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Peptide Critic Community

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  1. Randy the Rats Research Forum
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  3. MOTS-C: Dosing & Blood Pressure Meds
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MOTS-C: Dosing & Blood Pressure Meds

Scheduled Pinned Locked Moved Peptide Discussion
mots-cdosage-discussionother-peptide
35 Posts 6 Posters 4.6k Views 1 Watching
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  • E Online
    E Online
    Eleanor
    wrote on last edited by
    #1

    Looking for some deals on MOTS-C for early Fall use (after I finish current protocols) but have some questions that you fine, experienced folks might be able to answer.

    Using link below:
    https://peptideinitiative.com/peptides/mots-c

    It states a possible effect on blood pressure. Does anyone know if this is a lowering of BP or rise in BP? I have high BP.

    Do those who have a plethora of experience with this recommend the starting dose stated?

    Does it sting? I like extra BAC for stingers.

    Thank you for your kind attention while busy hunting bargains.

    Proud to be on a gubmint watch list

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    • EXTROPIANE Offline
      EXTROPIANE Offline
      EXTROPIAN
      wrote on last edited by EXTROPIAN
      #2

      Not sure on the degree of your blood pressure. Notnsure if youre on Ace inhibitors, beta blockers... If youre committing to optimize mitochondria? I would try Co-Q10 and Methylene Blue first. Still considering your blood pressure. You need to lower your inflation first. Foundation first and then you can consider researching with peptides on your own.

      "The truth about hypertension" Dr Trevor Backmeyer

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      • EXTROPIANE EXTROPIAN

        Not sure on the degree of your blood pressure. Notnsure if youre on Ace inhibitors, beta blockers... If youre committing to optimize mitochondria? I would try Co-Q10 and Methylene Blue first. Still considering your blood pressure. You need to lower your inflation first. Foundation first and then you can consider researching with peptides on your own.

        "The truth about hypertension" Dr Trevor Backmeyer

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        Eleanor
        wrote on last edited by
        #3

        @martinmarin said:

        Not sure on the degree of your blood pressure. Notnsure if youre on Ace inhibitors, beta blockers... If youre committing to optimize mitochondria? I would try Co-Q10 and Methylene Blue first. Still considering your blood pressure. You need to lower your inflation first. Foundation first and then you can consider researching with peptides on your own.

        Thank you for your reply. I think you mean my inflammation, which is well lowered. I'm researching SS-31 before MOTS-C. I really have no interest in Co-Q10 or MBlue. I have a personal program I'm trying to follow. Think I will go with 1/2 doses and monitor BP. Thanks much!

        Proud to be on a gubmint watch list

        EXTROPIANE 1 Reply Last reply
        1
        • FalcF Offline
          FalcF Offline
          Falc
          wrote on last edited by Falc
          #4

          I have been "diagnosed" with chronic hypertension, I am on week 9 of a 12-week cycle of MOTS-c daily at 1mg (M-F), and I have not noticed any increase of my baseline BP average since starting the MOTS-c. No sting at all for me, I usually pen it in the quad.

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          • FalcF Falc

            I have been "diagnosed" with chronic hypertension, I am on week 9 of a 12-week cycle of MOTS-c daily at 1mg (M-F), and I have not noticed any increase of my baseline BP average since starting the MOTS-c. No sting at all for me, I usually pen it in the quad.

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            Eleanor
            wrote on last edited by
            #5

            @Falc Thanks Falc, I appreciate the information.

            Proud to be on a gubmint watch list

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            • EXTROPIANE Offline
              EXTROPIANE Offline
              EXTROPIAN
              wrote on last edited by
              #6
              This post is deleted!
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              • Hammertime65H Offline
                Hammertime65H Offline
                Hammertime65
                wrote on last edited by
                #7

                I take Amlodipine, Chlorthalidone and dropped Lisinopril and spironolactone while running mots. My blood pressure has stayed the same. I've dropped 78 pounds so that helps also.

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                • Hammertime65H Hammertime65

                  I take Amlodipine, Chlorthalidone and dropped Lisinopril and spironolactone while running mots. My blood pressure has stayed the same. I've dropped 78 pounds so that helps also.

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                  Eleanor
                  wrote on last edited by
                  #8

                  @Hammertime65
                  Dropping the weight IMO helps more than anything; Dr's can rx overdose, one size fits all. I cut my BP rx's in half. Lisinopril was a real problem with a hacking cough that developed only one month after I started it; sounded like I was barking up a lung.

                  Proud to be on a gubmint watch list

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                    Eleanor
                    wrote on last edited by
                    #9

                    @gym.rat Thank you! I was actually looking for the link you have posted above. Less is always better as far as I'm concerned. If the starting dose is 1mg, it's 500mcg for me. Thank you very much!

                    Proud to be on a gubmint watch list

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                      Eleanor
                      wrote on last edited by
                      #10

                      @gym.rat Do you have a favored site where you like to buy BAC saline?

                      Proud to be on a gubmint watch list

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                        Eleanor
                        wrote on last edited by Eleanor
                        #11

                        Found it.
                        https://peptidetest.com/products/pfizer-hospira-bacteriostatic-sodium-chloride-for-injection-30-ml?_pos=1&_sid=321b006db&_ss=r
                        Looks like I probably need to wait until cooler weather to order this, per peptide test instructions that it might be more unstable that regular BAC.

                        Proud to be on a gubmint watch list

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                          Stevepep
                          wrote on last edited by
                          #12

                          @gym.rat super helpful I really want to try MotsC on a future cycle.

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                          • E Eleanor

                            @martinmarin said:

                            Not sure on the degree of your blood pressure. Notnsure if youre on Ace inhibitors, beta blockers... If youre committing to optimize mitochondria? I would try Co-Q10 and Methylene Blue first. Still considering your blood pressure. You need to lower your inflation first. Foundation first and then you can consider researching with peptides on your own.

                            Thank you for your reply. I think you mean my inflammation, which is well lowered. I'm researching SS-31 before MOTS-C. I really have no interest in Co-Q10 or MBlue. I have a personal program I'm trying to follow. Think I will go with 1/2 doses and monitor BP. Thanks much!

                            EXTROPIANE Offline
                            EXTROPIANE Offline
                            EXTROPIAN
                            wrote on last edited by EXTROPIAN
                            #13

                            @Eleanor Well if youre all in then MOTSC and NAD+ definitely to get the engines running. As soon as you get going in between the cycle throw in SS31. MOTSC signal what to do. NAD+ is the fuel to all mitochondria. SS31 repairs. A car analogy- You need a driver on board to to drive step on the pedal (MOTSC). You need the proper fuel (NAD+). Need a mechanic to repair and patch up the car and engine SS31. The engine cannot be repaired without a driver on low to no fuel? As far as I am concern there isn't anything left to move the needle but mitochondria. Give what you have of mitochondria to run the best they can. Then start repairing. All three do way more then what I described. When you get all three or along the way you will start Mitochondrial biogenesis (make more mitochondria). If you later wants to level up you can clears out dead mitochondria via a cellular process called mitochondria mitophagy by doing a MOTSC, NAD+ and Humanin. Personally I never done it but Humanin is in bucket list of peps. Man there are so many like FOXO4-p53, CRUNCH and of course NAD that clean up dead cells.

                            Here is a video of this guy who did a cleaning along the way. There are alot of jewels in there. All including Mitochondria optimizations and cleaning with peptides.

                            https://youtu.be/2SETwRnzvrw?is=Wmi5CvC4wPZoQ7Re

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                              Stevepep
                              wrote on last edited by
                              #14

                              @gym.rat What does of ss-31 the doses seem so high

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                                Eleanor
                                wrote on last edited by
                                #15

                                @gym.rat said:

                                @Eleanor Yes, I get all my Hospira BAC from peptidetest.com. Zero issues and good pricing. Been ordering from them for the last 12 months or so. In fact I just placed an order the other day b/c I'm about to do a cycle of SS-31 myself starting manana. Screenshot 2026-07-04 at 1.28.56 AM.png

                                Ok, well, it's 97 degrees here and up to 90% humidity. Most items delivered during height of heat and I don't get home until 6pm.

                                Proud to be on a gubmint watch list

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                                  Eleanor
                                  wrote on last edited by
                                  #16

                                  @gym.rat Understand and agree! I appreciate your help, I really do. I'm so tired; this is the first real time I've had off in 2 years. so...gotta do something. I plan to do SS31 & MOTSC separately.

                                  Proud to be on a gubmint watch list

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                                    Eleanor
                                    wrote on last edited by
                                    #17

                                    @gym.rat said:

                                    @Eleanor The product will be fine, just don't let it sit on your porch or in your mailbox unattended. I make sure I'm home the minute it arrives and off it goes to a room temp dark place.

                                    I can't be home, I'm at work and don't get home until 6pm.

                                    Proud to be on a gubmint watch list

                                    FalcF 1 Reply Last reply
                                    0
                                    • E Eleanor

                                      @gym.rat said:

                                      @Eleanor The product will be fine, just don't let it sit on your porch or in your mailbox unattended. I make sure I'm home the minute it arrives and off it goes to a room temp dark place.

                                      I can't be home, I'm at work and don't get home until 6pm.

                                      FalcF Offline
                                      FalcF Offline
                                      Falc
                                      wrote on last edited by
                                      #18

                                      @Eleanor Not sure about your area, but with UPS and FedEx both there is an option to have packages delivered to the local UPS/FedEx store. I have used it several times because I wasn't going to be at home when a package was delivered and is pretty convenient to stop by the store on the way home from work and pick it up.

                                      E 1 Reply Last reply
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                                      • FalcF Falc

                                        @Eleanor Not sure about your area, but with UPS and FedEx both there is an option to have packages delivered to the local UPS/FedEx store. I have used it several times because I wasn't going to be at home when a package was delivered and is pretty convenient to stop by the store on the way home from work and pick it up.

                                        E Online
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                                        Eleanor
                                        wrote on last edited by Eleanor
                                        #19

                                        @Falc Thanks Falc. Let me see who delivers peptidetest products. Great idea!

                                        Unfortunately, they use USPS and the PO I have near me I wouldn't have doggie biscuits delivered there.

                                        Proud to be on a gubmint watch list

                                        1 Reply Last reply
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                                        • vpeptidesV Offline
                                          vpeptidesV Offline
                                          vpeptides
                                          wrote on last edited by
                                          #20

                                          In context of mitochondrial stack, Humanin is worth mentioning too.

                                          attentiion is all you need

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