AOD-9604 Research Dosing Protocol
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@Randy Can you explain a little about the MOTS-C allergic reaction people are experiencing? What type of symptoms?
@maryshafer rash, hives anaphylaxis. Or nothing.
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@Randy the 10mg in a 3ml bottle is a lot? LA Pep sells this way only. I also noticed it ran clear immediately after introducing the BAC at 3ML. The Nexaph product has to be swiveled several minutes to run clear. Makes me wonder. Also noticed some clear specks in the bottle...look like sugar after about a week of being reconstituted. Never seen that before. Any thoughts? Thanks in advance for any input.
@maryshafer whos NAD has flakes?
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@maryshafer rash, hives anaphylaxis. Or nothing.
@Randy wow - thanks
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@maryshafer whos NAD has flakes?
@Randy LA Peptides which surprised me. They have good reviews and high test scores. Sorry i didn't clarify it wasn't Nexaph
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@Randy LA Peptides which surprised me. They have good reviews and high test scores. Sorry i didn't clarify it wasn't Nexaph
@randy sorry for the confusion. It isn't the NAD that had flakes it was the AOD-9604 I got from LA Pep.
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P PeptideCritic moved this topic from Weight Management Peptides on
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to be quite honest ive had zero effects at 250mcg split twice a day. thinking of bumping to 500 twice. like if all this gives my ts is gas its going to be a waste of 3 vials. lol
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AOD-9604 mobilizes fat out of the cells, but that fat must be then used up, or it will be stored again. That's why it needs to be paired with fasting or caloric restriction, which can be facilitated with GLP1 RA like Reta, and it's not very effective by itself, without a dietary change. That's why its studies were stopped.
attentiion is all you need
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AOD-9604 mobilizes fat out of the cells, but that fat must be then used up, or it will be stored again. That's why it needs to be paired with fasting or caloric restriction, which can be facilitated with GLP1 RA like Reta, and it's not very effective by itself, without a dietary change. That's why its studies were stopped.
@vpeptides yeah if you pair it with reta i think it helps. if i could find a source on bam or atx id probably add that.
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Currently Rosie rate on 10-12 of Tirzep, NAD+ tid, and would like to add AOD. Her last food is about 6pm, and it's just a few bites. She's gets up in the morning with me at 4:30, so thinking that's a long enough fast. AOD seems like an expensive experiment, esp when I'm not sure of her exercise (called into work a lot). What she really wants is Tesamorelin, but she's had skin cancer (1 spot on leg) and is old. Will ask about this on another thread because she really wants it!
Proud to be on a gubmint watch list
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Currently Rosie rate on 10-12 of Tirzep, NAD+ tid, and would like to add AOD. Her last food is about 6pm, and it's just a few bites. She's gets up in the morning with me at 4:30, so thinking that's a long enough fast. AOD seems like an expensive experiment, esp when I'm not sure of her exercise (called into work a lot). What she really wants is Tesamorelin, but she's had skin cancer (1 spot on leg) and is old. Will ask about this on another thread because she really wants it!
@Eleanor I am interested in this also because I had melanoma in situ last year, but would like to take tesa.
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.2-.5 mg. Start with .2 or lower to test tolerance and make sure you dont have a reaction.
As far as reconstituting https://www.youtube.com/watch?v=U5i_g6ZhAU0
@Randy thank you for the video. Have you had any luck transferring the AOD to a pen cartridge? With no air in it does it help prevent gel issues?
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@Eleanor I am interested in this also because I had melanoma in situ last year, but would like to take tesa.
@Hammertime65 I don't have melanoma, but have BC carcinoma on a leg (getting it cut out tomorrow). Depending upon how much is there, I'm going to low-dose Tesa, let it simmer a while before increase in dose. I'm more likely to die earlier from the visceral fat than something else, excluding 'accidents', etc.
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@hammertime65 Found this on Penguin. Will try Tesa test using a couple of vials at discount, plus a vile.
30% OFF + FREE Peptide per $150 spend – code: RESEARCH30 -
AOD-9604 is a modified C-terminal fragment of human growth hormone (177–191) commonly researched for its lipolytic and anti-lipogenic properties.
It does not meaningfully affect IGF-1 in human studies and tends to have a mild, well-tolerated profile.
Most research models use once-daily subcutaneous administration.Daily Dosing Protocol (Subcutaneous)
Standard Daily Range
YOUR RAT MUST BE FASTED 4 hours prior and 2 hours post injection
200–500 mcg once daily
Administered at approximately the same time each day.
Titration Schedule
Weeks 1–2
200 mcg daily
Establishes baseline tolerability.
Weeks 3–6
400 mcg daily
Mild step-up for increased activity.
Weeks 6–12 (OPTIONAL)
500 mcg daily
Often considered the “working dose.”
Common upper-end daily dose used in longer metabolic research cycles.
Cycle Length
Typical AOD-9604 research cycles:
6–12 weeks on protocol
Optional 2–4 week break before repeating, depending on research goals.
AOD is mild enough that some researchers run it continuously, but cyclical patterns are still common.
Alternate Approaches
Twice-Daily Split
200–300 mcg twice daily
Used when the goal is more constant lipolytic signaling throughout the day.
Training-Day Bias
Dose in the morning or pre-training, depending on preference.
No consensus on timing — daily consistency matters more.
Common Research Notes
AOD-9604’s effects tend to be subtle and cumulative rather than acute.
Works best when paired with caloric control or increased physical activity.
Side effects are minimal; occasional mild flushing or warmth at the injection site may occur.
Reconstitution Instructions
https://www.youtube.com/watch?v=U5i_g6ZhAU0@Randy Since the original video is was ripped away from us (Thanks alot traitor tube!!) Would you be willing to upload that AOD-9604 Reconstitution Video to Randytube or Rumble. I have been searching everywhere since hearing your mention of it on the Acetic Acid Video..
Thank you for sharing your knowledge with us all.
John -
@Randy Since the original video is was ripped away from us (Thanks alot traitor tube!!) Would you be willing to upload that AOD-9604 Reconstitution Video to Randytube or Rumble. I have been searching everywhere since hearing your mention of it on the Acetic Acid Video..
Thank you for sharing your knowledge with us all.
John@J_Viibe said:
@Randy Since the original video is was ripped away from us (Thanks alot traitor tube!!) Would you be willing to upload that AOD-9604 Reconstitution Video to Randytube or Rumble. I have been searching everywhere since hearing your mention of it on the Acetic Acid Video..
Thank you for sharing your knowledge with us all.
JohnI can sort of sum it up as I follow what Randy had in the video. Use good Bac water and if your AOD9604 quality is good you won’t have gelling. No need for any Acetic Acid.
I use 3ml of Hospira Bac water into 5mg vials of AOD-9604 and inject slowly down the side of the vial. Once all the bac water is in I slightly lift up the syringe so it sits above the liquid solution and then pull back on the syringe plunger to remove any excess air out of the vial that I am able to get and then take the syringe out of the vial completely. Then I gently roll for a couple mins, let it sit, repeat a couple more times, and I have a perfectly clear reconstituted vial of AOD-9604. I then put it through a filter and into a 3ml pen cartridge. I haven’t had a vial gel up ever since doing it this way.
Edit: I feel like the real game changer here in avoiding the gelling is removing the excess air from the vial. I think that’s what used to cause the gelling for me.
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