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Peptide Critic Community

Peptide Critic Community

  1. Randy the Rats Research Forum
  2. Supplies, Mixing & Storage
  3. Peptides that work with nasal sprays
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Peptides that work with nasal sprays

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  • MyBM MyB

    @bpc-157 post your medical/scientific sources.

    B Offline
    B Offline
    BPC-157
    wrote last edited by BPC-157
    #21

    @MyB be more specific with your question.

    you can just look up the Molecular Weight (Da) of any peptide online yourself.

    Peptide Approx. Molecular Weight (Da)
    examples:

    Glutathione ~307
    Noopept ~251
    KPV ~400
    Pinealon ~404
    Epithalon ~488
    Semax ~751
    Selank ~752
    TB-500 (fragment) ~889
    GHK-CU ~909
    AHK-CU ~900-950
    PE-22-28 ~900 (estimated)
    DSIP ~1,000 (borderline)

    Just to be clear: peptides that are >1000 Daltons can still be made to work in spray form like Melanotan II ~1,024 (Da) but they need permeation enhancers to be effective.

    you can't just use BAC water on any peptide mix it up and spray expecting results.

    the closer you get to 1000 the less effective they will be.
    Pinealon, Epithalon, Semax and Selank are widely "researched" intranasally because of their low molecular weight.

    B 1 Reply Last reply
    0
    • MyBM Offline
      MyBM Offline
      MyB
      wrote last edited by
      #22

      @bpc-157 I use the KISS (keep it simple stupid). When I say 500 daltons it’s because that’s the MW that can pass through skin for absorption. When I say 300 daltons it’s because it can pass to the bloodstream.
      You saying 1K dalton works but failing to mention a transporter is required is setting new researchers up for failure.
      When I ask for receipts on your citations I was expecting something like this. Which explains absorption pathways, molecular weights, types of transporters, and how lipo, hydro, and charge matter.
      https://pmc.ncbi.nlm.nih.gov/articles/PMC6254717/

      Peptides are only as good as your Bac Water

      1 Reply Last reply
      1
      • B BPC-157

        @MyB be more specific with your question.

        you can just look up the Molecular Weight (Da) of any peptide online yourself.

        Peptide Approx. Molecular Weight (Da)
        examples:

        Glutathione ~307
        Noopept ~251
        KPV ~400
        Pinealon ~404
        Epithalon ~488
        Semax ~751
        Selank ~752
        TB-500 (fragment) ~889
        GHK-CU ~909
        AHK-CU ~900-950
        PE-22-28 ~900 (estimated)
        DSIP ~1,000 (borderline)

        Just to be clear: peptides that are >1000 Daltons can still be made to work in spray form like Melanotan II ~1,024 (Da) but they need permeation enhancers to be effective.

        you can't just use BAC water on any peptide mix it up and spray expecting results.

        the closer you get to 1000 the less effective they will be.
        Pinealon, Epithalon, Semax and Selank are widely "researched" intranasally because of their low molecular weight.

        B Online
        B Online
        BeeKind
        wrote last edited by
        #23

        @BPC-157 oxytocin is over 1000k - that would explain why I have had zero reaction to it in nasal spray form.

        Just someone with a fridge full of research and a browser history that would concern my doctor.

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        • S Offline
          S Offline
          stevencarter
          wrote last edited by
          #24

          I was about to make oxytocin spray because I thought everyone was saying it worked Intranasally. Now @bpc-157 says it dont work. I tried it subq before I knew the difference in systemic effects going subq. 150mcg shot in the belly of my chupacabra gave him a headache like professor x in the one movie where they had the battle of the wheelchair minds with that homeless looking kid. Anyways oxytocin intranasally is a go or no go?

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          • D Offline
            D Offline
            diegoc
            wrote last edited by
            #25

            Honestly i didnt feel much, not even mixed with PT141

            I keep going back to SUBq on everything including semax but i whip up a nasal of semax and when im doing the protocol I inject subq in the morning and nasal in the afternoon.

            Im doing Melatonan1 subq and 5m in i start getting nausea, you see i dont see instant gratification with nasal

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