peptides using the nose-to-brain pathway.
-
@MyB be more specific with your question.
you can just look up the Molecular Weight (Da) of any peptide online yourself.
Peptide Approx. Molecular Weight (Da)
examples:Glutathione ~307
Noopept ~251
KPV ~400
Pinealon ~404
Epithalon ~488
Semax ~751
Selank ~752
TB-500 (fragment) ~889
GHK-CU ~909
AHK-CU ~900-950
PE-22-28 ~900 (estimated)
DSIP ~1,000 (borderline)Just to be clear: peptides that are >1000 Daltons can still be made to work in spray form like Melanotan II ~1,024 (Da) but they need permeation enhancers to be effective.
you can't just use BAC water on any peptide mix it up and spray expecting results.
the closer you get to 1000 the less effective they will be.
Pinealon, Epithalon, Semax and Selank are widely "researched" intranasally because of their low molecular weight. -
@bpc-157 I use the KISS (keep it simple stupid). When I say 500 daltons it’s because that’s the MW that can pass through skin for absorption. When I say 300 daltons it’s because it can pass to the bloodstream.
You saying 1K dalton works but failing to mention a transporter is required is setting new researchers up for failure.
When I ask for receipts on your citations I was expecting something like this. Which explains absorption pathways, molecular weights, types of transporters, and how lipo, hydro, and charge matter.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6254717/
Hello! It looks like you're interested in this conversation, but you don't have an account yet.
Getting fed up of having to scroll through the same posts each visit? When you register for an account, you'll always come back to exactly where you were before, and choose to be notified of new replies (either via email, or push notification). You'll also be able to save bookmarks and upvote posts to show your appreciation to other community members.
With your input, this post could be even better 💗
Register Login