Dihexa Research Protocols and Efficacy
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Dihexa is an oral peptide used for mental acuity and clarity. It is focused on neuroregeration and neuroplasticity. It is 10,000,000x higher potency than BDNF, which may or may not mean anything to you.
I am curious who has researched this, and what you have found. There is very little out there about it. Randy and I have talked about it a bit offline, but other than that, I have not seen much. I would like to see more. Also note that very few vendors are selling it. I am told this is in part because it is hard to make proper capsules.
I have run two research runs this year. 1 was 12.5mg x 60 days, and the other was 7.5mg x 50 days. I cannot honestly say with certainty that is helped, though I do feel ‘smarter’, it might be due to all the other changes, peptides, lifestyle improvements, and not drinking or using, ahem, recreational substances. (Weed, okay, no weed! Though I might get contact highs at the train station.)
Post here if you have researched dihexa, what your results were, where you sourced it, etc.
@ResearchCat yes from swiss.. i used compounded semax and selank , dihexa you dont feel it lime the others its a slow process but i noticed i was able to recall things in memory better. Ex i can never remember actors names or movies.. after few weeks i was just able to recall it. If you seen nick norwitz utube on it says same thing.
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It there anyone who has done semax, selnak, adamax, celebrolyson and dihexa? I interested in the comparisons? I am interested on the onset comparisons.
@EXTROPIAN I have researched Semax, Selank, and Dihexa. I think dihexa is tough to qualify (qualitate?), describe because it takes effect over time. Semax definitely makes me more alert, but also prone to annoyance. I only recently started playing with semax - i bought a vial from a friend - and now I need to buy a kit.
I think semax is interesting because I have noticed I am more willing to engage socially and conversations and meetings flow better. This is very interesting to me as I generally loathe work meetings and large social gatherings and semax could be useful for this without, you know, being meth.
I do think that the dihexa has made me sharper mentally, but it is hard to provide specifics beyond a general statement like, ‘I feel like mentally difficult tasks are easier and my mind is clearer.’ I still need to spend much less time on garbage activities.
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@kenhnsy Dihexa and DMSO. How did you mix it?
I put DMSO into a 3ml vial of 1g of Dihexa, hoping I could dispense it via a syringe and blunt needle.
Not so. It makes a viscous paste. So I used a micro scoop to meter it out for sublingual use. This definitely worked. But I can't be sure it was better than just cutting it with theanine powder, grinding it all in a mortar and pestle, then making pills.
I was going by someone's claim that the DMSO makes Dihexa more absorbant. I have no comparision to make even a poor data point. But this is an easy method. Just weigh everything and find a scoop volume that works out to your dose. -
Most of my knowledge of DMSO goes back to when I was a kid and people were using it for all sorts of things to rub on their skin for pain relief or performance enhancement. And then it disappeared as many sources for it disappeared. My understanding is that DMSO has exceedingly high absorption/penetration so whatever is in it or on your skin when you wipe it on is getting absorbed into your system.
I hadn’t heard of injecting dihexa, and I know it’s a bit challenging to make capsules consistently, or at least it is in this space. I suppose you could try dissolving it in DMSO and rub it on your skin, if you could measure consistently.
Edit: I guess pure DMSO is pretty cheap and available on Amazon if one was interested in experimentation. I think I just came up with a peptide cream business plan.
Yeah, well, I’m just here for the research, man. - The Dude
If I haven’t liked your post, no offense. I have exceeded my daily allowance.
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Most of my knowledge of DMSO goes back to when I was a kid and people were using it for all sorts of things to rub on their skin for pain relief or performance enhancement. And then it disappeared as many sources for it disappeared. My understanding is that DMSO has exceedingly high absorption/penetration so whatever is in it or on your skin when you wipe it on is getting absorbed into your system.
I hadn’t heard of injecting dihexa, and I know it’s a bit challenging to make capsules consistently, or at least it is in this space. I suppose you could try dissolving it in DMSO and rub it on your skin, if you could measure consistently.
Edit: I guess pure DMSO is pretty cheap and available on Amazon if one was interested in experimentation. I think I just came up with a peptide cream business plan.
I suppose you could try dissolving it in DMSO and rub it on your skin
I have been wanting to try this. This guy https://www.youtube.com/@ultimateformulations told me that an easy transdermal delivery vehicle is 40% DMSO and 60% glycerin. Watch out for the fact that 25% of people will smell DMSO as the worst body odor known to man. I found out the hard way.
Putting a dab onto a piece of paper medical tape would be pretty easy. However, given my notoriety as a peptide freak, I am hesitant to start walking around with pieces of tape attached randomly to my body parts. -
@kenhnsy Dihexa and DMSO. How did you mix it?
I put DMSO into a 3ml vial of 1g of Dihexa, hoping I could dispense it via a syringe and blunt needle.
Not so. It makes a viscous paste. So I used a micro scoop to meter it out for sublingual use. This definitely worked. But I can't be sure it was better than just cutting it with theanine powder, grinding it all in a mortar and pestle, then making pills.
I was going by someone's claim that the DMSO makes Dihexa more absorbant. I have no comparision to make even a poor data point. But this is an easy method. Just weigh everything and find a scoop volume that works out to your dose.@kenhnsy So you reconstituted 3ml of dmso in a 3ml bottle with 1g of dihexa to inject? My brother just stop there. DMSO is nothing to mess around with. I have a bottle of DMSO trying to figure out how to safely apply it. I just want to know how much you sublingual. Guess it worked.
Later I will test peptides transdermal or topical drug delivery and DMSO will be in the mix.
L-theamine and coffee the best!
2M
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I suppose you could try dissolving it in DMSO and rub it on your skin
I have been wanting to try this. This guy https://www.youtube.com/@ultimateformulations told me that an easy transdermal delivery vehicle is 40% DMSO and 60% glycerin. Watch out for the fact that 25% of people will smell DMSO as the worst body odor known to man. I found out the hard way.
Putting a dab onto a piece of paper medical tape would be pretty easy. However, given my notoriety as a peptide freak, I am hesitant to start walking around with pieces of tape attached randomly to my body parts.I suppose you could try dissolving it in DMSO and rub it on your skin
Watch out for the fact that 25% of people will smell DMSO as the worst body odor known to man.
Apparently, many of my coworkers are using DMSO and I only just now realized it.
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@kenhnsy So you reconstituted 3ml of dmso in a 3ml bottle with 1g of dihexa to inject? My brother just stop there. DMSO is nothing to mess around with. I have a bottle of DMSO trying to figure out how to safely apply it. I just want to know how much you sublingual. Guess it worked.
Later I will test peptides transdermal or topical drug delivery and DMSO will be in the mix.
L-theamine and coffee the best!
@kenhnsy So you reconstituted 3ml of dmso in a 3ml bottle with 1g of dihexa to inject?
NOT TO INJECT.
The ratio was something close to that. It did not make a solution and my DMSO was not RUO quality. Given the efficacy of sublingual use, I doubt it is worth going to the trouble of injecting. I could not find the solubility info for this mix and it is too expensive to play with.
I would have rather used a liquid dispensed through a syringe to meter for sublingual use. But DMSO is a weird substance that likes to freeze depending on what type of container it is in. So be sure you weigh everything as you go so you can know how much is in a given volume (scoop). -
@kenhnsy that’s great to hear. I hope I feel the same. I’m interested in the Adamax as well and have thought about ordering some.
I have some Cerebrolysin in the 2ml ampules. I’ve been nervous to try them as it’s my understanding the minimum dose is 2-5 ml intramuscularly which is above anything I’ve researched with to date.
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@kenhnsy So you reconstituted 3ml of dmso in a 3ml bottle with 1g of dihexa to inject? My brother just stop there. DMSO is nothing to mess around with. I have a bottle of DMSO trying to figure out how to safely apply it. I just want to know how much you sublingual. Guess it worked.
Later I will test peptides transdermal or topical drug delivery and DMSO will be in the mix.
L-theamine and coffee the best!
how much you sublingual
15 mg daily was plenty of an effect for me.
I have never had a problem handling DMSO nor taking a tablespoon orally. I think there is an urban fear that one will immediately dissolve into a puddle of amino acids if you touch it. -
I suppose you could try dissolving it in DMSO and rub it on your skin
Watch out for the fact that 25% of people will smell DMSO as the worst body odor known to man.
Apparently, many of my coworkers are using DMSO and I only just now realized it.
@ResearchCat I am going to open and take a wiff for science. Mine is still sealed.
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how much you sublingual
15 mg daily was plenty of an effect for me.
I have never had a problem handling DMSO nor taking a tablespoon orally. I think there is an urban fear that one will immediately dissolve into a puddle of amino acids if you touch it. -
@researchcat I had a similiar experience to yours with Semax. I did not like the effects of it at all. It made me highly irritable.
@researchcat I had a similiar experience to yours with Semax. I did not like the effects of it at all. It made me highly irritable.
I have only tried Adamax (but would love to try Dihexa at some point). I didn’t put two and two together right away but the Adamax made me not only a bit irritable most of the time, but also much more prone to angry outbursts.
Had to stop.Retired chemist & pharmacy tech.
Seeking lower $/mg, with robust COA’s -
@researchcat I had a similiar experience to yours with Semax. I did not like the effects of it at all. It made me highly irritable.
I have only tried Adamax (but would love to try Dihexa at some point). I didn’t put two and two together right away but the Adamax made me not only a bit irritable most of the time, but also much more prone to angry outbursts.
Had to stop.@CMEffie17 I have Semax, Selank, Adamax, Celebrolysin, NAD+, GHKcu, Retatrutide in 5-10ml nasal sprayers. Yes I am researching all intranasal, focusing on the brain. As for Adamax, I have 10mg in 8ml and it is nothing to sit around considering the half life. Perfect for an active life. Semax you have a little more control due to the shorter half life, it kick in right away. Selank for stress, anxiety, cognitive fatigue. Too much will put you sleep. You have to find their sweet spot. If you feel they are too much dilute and titrate up for better control. That goes with all nootropics and peptide that have a quick onset. Learn how to microdose and titrate up. I use to bite off pills till I felt it right. Be patient.
I been researching oral phamalogical and natural nootropics for years. Peptides are at a whole different level. This round of peptide I will be ordering Dihexa, Pinealon to research and looking for a good deal on NA-Selank. I will also restock on the following:
CDP- Choline
Modafinil
Bromantane
9-MeBc
Alpha gpc
Noopept
Adamax
Semax and Selank.
*Hint hint... looking for deals2M
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@CMEffie17 I have Semax, Selank, Adamax, Celebrolysin, NAD+, GHKcu, Retatrutide in 5-10ml nasal sprayers. Yes I am researching all intranasal, focusing on the brain. As for Adamax, I have 10mg in 8ml and it is nothing to sit around considering the half life. Perfect for an active life. Semax you have a little more control due to the shorter half life, it kick in right away. Selank for stress, anxiety, cognitive fatigue. Too much will put you sleep. You have to find their sweet spot. If you feel they are too much dilute and titrate up for better control. That goes with all nootropics and peptide that have a quick onset. Learn how to microdose and titrate up. I use to bite off pills till I felt it right. Be patient.
I been researching oral phamalogical and natural nootropics for years. Peptides are at a whole different level. This round of peptide I will be ordering Dihexa, Pinealon to research and looking for a good deal on NA-Selank. I will also restock on the following:
CDP- Choline
Modafinil
Bromantane
9-MeBc
Alpha gpc
Noopept
Adamax
Semax and Selank.
*Hint hint... looking for deals@CMEffie17 I have Semax, Selank, Adamax, Celebrolysin, NAD+, GHKcu, Retatrutide in 5-10ml nasal sprayers. Yes I am researching all intranasal, focusing on the brain. As for Adamax, I have 10mg in 8ml and it is nothing to sit around considering the half life. Perfect for an active life. Semax you have a little more control due to the shorter half life, it kick in right away. Selank for stress, anxiety, cognitive fatigue. Too much will put you sleep. You have to find their sweet spot. If you feel they are too much dilute and titrate up for better control. That goes with all nootropics and peptide that have a quick onset. Learn how to microdose and titrate up. I use to bite off pills till I felt it right. Be patient.
These are excellent points! Maybe I should try it again just a more dilute, or much smaller dose. Thanks for the encouragement! And good luck to you with all that you are doing which sounds (daunting!)
Impressed! 
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I'm very interested in dihexa from a neuroprotective standpoint. Seems you can get in lyophilized powder for subq/intranasal injection or in pill form?
One of my gray suppliers doesn't have it on 'her' sheet. I would view this as a long term protective play from using exogenous testosterone and overall aging.
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@kenhnsy that’s great to hear. I hope I feel the same. I’m interested in the Adamax as well and have thought about ordering some.
I have some Cerebrolysin in the 2ml ampules. I’ve been nervous to try them as it’s my understanding the minimum dose is 2-5 ml intramuscularly which is above anything I’ve researched with to date.
@TBone
I’m in the middle of trying this right now and I gotta tell you that this stuff injects im incredibly smoothly. It’s the weirdest thing. I did 3 mL in my butt threw a 28 gauge and it just goes in there without any discomfort.That said I’ve got the 5 mL vials and I’m disinclined to inject 5 mL at a time so I split it up into several doses about 2 to 3 mL every day.
You do need to make sure that you filter out any glass though
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