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Klotho / FLGR242 (albumin-bound new tech)

Scheduled Pinned Locked Moved Peptide Discussion
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586 Posts 41 Posters 62.9k Views 9 Watching
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  • mmpM mmp

    @mole In your body it will stick to albumin and swim around with it

    M Offline
    M Offline
    mole
    wrote last edited by
    #539

    @mmp Yup thx remember that - just don't understand the relationship to temperature.

    M 1 Reply Last reply
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    • M mole

      @mmp Yup thx remember that - just don't understand the relationship to temperature.

      M Offline
      M Offline
      mole
      wrote last edited by
      #540

      I emailed BLL again, hopefully they will respond.

      vpepsV 1 Reply Last reply
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      • M mole

        I emailed BLL again, hopefully they will respond.

        vpepsV Offline
        vpepsV Offline
        vpeps
        wrote last edited by vpeps
        #541

        @mole They will, but what can you expect to hear? Nobody knows what happened in your particular case for your particular conditions. It can be guessed it lost a few percents of the complete proteins (those are long about 200 amino acid molecules). But I guess nothing bad will happen if you use it, maybe just a slightly less effectiveness, which will be unmeasurable in the long run.

        Here is your answer in advance https://jaycampbell.com/blog/how-to-store-reconstituted-peptides/

        attentiion is all you need

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        • O Offline
          O Offline
          ogsteve
          wrote last edited by
          #542
          This post is deleted!
          1 Reply Last reply
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          • M Offline
            M Offline
            mole
            wrote last edited by
            #543

            Response from BLL - IMO very informative. As I said before, I love learning and never settle for answers that are "should be" "probably ok" and the likes.

            Here is the response:
            Thank you for the thoughtful question, and we’re glad to hear you’ve been pleased with the product.
            The two concepts are actually measuring different things. Stability in a vial refers to how well the reconstituted peptide maintains its chemical and physical integrity while being stored. Temperature, time, pH, light, oxidation, and other factors can contribute to degradation, which is why refrigeration is recommended after reconstitution.
            A half-life in the body, on the other hand, describes how quickly a compound is cleared or metabolized after it enters a biological system. The environment inside the body is very different from a vial sitting at room temperature. Protein binding, including albumin binding, can affect distribution and can protect a compound from rapid clearance or degradation, thereby extending its circulating half-life.
            So, a compound can require refrigerated storage after reconstitution while still having a comparatively long biological half-life at body temperature. The storage-stability timeframe and biological half-life are not directly interchangeable.
            Because our products are sold strictly for research use only, we aren't able to provide guidance regarding human administration or individual use. However, I hope this helps clarify the distinction between storage stability and biological half-life.

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            • ResearchCatR Offline
              ResearchCatR Offline
              ResearchCat
              wrote last edited by
              #544

              I’m sure those of you on the BLL mailing lists have seen the announcements that they are significantly lowering prices for klotho and FLGR242 going forward. For everyone else, regular pricing of $299/2 vials. Much more ‘affordable’ now. 😉

              Yeah, well, I’m just here for the research, man. - The Dude

              If I haven’t liked your post, no offense. I have exceeded my daily allowance.

              D 1 Reply Last reply
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              • ResearchCatR ResearchCat

                I’m sure those of you on the BLL mailing lists have seen the announcements that they are significantly lowering prices for klotho and FLGR242 going forward. For everyone else, regular pricing of $299/2 vials. Much more ‘affordable’ now. 😉

                D Offline
                D Offline
                denti
                wrote last edited by
                #545

                @ResearchCat said:

                I’m sure those of you on the BLL mailing lists have seen the announcements that they are significantly lowering prices for klotho and FLGR242 going forward. For everyone else, regular pricing of $299/2 vials. Much more ‘affordable’ now. 😉

                I did not get the email. Thanks for the update though.

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                • ResearchCatR Offline
                  ResearchCatR Offline
                  ResearchCat
                  wrote last edited by
                  #546

                  Well, it’s not a secret, so here you go.
                  IMG_3554.jpeg

                  Yeah, well, I’m just here for the research, man. - The Dude

                  If I haven’t liked your post, no offense. I have exceeded my daily allowance.

                  1 Reply Last reply
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                  • MacLeeezyM Offline
                    MacLeeezyM Offline
                    MacLeeezy
                    wrote last edited by MacLeeezy
                    #547

                    4 week update- I’ve been noticeably stronger in the gym lately and have actually set a few PR’s. Still way more vascular than normal. I’d been averaging 8-10lbs weight loss a month. Since starting FLGR it has slowed to maybe 1-2lbs but my smart scale shows fat decreasing and muscle increasing. Disclaimer: I started enclomaphine around the same time so there’s really no telling which one is doing the heavy lifting but my test went from 677 to 900 on 6.25mg of Enclo daily. Taking 2 vials of slim assist every Sunday. It’s either working, the increased testosterone is working, or isflex.jpg a top tier placebo. Either way I’m happy thus far

                    D P 2 Replies Last reply
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                    • MacLeeezyM MacLeeezy

                      4 week update- I’ve been noticeably stronger in the gym lately and have actually set a few PR’s. Still way more vascular than normal. I’d been averaging 8-10lbs weight loss a month. Since starting FLGR it has slowed to maybe 1-2lbs but my smart scale shows fat decreasing and muscle increasing. Disclaimer: I started enclomaphine around the same time so there’s really no telling which one is doing the heavy lifting but my test went from 677 to 900 on 6.25mg of Enclo daily. Taking 2 vials of slim assist every Sunday. It’s either working, the increased testosterone is working, or isflex.jpg a top tier placebo. Either way I’m happy thus far

                      D Offline
                      D Offline
                      denti
                      wrote last edited by
                      #548

                      @MacLeeezy said:

                      4 week update- I’ve been noticeably stronger in the gym lately and have actually set a few PR’s. Still way more vascular than normal. I’d been averaging 8-10lbs weight loss a month. Since starting FLGR it has slowed to maybe 1-2lbs but my smart scale shows fat decreasing and muscle increasing. Disclaimer: I started enclomaphine around the same time so there’s really no telling which one is doing the heavy lifting but my test went from 677 to 900 on 6.25mg of Enclo daily. Taking 2 vials of slim assist every Sunday. It’s either working, the increased testosterone is working, or is the a top tier placebo. Either way I’m happy thus far

                      I am also taking enclomiphine but 12.5mg 3x a week and 1 vial of slim assist (2mg FLGR) weekly. It's been 6 weeks for me. Did you titrate up to 2 vials of slim assist or did you just start off at 2 vials? I'm thinking of moving up on it but wondering if I should do 2 vials at once or split it between the week. Interested in hearing your protocol as we seem to be on the same thing.

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                      • MacLeeezyM Offline
                        MacLeeezyM Offline
                        MacLeeezy
                        wrote last edited by
                        #549

                        i started at a single vial for 2 weeks. and then went up to two vials. im told that i probably titrated up too fast but now that im here i should hold for 90 days before going any further.

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                        • ImaFrogNotaRatI Offline
                          ImaFrogNotaRatI Offline
                          ImaFrogNotaRat
                          wrote last edited by ImaFrogNotaRat
                          #550

                          Yesterday, JC hosted Mike Farber again who basically answered questions about Alpha-Klotho, FLGR-242, and BioLean, which will soon be available. He also mentioned the drop in price for the signature peptides. I do have the Jamie AI Executive Summary of the talk.

                          FLGR-242 Klotho Farber Jay.pdf

                          The epigenome is malleable. Squish responsibly.

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                          • D Offline
                            D Offline
                            denti
                            wrote last edited by
                            #551

                            I wish I bought more of Slim Assist in that deal a little while back. This pricing of 299/2 vials of FLGR242 is way too expensive in comparison to slim assist which came out to $17 a vial for me.

                            ImaFrogNotaRatI vpepsV 2 Replies Last reply
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                            • D denti

                              I wish I bought more of Slim Assist in that deal a little while back. This pricing of 299/2 vials of FLGR242 is way too expensive in comparison to slim assist which came out to $17 a vial for me.

                              ImaFrogNotaRatI Offline
                              ImaFrogNotaRatI Offline
                              ImaFrogNotaRat
                              wrote last edited by
                              #552

                              @denti I imagine there may be a holiday special coming up. 'tis the season to be scared and thankful?! 🎃 👹 🌽 🎄

                              The epigenome is malleable. Squish responsibly.

                              1 Reply Last reply
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                              • Mr SmurfM Offline
                                Mr SmurfM Offline
                                Mr Smurf
                                wrote last edited by
                                #553

                                20260927_150704.jpg
                                Stuffs pretty rad

                                P 1 Reply Last reply
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                                • D denti

                                  I wish I bought more of Slim Assist in that deal a little while back. This pricing of 299/2 vials of FLGR242 is way too expensive in comparison to slim assist which came out to $17 a vial for me.

                                  vpepsV Offline
                                  vpepsV Offline
                                  vpeps
                                  wrote last edited by
                                  #554

                                  @denti Slim Assist is still available.

                                  attentiion is all you need

                                  D 2 Replies Last reply
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                                  • vpepsV vpeps

                                    @denti Slim Assist is still available.

                                    D Offline
                                    D Offline
                                    denti
                                    wrote last edited by denti
                                    #555

                                    @vpeps said:

                                    @denti Slim Assist is still available.

                                    Really? Link me please.

                                    Edit: Sorry I am dumb. I see you did link me. Thank you.

                                    Edit 2: This comes out to about $32 a vial vs the $17 a couple months back. I think couple months ago it was on sale an then the jayc code on top to drop the price to $17 a vial.

                                    vpepsV 1 Reply Last reply
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                                    • T Offline
                                      T Offline
                                      The Spatalian
                                      wrote last edited by
                                      #556

                                      Been on FLGR for 15 weeks. Started at 2.5mg. After zero change. I upped to 5 the last 4 weeks. Have put on a few pounds of muscle. And FAT. But keep in mind. According to the manufacturer. You have to up your calories 50-75% above BMR. REALLY hard to do. I maintain my 170-200 grams of protein.
                                      Here's what Ive taken into account. I increased the intensity of strength training. Just because I don't want that to be a reason I'm not seeing gains. My Sleep averages 7.5 hours of quality sleep. I eliminated all other peptides. Just to not affect results.
                                      I'm 68. 180# 14% body fat (Dexa every month) been strength training for 50+ years. Retired from the fitness industry. Very disciplined.
                                      My take? Not worth the price. More hype than science (which there is none of) and think I should have gone a HG peptides route or just HGH. Do need to mention I've been on TRT for 8 years and maintain excellent blood markers across the board. Maybe I'm just a non responder?
                                      Good on all of those who claim huge increases in muscle mass after a couple of months. But...until I see MRI scans proving that. Or really know what's in the vials? I'll not continue FLGR-242

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                                      • P PeptidePete

                                        Quick follow-up on the new Kimera Chems Na Salt-form O-304. It's potent, I'm quite fine on 50-100mg of it vs 400-600mg of the free-acid versions being sold by EVERYONE else. Homework is your friend, once again.

                                        The 5-Amino-1MQ 50mg tabs from QSC are great, one less ting I have to pin and far more cost effective (cost per mg). No negs that I can discern.

                                        Again do your homework. For those who enjoy him, Nick Norwitz has some thought-provoking papers on both. Check his Substack.

                                        I'd suggest both of these are oriented towards those looking to fine-tune what is already a well optimized regimen and body.

                                        My research with SS-31 at 60mg per day, every day, remains ongoing.

                                        T Offline
                                        T Offline
                                        The Spatalian
                                        wrote last edited by
                                        #557

                                        @PeptidePete what's your monthly cost for SS-31 @ that dose? Must be a luxury car payment!

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                                        • D denti

                                          @vpeps said:

                                          @denti Slim Assist is still available.

                                          Really? Link me please.

                                          Edit: Sorry I am dumb. I see you did link me. Thank you.

                                          Edit 2: This comes out to about $32 a vial vs the $17 a couple months back. I think couple months ago it was on sale an then the jayc code on top to drop the price to $17 a vial.

                                          vpepsV Offline
                                          vpepsV Offline
                                          vpeps
                                          wrote last edited by
                                          #558

                                          @denti yes, they had one of their 50% off sales. I am sure they will have another one in the future. But they still keep that "buy 10 get 15 free" going for SlimAssist.

                                          attentiion is all you need

                                          1 Reply Last reply
                                          2

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